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Title: Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes

Abstract

General translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states. These elements include mRNA folding, upstream open reading frames, specific nucleotides flanking the initiating AUG codon, protein coding sequence length, and codon usage. The quantitative contributions of these sequence features and how and why they coordinate to control translation rates are not well understood.

Authors:
 [1];  [2]; ORCiD logo [3]
  1. University of California, Los Angeles, CA (United States). Department of Statistics, Department of Biomathematics, and Department of Human Genetics
  2. Fred Hutchinson Cancer Research Center, Seattle, WA (United States). Computational Biology Program, Public Health Sciences and Basic Sciences Division
  3. Lawrence Berkeley National Laboratory, Berkeley, CA (United States). Biological Systems and Engineering Division
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1626948
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Genome Biology (Online)
Additional Journal Information:
Journal Name: Genome Biology (Online); Journal Volume: 20; Journal Issue: 1; Journal ID: ISSN 1474-760X
Publisher:
BioMed Central
Country of Publication:
United States
Language:
English
Subject:
Biotechnology & Applied Microbiology; Genetics & Heredity

Citation Formats

Li, Jingyi Jessica, Chew, Guo-Liang, and Biggin, Mark Douglas. Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes. United States: N. p., 2019. Web. https://doi.org/10.1186/s13059-019-1761-9.
Li, Jingyi Jessica, Chew, Guo-Liang, & Biggin, Mark Douglas. Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes. United States. https://doi.org/10.1186/s13059-019-1761-9
Li, Jingyi Jessica, Chew, Guo-Liang, and Biggin, Mark Douglas. Fri . "Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes". United States. https://doi.org/10.1186/s13059-019-1761-9. https://www.osti.gov/servlets/purl/1626948.
@article{osti_1626948,
title = {Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes},
author = {Li, Jingyi Jessica and Chew, Guo-Liang and Biggin, Mark Douglas},
abstractNote = {General translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states. These elements include mRNA folding, upstream open reading frames, specific nucleotides flanking the initiating AUG codon, protein coding sequence length, and codon usage. The quantitative contributions of these sequence features and how and why they coordinate to control translation rates are not well understood.},
doi = {10.1186/s13059-019-1761-9},
journal = {Genome Biology (Online)},
number = 1,
volume = 20,
place = {United States},
year = {2019},
month = {8}
}

Journal Article:
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