Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes
Abstract
Cladosporium sphaerospermum, a dematiaceous saprophytic fungus commonly found in diverse environments, has been reported to cause allergy and other occasional diseases in humans. However, its basic biology and genetic information are largely unexplored. A clinical isolate C. sphaerospermum genome, UM 843, was re-sequenced and combined with previously generated sequences to form a model 26.89 Mb genome containing 9,652 predicted genes. Functional annotation on predicted genes suggests the ability of this fungus to degrade carbohydrate and protein complexes. Several putative peptidases responsible for lung tissue hydrolysis were identified. These genes shared high similarity with the Aspergillus peptidases. The UM 843 genome encodes a wide array of proteins involved in the biosynthesis of melanin, siderophores, cladosins and survival in high salinity environment. In addition, a total of 28 genes were predicted to be associated with allergy. Orthologous gene analysis together with 22 other Dothideomycetes showed genes uniquely present in UM 843 that encode four class 1 hydrophobins which may be allergens specific to Cladosporium. The mRNA of these hydrophobins were detected by RT-PCR. The genomic analysis of UM 843 contributes to the understanding of the biology and allergenicity of this widely-prevalent species.
- Authors:
-
- Univ. of Malaya, Kuala Lumpur (Malaysia). Faculty of Medicine. Dept. of Medical Microbiology
- Univ. Tunk Abdul Rahman, Selangor Darul Ehsan (Malaysia). Faculty of Medicine and Health Sciences. Dept. of Pre-Clinical Sciences
- Condon Genomics, Selangor Darul Ehsan (Malaysia)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1624838
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Scientific Reports
- Additional Journal Information:
- Journal Volume: 6; Journal Issue: 1; Journal ID: ISSN 2045-2322
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Science & Technology - Other Topics
Citation Formats
Yew, Su Mei, Chan, Chai Ling, Ngeow, Yun Fong, Toh, Yue Fen, Na, Shiang Ling, Lee, Kok Wei, Hoh, Chee-Choong, Yee, Wai-Yan, Ng, Kee Peng, and Kuan, Chee Sian. Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes. United States: N. p., 2016.
Web. doi:10.1038/srep27008.
Yew, Su Mei, Chan, Chai Ling, Ngeow, Yun Fong, Toh, Yue Fen, Na, Shiang Ling, Lee, Kok Wei, Hoh, Chee-Choong, Yee, Wai-Yan, Ng, Kee Peng, & Kuan, Chee Sian. Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes. United States. https://doi.org/10.1038/srep27008
Yew, Su Mei, Chan, Chai Ling, Ngeow, Yun Fong, Toh, Yue Fen, Na, Shiang Ling, Lee, Kok Wei, Hoh, Chee-Choong, Yee, Wai-Yan, Ng, Kee Peng, and Kuan, Chee Sian. Tue .
"Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes". United States. https://doi.org/10.1038/srep27008. https://www.osti.gov/servlets/purl/1624838.
@article{osti_1624838,
title = {Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes},
author = {Yew, Su Mei and Chan, Chai Ling and Ngeow, Yun Fong and Toh, Yue Fen and Na, Shiang Ling and Lee, Kok Wei and Hoh, Chee-Choong and Yee, Wai-Yan and Ng, Kee Peng and Kuan, Chee Sian},
abstractNote = {Cladosporium sphaerospermum, a dematiaceous saprophytic fungus commonly found in diverse environments, has been reported to cause allergy and other occasional diseases in humans. However, its basic biology and genetic information are largely unexplored. A clinical isolate C. sphaerospermum genome, UM 843, was re-sequenced and combined with previously generated sequences to form a model 26.89 Mb genome containing 9,652 predicted genes. Functional annotation on predicted genes suggests the ability of this fungus to degrade carbohydrate and protein complexes. Several putative peptidases responsible for lung tissue hydrolysis were identified. These genes shared high similarity with the Aspergillus peptidases. The UM 843 genome encodes a wide array of proteins involved in the biosynthesis of melanin, siderophores, cladosins and survival in high salinity environment. In addition, a total of 28 genes were predicted to be associated with allergy. Orthologous gene analysis together with 22 other Dothideomycetes showed genes uniquely present in UM 843 that encode four class 1 hydrophobins which may be allergens specific to Cladosporium. The mRNA of these hydrophobins were detected by RT-PCR. The genomic analysis of UM 843 contributes to the understanding of the biology and allergenicity of this widely-prevalent species.},
doi = {10.1038/srep27008},
journal = {Scientific Reports},
number = 1,
volume = 6,
place = {United States},
year = {Tue May 31 00:00:00 EDT 2016},
month = {Tue May 31 00:00:00 EDT 2016}
}
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Figure 1: Morphology of C. sphaerospermum UM 843. Colonial morphology front (a) and reverse (b) of C. sphaerospermum UM 843 on SDA after 7-day incubation. Light micrograph showing ramoconidia (d 1 and d 3) and conidia (d 2 and d 4). x 630 magnification, bars 20 $μ$m. Observation under scanningmore »
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