Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome

Cox, Michael J.; Huang, Yvonne J.; Fujimura, Kei E.; Liu, Jane T.; McKean, Michelle; Boushey, Homer A.; Segal, Mark R.; Brodie, Eoin L.; Cabana, Michael D.; Lynch, Susan V.; Bell, Thomas

doi:10.1371/journal.pone.0008745

Title: Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome

Journal Article · 17 January 2010 · PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0008745 · OSTI ID:1627394

Cox, Michael J. ^[1]; Huang, Yvonne J. ^[2]; Fujimura, Kei E. ^[3]; Liu, Jane T. ^[2]; McKean, Michelle ^[4]; Boushey, Homer A. ^[2]; Segal, Mark R. ^[5]; Brodie, Eoin L. ^[6]; Cabana, Michael D. ^[7]; Lynch, Susan V. ^[3]; Bell, Thomas

Univ. of California, San Francisco, CA (United States). Division Gastroenterology; DOE/OSTI
Univ. of California, San Francisco, CA (United States). Dept. of Medicine
Univ. of California, San Francisco, CA (United States). Division Gastroenterology
Univ. of California, San Francisco, CA (United States). Dept. of Pediatrics
Univ. of California, San Francisco, CA (United States). Dept. of Epidemiology and Biostatistics
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Earth Sciences Division. Ecology Dept.
Univ. of California, San Francisco, CA (United States). Dept. of Medicine; Univ. of California, San Francisco, CA (United States). Dept. of Pediatrics

Colonization of the infant gut by microorganisms over the first year of life is crucial for development of a balanced immune response. Early alterations in the gastrointestinal microbiota of neonates has been linked with subsequent development of asthma and atopy in older children. Here we describe high-resolution culture-independent analysis of stool samples from 6- month old infants fed daily supplements of Lactobacillus casei subsp. Rhamnosus (LGG) or placebo in a double-blind, randomized Trial of Infant Probiotic Supplementation (TIPS). Bacterial community composition was examined using a high-density microarray, the 16S rRNA PhyloChip, and the microbial assemblages of infants with either high or low LGG abundance were compared. Communities with high abundance of LGG exhibited promotion of phylogenetically clustered taxa including a number of other known probiotic species, and were significantly more even in their distribution of community members. Ecologically, these aspects are characteristic of communities that are more resistant to perturbation and outgrowth of pathogens. PhyloChip analysis also permitted identification of taxa negatively correlated with LGG abundance that have previously been associated with atopy, as well as those positively correlated that may prove useful alternative targets for investigation as alternative probiotic species. From these findings we hypothesize that a key mechanism for the protective effect of LGG supplementation on subsequent development of allergic disease is through promotion of a stable, even, and functionally redundant infant gastrointestinal community.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1627394

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 1 Vol. 5; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

References (56)

Microecology of the gastrointestinal tract and the immunological status under food allergy Kuvaeva, I. B.; Orlova, N. G.; Veselova, O. L. Food/Nahrung, Vol. 28, Issue 6-7 https://doi.org/10.1002/food.19840280645	journal	January 1984
Probiotics: Intestinal gatekeeping, immunomodulation, and hepatic injury Versalovic, James Hepatology, Vol. 46, Issue 3 https://doi.org/10.1002/hep.21916	journal	January 2007
High-Density Universal 16S rRNA Microarray Analysis Reveals Broader Diversity than Typical Clone Library When Sampling the Environment DeSantis, Todd Z.; Brodie, Eoin L.; Moberg, Jordan P. Microbial Ecology, Vol. 53, Issue 3 https://doi.org/10.1007/s00248-006-9134-9	journal	March 2007
The measurement of diversity in different types of biological collections Pielou, E. C. Journal of Theoretical Biology, Vol. 13 https://doi.org/10.1016/0022-5193(66)90013-0	journal	December 1966
Eukaryotic signature proteins ofProsthecobacter dejongeiiandGemmatasp. Wa-1 as revealed by in silico analysis Staley, James T.; Bouzek, Heather; Jenkins, Cheryl FEMS Microbiology Letters, Vol. 243, Issue 1 https://doi.org/10.1016/j.femsle.2004.11.034	journal	February 2005
Evaluation of immunomodulation by Lactobacillus casei Shirota: Immune function, autoimmunity and gene expression Baken, Kirsten A.; Ezendam, Janine; Gremmer, Eric R. International Journal of Food Microbiology, Vol. 112, Issue 1 https://doi.org/10.1016/j.ijfoodmicro.2006.06.009	journal	October 2006
Effects of probiotic bacteria and their genomic DNA on TH1/TH2-cytokine production by peripheral blood mononuclear cells (PBMCs) of healthy and allergic subjects Ghadimi, D.; Folsterholst, R.; Devrese, M. Immunobiology, Vol. 213, Issue 8 https://doi.org/10.1016/j.imbio.2008.02.001	journal	October 2008
Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma Gereda, Je; Leung, Dym; Thatayatikom, A. The Lancet, Vol. 355, Issue 9216 https://doi.org/10.1016/s0140-6736(00)02239-x	journal	May 2000
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial Kalliomäki, Marko; Salminen, Seppo; Arvilommi, Heikki The Lancet, Vol. 357, Issue 9262 https://doi.org/10.1016/s0140-6736(00)04259-8	journal	April 2001
Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial Kalliomäki, Marko; Salminen, Seppo; Poussa, Tuija The Lancet, Vol. 361, Issue 9372 https://doi.org/10.1016/s0140-6736(03)13490-3	journal	May 2003
Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains Maassen, Catharina B. M.; van Holten-Neelen, Conny; Balk, Fräncis Vaccine, Vol. 18, Issue 23 https://doi.org/10.1016/s0264-410x(99)00378-3	journal	May 2000
Immunomodulatory effects of probiotics in different stages of life Nova, Esther; Wärnberg, Julia; Gómez-Martínez, Sonia British Journal of Nutrition, Vol. 98, Issue S1 https://doi.org/10.1017/s0007114507832983	journal	October 2007
Selective progressive response of soil microbial community to wild oat roots DeAngelis, Kristen M.; Brodie, Eoin L.; DeSantis, Todd Z. The ISME Journal, Vol. 3, Issue 2 https://doi.org/10.1038/ismej.2008.103	journal	November 2008
Environmental microarray analyses of Antarctic soil microbial communities Yergeau, Etienne; Schoondermark-Stolk, Sung A.; Brodie, Eoin L. The ISME Journal, Vol. 3, Issue 3 https://doi.org/10.1038/ismej.2008.111	journal	November 2008
Innate immune recognition of the indigenous microbial flora Rakoff-Nahoum, S.; Medzhitov, R. Mucosal Immunology, Vol. 1 https://doi.org/10.1038/mi.2008.49	journal	November 2008
Getting to the core of the gut microbiome Tschöp, Matthias H.; Hugenholtz, Philip; Karp, Christopher L. Nature Biotechnology, Vol. 27, Issue 4 https://doi.org/10.1038/nbt0409-344	journal	April 2009
Obesity alters gut microbial ecology Ley, R. E.; Backhed, F.; Turnbaugh, P. Proceedings of the National Academy of Sciences, Vol. 102, Issue 31 https://doi.org/10.1073/pnas.0504978102	journal	July 2005
Urban aerosols harbor diverse and dynamic bacterial populations Brodie, E. L.; DeSantis, T. Z.; Parker, J. P. M. Proceedings of the National Academy of Sciences, Vol. 104, Issue 1, p. 299-304 https://doi.org/10.1073/pnas.0608255104	journal	December 2006
A Longitudinal Analysis on the Association Between Antibiotic Use, Intestinal Microflora, and Wheezing During the First Year of Life Verhulst, Stijn L.; Vael, Carl; Beunckens, Caroline Journal of Asthma, Vol. 45, Issue 9 https://doi.org/10.1080/02770900802339734	journal	January 2008
New Functional ProbioticLactobacillus sakeiProbio 65 Alleviates Atopic Symptoms in the Mouse Park, Chun Wook; Youn, Myoungsub; Jung, Young-Mi Journal of Medicinal Food, Vol. 11, Issue 3 https://doi.org/10.1089/jmf.2007.0144	journal	September 2008
Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation Letunic, I.; Bork, P. Bioinformatics, Vol. 23, Issue 1 https://doi.org/10.1093/bioinformatics/btl529	journal	October 2006
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix Price, M. N.; Dehal, P. S.; Arkin, A. P. Molecular Biology and Evolution, Vol. 26, Issue 7 https://doi.org/10.1093/molbev/msp077	journal	April 2009
Prophylactic Probiotics for Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Newborns Samanta, M.; Sarkar, M.; Ghosh, P. Journal of Tropical Pediatrics, Vol. 55, Issue 2 https://doi.org/10.1093/tropej/fmn091	journal	October 2008
Probiotics and Irritable Bowel Syndrome Barbara, Giovanni; Stanghellini, Vincenzo; Cremon, Cesare Journal of Clinical Gastroenterology, Vol. 42, Issue Supplement 3 https://doi.org/10.1097/mcg.0b013e31817da129	journal	September 2008
Changes in oral microbial profiles after periodontal treatment as determined by molecular analysis of 16S rRNA genes Sakamoto, Mitsuo; Huang, Yi; Ohnishi, Mayuko Journal of Medical Microbiology, Vol. 53, Issue 6 https://doi.org/10.1099/jmm.0.45576-0	journal	June 2004
Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study Williams, E. A.; Stimpson, J.; Wang, D. Alimentary Pharmacology & Therapeutics, Vol. 29, Issue 1 https://doi.org/10.1111/j.1365-2036.2008.03848.x	journal	January 2009
The role of the intestinal microbiota in the development of atopic disorders Penders, J.; Stobberingh, E. E.; Brandt, P. A. van den Allergy, Vol. 62, Issue 11 https://doi.org/10.1111/j.1398-9995.2007.01462.x	journal	November 2007
Intestinal microflora of Estonian and Swedish infants Sepp, E.; Julge, K.; Vasar, M. Acta Paediatrica, Vol. 86, Issue 9 https://doi.org/10.1111/j.1651-2227.1997.tb15178.x	journal	September 1997
Host-Bacterial Mutualism in the Human Intestine Backhed, F. Science, Vol. 307, Issue 5717 https://doi.org/10.1126/science.1104816	journal	March 2005
Diversity of the Human Intestinal Microbial Flora Eckburg, P. B. Science, Vol. 308, Issue 5728 https://doi.org/10.1126/science.1110591	journal	June 2005
Metagenomic Analysis of the Human Distal Gut Microbiome Gill, S. R.; Pop, M.; DeBoy, R. T. Science, Vol. 312, Issue 5778 https://doi.org/10.1126/science.1124234	journal	June 2006
Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin Cash, H. L. Science, Vol. 313, Issue 5790 https://doi.org/10.1126/science.1127119	journal	August 2006
Application of a High-Density Oligonucleotide Microarray Approach To Study Bacterial Population Dynamics during Uranium Reduction and Reoxidation Brodie, E. L.; DeSantis, T. Z.; Joyner, D. C. Applied and Environmental Microbiology, Vol. 72, Issue 9 https://doi.org/10.1128/aem.00246-06	journal	September 2006
Bacterial Diversity Analysis of Huanglongbing Pathogen-Infected Citrus, Using PhyloChip Arrays and 16S rRNA Gene Clone Library Sequencing Sagaram, U. S.; DeAngelis, K. M.; Trivedi, P. Applied and Environmental Microbiology, Vol. 75, Issue 6 https://doi.org/10.1128/aem.02404-08	journal	January 2009
Microbial Diversity of Hydrothermal Sediments in the Guaymas Basin: Evidence for Anaerobic Methanotrophic Communities Teske, A.; Hinrichs, K. -U.; Edgcomb, V. Applied and Environmental Microbiology, Vol. 68, Issue 4 https://doi.org/10.1128/aem.68.4.1994-2007.2002	journal	April 2002
Proposed Model: Mechanisms of Immunomodulation Induced by Probiotic Bacteria Galdeano, C. Maldonado; de Moreno de LeBlanc, A.; Vinderola, G. Clinical and Vaccine Immunology, Vol. 14, Issue 5 https://doi.org/10.1128/cvi.00406-06	journal	May 2007
Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric Infection Sekirov, I.; Tam, N. M.; Jogova, M. Infection and Immunity, Vol. 76, Issue 10 https://doi.org/10.1128/iai.00319-08	journal	August 2008
Host Transmission of Salmonella enterica Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal Microbiota Lawley, Trevor D.; Bouley, Donna M.; Hoy, Yana E. Infection and Immunity, Vol. 76, Issue 1 https://doi.org/10.1128/iai.01189-07	journal	October 2007
Changes in Periodontal Health Status Are Associated with Bacterial Community Shifts as Assessed by Quantitative 16S Cloning and Sequencing Kumar, P. S.; Leys, E. J.; Bryk, J. M. Journal of Clinical Microbiology, Vol. 44, Issue 10 https://doi.org/10.1128/jcm.00317-06	journal	October 2006
Loss of Bacterial Diversity during Antibiotic Treatment of Intubated Patients Colonized with Pseudomonas aeruginosa Flanagan, J. L.; Brodie, E. L.; Weng, L. Journal of Clinical Microbiology, Vol. 45, Issue 6 https://doi.org/10.1128/jcm.02187-06	journal	April 2007
Football position and atopy--both subject to the birth order effect? Perkin, M. R. BMJ, Vol. 327, Issue 7429 https://doi.org/10.1136/bmj.327.7429.1473	journal	December 2003
Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study Penders, J.; Thijs, C.; van den Brandt, P. A. Gut, Vol. 56, Issue 5 https://doi.org/10.1136/gut.2006.100164	journal	May 2007
Phylogenies and Community Ecology Webb, Campbell O.; Ackerly, David D.; McPeek, Mark A. Annual Review of Ecology and Systematics, Vol. 33, Issue 1 https://doi.org/10.1146/annurev.ecolsys.33.010802.150448	journal	November 2002
Oral Treatment with Live Lactobacillus reuteri Inhibits the Allergic Airway Response in Mice Forsythe, Paul; Inman, Mark D.; Bienenstock, John American Journal of Respiratory and Critical Care Medicine, Vol. 175, Issue 6 https://doi.org/10.1164/rccm.200606-821oc	journal	March 2007
Exploring the Association between Severe Respiratory Syncytial Virus Infection and Asthma Thomsen, Simon Francis; van der Sluis, Sophie; Stensballe, Lone G. American Journal of Respiratory and Critical Care Medicine, Vol. 179, Issue 12 https://doi.org/10.1164/rccm.200809-1471oc	journal	June 2009
Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice Hrncir, Tomas; Stepankova, Renata; Kozakova, Hana BMC Immunology, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2172-9-65	journal	November 2008
Microbes Colonize a Baby’s Gut with Distinction Gross, Liza PLoS Biology, Vol. 5, Issue 7 https://doi.org/10.1371/journal.pbio.0050191	journal	June 2007
Gut Reaction: Pyrosequencing Provides the Poop on Distal Gut Bacteria O'Day, Kira PLoS Biology, Vol. 6, Issue 11 https://doi.org/10.1371/journal.pbio.0060295	journal	November 2008
Comparative Analysis of Human Gut Microbiota by Barcoded Pyrosequencing Andersson, Anders F.; Lindberg, Mathilda; Jakobsson, Hedvig PLoS ONE, Vol. 3, Issue 7 https://doi.org/10.1371/journal.pone.0002836	journal	July 2008
Avian Incubation Inhibits Growth and Diversification of Bacterial Assemblages on Eggs Shawkey, Matthew D.; Firestone, Mary K.; Brodie, Eoin L. PLoS ONE, Vol. 4, Issue 2 https://doi.org/10.1371/journal.pone.0004522	journal	February 2009
Microbial Manipulation of Immune Function for Asthma Prevention: Inferences from Clinical Trials Yoo, J.; Tcheurekdjian, H.; Lynch, S. V. Proceedings of the American Thoracic Society, Vol. 4, Issue 3 https://doi.org/10.1513/pats.200702-033aw	journal	July 2007
Immunomodulation, Part V: Probiotics Bell, Susan Givens Neonatal Network, Vol. 26, Issue 1 https://doi.org/10.1891/0730-0832.26.1.57	journal	January 2007
Bioconductor : open software development for computational biology and bioinformatics C., Gentleman, Robert; J., Carey, Vincent; M., Bates, Douglas BioMed Central https://doi.org/10.21256/zhaw-1907	text	January 2004
Probiotics for the Treatment or Prevention of Atopic Dermatitis Betsi, Gregoria I.; Papadavid, Evangelia; Falagas, Matthew E. American Journal of Clinical Dermatology, Vol. 9, Issue 2 https://doi.org/10.2165/00128071-200809020-00002	journal	January 2008
Pandemic of Atopic Diseases - A Lack of Microbial Exposure in Early Infancy? Kalliomaki, M.; Isolauri, E. Current Drug Target -Infectious Disorders, Vol. 2, Issue 3 https://doi.org/10.2174/1568005023342452	journal	September 2002
Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome Barrett, Jacqueline S.; Canale, Kim EK; Gearry, Richard B. World Journal of Gastroenterology, Vol. 14, Issue 32 https://doi.org/10.3748/wjg.14.5020	journal	January 2008

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Bugs for atopy: the Lactobacillus rhamnosus GG strategy for food allergy prevention and treatment in children Cosenza, L.; Nocerino, R.; Di Scala, C. Beneficial Microbes, Vol. 6, Issue 2 https://doi.org/10.3920/bm2014.0158	journal	January 2015
Amelioration of DSS-induced murine colitis by VSL#3 supplementation is primarily associated with changes in ileal microbiota composition. Mar, Jordan S.; Nagalingam, Nabeetha A.; Song, Yuanlin Gut Microbes, Vol. 5, Issue 4 https://doi.org/10.4161/gmic.32147	journal	July 2014
Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data Lahti, Leo; Salonen, Anne; Kekkonen, Riina A. PeerJ, Vol. 1 https://doi.org/10.7717/peerj.32	journal	January 2013

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