Statistical density modification with non-crystallographic symmetry

Journal Article · 26 November 2002 · Acta Crystallographica. Section D: Biological Crystallography

DOI: https://doi.org/10.1107/s0907444902016360 · OSTI ID:1625652

Terwilliger, Thomas C. ^[1]

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1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States); DOE/OSTI

Statistical density modi®cation is a technique for phase improvement through a calculation of the posterior probability of the phases, given experimental phase information and expectations about features of the electron-density map. The technique can take advantage of both estimates of electron density in the map and uncertainties or probability distributions for those estimates. For crystals with noncrystallographic symmetry (NCS), this allows the use of the expected similarity of electron density at NCS-related points without requiring an implicit assumption that these regions are identical.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division
• Grant/Contract Number: AC52-06NA25396
• OSTI ID: 1625652
• Journal Information: Acta Crystallographica. Section D: Biological Crystallography, Journal Name: Acta Crystallographica. Section D: Biological Crystallography Journal Issue: 12 Vol. 58; ISSN ABCRE6; ISSN 0907-4449
• Publisher: International Union of CrystallographyCopyright Statement
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
Biochemistry & molecular biology
Biophysics
Crystallography
Density modificatin
Non-crystallographic symmetry