Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration

Journal Article · 19 March 1951 · Journal of General Physiology

DOI: https://doi.org/10.1085/jgp.34.4.411 · OSTI ID:1629508

Sheppard, C. W. ^[1]; Martin, W. R. ^[2]; Beyl, Gertrude ^[2]

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1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology Division; DOE/OSTI
2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology Division

Sodium and potassium exchange has been studied in the blood of the sheep, dog, cow, and man. The potassium exchange rate in human cells is practically unaltered by increasing the plasma potassium concentration approximately threefold. Comparing the results in different species the exchange rate for potassium shows a rough correlation with the intracellular amount of the element. Expressed in per cent of the cellular content sodium tends to exchange more rapidly than potassium. In three instances the specific activity curves deviate from the simple exponential behavior of a two compartment system. In the exchange of potassium in canine blood the deviation is caused by the presence of a rapidly exchanging fraction in the buffy coat cells. Such an effect does not account for the inhomogeneity of sodium exchange in human blood.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
• Grant/Contract Number: AC05-00OR22725
• OSTI ID: 1629508
• Journal Information: Journal of General Physiology, Journal Name: Journal of General Physiology Journal Issue: 4 Vol. 34; ISSN 0022-1295
• Publisher: Rockefeller University PressCopyright Statement
• Country of Publication: United States
• Language: English