Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

Gazave, Eve; Lapébie, Pascal; Richards, Gemma S.; Brunet, Frédéric; Ereskovsky, Alexander V.; Degnan, Bernard M.; Borchiellini, Carole; Vervoort, Michel; Renard, Emmanuelle

doi:10.1186/1471-2148-9-249

Title: Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

Journal Article · 13 October 2009 · BMC Evolutionary Biology (Online)

DOI: https://doi.org/10.1186/1471-2148-9-249 · OSTI ID:1626382

Gazave, Eve ^[1]; Lapébie, Pascal ^[1]; Richards, Gemma S. ^[2]; Brunet, Frédéric ^[3]; Ereskovsky, Alexander V. ^[4]; Degnan, Bernard M. ^[2]; Borchiellini, Carole ^[1]; Vervoort, Michel ^[5]; Renard, Emmanuelle ^[1]

Aix-Marseille Universités, Marseille (France)
Univ. of Queensland, Brisbane, QLD (Australia)
Université de Lyon (France)
Aix-Marseille Universités, Marseille (France); St. Petersburg State Univ. (Russian Federation)
Université Paris Diderot (France)

Background: Of the 20 or so signal transduction pathways that orchestrate cell-cell interactions in metazoans, seven are involved during development. One of these is the Notch signalling pathway which regulates cellular identity, proliferation, differentiation and apoptosis via the developmental processes of lateral inhibition and boundary induction. In light of this essential role played in metazoan development, we surveyed a wide range of eukaryotic genomes to determine the origin and evolution of the components and auxiliary factors that compose and modulate this pathway. Results: We searched for 22 components of the Notch pathway in 35 different species that represent 8 major clades of eukaryotes, performed phylogenetic analyses and compared the domain compositions of the two fundamental molecules: the receptor Notch and its ligands Delta/ Jagged. We confirm that a Notch pathway, with true receptors and ligands is specific to the Metazoa. This study also sheds light on the deep ancestry of a number of genes involved in this pathway, while other members are revealed to have a more recent origin. The origin of several components can be accounted for by the shuffling of pre-existing protein domains, or via lateral gene transfer. In addition, certain domains have appeared de novo more recently, and can be considered metazoan synapomorphies. Conclusion: The Notch signalling pathway emerged in Metazoa via a diversity of molecular mechanisms, incorporating both novel and ancient protein domains during eukaryote evolution. Thus, a functional Notch signalling pathway was probably present in Urmetazoa.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1626382

Journal Information:: BMC Evolutionary Biology (Online), Vol. 9, Issue 1; ISSN 1471-2148

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

References (197)

The Pfam protein families database Finn, R. D.; Tate, J.; Mistry, J. Nucleic Acids Research, Vol. 36, Issue Database https://doi.org/10.1093/nar/gkm960	journal	December 2007
From the Notch Signaling Pathway to Ribosome Biogenesis Chantha, SierChing; Tebbji, Faiza; Matton, Daniel P. Plant Signaling & Behavior, Vol. 2, Issue 3 https://doi.org/10.4161/psb.2.3.3724	journal	May 2007
Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila Sun, X.; Artavanis-Tsakonas, S. Development, Vol. 124, Issue 17 https://doi.org/10.1242/dev.124.17.3439	journal	September 1997
SMART 6: recent updates and new developments Letunic, I.; Doerks, T.; Bork, P. Nucleic Acids Research, Vol. 37, Issue Database https://doi.org/10.1093/nar/gkn808	journal	January 2009
The 20 years of PROSITE Hulo, N.; Bairoch, A.; Bulliard, V. Nucleic Acids Research, Vol. 36, Issue Database https://doi.org/10.1093/nar/gkm977	journal	December 2007
Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom Huminiecki, Lukasz; Goldovsky, Leon; Freilich, Shiri BMC Evolutionary Biology, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2148-9-28	journal	January 2009
The Deep Roots of Eukaryotes Baldauf, S. L. Science, Vol. 300, Issue 5626 https://doi.org/10.1126/science.1085544	journal	June 2003
The interplay between DSL proteins and ubiquitin ligases in Notch signaling Pitsouli, Chrysoula; Delidakis, Christos Development, Vol. 132, Issue 18 https://doi.org/10.1242/dev.01979	journal	September 2005
Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis Chen, Wenbiao; Casey Corliss, D. Developmental Biology, Vol. 267, Issue 2 https://doi.org/10.1016/j.ydbio.2003.11.010	journal	March 2004
Expansion of Protein Domain Repeats Björklund, Åsa K.; Ekman, Diana; Elofsson, Arne PLoS Computational Biology, Vol. 2, Issue 8 https://doi.org/10.1371/journal.pcbi.0020114	journal	August 2006
Placozoa – no longer a phylum of one Voigt, Oliver; Collins, Allen G.; Pearse, Vicki Buchsbaum Current Biology, Vol. 14, Issue 22 https://doi.org/10.1016/j.cub.2004.10.036	journal	November 2004
Isolation and Characterization of the Notch Ligand Delta4 Rao, Prakash K.; Dorsch, Marion; Chickering, Troy Experimental Cell Research, Vol. 260, Issue 2 https://doi.org/10.1006/excr.2000.5034	journal	November 2000
Notch Ligands Are Substrates for Protein O- Fucosyltransferase-1 and Fringe Panin, Vladislav M.; Shao, Li; Lei, Liang Journal of Biological Chemistry, Vol. 277, Issue 33 https://doi.org/10.1074/jbc.M204445200	journal	May 2002
Concatenated Analysis Sheds Light on Early Metazoan Evolution and Fuels a Modern “Urmetazoon” Hypothesis Schierwater, Bernd; Eitel, Michael; Jakob, Wolfgang PLoS Biology, Vol. 7, Issue 1 https://doi.org/10.1371/journal.pbio.1000020	journal	January 2009
Matrix-mediated canal formation in primmorphs from the sponge Suberites domuncula involves the expression of a CD36 receptor-ligand system Müller, Werner E. G.; Thakur, Narsinh L.; Ushijima, Hiroshi Journal of Cell Science, Vol. 117, Issue 12 https://doi.org/10.1242/jcs.01083	journal	May 2004
Notch Signaling: From the Outside In Mumm, Jeffrey S.; Kopan, Raphael Developmental Biology, Vol. 228, Issue 2 https://doi.org/10.1006/dbio.2000.9960	journal	December 2000
Lateral Gene Transfer and Metabolic Adaptation in the Human Parasite Trichomonas vaginalis de Koning, Audrey P.; Brinkman, Fiona S. L.; Jones, Steven J. M. Molecular Biology and Evolution, Vol. 17, Issue 11 https://doi.org/10.1093/oxfordjournals.molbev.a026275	journal	November 2000
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Frise, E.; Knoblich, J. A.; Younger-Shepherd, S. Proceedings of the National Academy of Sciences, Vol. 93, Issue 21 https://doi.org/10.1073/pnas.93.21.11925	journal	October 1996
The Drosophila melanogaster Suppressor of deltex Gene, a Regulator of the Notch Receptor Signaling Pathway, Is an E3 Class Ubiquitin Ligase Cornell, M.; Evans, D. A. P.; Mann, R. Genetics, Vol. 152, Issue 2 https://doi.org/10.1093/genetics/152.2.567	journal	June 1999
The ankyrin repeat: a diversity of interactions on a common structural framework Sedgwick, Steven G.; Smerdon, Stephen J. Trends in Biochemical Sciences, Vol. 24, Issue 8 https://doi.org/10.1016/S0968-0004(99)01426-7	journal	August 1999
The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function van Nocker, Steven; Ludwig, Philip BMC Genomics, Vol. 4, Issue 1 https://doi.org/10.1186/1471-2164-4-50	journal	December 2003
MRBAYES: Bayesian inference of phylogenetic trees Huelsenbeck, J. P.; Ronquist, F. Bioinformatics, Vol. 17, Issue 8 https://doi.org/10.1093/bioinformatics/17.8.754	journal	August 2001
Genesis and Expansion of Metazoan Transcription Factor Gene Classes Larroux, Claire; Luke, Graham N.; Koopman, Peter Molecular Biology and Evolution, Vol. 25, Issue 5 https://doi.org/10.1093/molbev/msn047	journal	February 2008
Fungal CSL transcription factors Převorovský, Martin; Půta, František; Folk, Petr BMC Genomics, Vol. 8, Issue 1 https://doi.org/10.1186/1471-2164-8-233	journal	July 2007
A Kingdom-Level Phylogeny of Eukaryotes Based on Combined Protein Data Baldauf, S. L. Science, Vol. 290, Issue 5493 https://doi.org/10.1126/science.290.5493.972	journal	November 2000
Basic local alignment search tool Altschul, Stephen F.; Gish, Warren; Miller, Webb Journal of Molecular Biology, Vol. 215, Issue 3, p. 403-410 https://doi.org/10.1016/S0022-2836(05)80360-2	journal	October 1990
Sponge paraphyly and the origin of Metazoa: Sponge paraphyly Borchiellini, C.; Manuel, M.; Alivon, E. Journal of Evolutionary Biology, Vol. 14, Issue 1 https://doi.org/10.1046/j.1420-9101.2001.00244.x	journal	January 2001
Evolution of distinct EGF domains with specific functions Wouters, Merridee A.; Rigoutsos, Isidore; Chu, Carmen K. Protein Science, Vol. 14, Issue 4 https://doi.org/10.1110/ps.041207005	journal	April 2005
MUSCLE: a multiple sequence alignment method with reduced time and space complexity Edgar, Robert C. BMC Bioinformatics, Vol. 5, Issue 1, p. 113 https://doi.org/10.1186/1471-2105-5-113	journal	August 2004
Notch Signaling: Cell Fate Control and Signal Integration in Development Artavanis-Tsakonas, S. Science, Vol. 284, Issue 5415 https://doi.org/10.1126/science.284.5415.770	journal	April 1999
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families Clark, R. F.; Hutton, M.; Fuldner, M. Nature Genetics, Vol. 11, Issue 2 https://doi.org/10.1038/ng1095-219	journal	October 1995
Mastermind is a putative activator for Notch Petcherski, Andrei G.; Kimble, Judith Current Biology, Vol. 10, Issue 13 https://doi.org/10.1016/S0960-9822(00)00577-7	journal	June 2000
Furin cleavage is not a requirement for Drosophila Notch function Kidd, Simon; Lieber, Toby Mechanisms of Development, Vol. 115, Issue 1-2 https://doi.org/10.1016/S0925-4773(02)00120-X	journal	July 2002
The Unicellular Ancestry of Animal Development King, Nicole Developmental Cell, Vol. 7, Issue 3 https://doi.org/10.1016/j.devcel.2004.08.010	journal	September 2004
Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics Simionato, Elena; Ledent, Valérie; Richards, Gemma BMC Evolutionary Biology, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2148-7-33	journal	January 2007
A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1 Mumm, Jeffrey S.; Schroeter, Eric H.; Saxena, Meera T. Molecular Cell, Vol. 5, Issue 2 https://doi.org/10.1016/S1097-2765(00)80416-5	journal	February 2000
Evolutionary genomics of nucleo-cytoplasmic large DNA viruses Iyer, Lakshminarayan M.; Balaji, S.; Koonin, Eugene V. Virus Research, Vol. 117, Issue 1 https://doi.org/10.1016/j.virusres.2006.01.009	journal	April 2006
Regulation of Notch Signaling Activity Schweisguth, François Current Biology, Vol. 14, Issue 3 https://doi.org/10.1016/j.cub.2004.01.023	journal	February 2004
A unifying model for functional difference and redundancy of presenilin-1 and -2 in cell apoptosis and differentiation Hashimoto-Gotoh, Tamotsu; Tsujimura, Atsushi; Watanabe, Yoshihisa Gene, Vol. 323 https://doi.org/10.1016/j.gene.2003.09.010	journal	December 2003
Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats Wharton, Kristi A.; Johansen, Kristen M.; Xu, Tian Cell, Vol. 43, Issue 3 https://doi.org/10.1016/0092-8674(85)90229-6	journal	December 1985
Eukaryotic Signalling Domain Homologues in Archaea and Bacteria. Ancient Ancestry and Horizontal Gene Transfer Ponting, C. P.; Aravind, L.; Schultz, J. Journal of Molecular Biology, Vol. 289, Issue 4 https://doi.org/10.1006/jmbi.1999.2827	journal	June 1999
Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity Royet, J. The EMBO Journal, Vol. 17, Issue 24 https://doi.org/10.1093/emboj/17.24.7351	journal	December 1998
Moonlighting activity of presenilin in plants is independent of -secretase and evolutionarily conserved Khandelwal, A.; Chandu, D.; Roe, C. M. Proceedings of the National Academy of Sciences, Vol. 104, Issue 33 https://doi.org/10.1073/pnas.0702038104	journal	August 2007
Notch signaling: the demise of elegant simplicity Kadesch, Tom Current Opinion in Genetics & Development, Vol. 14, Issue 5 https://doi.org/10.1016/j.gde.2004.07.007	journal	October 2004
neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development Lai, E. C.; Rubin, G. M. Proceedings of the National Academy of Sciences, Vol. 98, Issue 10 https://doi.org/10.1073/pnas.101135498	journal	May 2001
The strawberry notch gene functions with Notch in common developmental pathways Coyle-Thompson, C. A.; Banerjee, U. Development, Vol. 119, Issue 2 https://doi.org/10.1242/dev.119.2.377	journal	October 1993
Phylogeny.fr: robust phylogenetic analysis for the non-specialist Dereeper, A.; Guignon, V.; Blanc, G. Nucleic Acids Research, Vol. 36, Issue Web Server https://doi.org/10.1093/nar/gkn180	journal	May 2008
Evolution of novel genes Long, Manyuan Current Opinion in Genetics & Development, Vol. 11, Issue 6 https://doi.org/10.1016/S0959-437X(00)00252-5	journal	December 2001
Mutational and Energetic Studies of Notch1 Transcription Complexes Del Bianco, Cristina; Aster, Jon C.; Blacklow, Stephen C. Journal of Molecular Biology, Vol. 376, Issue 1 https://doi.org/10.1016/j.jmb.2007.11.061	journal	February 2008
Notch signalling: a simple pathway becomes complex Bray, Sarah J. Nature Reviews Molecular Cell Biology, Vol. 7, Issue 9 https://doi.org/10.1038/nrm2009	journal	September 2006
Sponge Genes Provide New Insight into the Evolutionary Origin of the Neurogenic Circuit Richards, Gemma S.; Simionato, Elena; Perron, Muriel Current Biology, Vol. 18, Issue 15 https://doi.org/10.1016/j.cub.2008.06.074	journal	August 2008
The Notch ‘gospel’: Workshop on Notch Signalling in Development and Cancer Radtke, Freddy; Schweisguth, Francois; Pear, Warren EMBO reports, Vol. 6, Issue 12 https://doi.org/10.1038/sj.embor.7400585	journal	December 2005
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Lai, Eric C.; Roegiers, Fabrice; Qin, Xiaoli Development, Vol. 132, Issue 10 https://doi.org/10.1242/dev.01825	journal	May 2005
Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo Gu, Y.; Hukriede, N. A.; Fleming, R. J. Development, Vol. 121, Issue 3 https://doi.org/10.1242/dev.121.3.855	journal	March 1995
The Trichoplax genome and the nature of placozoans Srivastava, Mansi; Begovic, Emina; Chapman, Jarrod Nature, Vol. 454, Issue 7207 https://doi.org/10.1038/nature07191	journal	August 2008
A genomewide survey of developmentally relevant genes in Ciona intestinalis: V. Genes for receptor tyrosine kinase pathway and Notch signaling pathway Satou, Yutaka; Sasakura, Yasunori; Yamada, Lixy Development Genes and Evolution, Vol. 213, Issue 5-6 https://doi.org/10.1007/s00427-003-0317-9	journal	May 2003
Building γ-secretase – the bits and pieces Spasic, Dragana; Annaert, Wim Journal of Cell Science, Vol. 121, Issue 4 https://doi.org/10.1242/jcs.015255	journal	February 2008
Underexpression of the plant NOTCHLESS gene, encoding a WD-repeat protein, causes pleitropic phenotype during plant development Chantha, Sier-Ching; Matton, Daniel P. Planta, Vol. 225, Issue 5 https://doi.org/10.1007/s00425-006-0420-z	journal	November 2006
ADAMs are present in fungi: Identification of two novel ADAM genes in Aspergillus fumigatus Lavens, Sandra E.; Rovira-Graells, Núria; Birch, Mike FEMS Microbiology Letters, Vol. 248, Issue 1 https://doi.org/10.1016/j.femsle.2005.05.017	journal	July 2005
The ancient regulatory-protein family of WD-repeat proteins Neer, Eva J.; Schmidt, Carl J.; Nambudripad, Raman Nature, Vol. 371, Issue 6495 https://doi.org/10.1038/371297a0	journal	September 1994
LIN-12/Notch signaling: lessons from worms and flies Greenwald, I. Genes & Development, Vol. 12, Issue 12 https://doi.org/10.1101/gad.12.12.1751	journal	June 1998
Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila Le Borgne, Roland; Remaud, Sylvie; Hamel, Sophie PLoS Biology, Vol. 3, Issue 4 https://doi.org/10.1371/journal.pbio.0030096	journal	March 2005
SUPERFAMILY—sophisticated comparative genomics, data mining, visualization and phylogeny Wilson, Derek; Pethica, Ralph; Zhou, Yiduo Nucleic Acids Research, Vol. 37, Issue suppl_1 https://doi.org/10.1093/nar/gkn762	journal	November 2008
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture Ingham, Robert J.; Gish, Gerald; Pawson, Tony Oncogene, Vol. 23, Issue 11 https://doi.org/10.1038/sj.onc.1207436	journal	March 2004
Fringe forms a complex with Notch Ju, Bong-Gun; Jeong, Sangyun; Bae, Eunkyung Nature, Vol. 405, Issue 6783 https://doi.org/10.1038/35012090	journal	May 2000
Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA Wilson, Jeffrey J.; Kovall, Rhett A. Cell, Vol. 124, Issue 5 https://doi.org/10.1016/j.cell.2006.01.035	journal	March 2006
Phylogenomics Revives Traditional Views on Deep Animal Relationships Philippe, Hervé; Derelle, Romain; Lopez, Philippe Current Biology, Vol. 19, Issue 8 https://doi.org/10.1016/j.cub.2009.02.052	journal	April 2009
Bayesian and maximum likelihood phylogenetic analyses of protein sequence data under relative branch-length differences and model violation Mar, Jessica C.; Harlow, Timothy J.; Ragan, Mark A. BMC Evolutionary Biology, Vol. 5, Issue 1, p. 8 https://doi.org/10.1186/1471-2148-5-8	journal	January 2005
Complex of Pregnancy-associated Plasma Protein-A and the Proform of Eosinophil Major Basic Protein Overgaard, Michael T.; Sørensen, Esben S.; Stachowiak, Damian Journal of Biological Chemistry, Vol. 278, Issue 4 https://doi.org/10.1074/jbc.M208777200	journal	January 2003
Differential Effects of Drosophila Mastermind on Asymmetric Cell Fate Specification and Neuroblast Formation Yedvobnick, Barry; Kumar, Anumeha; Chaudhury, Padmashree Genetics, Vol. 166, Issue 3 https://doi.org/10.1534/genetics.166.3.1281	journal	March 2004
Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology Huelsenbeck, J. P. Science, Vol. 294, Issue 5550 https://doi.org/10.1126/science.1065889	journal	December 2001
Notch Signaling: A Dance of Proteins Changing Partners Kadesch, Tom Experimental Cell Research, Vol. 260, Issue 1 https://doi.org/10.1006/excr.2000.4921	journal	October 2000
Characterization of the plant Notchless homolog, a WD repeat protein involved in seed development Chantha, Sier-Ching; Emerald, B. Starling; Matton, Daniel P. Plant Molecular Biology, Vol. 62, Issue 6 https://doi.org/10.1007/s11103-006-9064-4	journal	September 2006
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway Kao, H. -Y.; Ordentlich, P.; Koyano-Nakagawa, N. Genes & Development, Vol. 12, Issue 15 https://doi.org/10.1101/gad.12.15.2269	journal	August 1998
1998 warkany lecture: Signaling pathways in development Gerhart, John Teratology, Vol. 60, Issue 4 https://doi.org/10.1002/(SICI)1096-9926(199910)60:4<226::AID-TERA7>3.0.CO;2-W	journal	October 1999
The evolution of signalling pathways in animal development Pires-daSilva, André; Sommer, Ralf J. Nature Reviews Genetics, Vol. 4, Issue 1 https://doi.org/10.1038/nrg977	journal	January 2003
Review: How was metazoan threshold crossed? The hypothetical Urmetazoa Müller, Werner E. G. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Vol. 129, Issue 2-3 https://doi.org/10.1016/S1095-6433(00)00360-3	journal	June 2001
Choosing BLAST options for better detection of orthologs as reciprocal best hits Moreno-Hagelsieb, G.; Latimer, K. Bioinformatics, Vol. 24, Issue 3 https://doi.org/10.1093/bioinformatics/btm585	journal	November 2007
An unusual choanoflagellate protein released by Hedgehog autocatalytic processing Snell, Elizabeth A.; Brooke, Nina M.; Taylor, William R. Proceedings of the Royal Society B: Biological Sciences, Vol. 273, Issue 1585 https://doi.org/10.1098/rspb.2005.3263	journal	November 2005
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans King, Nicole; Westbrook, M. Jody; Young, Susan L. Nature, Vol. 451, Issue 7180 https://doi.org/10.1038/nature06617	journal	February 2008
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA Kovall, Rhett A.; Hendrickson, Wayne A. The EMBO Journal, Vol. 23, Issue 17 https://doi.org/10.1038/sj.emboj.7600349	journal	August 2004
Evolution of the holozoan ribosome biogenesis regulon Brown, Seth J.; Cole, Michael D.; Erives, Albert J. BMC Genomics, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2164-9-442	journal	September 2008
The Notch1 receptor is cleaved constitutively by a furin-like convertase Logeat, F.; Bessia, C.; Brou, C. Proceedings of the National Academy of Sciences, Vol. 95, Issue 14 https://doi.org/10.1073/pnas.95.14.8108	journal	July 1998
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos Uemura, Tadashi; Shepherd, Susan; Ackerman, Larry Cell, Vol. 58, Issue 2 https://doi.org/10.1016/0092-8674(89)90849-0	journal	July 1989
Confidence Limits on Phylogenies: An Approach Using the Bootstrap Felsenstein, Joseph Evolution, Vol. 39, Issue 4, p. 783-791 https://doi.org/10.2307/2408678	journal	July 1985
Gene Loss, Protein Sequence Divergence, Gene Dispensability, Expression Level, and Interactivity Are Correlated in Eukaryotic Evolution Krylov, D. M. Genome Research, Vol. 13, Issue 10 https://doi.org/10.1101/gr.1589103	journal	October 2003
Hundreds of ankyrin-like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally? Bork, Peer Proteins: Structure, Function, and Genetics, Vol. 17, Issue 4 https://doi.org/10.1002/prot.340170405	journal	December 1993
Phylogenetic analysis of Amphioxus genes of the proprotein convertase family, including aPC6C, a marker of epithelial fusions during embryology Bertrand, Stéphanie; Camasses, Alain; Paris, Mathilde International Journal of Biological Sciences https://doi.org/10.7150/ijbs.2.125	journal	January 2006
Ankyrin Repeat: A Unique Motif Mediating Protein−Protein Interactions ^† Li, Junan; Mahajan, Anjali; Tsai, Ming-Daw Biochemistry, Vol. 45, Issue 51 https://doi.org/10.1021/bi062188q	journal	December 2006
Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine Gagnon, Jeffrey; Mayne, Janice; Mbikay, Majambu Regulatory Peptides, Vol. 152, Issue 1-3 https://doi.org/10.1016/j.regpep.2008.07.006	journal	January 2009
Notch Signaling Pathway Ehebauer, M.; Hayward, P.; Martinez-Arias, A. Science's STKE, Vol. 2006, Issue 364 https://doi.org/10.1126/stke.3642006cm7	journal	November 2006
MUSCLE: multiple sequence alignment with high accuracy and high throughput Edgar, R. C. Nucleic Acids Research, Vol. 32, Issue 5, p. 1792-1797 https://doi.org/10.1093/nar/gkh340	journal	March 2004
The role of presenilin cofactors in the γ-secretase complex Takasugi, Nobumasa; Tomita, Taisuke; Hayashi, Ikuo Nature, Vol. 422, Issue 6930 https://doi.org/10.1038/nature01506	journal	March 2003
Genome assembly forensics: finding the elusive mis-assembly Phillippy, Adam M.; Schatz, Michael C.; Pop, Mihai Genome Biology, Vol. 9, Issue 3 https://doi.org/10.1186/gb-2008-9-3-r55	journal	January 2008
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling Barolo, S. Genes & Development, Vol. 16, Issue 10 https://doi.org/10.1101/gad.976502	journal	May 2002
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation Francis, Ross; McGrath, Garth; Zhang, Jianhuan Developmental Cell, Vol. 3, Issue 1 https://doi.org/10.1016/S1534-5807(02)00189-2	journal	July 2002
PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization Nakai, Kenta; Horton, Paul Trends in Biochemical Sciences, Vol. 24, Issue 1 https://doi.org/10.1016/S0968-0004(98)01336-X	journal	January 1999
Notch signaling during larval and juvenile development in the polychaete annelid Capitella sp. I Thamm, Katrin; Seaver, Elaine C. Developmental Biology, Vol. 320, Issue 1 https://doi.org/10.1016/j.ydbio.2008.04.015	journal	August 2008
Phylogenetic Context and Basal Metazoan Model Systems Collins, A. G. Integrative and Comparative Biology, Vol. 45, Issue 4 https://doi.org/10.1093/icb/45.4.585	journal	August 2005
CDD: a conserved domain database for interactive domain family analysis Marchler-Bauer, A.; Anderson, J. B.; Derbyshire, M. K. Nucleic Acids Research, Vol. 35, Issue Database https://doi.org/10.1093/nar/gkl951	journal	January 2007
The presenilins Tandon, Anurag; Fraser, Paul Genome Biology, Vol. 3, Issue 11, p. reviews3014.1 https://doi.org/10.1186/gb-2002-3-11-reviews3014	journal	January 2002
InterProScan: protein domains identifier Quevillon, E.; Silventoinen, V.; Pillai, S. Nucleic Acids Research, Vol. 33, Issue Web Server https://doi.org/10.1093/nar/gki442	journal	July 2005
deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Xu, T.; Artavanis-Tsakonas, S. Genetics, Vol. 126, Issue 3 https://doi.org/10.1093/genetics/126.3.665	journal	November 1990
kuzbanian-mediated cleavage of Drosophila Notch Lieber, T. Genes & Development, Vol. 16, Issue 2 https://doi.org/10.1101/gad.942302	journal	January 2002
Lineage-specific loss and divergence of functionally linked genes in eukaryotes Aravind, L.; Watanabe, H.; Lipman, D. J. Proceedings of the National Academy of Sciences, Vol. 97, Issue 21 https://doi.org/10.1073/pnas.200346997	journal	October 2000
fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development Irvine, Kenneth D.; Wieschaus, Eric Cell, Vol. 79, Issue 4 https://doi.org/10.1016/0092-8674(94)90545-2	journal	November 1994
Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning Adamska, Maja; Degnan, Sandie M.; Green, Kathryn M. PLoS ONE, Vol. 2, Issue 10 https://doi.org/10.1371/journal.pone.0001031	journal	October 2007
Why is delta endocytosis required for effective activation of notch? Chitnis, Ajay Developmental Dynamics, Vol. 235, Issue 4 https://doi.org/10.1002/dvdy.20683	journal	January 2006
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Schroeter, Eric H.; Kisslinger, Jeffrey A.; Kopan, Raphael Nature, Vol. 393, Issue 6683 https://doi.org/10.1038/30756	journal	May 1998
The evolutionary origin of hedgehog proteins Adamska, Maja; Matus, David Q.; Adamski, Marcin Current Biology, Vol. 17, Issue 19 https://doi.org/10.1016/j.cub.2007.08.010	journal	October 2007
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function Cleary, James P.; Walsh, Dominic M.; Hofmeister, Jacki J. Nature Neuroscience, Vol. 8, Issue 1 https://doi.org/10.1038/nn1372	journal	December 2004
Comparative analysis of neurogenesis in the myriapod Glomeris marginata (Diplopoda) suggests more similarities to chelicerates than to insects Dove, Hilary; Stollewerk, Angelika Development, Vol. 130, Issue 10 https://doi.org/10.1242/dev.00442	journal	May 2003
Effects of Branch Length Uncertainty on Bayesian Posterior Probabilities for Phylogenetic Hypotheses Kolaczkowski, Bryan; Thornton, Joseph W. Molecular Biology and Evolution, Vol. 24, Issue 9 https://doi.org/10.1093/molbev/msm141	journal	July 2007
The transcription factor NF-κB in the demosponge Amphimedon queenslandica: insights on the evolutionary origin of the Rel homology domain Gauthier, Marie; Degnan, Bernard M. Development Genes and Evolution, Vol. 218, Issue 1 https://doi.org/10.1007/s00427-007-0197-5	journal	January 2008
Presenilin 1: more than just γ-secretase Raemaekers, T.; Esselens, C.; Annaert, W. Biochemical Society Transactions, Vol. 33, Issue 4 https://doi.org/10.1042/BST0330559	journal	August 2005
Role of the Ram Domain and Ankyrin Repeats on Notch Signaling and Activity in Cells of Osteoblastic Lineage Deregowski, Valerie; Gazzerro, Elisabetta; Priest, Leah Journal of Bone and Mineral Research, Vol. 21, Issue 8 https://doi.org/10.1359/jbmr.060505	journal	May 2006
The genome reduction hypothesis and the phylogeny of eukaryotes Bapteste, Eric; Gribaldo, Simonetta Trends in Genetics, Vol. 19, Issue 12 https://doi.org/10.1016/j.tig.2003.10.004	journal	December 2003
SMART, a simple modular architecture research tool: Identification of signaling domains Schultz, J.; Milpetz, F.; Bork, P. Proceedings of the National Academy of Sciences, Vol. 95, Issue 11 https://doi.org/10.1073/pnas.95.11.5857	journal	May 1998
Highly Conserved O -Fucose Sites Have Distinct Effects on Notch1 Function Rampal, Raajit; Arboleda-Velasquez, Joseph F.; Nita-Lazar, Alexandra Journal of Biological Chemistry, Vol. 280, Issue 37 https://doi.org/10.1074/jbc.M506104200	journal	July 2005
Evolutionary connections between bacterial and eukaryotic signaling systems: a genomic perspective Aravind, L.; Anantharaman, Vivek; Iyer, Lakshminaryan M. Current Opinion in Microbiology, Vol. 6, Issue 5 https://doi.org/10.1016/j.mib.2003.09.003	journal	October 2003
The roles of receptor and ligand endocytosis in regulating Notch signaling Le Borgne, Roland; Bardin, Allison; Schweisguth, François Development, Vol. 132, Issue 8 https://doi.org/10.1242/dev.01789	journal	April 2005
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling Fortini, Mark E. Nature Reviews Molecular Cell Biology, Vol. 3, Issue 9 https://doi.org/10.1038/nrm910	journal	September 2002
The Notch signaling pathway in the cnidarian Hydra Käsbauer, Tina; Towb, Par; Alexandrova, Olga Developmental Biology, Vol. 303, Issue 1 https://doi.org/10.1016/j.ydbio.2006.11.022	journal	March 2007
Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif Bürglin, Thomas R. BMC Genomics, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2164-9-127	journal	January 2008
An overview of the Notch signalling pathway Baron, M. Seminars in Cell & Developmental Biology, Vol. 14, Issue 2 https://doi.org/10.1016/S1084-9521(02)00179-9	journal	April 2003
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Sanchez-Irizarry, C. Molecular and Cellular Biology, Vol. 24, Issue 21, p. 9265-9273 https://doi.org/10.3410/f.1025565.300753	journal	November 2004
Notch, a Universal Arbiter of Cell Fate Decisions Ehebauer, M.; Hayward, P.; Arias, A. M. Science, Vol. 314, Issue 5804 https://doi.org/10.1126/science.1134042	journal	December 2006
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis Rogers, S.; Wells, R.; Rechsteiner, M. Science, Vol. 234, Issue 4774 https://doi.org/10.1126/science.2876518	journal	October 1986
Notch Subunit Heterodimerization and Prevention of Ligand-Independent Proteolytic Activation Depend, Respectively, on a Novel Domain and the LNR Repeats Sanchez-Irizarry, C.; Carpenter, A. C.; Weng, A. P. Molecular and Cellular Biology, Vol. 24, Issue 21 https://doi.org/10.1128/MCB.24.21.9265-9273.2004	journal	October 2004
AmphioxusAmphiDelta: evolution of delta protein structure, segmentation, and neurogenesis Rasmussen, Stacy L. K.; Holland, Linda Z.; Schubert, Michael genesis, Vol. 45, Issue 3 https://doi.org/10.1002/dvg.20278	journal	January 2007
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood Guindon, Stéphane; Gascuel, Olivier Systematic Biology, Vol. 52, Issue 5 https://doi.org/10.1080/10635150390235520	journal	October 2003
Why is delta endocytosis required for effective activation of notch? Chitnis, Ajay Developmental Dynamics, Vol. 235, Issue 4 https://doi.org/10.1002/dvdy.20683	journal	January 2006
Notch Signaling: From the Outside In Mumm, Jeffrey S.; Kopan, Raphael Developmental Biology, Vol. 228, Issue 2 https://doi.org/10.1006/dbio.2000.9960	journal	December 2000
Isolation and Characterization of the Notch Ligand Delta4 Rao, Prakash K.; Dorsch, Marion; Chickering, Troy Experimental Cell Research, Vol. 260, Issue 2 https://doi.org/10.1006/excr.2000.5034	journal	November 2000
Eukaryotic Signalling Domain Homologues in Archaea and Bacteria. Ancient Ancestry and Horizontal Gene Transfer Ponting, C. P.; Aravind, L.; Schultz, J. Journal of Molecular Biology, Vol. 289, Issue 4 https://doi.org/10.1006/jmbi.1999.2827	journal	June 1999
The transcription factor NF-κB in the demosponge Amphimedon queenslandica: insights on the evolutionary origin of the Rel homology domain Gauthier, Marie; Degnan, Bernard M. Development Genes and Evolution, Vol. 218, Issue 1 https://doi.org/10.1007/s00427-007-0197-5	journal	January 2008
Genetic diversity of Amomum xanthioides and its related species from Southeast Asia and China Sone, Mikako; Zhu, Shu; Cheng, Xiao Journal of Natural Medicines, Vol. 75, Issue 4 https://doi.org/10.1007/s11418-021-01512-2	journal	May 2021
Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats Wharton, Kristi A.; Johansen, Kristen M.; Xu, Tian Cell, Vol. 43, Issue 3 https://doi.org/10.1016/0092-8674(85)90229-6	journal	December 1985
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos Uemura, Tadashi; Shepherd, Susan; Ackerman, Larry Cell, Vol. 58, Issue 2 https://doi.org/10.1016/0092-8674(89)90849-0	journal	July 1989
Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA Wilson, Jeffrey J.; Kovall, Rhett A. Cell, Vol. 124, Issue 5 https://doi.org/10.1016/j.cell.2006.01.035	journal	March 2006
The evolutionary origin of hedgehog proteins Adamska, Maja; Matus, David Q.; Adamski, Marcin Current Biology, Vol. 17, Issue 19 https://doi.org/10.1016/j.cub.2007.08.010	journal	October 2007
Phylogenomics Revives Traditional Views on Deep Animal Relationships Philippe, Hervé; Derelle, Romain; Lopez, Philippe Current Biology, Vol. 19, Issue 8 https://doi.org/10.1016/j.cub.2009.02.052	journal	April 2009
The Unicellular Ancestry of Animal Development King, Nicole Developmental Cell, Vol. 7, Issue 3 https://doi.org/10.1016/j.devcel.2004.08.010	journal	September 2004
Evolutionary connections between bacterial and eukaryotic signaling systems: a genomic perspective Aravind, L.; Anantharaman, Vivek; Iyer, Lakshminaryan M. Current Opinion in Microbiology, Vol. 6, Issue 5 https://doi.org/10.1016/j.mib.2003.09.003	journal	October 2003
The genome reduction hypothesis and the phylogeny of eukaryotes Bapteste, Eric; Gribaldo, Simonetta Trends in Genetics, Vol. 19, Issue 12 https://doi.org/10.1016/j.tig.2003.10.004	journal	December 2003
Amphioxus AmphiDelta: Evolution of delta protein structure, segmentation, and neurogenesis Rasmussen, Stacy L.; Holland, Linda Z.; Schubert, Michael Developmental Biology, Vol. 306, Issue 1 https://doi.org/10.1016/j.ydbio.2007.03.547	journal	June 2007
Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane Blaumueller, Christine M.; Qi, Huilin; Zagouras, Panayiotis Cell, Vol. 90, Issue 2 https://doi.org/10.1016/s0092-8674(00)80336-0	journal	July 1997
ADAMs: focus on the protease domain Black, Roy A.; White, Judith M. Current Opinion in Cell Biology, Vol. 10, Issue 5 https://doi.org/10.1016/s0955-0674(98)80042-2	journal	October 1998
Eukaryotic Evolution: Getting to the Root of the Problem Simpson, Alastair G. B.; Roger, Andrew J. Current Biology, Vol. 12, Issue 20 https://doi.org/10.1016/s0960-9822(02)01207-1	journal	October 2002
A Novel Proteolytic Cleavage Involved in Notch Signaling Brou, Christel; Logeat, Frédérique; Gupta, Neetu Molecular Cell, Vol. 5, Issue 2 https://doi.org/10.1016/s1097-2765(00)80417-7	journal	February 2000
Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta Itoh, Motoyuki; Kim, Cheol-Hee; Palardy, Gregory Developmental Cell, Vol. 4, Issue 1 https://doi.org/10.1016/s1534-5807(02)00409-4	journal	January 2003
Fringe forms a complex with Notch Ju, Bong-Gun; Jeong, Sangyun; Bae, Eunkyung Nature, Vol. 405, Issue 6783 https://doi.org/10.1038/35012090	journal	May 2000
The ancient regulatory-protein family of WD-repeat proteins Neer, Eva J.; Schmidt, Carl J.; Nambudripad, Raman Nature, Vol. 371, Issue 6495 https://doi.org/10.1038/371297a0	journal	September 1994
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans King, Nicole; Westbrook, M. Jody; Young, Susan L. Nature, Vol. 451, Issue 7180 https://doi.org/10.1038/nature06617	journal	February 2008
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families Clark, R. F.; Hutton, M.; Fuldner, M. Nature Genetics, Vol. 11, Issue 2 https://doi.org/10.1038/ng1095-219	journal	October 1995
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling Fortini, Mark E. Nature Reviews Molecular Cell Biology, Vol. 3, Issue 9 https://doi.org/10.1038/nrm910	journal	September 2002
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA Kovall, Rhett A.; Hendrickson, Wayne A. The EMBO Journal, Vol. 23, Issue 17 https://doi.org/10.1038/sj.emboj.7600349	journal	August 2004
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture Ingham, Robert J.; Gish, Gerald; Pawson, Tony Oncogene, Vol. 23, Issue 11 https://doi.org/10.1038/sj.onc.1207436	journal	March 2004
neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development Lai, E. C.; Rubin, G. M. Proceedings of the National Academy of Sciences, Vol. 98, Issue 10 https://doi.org/10.1073/pnas.101135498	journal	May 2001
Lineage-specific loss and divergence of functionally linked genes in eukaryotes Aravind, L.; Watanabe, H.; Lipman, D. J. Proceedings of the National Academy of Sciences, Vol. 97, Issue 21 https://doi.org/10.1073/pnas.200346997	journal	October 2000
The Notch1 receptor is cleaved constitutively by a furin-like convertase Logeat, F.; Bessia, C.; Brou, C. Proceedings of the National Academy of Sciences, Vol. 95, Issue 14 https://doi.org/10.1073/pnas.95.14.8108	journal	July 1998
Presenilin-dependent γ-Secretase-like Intramembrane Cleavage of ErbB4 Lee, Hahn-Jun; Jung, Kwang-Mook; Huang, Yang Z. Journal of Biological Chemistry, Vol. 277, Issue 8 https://doi.org/10.1074/jbc.m110371200	journal	February 2002
Structural Requirements for Assembly of the CSL·Intracellular Notch1·Mastermind-like 1 Transcriptional Activation Complex Nam, Yunsun; Weng, Andrew P.; Aster, Jon C. Journal of Biological Chemistry, Vol. 278, Issue 23 https://doi.org/10.1074/jbc.m301567200	journal	March 2003
Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain McGill, Melanie A.; McGlade, C. Jane Journal of Biological Chemistry, Vol. 278, Issue 25 https://doi.org/10.1074/jbc.m302827200	journal	June 2003
The NHR1 Domain of Neuralized Binds Delta and Mediates Delta Trafficking and Notch Signaling Commisso, Cosimo; Boulianne, Gabrielle L. Molecular Biology of the Cell, Vol. 18, Issue 1 https://doi.org/10.1091/mbc.e06-08-0753	journal	January 2007
Choosing BLAST options for better detection of orthologs as reciprocal best hits Moreno-Hagelsieb, G.; Latimer, K. Bioinformatics, Vol. 24, Issue 3 https://doi.org/10.1093/bioinformatics/btm585	journal	November 2007
Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity Royet, J. The EMBO Journal, Vol. 17, Issue 24 https://doi.org/10.1093/emboj/17.24.7351	journal	December 1998
The Drosophila melanogaster Suppressor of deltex Gene, a Regulator of the Notch Receptor Signaling Pathway, Is an E3 Class Ubiquitin Ligase Cornell, M.; Evans, D. A. P.; Mann, R. Genetics, Vol. 152, Issue 2 https://doi.org/10.1093/genetics/152.2.567	journal	June 1999
InterProScan: protein domains identifier Quevillon, E.; Silventoinen, V.; Pillai, S. Nucleic Acids Research, Vol. 33, Issue Web Server https://doi.org/10.1093/nar/gki442	journal	July 2005
The Pfam protein families database Finn, R. D.; Tate, J.; Mistry, J. Nucleic Acids Research, Vol. 36, Issue Database https://doi.org/10.1093/nar/gkm960	journal	December 2007
Phylogeny.fr: robust phylogenetic analysis for the non-specialist Dereeper, A.; Guignon, V.; Blanc, G. Nucleic Acids Research, Vol. 36, Issue Web Server https://doi.org/10.1093/nar/gkn180	journal	May 2008
SUPERFAMILY—sophisticated comparative genomics, data mining, visualization and phylogeny Wilson, Derek; Pethica, Ralph; Zhou, Yiduo Nucleic Acids Research, Vol. 37, Issue suppl_1 https://doi.org/10.1093/nar/gkn762	journal	November 2008
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway Kao, H. -Y.; Ordentlich, P.; Koyano-Nakagawa, N. Genes & Development, Vol. 12, Issue 15 https://doi.org/10.1101/gad.12.15.2269	journal	August 1998
kuzbanian-mediated cleavage of Drosophila Notch Lieber, T. Genes & Development, Vol. 16, Issue 2 https://doi.org/10.1101/gad.942302	journal	January 2002
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling Barolo, S. Genes & Development, Vol. 16, Issue 10 https://doi.org/10.1101/gad.976502	journal	May 2002
Developmental expression of transcription factor genes in a demosponge: insights into the origin of metazoan multicellularity Larroux, Claire; Fahey, Bryony; Liubicich, Danielle Evolution Development, Vol. 8, Issue 2 https://doi.org/10.1111/j.1525-142x.2006.00086.x	journal	March 2006
Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology Huelsenbeck, J. P. Science, Vol. 294, Issue 5550 https://doi.org/10.1126/science.1065889	journal	December 2001
Rooting the Eukaryote Tree by Using a Derived Gene Fusion Stechmann, A. Science, Vol. 297, Issue 5578 https://doi.org/10.1126/science.1071196	journal	July 2002
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis Rogers, S.; Wells, R.; Rechsteiner, M. Science, Vol. 234, Issue 4774 https://doi.org/10.1126/science.2876518	journal	October 1986
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain Fisher, A. L.; Ohsako, S.; Caudy, M. Molecular and Cellular Biology, Vol. 16, Issue 6 https://doi.org/10.1128/mcb.16.6.2670	journal	June 1996
Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway Tang, Haiyan; Rompani, Santiago B.; Atkins, Joshua B. Molecular and Cellular Biology, Vol. 25, Issue 8 https://doi.org/10.1128/mcb.25.8.2899-2909.2005	journal	April 2005
The Murine Ortholog of Notchless , a Direct Regulator of the Notch Pathway in Drosophila melanogaster , Is Essential for Survival of Inner Cell Mass Cells Cormier, Sarah; Le Bras, Stéphanie; Souilhol, Céline Molecular and Cellular Biology, Vol. 26, Issue 9 https://doi.org/10.1128/mcb.26.9.3541-3549.2006	journal	May 2006
MUSCLE: a multiple sequence alignment method with reduced time and space complexity Edgar, Robert C. BMC Bioinformatics, Vol. 5, Issue 1, p. 113 https://doi.org/10.1186/1471-2105-5-113	journal	August 2004
The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function van Nocker, Steven; Ludwig, Philip BMC Genomics, Vol. 4, Issue 1 https://doi.org/10.1186/1471-2164-4-50	journal	December 2003
Fungal CSL transcription factors Převorovský, Martin; Půta, František; Folk, Petr BMC Genomics, Vol. 8, Issue 1 https://doi.org/10.1186/1471-2164-8-233	journal	July 2007
Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif Bürglin, Thomas R. BMC Genomics, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2164-9-127	journal	January 2008
Evolution of the holozoan ribosome biogenesis regulon Brown, Seth J.; Cole, Michael D.; Erives, Albert J. BMC Genomics, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2164-9-442	journal	September 2008
The roles of receptor and ligand endocytosis in regulating Notch signaling Le Borgne, Roland; Bardin, Allison; Schweisguth, François Development, Vol. 132, Issue 8 https://doi.org/10.1242/dev.01789	journal	April 2005
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Lai, Eric C.; Roegiers, Fabrice; Qin, Xiaoli Development, Vol. 132, Issue 10 https://doi.org/10.1242/dev.01825	journal	May 2005
The interplay between DSL proteins and ubiquitin ligases in Notch signaling Pitsouli, Chrysoula; Delidakis, Christos Development, Vol. 132, Issue 18 https://doi.org/10.1242/dev.01979	journal	September 2005
The strawberry notch gene functions with Notch in common developmental pathways Coyle-Thompson, C. A.; Banerjee, U. Development, Vol. 119, Issue 2 https://doi.org/10.1242/dev.119.2.377	journal	October 1993
Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo Gu, Y.; Hukriede, N. A.; Fleming, R. J. Development, Vol. 121, Issue 3 https://doi.org/10.1242/dev.121.3.855	journal	March 1995
Building γ-secretase – the bits and pieces Spasic, Dragana; Annaert, Wim Journal of Cell Science, Vol. 121, Issue 4 https://doi.org/10.1242/jcs.015255	journal	February 2008
Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila Le Borgne, Roland; Remaud, Sylvie; Hamel, Sophie PLoS Biology, Vol. 3, Issue 4 https://doi.org/10.1371/journal.pbio.0030096	journal	March 2005
Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning Adamska, Maja; Degnan, Sandie M.; Green, Kathryn M. PLoS ONE, Vol. 2, Issue 10 https://doi.org/10.1371/journal.pone.0001031	journal	October 2007
Differential Effects of Drosophila Mastermind on Asymmetric Cell Fate Specification and Neuroblast Formation Yedvobnick, Barry; Kumar, Anumeha; Chaudhury, Padmashree Genetics, Vol. 166, Issue 3 https://doi.org/10.1534/genetics.166.3.1281	journal	March 2004
From the Notch Signaling Pathway to Ribosome Biogenesis Chantha, SierChing; Tebbji, Faiza; Matton, Daniel P. Plant Signaling & Behavior, Vol. 2, Issue 3 https://doi.org/10.4161/psb.2.3.3724	journal	May 2007

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The Notch pathway in the annelid Platynereis : insights into chaetogenesis and neurogenesis processes Gazave, Eve; Lemaître, Quentin I. B.; Balavoine, Guillaume Open Biology, Vol. 7, Issue 2 https://doi.org/10.1098/rsob.160242	journal	February 2017
Active Notch Signaling is Required for Arm Regeneration in a Brittle Star Mashanov, Vladimir; Akiona, Jennifer; Khoury, Maleana PLOS ONE https://doi.org/10.1101/2019.12.13.875401	posted_content	January 2019
Gene family innovation, conservation and loss on the animal stem lineage Richter, Daniel J.; Fozouni, Parinaz; Eisen, Michael B. eLife, Vol. 7 https://doi.org/10.7554/elife.34226	journal	May 2018
Protective Effect of Curcumin on Acute Airway Inflammation of Allergic Asthma in Mice Through Notch1–GATA3 Signaling Pathway Chong, Lei; Zhang, Weixi; Nie, Ying Inflammation, Vol. 37, Issue 5 https://doi.org/10.1007/s10753-014-9873-6	journal	April 2014
Ubiquitylation-independent activation of Notch signalling by Delta Berndt, Nicole; Seib, Ekaterina; Kim, Soya eLife, Vol. 6 https://doi.org/10.7554/elife.27346	journal	September 2017
Insights into Frizzled evolution and new perspectives: Evolution of Frizzled receptor Schenkelaars, Quentin; Fierro-Constain, Laura; Renard, Emmanuelle Evolution & Development, Vol. 17, Issue 2 https://doi.org/10.1111/ede.12115	journal	March 2015
The use of β-cell transcription factors in engineering artificial β cells from non-pancreatic tissue Gerace, D.; Martiniello-Wilks, R.; O'Brien, B. A. Gene Therapy, Vol. 22, Issue 1 https://doi.org/10.1038/gt.2014.93	journal	October 2014
Understanding Animal Evolution: The Added Value of Sponge Transcriptomics and Genomics: The disconnect between gene content and body plan evolution Renard, Emmanuelle; Leys, Sally P.; Wörheide, Gert BioEssays, Vol. 40, Issue 9 https://doi.org/10.1002/bies.201700237	journal	August 2018
Radula diversification promotes ecomorph divergence in an adaptive radiation of freshwater snails Hilgers, Leon; Hartmann, Stefanie; Pfaender, Jobst https://doi.org/10.1101/2020.01.17.910034	posted_content	January 2020
Cellular and molecular processes leading to embryo formation in sponges: evidences for high conservation of processes throughout animal evolution Ereskovsky, Alexander V.; Renard, Emmanuelle; Borchiellini, Carole Development Genes and Evolution, Vol. 223, Issue 1-2 https://doi.org/10.1007/s00427-012-0399-3	journal	April 2012
De novo draft assembly of the Botrylloides leachii genome provides further insight into tunicate evolution Blanchoud, Simon; Rutherford, Kim; Zondag, Lisa Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-23749-w	journal	April 2018
The expression of Delta ligands in the sponge Amphimedon queenslandica suggests an ancient role for Notch signaling in metazoan development Richards, Gemma S.; Degnan, Bernard M. EvoDevo, Vol. 3, Issue 1 https://doi.org/10.1186/2041-9139-3-15	journal	January 2012
A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development Toonen, Joseph A.; Ronchetti, Adam; Sidjanin, D. J. PLOS ONE, Vol. 11, Issue 5 https://doi.org/10.1371/journal.pone.0156184	journal	May 2016
Comparative transcriptomics enlarges the toolkit of known developmental genes in mollusks De Oliveira, A. L.; Wollesen, T.; Kristof, A. BMC Genomics, Vol. 17, Issue 1 https://doi.org/10.1186/s12864-016-3080-9	journal	November 2016
Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway Wu, Jun; Ding, Dan-hua; Li, Qian-qian Frontiers in Cellular Neuroscience, Vol. 13 https://doi.org/10.3389/fncel.2019.00019	journal	February 2019
A Framework for the Establishment of a Cnidarian Gene Regulatory Network for “Endomesoderm” Specification: The Inputs of ß-Catenin/TCF Signaling Röttinger, Eric; Dahlin, Paul; Martindale, Mark Q. PLoS Genetics, Vol. 8, Issue 12 https://doi.org/10.1371/journal.pgen.1003164	journal	December 2012
How Weird is The Worm? Evolution of the Developmental Gene Toolkit in Caenorhabditis elegans Baker, Emily A.; Woollard, Alison Journal of Developmental Biology, Vol. 7, Issue 4 https://doi.org/10.3390/jdb7040019	journal	September 2019
Metabolic and Chaperone Gene Loss Marks the Origin of Animals: Evidence for Hsp104 and Hsp78 Chaperones Sharing Mitochondrial Enzymes as Clients Erives, Albert J.; Fassler, Jan S. PLOS ONE, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pone.0117192	journal	February 2015
Protective Effect of Curcumin on Acute Airway Inflammation of Allergic Asthma in Mice Through Notch1–GATA3 Signaling Pathway Chong, Lei; Zhang, Weixi; Nie, Ying Inflammation, Vol. 37, Issue 5 https://doi.org/10.1007/s10753-014-9873-6	journal	April 2014
Notch signalling defines critical boundary during budding in Hydra Münder, Sandra; Käsbauer, Tina; Prexl, Andrea Developmental Biology, Vol. 344, Issue 1 https://doi.org/10.1016/j.ydbio.2010.05.517	journal	August 2010
Correction: Corrigendum: Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD Møller, Svenning Rune; Yi, Xueying; Velásquez, Silvia Melina Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/srep46774	journal	May 2017
The Evolution of the GPCR Signaling System in Eukaryotes: Modularity, Conservation, and the Transition to Metazoan Multicellularity de Mendoza, Alex; Sebé-Pedrós, Arnau; Ruiz-Trillo, Iñaki Genome Biology and Evolution, Vol. 6, Issue 3 https://doi.org/10.1093/gbe/evu038	journal	February 2014
The Conservation of the Germline Multipotency Program, from Sponges to Vertebrates: A Stepping Stone to Understanding the Somatic and Germline Origins Fierro-Constaín, Laura; Schenkelaars, Quentin; Gazave, Eve Genome Biology and Evolution https://doi.org/10.1093/gbe/evw289	journal	January 2017
A phylogenetic view and functional annotation of the animal β1,3-glycosyltransferases of the GT31 CAZy family Petit, Daniel; Teppa, Roxana Elin; Harduin-Lepers, Anne Glycobiology, Vol. 31, Issue 3 https://doi.org/10.1093/glycob/cwaa086	journal	September 2020
Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions Conaco, Cecilia; Neveu, Pierre; Zhou, Hongjun BMC Genomics, Vol. 13, Issue 1 https://doi.org/10.1186/1471-2164-13-209	journal	May 2012
Uncovering the genetic basis for early isogamete differentiation: a case study of Ectocarpus siliculosus Lipinska, Agnieszka P.; D’hondt, Sofie; Van Damme, Els JM BMC Genomics, Vol. 14, Issue 1 https://doi.org/10.1186/1471-2164-14-909	journal	January 2013
History of a prolific family: the Hes/Hey-related genes of the annelid Platynereis Gazave, Eve; Guillou, Aurélien; Balavoine, Guillaume EvoDevo, Vol. 5, Issue 1 https://doi.org/10.1186/2041-9139-5-29	journal	January 2014
Comparative transcriptomics enlarges the toolkit of known developmental genes in mollusks De Oliveira, A. L.; Wollesen, T.; Kristof, A. BMC Genomics, Vol. 17, Issue 1 https://doi.org/10.1186/s12864-016-3080-9	journal	November 2016
A Framework for the Establishment of a Cnidarian Gene Regulatory Network for “Endomesoderm” Specification: The Inputs of ß-Catenin/TCF Signaling Röttinger, Eric; Dahlin, Paul; Martindale, Mark Q. PLoS Genetics, Vol. 8, Issue 12 https://doi.org/10.1371/journal.pgen.1003164	journal	December 2012
The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti Chang, Chia-Hao; Liu, Yu-Ting; Weng, Shih-Che PLOS Neglected Tropical Diseases, Vol. 12, Issue 3 https://doi.org/10.1371/journal.pntd.0006307	journal	March 2018
A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development Toonen, Joseph A.; Ronchetti, Adam; Sidjanin, D. J. PLOS ONE, Vol. 11, Issue 5 https://doi.org/10.1371/journal.pone.0156184	journal	May 2016
Increased nucleoside diphosphate kinase activity induces white spot syndrome virus infection in Litopenaeus vannamei Liu, Peng-fei; Liu, Qing-hui; Wu, Yin PLOS ONE, Vol. 12, Issue 5 https://doi.org/10.1371/journal.pone.0175741	journal	May 2017
A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity LaFoya, Bryce; Munroe, Jordan A.; Albig, Allan R. PLOS ONE, Vol. 14, Issue 1 https://doi.org/10.1371/journal.pone.0210607	journal	January 2019
Exon 3 of theNUMBGene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2 Confalonieri, Stefano; Colaluca, Ivan Nicola; Basile, Andrea G3 Genes\|Genomes\|Genetics, Vol. 9, Issue 10 https://doi.org/10.1534/g3.119.400494	journal	October 2019
Delta-Notch signalling in segmentation Liao, Bo-Kai; Oates, Andrew C. The Francis Crick Institute https://doi.org/10.25418/crick.15179679.v1	text	January 2021
Notch Signaling Pathway and Endocrine Resistance in Breast Cancer Bai, Jing-Wen; Wei, Min; Li, Ji-Wei Frontiers in Pharmacology, Vol. 11 https://doi.org/10.3389/fphar.2020.00924	journal	June 2020
Physiology and Evolution of Voltage-Gated Calcium Channels in Early Diverging Animal Phyla: Cnidaria, Placozoa, Porifera and Ctenophora Senatore, Adriano; Raiss, Hamad; Le, Phuong Frontiers in Physiology, Vol. 7 https://doi.org/10.3389/fphys.2016.00481	journal	November 2016
The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers Varghese, Elizabeth; Samuel, Samson; Abotaleb, Mariam Cancers, Vol. 10, Issue 10 https://doi.org/10.3390/cancers10100346	journal	September 2018
Notch Signaling Pathway and Human Placenta Zhao, Wei-Xiu; Lin, Jian-Hua International Journal of Medical Sciences, Vol. 9, Issue 6 https://doi.org/10.7150/ijms.4593	journal	January 2012
C. elegans GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool Lee, ChangHwan; Sorensen, Erika B.; Lynch, Tina R. eLife, Vol. 5 https://doi.org/10.7554/elife.18370	journal	October 2016
Ubiquitylation-independent activation of Notch signalling by Delta Berndt, Nicole; Seib, Ekaterina; Kim, Soya eLife, Vol. 6 https://doi.org/10.7554/elife.27346	journal	September 2017
We are not so special Lewis, Zachary R.; Dunn, Casey W. eLife, Vol. 7 https://doi.org/10.7554/elife.38726	journal	July 2018

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