Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension

Warner, Stephen J.; Longmore, Gregory D.

doi:10.1083/jcb.200906047

Title: Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension

Journal Article · 05 October 2009 · Journal of Cell Biology

DOI: https://doi.org/10.1083/jcb.200906047 · OSTI ID:1625155

Warner, Stephen J. ^[1]; Longmore, Gregory D. ^[2]

Washington Univ., St. Louis, MO (United States). Dept. of Medicine; Washington Univ., St. Louis, MO (United States). Dept. of Medicine and Department of Cell Biology and Physiology; DOE/OSTI
Washington Univ., St. Louis, MO (United States). Dept. of Medicine; Washington Univ., St. Louis, MO (United States). Dept. of Medicine and Department of Cell Biology and Physiology

In epithelia, cells are arranged in an orderly pattern with a defined orientation and shape. Cadherin containing apical adherens junctions (AJs) and the associated actomyosin cytoskeleton likely contribute to epithelial cell shape by providing apical tension. The Rho guanosine triphosphatases are well known regulators of cell junction formation, maintenance, and function. Specifically, Rho promotes actomyosin activity and cell contractility; however, what controls and localizes this Rho activity as epithelia remodel is unresolved. Using mosaic clonal analysis in the Drosophila melanogaster pupal eye, we find that Cdc42 is critical for limiting apical cell tension by antagonizing Rho activity at AJs. Cdc42 localizes Par6–atypical protein kinase C (aPKC) to AJs, where this complex limits Rho1 activity and thus actomyosin contractility, independent of its effects on Wiskott-Aldrich syndrome protein and p21-activated kinase. Thus, in addition to its role in the establishment and maintenance of apical–basal polarity in forming epithelia, the Cdc42–Par6–aPKC polarity complex is required to limit Rho activity at AJs and thus modulate apical tension so as to shape the final epithelium.

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Research Organization:: Washington Univ., St. Louis, MO (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; National Institutes of Health (NIH)

OSTI ID:: 1625155

Journal Information:: Journal of Cell Biology, Journal Name: Journal of Cell Biology Journal Issue: 1 Vol. 187; ISSN 0021-9525

Publisher:: Rockefeller University PressCopyright Statement

Country of Publication:: United States

Language:: English

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