Genetic Interference: Don't Stand So Close to Me

Berchowitz, Luke; Copenhaver, Gregory

doi:10.2174/138920210790886835

Title: Genetic Interference: Don't Stand So Close to Me

Journal Article · 01 April 2010 · Current Genomics

DOI: https://doi.org/10.2174/138920210790886835 · OSTI ID:1628003

Berchowitz, Luke ^[1]; Copenhaver, Gregory ^[2]

Univ. of North Carolina, Chapel Hill, NC (United States). The Carolina Center for Genome Science. Dept. of Biology; DOE/OSTI
Univ. of North Carolina, Chapel Hill, NC (United States). The Carolina Center for Genome Science. Dept. of Biology

Meiosis is a dynamic process during which chromosomes undergo condensation, pairing, crossing-over and disjunction. Stringent regulation of the distribution and quantity of meiotic crossovers is critical for proper chromosome segregation in many organisms. In humans, aberrant crossover placement and the failure to faithfully segregate meiotic chromosomes often results in severe genetic disorders such as Down syndrome and Edwards syndrome. In most sexually reproducing organisms, crossovers are more evenly spaced than would be expected from a random distribution. This phenomenon, termed interference, was first reported in the early 20th century by Drosophila geneticists and has been subsequently observed in a vast range of organisms from yeasts to humans. Yet, many questions regarding the behavior and mechanism of interference remain poorly understood. In this review, we examine results new and old, from a wide range of organisms, to begin to understand the progress and remaining challenges to understanding the fundamental unanswered questions regarding genetic interference.

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Research Organization:: Univ. of North Carolina, Chapel Hill, NC (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: FG02-05ER15651

OSTI ID:: 1628003

Journal Information:: Current Genomics, Journal Name: Current Genomics Journal Issue: 2 Vol. 11; ISSN 1389-2029

Publisher:: Bentham Science PublishersCopyright Statement

Country of Publication:: United States

Language:: English

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Engineering meiotic recombination pathways in rice Fayos, Ian; Mieulet, Delphine; Petit, Julie Plant Biotechnology Journal, Vol. 17, Issue 11 https://doi.org/10.1111/pbi.13189	journal	June 2019
Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis Osman, Kim; Yang, Jianhua; Roitinger, Elisabeth The Plant Journal, Vol. 93, Issue 1 https://doi.org/10.1111/tpj.13752	journal	December 2017
Recombination suppression in heterozygotes for a pericentric inversion induces the interchromosomal effect on crossovers in Arabidopsis Termolino, Pasquale; Falque, Matthieu; Aiese Cigliano, Riccardo The Plant Journal, Vol. 100, Issue 6 https://doi.org/10.1111/tpj.14505	journal	October 2019
FANCM Limits Meiotic Crossovers Crismani, W.; Girard, C.; Froger, N. Science, Vol. 336, Issue 6088 https://doi.org/10.1126/science.1220381	journal	June 2012
Genome analysis and avirulence gene cloning using a high-density RADseq linkage map of the flax rust fungus, Melampsora lini Anderson, Claire; Khan, Muhammad Adil; Catanzariti, Ann-Maree BMC Genomics, Vol. 17, Issue 1 https://doi.org/10.1186/s12864-016-3011-9	journal	August 2016
Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits Aggarwal, Dau Dayal; Rashkovetsky, Eugenia; Michalak, Pawel BMC Biology, Vol. 13, Issue 1 https://doi.org/10.1186/s12915-015-0206-5	journal	November 2015
Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission Wong, Wesley; Wenger, Edward A.; Hartl, Daniel L. PLOS Computational Biology, Vol. 14, Issue 1 https://doi.org/10.1371/journal.pcbi.1005923	journal	January 2018
Reduced Crossover Interference and Increased ZMM-Independent Recombination in the Absence of Tel1/ATM Anderson, Carol M.; Oke, Ashwini; Yam, Phoebe PLOS Genetics, Vol. 11, Issue 8 https://doi.org/10.1371/journal.pgen.1005478	journal	August 2015
Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination Su, Hang; Cheng, Zhihao; Huang, Jiyue PLOS Genetics, Vol. 13, Issue 5 https://doi.org/10.1371/journal.pgen.1006827	journal	May 2017
Elevated temperature increases meiotic crossover frequency via the interfering (Type I) pathway in Arabidopsis thaliana Modliszewski, Jennifer L.; Wang, Hongkuan; Albright, Ashley R. PLOS Genetics, Vol. 14, Issue 5 https://doi.org/10.1371/journal.pgen.1007384	journal	May 2018
Interhomolog polymorphism shapes meiotic crossover within the Arabidopsis RAC1 and RPP13 disease resistance genes Serra, Heïdi; Choi, Kyuha; Zhao, Xiaohui PLOS Genetics, Vol. 14, Issue 12 https://doi.org/10.1371/journal.pgen.1007843	journal	December 2018
A first genetic portrait of synaptonemal complex variation Wang, Richard J.; Dumont, Beth L.; Jing, Peicheng PLOS Genetics, Vol. 15, Issue 8 https://doi.org/10.1371/journal.pgen.1008337	journal	August 2019
A Whole-Chromosome Analysis of Meiotic Recombination in Drosophila melanogaster Miller, Danny E.; Takeo, Satomi; Nandanan, Kavyasree G3: Genes\|Genomes\|Genetics, Vol. 2, Issue 2 https://doi.org/10.1534/g3.111.001396	journal	February 2012
Fine-Scale Mapping of the Nasonia Genome to Chromosomes Using a High-Density Genotyping Microarray Desjardins, Christopher A.; Gadau, Jürgen; Lopez, Jacqueline A. G3: Genes\|Genomes\|Genetics, Vol. 3, Issue 2 https://doi.org/10.1534/g3.112.004739	journal	February 2013
Meiotic and Mitotic Recombination in Meiosis Kohl, Kathryn P.; Sekelsky, Jeff Genetics, Vol. 194, Issue 2 https://doi.org/10.1534/genetics.113.150581	journal	June 2013
Whole-Genome Analysis of Individual Meiotic Events in Drosophila melanogaster Reveals That Noncrossover Gene Conversions Are Insensitive to Interference and the Centromere Effect Miller, Danny E.; Smith, Clarissa B.; Kazemi, Nazanin Yeganeh Genetics, Vol. 203, Issue 1 https://doi.org/10.1534/genetics.115.186486	journal	May 2016
Female Meiosis: Synapsis, Recombination, and Segregation in Drosophila melanogaster Hughes, Stacie E.; Miller, Danny E.; Miller, Angela L. Genetics, Vol. 208, Issue 3 https://doi.org/10.1534/genetics.117.300081	journal	February 2018
Plasticity of Meiotic Recombination Rates in Response to Temperature in Arabidopsis Lloyd, Andrew; Morgan, Chris; H. Franklin, F. Chris Genetics, Vol. 208, Issue 4 https://doi.org/10.1534/genetics.117.300588	journal	March 2018
Modelling Sex-Specific Crossover Patterning in Arabidopsis Lloyd, Andrew; Jenczewski, Eric Genetics, Vol. 211, Issue 3 https://doi.org/10.1534/genetics.118.301838	journal	January 2019
Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination Hang, Su,; Yingxiang, Wang,; Jiyue, Huang, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/k8tj-8k59	text	January 2017
Meiotic and Mitotic Recombination in Meiosis J., Sekelsky,; P., Kohl, K. The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/mfcf-2r36	text	January 2013
Interhomolog polymorphism shapes meiotic crossover within the Arabidopsis RAC1 and RPP13 disease resistance genes. Serra, Heïdi; Choi, Kyuha; Zhao, Xiaohui Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.34804	text	January 2018
The genomic landscape of meiotic crossovers and gene conversions in Arabidopsis thaliana Wijnker, Erik; James, Geo Velikkakam; Ding, Jia arXiv https://doi.org/10.48550/arxiv.1311.3236	preprint	January 2013
The genomic landscape of meiotic crossovers and gene conversions in Arabidopsis thaliana Wijnker, Erik; Velikkakam James, Geo; Ding, Jia eLife, Vol. 2 https://doi.org/10.7554/elife.01426	journal	December 2013

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59 BASIC BIOLOGICAL SCIENCES
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Title: Genetic Interference: Don't Stand So Close to Me

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