Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects

Everett, James; Collingwood, Joanna F.; Tjendana-Tjhin, Vindy; Brooks, Jake; Lermyte, Frederik; Plascencia-Villa, Germán; Hands-Portman, Ian; Dobson, Jon; Perry, George; Telling, Neil D.

doi:10.1039/c7nr06794a

Title: Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects

Journal Article · 24 April 2018 · Nanoscale

DOI: https://doi.org/10.1039/c7nr06794a · OSTI ID:1624949

Everett, James ^[1];

^[2];

^[3]; Hands-Portman, Ian ^[4];

^[5];

^[6];

^[1]

Institute for Science and Technology in Medicine; Thornburrow Drive; Keele University; Staffordshire; UK
Warwick Engineering in Biomedicine; School of Engineering; Library Road; University of Warwick; Coventry
Department of Physics and Astronomy. The University of Texas at San Antonio (UTSA); San Antonio; USA
School of Life Sciences; Gibbet Hill Campus; University of Warwick; Coventry; UK
Department of Materials Science and Engineering; University of Florida; Gainesville; USA; J. Crayton Pruitt Family Department of Biomedical Engineering
Department of Biology and UTSA Neurosciences Institute. The University of Texas at San Antonio (UTSA); San Antonio; USA

Synchrotron soft X-ray nano-imaging and spectromicroscopy reveals iron and calcium biomineralization in Alzheimer's disease amyloid plaques.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1624949

Journal Information:: Nanoscale, Vol. 10, Issue 25; ISSN 2040-3364

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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The dysregulation of intracellular calcium in Alzheimer disease Supnet, Charlene; Bezprozvanny, Ilya Cell Calcium, Vol. 47, Issue 2 https://doi.org/10.1016/j.ceca.2009.12.014	journal	February 2010
Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease Telling, Neil D.; Everett, James; Collingwood, Joanna F. Cell Chemical Biology, Vol. 24, Issue 10 https://doi.org/10.1016/j.chembiol.2017.07.014	journal	October 2017
Electron nanodiffraction and high-resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin Quintana, C.; Cowley, J. M.; Marhic, C. Journal of Structural Biology, Vol. 147, Issue 2 https://doi.org/10.1016/j.jsb.2004.03.001	journal	August 2004
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer’s disease Miller, Lisa M.; Wang, Qi; Telivala, Tejas P. Journal of Structural Biology, Vol. 155, Issue 1 https://doi.org/10.1016/j.jsb.2005.09.004	journal	July 2006
The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin Peters, Douglas G.; Connor, James R.; Meadowcroft, Mark D. Neurobiology of Disease, Vol. 81 https://doi.org/10.1016/j.nbd.2015.08.007	journal	September 2015
Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice Dhenain, Marc; El Tannir El Tayara, Nadine; Wu, Ting-Di Neurobiology of Aging, Vol. 30, Issue 1 https://doi.org/10.1016/j.neurobiolaging.2007.05.018	journal	January 2009
Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks Kuchibhotla, Kishore V.; Goldman, Samuel T.; Lattarulo, Carli R. Neuron, Vol. 59, Issue 2 https://doi.org/10.1016/j.neuron.2008.06.008	journal	July 2008
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Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimer’s Disease Peptide β-Amyloid Everett, James; Céspedes, Eva; Shelford, Leigh R. Inorganic Chemistry, Vol. 53, Issue 6 https://doi.org/10.1021/ic402406g	journal	February 2014
Oxygen Spectroscopy and Polarization-Dependent Imaging Contrast (PIC)-Mapping of Calcium Carbonate Minerals and Biominerals DeVol, Ross T.; Metzler, Rebecca A.; Kabalah-Amitai, Lee The Journal of Physical Chemistry B, Vol. 118, Issue 28 https://doi.org/10.1021/jp503700g	journal	May 2014
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