Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium
Abstract
Like Streptococcus mutans, lactobacilli are commonly isolated from carious sites, although their exact role in caries development remains unclear. This study used mixed-species models to analyze biofilm formation by major groups of oral lactobacilli, including L. casei, L. fermentum, L. rhamnosus, L. salivarius ssp. salivarius, and L. gasseri. The results showed that lactobacilli did not form good biofilms when grown alone, although differences existed between different species. When grown together with S. mutans, biofilm formation by L. gasseri and L. rhamnosus was increased by 2-log (P < 0.001), while biofilms by L. fermentum reduced by >1-log (P < 0.001). L. casei enhanced biofilm formation by ~2-log when grown with S. mutans wild-type, but no such effects were observed with S. mutans deficient of glucosyltransferase GtfB and adhesin P1. Both S. mutans and L. casei in dual-species enhanced resistance to acid killing with increases of survival rate by >1-log (P < 0.001), but drastically reduced the survival rates following exposure to hydrogen peroxide (P < 0.001), as compared to the respective mono-species cultures. When analyzed by RNA-seq, more than 134 genes were identified in S. mutans in dual-species with L. casei as either up- or down-regulated when compared to those grownmore »
- Authors:
-
- Louisiana State University Health Sciences Center, New Orleans, LA, (United States). Center of Oral and Craniofacial Biology, Dept. of Comprehensive Dentistry and Biomaterials, Dept. of Microbiology, Immunology and Parasitology
- Center of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA (United States)
- Department of Comprehensive Dentistry and Biomaterials, Louisiana State University Health Sciences Center, New Orleans, LA, (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Genome Science Group, Bioscience Div.
- Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, (United States)
- Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
- OSTI Identifier:
- 1628034
- Grant/Contract Number:
- AC52-06NA25396; DE19452; DE25348
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Frontiers in Cellular and Infection Microbiology
- Additional Journal Information:
- Journal Volume: 7; Journal ID: ISSN 2235-2988
- Publisher:
- Frontiers Research Foundation
- Country of Publication:
- United States
- Language:
- English
- Subject:
- Immunology; Microbiology
Citation Formats
Wen, Zezhang T., Liao, Sumei, Bitoun, Jacob P., De, Arpan, Jorgensen, Ashton, Feng, Shihai, Xu, Xiaoming, Chain, Patrick S. G., Caufield, Page W., Koo, Hyun, and Li, Yihong. Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium. United States: N. p., 2017.
Web. doi:10.3389/fcimb.2017.00524.
Wen, Zezhang T., Liao, Sumei, Bitoun, Jacob P., De, Arpan, Jorgensen, Ashton, Feng, Shihai, Xu, Xiaoming, Chain, Patrick S. G., Caufield, Page W., Koo, Hyun, & Li, Yihong. Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium. United States. https://doi.org/10.3389/fcimb.2017.00524
Wen, Zezhang T., Liao, Sumei, Bitoun, Jacob P., De, Arpan, Jorgensen, Ashton, Feng, Shihai, Xu, Xiaoming, Chain, Patrick S. G., Caufield, Page W., Koo, Hyun, and Li, Yihong. Wed .
"Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium". United States. https://doi.org/10.3389/fcimb.2017.00524. https://www.osti.gov/servlets/purl/1628034.
@article{osti_1628034,
title = {Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium},
author = {Wen, Zezhang T. and Liao, Sumei and Bitoun, Jacob P. and De, Arpan and Jorgensen, Ashton and Feng, Shihai and Xu, Xiaoming and Chain, Patrick S. G. and Caufield, Page W. and Koo, Hyun and Li, Yihong},
abstractNote = {Like Streptococcus mutans, lactobacilli are commonly isolated from carious sites, although their exact role in caries development remains unclear. This study used mixed-species models to analyze biofilm formation by major groups of oral lactobacilli, including L. casei, L. fermentum, L. rhamnosus, L. salivarius ssp. salivarius, and L. gasseri. The results showed that lactobacilli did not form good biofilms when grown alone, although differences existed between different species. When grown together with S. mutans, biofilm formation by L. gasseri and L. rhamnosus was increased by 2-log (P < 0.001), while biofilms by L. fermentum reduced by >1-log (P < 0.001). L. casei enhanced biofilm formation by ~2-log when grown with S. mutans wild-type, but no such effects were observed with S. mutans deficient of glucosyltransferase GtfB and adhesin P1. Both S. mutans and L. casei in dual-species enhanced resistance to acid killing with increases of survival rate by >1-log (P < 0.001), but drastically reduced the survival rates following exposure to hydrogen peroxide (P < 0.001), as compared to the respective mono-species cultures. When analyzed by RNA-seq, more than 134 genes were identified in S. mutans in dual-species with L. casei as either up- or down-regulated when compared to those grown alone. The up-regulated genes include those for superoxide dismutase, NADH oxidase, and members of the mutanobactin biosynthesis cluster. Among the down-regulated genes were those for GtfB and alternative sigma factor SigX. These results further suggest that interactions between S. mutans and oral lactobacilli are species-specific and may have significant impact on cariogenic potential of the community.},
doi = {10.3389/fcimb.2017.00524},
journal = {Frontiers in Cellular and Infection Microbiology},
number = ,
volume = 7,
place = {United States},
year = {Wed Dec 20 00:00:00 EST 2017},
month = {Wed Dec 20 00:00:00 EST 2017}
}
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