Maintaining Genome Integrity during Seed Development in Phaseolus vulgaris L.: Evidence from a Transcriptomic Profiling Study

Parreira, José; Balestrazzi, Alma; Fevereiro, Pedro; Araújo, Susana

doi:10.3390/genes9100463

Title: Maintaining Genome Integrity during Seed Development in Phaseolus vulgaris L.: Evidence from a Transcriptomic Profiling Study

Journal Article · 20 September 2018 · Genes

DOI: https://doi.org/10.3390/genes9100463 · OSTI ID:1628326

Parreira, José ^[1]; Balestrazzi, Alma ^[2]; Fevereiro, Pedro ^[3]; Araújo, Susana ^[4]

Universidade Nova de Lisboa, Oeiras (Portugal). Instituto de Tecnologia Química e Biológica António Xavier. Plant Cell Biotechnology Lab.; DOE/OSTI
Univ. of Pavia (Italy). Dept. of Biology and Biotechnology. Plant Biotechnology Lab.
Universidade Nova de Lisboa, Oeiras (Portugal). Instituto de Tecnologia Química e Biológica António Xavier. Plant Cell Biotechnology Lab.; Univ. of Lisbon (Portugal). Faculdade de Ciencias. Dept. de Biologia Vegetal
Universidade Nova de Lisboa, Oeiras (Portugal). Instituto de Tecnologia Química e Biológica António Xavier. Plant Cell Biotechnology Lab.; Univ. of Pavia (Italy). Dept. of Biology and Biotechnology. Plant Biotechnology Lab.

The maintenance of genome integrity is crucial in seeds, due to the constant challenge of several endogenous and exogenous factors. The knowledge concerning DNA damage response and chromatin remodeling during seed development is still scarce, especially in Phaseolus vulgaris L. A transcriptomic profiling of the expression of genes related to DNA damage response/chromatin remodeling mechanisms was performed in P. vulgaris seeds at four distinct developmental stages, spanning from late embryogenesis to seed desiccation. Of the 14,001 expressed genes identified using massive analysis of cDNA ends, 301 belong to the DNA MapMan category. In late embryogenesis, a high expression of genes related to DNA damage sensing and repair suggests there is a tight control of DNA integrity. At the end of filling and the onset of seed dehydration, the upregulation of genes implicated in sensing of DNA double-strand breaks suggests that genome integrity is challenged. The expression of chromatin remodelers seems to imply a concomitant action of chromatin remodeling with DNA repair machinery, maintaining genome stability. The expression of genes related to nucleotide excision repair and chromatin structure is evidenced during the desiccation stage. An overview of the genes involved in DNA damage response and chromatin remodeling during P. vulgaris seed development is presented, providing insights into the mechanisms used by developing seeds to cope with DNA damage.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1628326

Journal Information:: Genes, Journal Name: Genes Journal Issue: 10 Vol. 9; ISSN 2073-4425

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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The Plant DNA Damage Response: Signaling Pathways Leading to Growth Inhibition and Putative Role in Response to Stress Conditions Nisa, Maher-Un; Huang, Ying; Benhamed, Moussa Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.00653	journal	May 2019
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