Protein annotation as term categorization in the gene ontology using word proximity networks

Journal Article · 24 May 2005 · BMC Bioinformatics

DOI: https://doi.org/10.1186/1471-2105-6-s1-s20 · OSTI ID:1626313

Verspoor, Karin ^[1]; Cohn, Judith ^[1]; Joslyn, Cliff ^[1]; Mniszewski, Sue ^[1]; Rechtsteiner, Andreas ^[1]; Rocha, Luis M. ^[2]; Simas, Tiago ^[3]

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1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2. Indiana Univ., Bloomington, IN (United States). School of Informatics, Cognitive Science Program
3. Indiana Univ., Bloomington, IN (United States). Cognitive Science Program

Background: We participated in the BioCreAtIvE Task 2, which addressed the annotation of proteins into the Gene Ontology (GO) based on the text of a given document and the selection of evidence text from the document justifying that annotation. We approached the task utilizing several combinations of two distinct methods: an unsupervised algorithm for expanding words associated with GO nodes, and an annotation methodology which treats annotation as categorization of terms from a protein's document neighborhood into the GO. Results: The evaluation results indicate that the method for expanding words associated with GO nodes is quite powerful; we were able to successfully select appropriate evidence text for a given annotation in 38% of Task 2.1 queries by building on this method. The term categorization methodology achieved a precision of 16% for annotation within the correct extended family in Task 2.2, though we show through subsequent analysis that this can be improved with a different parameter setting. Our architecture proved not to be very successful on the evidence text component of the task, in the configuration used to generate the submitted results. Conclusion: The initial results show promise for both of the methods we explored, and we are planning to integrate the methods more closely to achieve better results overall.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
• Grant/Contract Number: AC52-06NA25396
• OSTI ID: 1626313
• Journal Information: BMC Bioinformatics, Vol. 6, Issue Suppl 1; ISSN 1471-2105
• Publisher: BioMed CentralCopyright Statement
• Country of Publication: United States
• Language: English