The C‐Terminal Domain of α‐Synuclein Confers Steric Stabilization on Synaptic Vesicle‐Like Surfaces

Chung, Peter J.; Hwang, Hyeondo Luke; Slaw, Benjamin R.; Leong, Alessandra; Adams, Erin J.; Lee, Ka Yee C.

doi:10.1002/admi.201902151

Title: The C‐Terminal Domain of α‐Synuclein Confers Steric Stabilization on Synaptic Vesicle‐Like Surfaces

Authors:

^[1]; Hwang, Hyeondo Luke ^[2]; Slaw, Benjamin R. ^[2]; Leong, Alessandra ^[2]; Adams, Erin J. ^[3];

^[1]

Department of Chemistry The University of Chicago Chicago IL 60637 USA, James Franck Institute The University of Chicago Chicago IL 60637 USA, Institute for Biophysical Dynamics The University of Chicago Chicago IL 60637 USA
Department of Chemistry The University of Chicago Chicago IL 60637 USA
Department of Biochemistry and Molecular Biology The University of Chicago Chicago IL 60637 USA

Publication Date:: 2020-05-27

Sponsoring Org.:: USDOE

OSTI Identifier:: 1630949

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Advanced Materials Interfaces

Additional Journal Information:: Journal Name: Advanced Materials Interfaces Journal Volume: 7 Journal Issue: 14; Journal ID: ISSN 2196-7350

Publisher:: Wiley Blackwell (John Wiley & Sons)

Country of Publication:: Germany

Language:: English

Citation Formats


                    Chung, Peter J., Hwang, Hyeondo Luke, Slaw, Benjamin R., Leong, Alessandra, Adams, Erin J., and Lee, Ka Yee C. The C‐Terminal Domain of α‐Synuclein Confers Steric Stabilization on Synaptic Vesicle‐Like Surfaces.  Germany: N. p., 2020. 
Web.  doi:10.1002/admi.201902151.

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                    Chung, Peter J., Hwang, Hyeondo Luke, Slaw, Benjamin R., Leong, Alessandra, Adams, Erin J., & Lee, Ka Yee C. The C‐Terminal Domain of α‐Synuclein Confers Steric Stabilization on Synaptic Vesicle‐Like Surfaces.  Germany.  https://doi.org/10.1002/admi.201902151

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                    Chung, Peter J., Hwang, Hyeondo Luke, Slaw, Benjamin R., Leong, Alessandra, Adams, Erin J., and Lee, Ka Yee C. Wed .  
"The C‐Terminal Domain of α‐Synuclein Confers Steric Stabilization on Synaptic Vesicle‐Like Surfaces".  Germany.  https://doi.org/10.1002/admi.201902151.

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@article{osti_1630949,

  title        = {The C‐Terminal Domain of α‐Synuclein Confers Steric Stabilization on Synaptic Vesicle‐Like Surfaces},

  author       = {Chung, Peter J. and Hwang, Hyeondo Luke and Slaw, Benjamin R. and Leong, Alessandra and Adams, Erin J. and Lee, Ka Yee C.},

  abstractNote = {},

  doi          = {10.1002/admi.201902151},

  journal      = {Advanced Materials Interfaces},

  number       = 14,

  volume       = 7,

  place        = {Germany},

  year         = {2020},

  month        = {5}

}

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Title: The C‐Terminal Domain of α‐Synuclein Confers Steric Stabilization on Synaptic Vesicle‐Like Surfaces

Citation Formats

Calcium-Triggered Membrane Interaction of the α-Synuclein Acidic Tail † journal, September 2006

Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities journal, October 2012

Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli journal, December 2010

Osmotic Shock-Triggered Assembly of Highly Charged, Nanoparticle-Supported Membranes journal, October 2018

Direct Measurement of Polyethylene Glycol Induced Depletion Attraction between Lipid Bilayers journal, January 1996

α-Synuclein Sterically Stabilizes Spherical Nanoparticle-Supported Lipid Bilayers journal, February 2019

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Polyelectrolyte Brush Interaction with Multivalent Ions journal, November 1999

Synucleins in synaptic plasticity and neurodegenerative disorders journal, September 1999

Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain journal, December 2004

Conformational Properties of the SDS-Bound State of α-Synuclein Probed by Limited Proteolysis: Unexpected Rigidity of the Acidic C-Terminal Tail † journal, September 2006

Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment journal, July 2016

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The Aggregation and Fibrillation of α-Synuclein journal, September 2006

Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules journal, October 2015

Distinct Roles of the N-terminal-binding Domain and the C-terminal-solubilizing Domain of α-Synuclein, a Molecular Chaperone journal, May 2002

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction journal, February 2018

Swelling and collapse of polyelectrolyte gels in equilibrium with monovalent and divalent electrolyte solutions journal, January 2009

Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules journal, November 2015

α-Synuclein as an intrinsically disordered monomer - fact or artefact? journal, September 2013

Aggregation promoting C-terminal truncation of -synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations journal, January 2005

Aggregation of Heterogeneously Charged Colloids journal, May 2016

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded † journal, January 1996

Colloid stabilization with grafted polyelectrolytes journal, May 1991

Alpha-Synuclein Function and Dysfunction on Cellular Membranes journal, December 2014

Depletion-Induced Shape and Size Selection of Gold Nanoparticles journal, April 2010

An improved fit to Website osmotic pressure data journal, September 1997

The number of α-synuclein proteins per vesicle gives insights into its physiological function journal, August 2016

Synucleins Have Multiple Effects on Presynaptic Architecture journal, January 2017

Calcium-Triggered Membrane Interaction of the α-Synuclein Acidic Tail ^†
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Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
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Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli
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Osmotic Shock-Triggered Assembly of Highly Charged, Nanoparticle-Supported Membranes
journal, October 2018

Direct Measurement of Polyethylene Glycol Induced Depletion Attraction between Lipid Bilayers
journal, January 1996

α-Synuclein Sterically Stabilizes Spherical Nanoparticle-Supported Lipid Bilayers
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Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright
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Polyelectrolyte Brush Interaction with Multivalent Ions
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Synucleins in synaptic plasticity and neurodegenerative disorders
journal, September 1999

Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain
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Conformational Properties of the SDS-Bound State of α-Synuclein Probed by Limited Proteolysis: Unexpected Rigidity of the Acidic C-Terminal Tail ^†
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Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
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Tryptophan Probes at the α-Synuclein and Membrane Interface
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The Aggregation and Fibrillation of α-Synuclein
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Distinct Roles of the N-terminal-binding Domain and the C-terminal-solubilizing Domain of α-Synuclein, a Molecular Chaperone
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C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
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Swelling and collapse of polyelectrolyte gels in equilibrium with monovalent and divalent electrolyte solutions
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NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded ^†
journal, January 1996

Colloid stabilization with grafted polyelectrolytes
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Depletion-Induced Shape and Size Selection of Gold Nanoparticles
journal, April 2010

An improved fit to Website osmotic pressure data
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