Selective Lanthanide Sensing with Gold Nanoparticles and Hydroxypyridinone Chelators

Journal Article · 22 January 2020 · Inorganic Chemistry

DOI: https://doi.org/10.1021/acs.inorgchem.9b03393 · OSTI ID:1631627

Pallares, Roger M. ^[1]; Carter, Korey P.  ^[1]; Zeltmann, Steven E. ^[1]; Tratnjek, Toni ^[2]; Minor, Andrew M. ^[3]; Abergel, Rebecca J.  ^[3]

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1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States
3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)

The octadentate hydroxypyridinone chelator 3,4,3-LI(1,2-HOPO) is a promising therapeutic agent because of its high affinity for f-block elements and noncytotoxicity at medical dosages. The interaction between 3,4,3-LI(1,2-HOPO) and other biomedically relevant metals such as gold, however, has not been explored. Gold nanoparticles functionalized with chelators have demonstrated great potential in theranostics, yet thus far, no protocol that combines 3,4,3-LI(1,2-HOPO) and colloidal gold has been developed. Here, we characterize the solution thermodynamic properties of the complexes formed between 3,4,3-LI(1,2-HOPO) and Au³⁺ ions and demonstrate how under specific pH conditions the chelator promotes the growth of gold nanoparticles, acting as both reducing and stabilizing agent. 3,4,3-LI(1,2-HOPO) ligands on the nanoparticle surface remain active and selective toward f-block elements, as evidenced by gold nanoparticle selective aggregation. Finally, a new colorimetric assay capable of reaching the detection levels necessary for the quantification of lanthanides in waste from industrial processes is developed based on the inhibition of particle growth by lanthanides.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division
• Grant/Contract Number: AC02-05CH11231
• OSTI ID: 1631627
• Journal Information: Inorganic Chemistry, Journal Name: Inorganic Chemistry Journal Issue: 3 Vol. 59; ISSN 0020-1669; ISSN 1520-510X
• Publisher: American Chemical Society (ACS)Copyright Statement
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
gold
lanthanides
mechanisms of action
metal nanoparticles
nanoparticles