Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration

Sheppard, C. W.; Martin, W. R.; Beyl, Gertrude

doi:10.1085/jgp.34.4.411

Title: Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration

Abstract

Sodium and potassium exchange has been studied in the blood of the sheep, dog, cow, and man. The potassium exchange rate in human cells is practically unaltered by increasing the plasma potassium concentration approximately threefold. Comparing the results in different species the exchange rate for potassium shows a rough correlation with the intracellular amount of the element. Expressed in per cent of the cellular content sodium tends to exchange more rapidly than potassium. In three instances the specific activity curves deviate from the simple exponential behavior of a two compartment system. In the exchange of potassium in canine blood the deviation is caused by the presence of a rapidly exchanging fraction in the buffy coat cells. Such an effect does not account for the inhomogeneity of sodium exchange in human blood.

Authors:

Sheppard, C. W. ^[1]; Martin, W. R. ^[1]; Beyl, Gertrude ^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology Division

Publication Date:: 1951-03-20

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

OSTI Identifier:: 1629508

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: Journal of General Physiology

Additional Journal Information:: Journal Volume: 34; Journal Issue: 4; Journal ID: ISSN 0022-1295

Publisher:: Rockefeller University Press

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Sheppard, C. W., Martin, W. R., and Beyl, Gertrude. Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration.  United States: N. p., 1951. 
Web.  doi:10.1085/jgp.34.4.411.

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                    Sheppard, C. W., Martin, W. R., & Beyl, Gertrude. Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration.  United States.  https://doi.org/10.1085/jgp.34.4.411

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                    Sheppard, C. W., Martin, W. R., and Beyl, Gertrude. Tue .  
"Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration".  United States.  https://doi.org/10.1085/jgp.34.4.411.  https://www.osti.gov/servlets/purl/1629508.

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@article{osti_1629508,

  title        = {Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration},

  author       = {Sheppard, C. W. and Martin, W. R. and Beyl, Gertrude},

  abstractNote = {Sodium and potassium exchange has been studied in the blood of the sheep, dog, cow, and man. The potassium exchange rate in human cells is practically unaltered by increasing the plasma potassium concentration approximately threefold. Comparing the results in different species the exchange rate for potassium shows a rough correlation with the intracellular amount of the element. Expressed in per cent of the cellular content sodium tends to exchange more rapidly than potassium. In three instances the specific activity curves deviate from the simple exponential behavior of a two compartment system. In the exchange of potassium in canine blood the deviation is caused by the presence of a rapidly exchanging fraction in the buffy coat cells. Such an effect does not account for the inhomogeneity of sodium exchange in human blood.},

  doi          = {10.1085/jgp.34.4.411},

  journal      = {Journal of General Physiology},

  number       = 4,

  volume       = 34,

  place        = {United States},

  year         = {1951},

  month        = {3}

}

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Works referenced in this record:

Do the potassium ions inside the muscle cells and blood corpuscles exchange with those present in the plasma?
journal, October 1939

Hahn, L. A.; Hevesy, G. Ch.; Rebbe, O. H.
Biochemical Journal, Vol. 33, Issue 10
DOI: 10.1042/bj0331549

Rate of Potassium Exchange of the Human Erythrocyte
journal, July 1950

Raker, John W.; Taylor, Isaac M.; Weller, John M.
Journal of General Physiology, Vol. 33, Issue 6
DOI: 10.1085/jgp.33.6.691

Permeability of Erythrocytes to Radioactive Potassium
journal, November 1941

Mullins, L. J.; Fenn, W. O.; Noonan, T. R.
American Journal of Physiology-Legacy Content, Vol. 135, Issue 1
DOI: 10.1152/ajplegacy.1941.135.1.93

Permeability of Red Corpuscles of the Dog to Sodium Ion.
journal, June 1939

Cohn, W. E.; Cohn, E. T.
Experimental Biology and Medicine, Vol. 41, Issue 2
DOI: 10.3181/00379727-41-10705

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Similar Records

Title: Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration

Abstract

Citation Formats

Do the potassium ions inside the muscle cells and blood corpuscles exchange with those present in the plasma? journal, October 1939

Rate of Potassium Exchange of the Human Erythrocyte journal, July 1950

Permeability of Erythrocytes to Radioactive Potassium journal, November 1941

Permeability of Red Corpuscles of the Dog to Sodium Ion. journal, June 1939

Do the potassium ions inside the muscle cells and blood corpuscles exchange with those present in the plasma?
journal, October 1939

Rate of Potassium Exchange of the Human Erythrocyte
journal, July 1950

Permeability of Erythrocytes to Radioactive Potassium
journal, November 1941

Permeability of Red Corpuscles of the Dog to Sodium Ion.
journal, June 1939