Systems and Photosystems: Cellular Limits of Autotrophic Productivity in Cyanobacteria
Abstract
Recent advances in the modeling of microbial growth and metabolism have shown that growth rate critically depends upon the optimal allocation of finite proteomic resources among different cellular functions and that modeling growth rates becomes more realistic with the explicit accounting for the costs of macromolecular synthesis, most importantly, protein expression. The “proteomic constraint” is considered together with its application to understanding photosynthetic microbial growth. The central hypothesis is that physical limits of cellular space (and corresponding solvation capacity) in conjunction with cell surface-to-volume ratios represent the underlying constraints on the maximal rate of autotrophic microbial growth. The limitation of cellular space thus constrains the size the total complement of macromolecules, dissolved ions, and metabolites. To a first approximation, the upper limit in the cellular amount of the total proteome is bounded this space limit. This predicts that adaptation to osmotic stress will result in lower maximal growth rates due to decreased cellular concentrations of core metabolic proteins necessary for cell growth owing the accumulation of compatible osmolytes, as surmised previously. The finite capacity of membrane and cytoplasmic space also leads to the hypothesis that the species-specific differences in maximal growth rates likely reflect differences in the allocation of spacemore »
- Authors:
-
- Oklahoma State Univ., Stillwater, OK (United States). Dept. of Microbiology and Molecular Genetics
- Publication Date:
- Research Org.:
- Oklahoma State Univ., Stillwater, OK (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1629926
- Grant/Contract Number:
- FG02-08ER15968
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Frontiers in Bioengineering and Biotechnology
- Additional Journal Information:
- Journal Volume: 3; Journal ID: ISSN 2296-4185
- Publisher:
- Frontiers Research Foundation
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; cyanobacteria; growth rate; molecular crowding; optimization; photosynthesis; ribosomes
Citation Formats
Burnap, Robert L. Systems and Photosystems: Cellular Limits of Autotrophic Productivity in Cyanobacteria. United States: N. p., 2015.
Web. doi:10.3389/fbioe.2015.00001.
Burnap, Robert L. Systems and Photosystems: Cellular Limits of Autotrophic Productivity in Cyanobacteria. United States. https://doi.org/10.3389/fbioe.2015.00001
Burnap, Robert L. Tue .
"Systems and Photosystems: Cellular Limits of Autotrophic Productivity in Cyanobacteria". United States. https://doi.org/10.3389/fbioe.2015.00001. https://www.osti.gov/servlets/purl/1629926.
@article{osti_1629926,
title = {Systems and Photosystems: Cellular Limits of Autotrophic Productivity in Cyanobacteria},
author = {Burnap, Robert L.},
abstractNote = {Recent advances in the modeling of microbial growth and metabolism have shown that growth rate critically depends upon the optimal allocation of finite proteomic resources among different cellular functions and that modeling growth rates becomes more realistic with the explicit accounting for the costs of macromolecular synthesis, most importantly, protein expression. The “proteomic constraint” is considered together with its application to understanding photosynthetic microbial growth. The central hypothesis is that physical limits of cellular space (and corresponding solvation capacity) in conjunction with cell surface-to-volume ratios represent the underlying constraints on the maximal rate of autotrophic microbial growth. The limitation of cellular space thus constrains the size the total complement of macromolecules, dissolved ions, and metabolites. To a first approximation, the upper limit in the cellular amount of the total proteome is bounded this space limit. This predicts that adaptation to osmotic stress will result in lower maximal growth rates due to decreased cellular concentrations of core metabolic proteins necessary for cell growth owing the accumulation of compatible osmolytes, as surmised previously. The finite capacity of membrane and cytoplasmic space also leads to the hypothesis that the species-specific differences in maximal growth rates likely reflect differences in the allocation of space to niche-specific proteins with the corresponding diminution of space devoted to other functions including proteins of core autotrophic metabolism, which drive cell reproduction. An optimization model for autotrophic microbial growth, the autotrophic replicator model, was developed based upon previous work investigating heterotrophic growth. The present model describes autotrophic growth in terms of the allocation protein resources among core functional groups including the photosynthetic electron transport chain, light-harvesting antennae, and the ribosome groups.},
doi = {10.3389/fbioe.2015.00001},
journal = {Frontiers in Bioengineering and Biotechnology},
number = ,
volume = 3,
place = {United States},
year = {Tue Jan 20 00:00:00 EST 2015},
month = {Tue Jan 20 00:00:00 EST 2015}
}
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journal, April 2014
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Ethanol Synthesis by Genetic Engineering in Cyanobacteria
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The Growth of Bacterial Cultures
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journal, January 2008
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A Coarse-Grained Biophysical Model of E. coli and Its Application to Perturbation of the rRNA Operon Copy Number
journal, May 2008
- Tadmor, Arbel D.; Tlusty, Tsvi
- PLoS Computational Biology, Vol. 4, Issue 5
Flux Balance Analysis of Cyanobacterial Metabolism: The Metabolic Network of Synechocystis sp. PCC 6803
journal, June 2013
- Knoop, Henning; Gründel, Marianne; Zilliges, Yvonne
- PLoS Computational Biology, Vol. 9, Issue 6
Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast
journal, August 2010
- Barton, Michael D.; Delneri, Daniela; Oliver, Stephen G.
- PLoS ONE, Vol. 5, Issue 8
Comparison of Photoacclimation in Twelve Freshwater Photoautotrophs (Chlorophyte, Bacillaryophyte, Cryptophyte and Cyanophyte) Isolated from a Natural Community
journal, March 2013
- Deblois, Charles P.; Marchand, Axelle; Juneau, Philippe
- PLoS ONE, Vol. 8, Issue 3
New cell-based model of photosynthesis and photo-acclimation: accumulation and mobilisation of energy reserves in phytoplankton
journal, May 2009
- Ross, On; Geider, Rj
- Marine Ecology Progress Series, Vol. 383
Transcription Profiling of the Model Cyanobacterium Synechococcus sp. Strain PCC 7002 by Next-Gen (SOLiD™) Sequencing of cDNA
journal, January 2011
- Ludwig, Marcus; Bryant, Donald A.
- Frontiers in Microbiology, Vol. 2
Synthetic biology of cyanobacteria: unique challenges and opportunities
journal, January 2013
- Berla, Bertram M.; Saha, Rajib; Immethun, Cheryl M.
- Frontiers in Microbiology, Vol. 4
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