Structural insights into the mechanism of oxidative activation of heme-free H-NOX from Vibrio cholerae

Mukhopadhyay, Roma; Chacón, Kelly N.; Jarvis, Jacqueline M.; Talipov, Marat R.; Yukl, Erik T.

doi:10.1042/bcj20200124

Title: Structural insights into the mechanism of oxidative activation of heme-free H-NOX from Vibrio cholerae

Journal Article · 23 March 2020 · Biochemical Journal

DOI: https://doi.org/10.1042/bcj20200124 · OSTI ID:1624989

Mukhopadhyay, Roma ^[1]; Chacón, Kelly N. ^[2]; Jarvis, Jacqueline M. ^[3]; Talipov, Marat R. ^[1];

^[1]

New Mexico State Univ., Las Cruces, NM (United States). Dept. of Chemistry and Biochemistry
Reed College, Portland, OR (United States). Dept. of Chemistry
New Mexico State Univ., Las Cruces, NM (United States). Dept. of Plant and Environmental Sciences

Bacterial heme nitric oxide/oxygen (H-NOX) domains are nitric oxide (NO) or oxygen sensors. This activity is mediated through binding of the ligand to a heme cofactor. However, H-NOX from Vibrio cholerae (Vc H-NOX) can be easily purified in a heme-free state that is capable of reversibly responding to oxidation, suggesting a heme-independent function as a redox sensor. This occurs by oxidation of Cys residues at a zinc-binding site conserved in a subset of H-NOX homologs. Remarkably, zinc is not lost from the protein upon oxidation, although its ligation environment is significantly altered. Using a combination of computational and experimental approaches, we have characterized localized structural changes that accompany the formation of specific disulfide bonds between Cys residues upon oxidation. Furthermore, the larger-scale structural changes accompanying oxidation appear to mimic those changes observed upon NO binding to the heme-bound form. Thus, Vc H-NOX and its homologs may act as both redox and NO sensors by completely separate mechanisms.

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Research Organization:: SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 1624989

Journal Information:: Biochemical Journal, Vol. 477, Issue 6; ISSN 0264-6021

Publisher:: Biochemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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The Selectivity of Vibrio cholerae H-NOX for Gaseous Ligands Follows the “Sliding Scale Rule” Hypothesis. Ligand Interactions with both Ferrous and Ferric Vc H-NOX Wu, Gang; Liu, Wen; Berka, Vladimir Biochemistry, Vol. 52, Issue 52 https://doi.org/10.1021/bi401408x	journal	December 2013
Shewanella oneidensis MR-1 H-NOX Regulation of a Histidine Kinase by Nitric Oxide ^† Price, Mark S.; Chao, Lily Y.; Marletta, Michael A. Biochemistry, Vol. 46, Issue 48 https://doi.org/10.1021/bi7019035	journal	December 2007
Discovery of a Nitric Oxide Responsive Quorum Sensing Circuit in Vibrio harveyi Henares, Bernadette M.; Higgins, Kate E.; Boon, Elizabeth M. ACS Chemical Biology, Vol. 7, Issue 8 https://doi.org/10.1021/cb300215t	journal	May 2012
Probing the Function of Heme Distortion in the H-NOX Family Olea, Charles; Boon, Elizabeth M.; Pellicena, Patricia ACS Chemical Biology, Vol. 3, Issue 11 https://doi.org/10.1021/cb800185h	journal	November 2008
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Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning Hopkins, Chad W.; Le Grand, Scott; Walker, Ross C. Journal of Chemical Theory and Computation, Vol. 11, Issue 4 https://doi.org/10.1021/ct5010406	journal	March 2015
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59 BASIC BIOLOGICAL SCIENCES
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