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Title: Biophysics at the coffee shop: lessons learned working with George Oster

Abstract

Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous research accomplishments, but also through the many students and postdocs he mentored over his long career. Those of us fortunate enough to have worked with George agree that his sharp intellect, physical intuition, and passion for scientific inquiry not only inspired us as scientists but also greatly influenced the way we conduct research. We would like to share a few important lessons we learned from George in honor of his memory and with the hope that they may inspire future generations of scientists.

Authors:
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8];  [9];  [10];  [11];  [12];
+ Show Author Affiliations
  1. Rice University, Houston, TX (United States). Departments of Bioengineering, Biosciences, and Chemistry and Center for Theoretical Biological Physics
  2. Virginia Tech, Blacksburg, VA (United States). Dept. of Biological Sciences
  3. Univ. of Pittsburgh, Pittsburgh, PA (United States). Dept. of Computational and Systems Biology and UPMC-Hillman Cancer Center, School of Medicine
  4. Johns Hopkins Univ., Baltimore, MD (United States). Dept. of Cell Biology and Center for Cell Dynamics, School of Medicine
  5. Univ. of North Carolina at Chapel Hill, Chapel Hill, NC (United States). Dept. of Pharmacology, School of Medicine
  6. Univ. of California, San Francisco, San Francisco, CA (United States). Cardiovascular Research Institute, School of Pharmacy
  7. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  8. Rockefeller University, New York, NY (United States). Center for Studies in Physics and Biology
  9. Univ. of California, San Diego, La Jolla, CA (United States). Dept. of Mechanical and Aerospace Engineering
  10. Johns Hopkins Univ., Baltimore, MD (United States). Dept. of Mechanical Engineering, Whiting School of Engineering
  11. Univ. of California, Santa Cruz, Santa Cruz, CA (United States). Dept. of Applied Mathematics and Statistics
  12. Univ. of Arizona, Tucson, AZ (United States). Dept. of Physics and Dept. of Molecular and Cellular Biology
Publication Date:
Research Org.:
Lawrence Livermore National Lab (LLNL), Livermore, CA (United States); Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF); Johns Hopkins University
OSTI Identifier:
1625251
Alternate Identifier(s):
OSTI ID: 1839873
Report Number(s):
LLNL-JRNL-788697
Journal ID: ISSN 1059-1524
Grant/Contract Number:  
AC52-07NA27344; MCB-1616755; DMS-1462049
Resource Type:
Accepted Manuscript
Journal Name:
Molecular Biology of the Cell
Additional Journal Information:
Journal Volume: 30; Journal Issue: 16; Journal ID: ISSN 1059-1524
Publisher:
American Society for Cell Biology
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Cell biology

Citation Formats

Igoshin, Oleg A., Chen, Jing, Xing, Jianhua, Liu, Jian, Elston, Timothy C., Grabe, Michael, Kim, Kenneth S., Nirody, Jasmine A., Rangamani, Padmini, Sun, Sean X., Wang, Hongyun, Wolgemuth, Charles, and Mogilner, Alex. Biophysics at the coffee shop: lessons learned working with George Oster. United States: N. p., 2019. Web. doi:10.1091/mbc.e19-02-0107.
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Igoshin, Oleg A., Chen, Jing, Xing, Jianhua, Liu, Jian, Elston, Timothy C., Grabe, Michael, Kim, Kenneth S., Nirody, Jasmine A., Rangamani, Padmini, Sun, Sean X., Wang, Hongyun, Wolgemuth, Charles, & Mogilner, Alex. Biophysics at the coffee shop: lessons learned working with George Oster. United States. https://doi.org/10.1091/mbc.e19-02-0107
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Igoshin, Oleg A., Chen, Jing, Xing, Jianhua, Liu, Jian, Elston, Timothy C., Grabe, Michael, Kim, Kenneth S., Nirody, Jasmine A., Rangamani, Padmini, Sun, Sean X., Wang, Hongyun, Wolgemuth, Charles, and Mogilner, Alex. Mon . "Biophysics at the coffee shop: lessons learned working with George Oster". United States. https://doi.org/10.1091/mbc.e19-02-0107. https://www.osti.gov/servlets/purl/1625251.
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@article{osti_1625251,
title = {Biophysics at the coffee shop: lessons learned working with George Oster},
author = {Igoshin, Oleg A. and Chen, Jing and Xing, Jianhua and Liu, Jian and Elston, Timothy C. and Grabe, Michael and Kim, Kenneth S. and Nirody, Jasmine A. and Rangamani, Padmini and Sun, Sean X. and Wang, Hongyun and Wolgemuth, Charles and Mogilner, Alex},
abstractNote = {Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous research accomplishments, but also through the many students and postdocs he mentored over his long career. Those of us fortunate enough to have worked with George agree that his sharp intellect, physical intuition, and passion for scientific inquiry not only inspired us as scientists but also greatly influenced the way we conduct research. We would like to share a few important lessons we learned from George in honor of his memory and with the hope that they may inspire future generations of scientists.},
doi = {10.1091/mbc.e19-02-0107},
journal = {Molecular Biology of the Cell},
number = 16,
volume = 30,
place = {United States},
year = {2019},
month = {7}
}
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Publisher's Version of Record
https://doi.org/10.1091/mbc.e19-02-0107
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The neural origins of shell structure and pattern in aquatic mollusks
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Endocytic vesicle scission by lipid phase boundary forces
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  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 27
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Induction of coordinated movement of Myxococcus xanthus cells
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