Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration
Abstract
Sodium and potassium exchange has been studied in the blood of the sheep, dog, cow, and man. The potassium exchange rate in human cells is practically unaltered by increasing the plasma potassium concentration approximately threefold. Comparing the results in different species the exchange rate for potassium shows a rough correlation with the intracellular amount of the element. Expressed in per cent of the cellular content sodium tends to exchange more rapidly than potassium. In three instances the specific activity curves deviate from the simple exponential behavior of a two compartment system. In the exchange of potassium in canine blood the deviation is caused by the presence of a rapidly exchanging fraction in the buffy coat cells. Such an effect does not account for the inhomogeneity of sodium exchange in human blood.
- Authors:
-
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology Division
- Publication Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
- OSTI Identifier:
- 1629508
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of General Physiology
- Additional Journal Information:
- Journal Volume: 34; Journal Issue: 4; Journal ID: ISSN 0022-1295
- Publisher:
- Rockefeller University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Sheppard, C. W., Martin, W. R., and Beyl, Gertrude. Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration. United States: N. p., 1951.
Web. doi:10.1085/jgp.34.4.411.
Sheppard, C. W., Martin, W. R., & Beyl, Gertrude. Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration. United States. https://doi.org/10.1085/jgp.34.4.411
Sheppard, C. W., Martin, W. R., and Beyl, Gertrude. Tue .
"Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration". United States. https://doi.org/10.1085/jgp.34.4.411. https://www.osti.gov/servlets/purl/1629508.
@article{osti_1629508,
title = {Cation exchange between cells and plasma of mammalian blood: II. Sodium and potassium exchange in the sheep, dog, cow, and man and the effect of varying the plasma potassium concentration},
author = {Sheppard, C. W. and Martin, W. R. and Beyl, Gertrude},
abstractNote = {Sodium and potassium exchange has been studied in the blood of the sheep, dog, cow, and man. The potassium exchange rate in human cells is practically unaltered by increasing the plasma potassium concentration approximately threefold. Comparing the results in different species the exchange rate for potassium shows a rough correlation with the intracellular amount of the element. Expressed in per cent of the cellular content sodium tends to exchange more rapidly than potassium. In three instances the specific activity curves deviate from the simple exponential behavior of a two compartment system. In the exchange of potassium in canine blood the deviation is caused by the presence of a rapidly exchanging fraction in the buffy coat cells. Such an effect does not account for the inhomogeneity of sodium exchange in human blood.},
doi = {10.1085/jgp.34.4.411},
journal = {Journal of General Physiology},
number = 4,
volume = 34,
place = {United States},
year = {1951},
month = {3}
}
Works referenced in this record:
Do the potassium ions inside the muscle cells and blood corpuscles exchange with those present in the plasma?
journal, October 1939
- Hahn, L. A.; Hevesy, G. Ch.; Rebbe, O. H.
- Biochemical Journal, Vol. 33, Issue 10
Rate of Potassium Exchange of the Human Erythrocyte
journal, July 1950
- Raker, John W.; Taylor, Isaac M.; Weller, John M.
- Journal of General Physiology, Vol. 33, Issue 6
Permeability of Erythrocytes to Radioactive Potassium
journal, November 1941
- Mullins, L. J.; Fenn, W. O.; Noonan, T. R.
- American Journal of Physiology-Legacy Content, Vol. 135, Issue 1
Permeability of Red Corpuscles of the Dog to Sodium Ion.
journal, June 1939
- Cohn, W. E.; Cohn, E. T.
- Experimental Biology and Medicine, Vol. 41, Issue 2