Antibody Responses during Hepatitis B Viral Infection
Abstract
Hepatitis B is a DNA virus that infects liver cells and can cause both acute and chronic disease. It is believed that both viral and host factors are responsible for determining whether the infection is cleared or becomes chronic. Here we investigate the mechanism of protection by developing a mathematical model of the antibody response following hepatitis B virus (HBV) infection. We fitted the model to data from seven infected adults identified during acute infection and determined the ability of the virus to escape neutralization through overproduction of non-infectious subviral particles, which have HBs proteins on their surface, but do not contain nucleocapsid protein and viral nucleic acids. We showed that viral clearance can be achieved for high anti-HBV antibody levels, as in vaccinated individuals, when: (1) the rate of synthesis of hepatitis B subviral particles is slow; (2) the rate of synthesis of hepatitis B subviral particles is high but either anti-HBV antibody production is fast, the antibody affinity is high, or the levels of pre-existent HBV-specific antibody at the time of infection are high, as could be attained by vaccination. We further showed that viral clearance can be achieved for low equilibrium antiHBV antibody levels, as in unvaccinatedmore »
- Authors:
-
- Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States). Dept. of Mathematics
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
- OSTI Identifier:
- 1627236
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Computational Biology (Online)
- Additional Journal Information:
- Journal Name: PLoS Computational Biology (Online); Journal Volume: 10; Journal Issue: 7; Journal ID: ISSN 1553-7358
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 97 MATHEMATICS AND COMPUTING; Biochemistry & Molecular Biology; Mathematical & Computational Biology
Citation Formats
Ciupe, Stanca M., Ribeiro, Ruy M., and Perelson, Alan S. Antibody Responses during Hepatitis B Viral Infection. United States: N. p., 2014.
Web. doi:10.1371/journal.pcbi.1003730.
Ciupe, Stanca M., Ribeiro, Ruy M., & Perelson, Alan S. Antibody Responses during Hepatitis B Viral Infection. United States. https://doi.org/10.1371/journal.pcbi.1003730
Ciupe, Stanca M., Ribeiro, Ruy M., and Perelson, Alan S. Thu .
"Antibody Responses during Hepatitis B Viral Infection". United States. https://doi.org/10.1371/journal.pcbi.1003730. https://www.osti.gov/servlets/purl/1627236.
@article{osti_1627236,
title = {Antibody Responses during Hepatitis B Viral Infection},
author = {Ciupe, Stanca M. and Ribeiro, Ruy M. and Perelson, Alan S.},
abstractNote = {Hepatitis B is a DNA virus that infects liver cells and can cause both acute and chronic disease. It is believed that both viral and host factors are responsible for determining whether the infection is cleared or becomes chronic. Here we investigate the mechanism of protection by developing a mathematical model of the antibody response following hepatitis B virus (HBV) infection. We fitted the model to data from seven infected adults identified during acute infection and determined the ability of the virus to escape neutralization through overproduction of non-infectious subviral particles, which have HBs proteins on their surface, but do not contain nucleocapsid protein and viral nucleic acids. We showed that viral clearance can be achieved for high anti-HBV antibody levels, as in vaccinated individuals, when: (1) the rate of synthesis of hepatitis B subviral particles is slow; (2) the rate of synthesis of hepatitis B subviral particles is high but either anti-HBV antibody production is fast, the antibody affinity is high, or the levels of pre-existent HBV-specific antibody at the time of infection are high, as could be attained by vaccination. We further showed that viral clearance can be achieved for low equilibrium antiHBV antibody levels, as in unvaccinated individuals, when a strong cellular immune response controls early infection.},
doi = {10.1371/journal.pcbi.1003730},
journal = {PLoS Computational Biology (Online)},
number = 7,
volume = 10,
place = {United States},
year = {Thu Jul 31 00:00:00 EDT 2014},
month = {Thu Jul 31 00:00:00 EDT 2014}
}
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