In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Jiang, Wei; Birtley, James R.; Hung, Shu-Chen; Wang, Weiqi; Chiou, Shin-Heng; Macaubas, Claudia; Kornum, Birgitte; Tian, Lu; Huang, Huang; Adler, Lital; Weaver, Grant; Lu, Liying; Ilstad-Minnihan, Alexandra; Somasundaram, Sriram; Ayyangar, Sashi; Davis, Mark M.; Stern, Lawrence J.; Mellins, Elizabeth D.

doi:10.1038/s41467-019-13234-x

Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4⁺ T cells in narcolepsy patients and controls

Journal Article · 20 November 2019 · Nature Communications

DOI: https://doi.org/10.1038/s41467-019-13234-x · OSTI ID:1624216

^[1];

^[2]; Hung, Shu-Chen ^[3];

^[4]; Chiou, Shin-Heng ^[5]; Macaubas, Claudia ^[3]; Kornum, Birgitte ^[6]; Tian, Lu ^[7];

^[5]; Adler, Lital ^[1];

^[2]; Lu, Liying ^[2]; Ilstad-Minnihan, Alexandra ^[1];

^[1]; Ayyangar, Sashi ^[1];

^[8];

^[2];

^[3]

Stanford Univ., CA (United States), University School of Medicine, Dept. of Pediatrics - Human Gene Therapy
University of Massachusetts Medical School, MA (United States), Dept of Pathology
Stanford Univ., CA (United States), University School of Medicine, Dept. of Pediatrics - Human Gene Therapy; Stanford Univ., CA (United States), University School of Medicine, Stanford Immunology
Stanford Univ., CA (United States), University School of Medicine, Human Immune Monitoring Ctr
Stanford Univ., CA (United States), University School of Medicine, Institute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology
Danish Center for Sleep Medicine, Dept of Clinical Neurophysiology, (Denmark)
Stanford Univ., CA (United States), University School of Medicine, Dept of Biomedical Data Science
Stanford Univ., CA (United States), University School of Medicine, Stanford Immunology;Stanford Univ., CA (United States), Institute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology; Stanford Univ., CA (United States), Howard Hughes Medical Institute

Not provided.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1624216

Journal Information:: Nature Communications, Vol. 10, Issue 1; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 29 works

Citation information provided by
Web of Science

References (93)

The Epidemiology of Narcolepsy Longstreth, W. T.; Koepsell, Thomas D.; Ton, Thanh G. Sleep, Vol. 30, Issue 1 https://doi.org/10.1093/sleep/30.1.13	journal	January 2007
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Peyron, Christelle; Faraco, Juliette; Rogers, William Nature Medicine, Vol. 6, Issue 9 https://doi.org/10.1038/79690	journal	September 2000
DQ (rather than DR) gene marks susceptibility to narcolepsy Matsuki, Kazumasa; Grumet, F. Carl; Lin, Xiaoyan The Lancet, Vol. 339, Issue 8800 https://doi.org/10.1016/0140-6736(92)90571-J	journal	April 1992
DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe Tafti, Mehdi; Hor, Hyun; Dauvilliers, Yves Sleep, Vol. 37, Issue 1 https://doi.org/10.5665/sleep.3300	journal	January 2014
Narcolepsy is strongly associated with the T-cell receptor alpha locus Hallmayer, Joachim; Faraco, Juliette; Lin, Ling Nature Genetics, Vol. 41, Issue 6 https://doi.org/10.1038/ng.372	journal	May 2009
Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic Han, Fang; Faraco, Juliette; Dong, Xiao Song PLoS Genetics, Vol. 9, Issue 10 https://doi.org/10.1371/journal.pgen.1003880	journal	October 2013
Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy Luo, Guo; Ambati, Aditya; Lin, Ling Proceedings of the National Academy of Sciences, Vol. 115, Issue 52 https://doi.org/10.1073/pnas.1818150116	journal	December 2018
Common variants in P2RY11 are associated with narcolepsy Kornum, Birgitte R.; Kawashima, Minae; Faraco, Juliette Nature Genetics, Vol. 43, Issue 1 https://doi.org/10.1038/ng.734	journal	December 2010
ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy Faraco, Juliette; Lin, Ling; Kornum, Birgitte Rahbek PLoS Genetics, Vol. 9, Issue 2 https://doi.org/10.1371/journal.pgen.1003270	journal	February 2013
Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients Cvetkovic-Lopes, Vesna; Bayer, Laurence; Dorsaz, Stéphane Journal of Clinical Investigation, Vol. 120, Issue 3 https://doi.org/10.1172/JCI41366	journal	March 2010
Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus Saariaho, Anna-Helena; Vuorela, Arja; Freitag, Tobias L. Journal of Autoimmunity, Vol. 63 https://doi.org/10.1016/j.jaut.2015.07.006	journal	September 2015
Detection of Autoantibodies Against Hypocretin, hcrtr1, and hcrtr2 in Narcolepsy: Anti-Hcrt System Antibody in Narcolepsy Tanaka, Susumu; >Honda, Yutaka; Inoue, Yuichi Sleep, Vol. 29, Issue 5 https://doi.org/10.1093/sleep/29.5.633	journal	May 2006
Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 Ahmed, Syed Sohail; Volkmuth, Wayne; Duca, José Science Translational Medicine, Vol. 7, Issue 294 https://doi.org/10.1126/scitranslmed.aab2354	journal	July 2015
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases Luo, Guo; Lin, Ling; Jacob, Louis PLOS ONE, Vol. 12, Issue 12 https://doi.org/10.1371/journal.pone.0187305	journal	December 2017
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice Bernard-Valnet, Raphaël; Yshii, Lidia; Quériault, Clémence Proceedings of the National Academy of Sciences, Vol. 113, Issue 39 https://doi.org/10.1073/pnas.1603325113	journal	September 2016
CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens Pedersen, Natasja Wulff; Holm, Anja; Kristensen, Nikolaj Pagh Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-08774-1	journal	February 2019
Re-examining the Nature and Function of Self-Reactive T cells Richards, David M.; Kyewski, Bruno; Feuerer, Markus Trends in Immunology, Vol. 37, Issue 2 https://doi.org/10.1016/j.it.2015.12.005	journal	February 2016
High-dimensional single-cell analysis reveals the immune signature of narcolepsy Hartmann, Felix J.; Bernard-Valnet, Raphaël; Quériault, Clémence The Journal of Experimental Medicine, Vol. 213, Issue 12 https://doi.org/10.1084/jem.20160897	journal	November 2016
Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells Lecendreux, Michel; Churlaud, Guillaume; Pitoiset, Fabien PLOS ONE, Vol. 12, Issue 1 https://doi.org/10.1371/journal.pone.0169836	journal	January 2017
CD4+ T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1 Ramberger, Melanie; Högl, Birgit; Stefani, Ambra Sleep, Vol. 40, Issue 3 https://doi.org/10.1093/sleep/zsw070	journal	December 2016
T cells in patients with narcolepsy target self-antigens of hypocretin neurons Latorre, Daniela; Kallweit, Ulf; Armentani, Eric Nature, Vol. 562, Issue 7725 https://doi.org/10.1038/s41586-018-0540-1	journal	September 2018
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding Sibener, Leah V.; Fernandes, Ricardo A.; Kolawole, Elizabeth M. Cell, Vol. 174, Issue 3 https://doi.org/10.1016/j.cell.2018.06.017	journal	July 2018
Linking T-cell receptor sequence to functional phenotype at the single-cell level Han, Arnold; Glanville, Jacob; Hansmann, Leo Nature Biotechnology, Vol. 32, Issue 7 https://doi.org/10.1038/nbt.2938	journal	June 2014
Identifying specificity groups in the T cell receptor repertoire Glanville, Jacob; Huang, Huang; Nau, Allison Nature, Vol. 547, Issue 7661 https://doi.org/10.1038/nature22976	journal	June 2017
Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization Newell, Evan W.; Sigal, Natalia; Nair, Nitya Nature Biotechnology, Vol. 31, Issue 7 https://doi.org/10.1038/nbt.2593	journal	June 2013
Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults Su, Laura F.; Kidd, Brian A.; Han, Arnold Immunity, Vol. 38, Issue 2 https://doi.org/10.1016/j.immuni.2012.10.021	journal	February 2013
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes Bentzen, Amalie Kai; Marquard, Andrea Marion; Lyngaa, Rikke Nature Biotechnology, Vol. 34, Issue 10 https://doi.org/10.1038/nbt.3662	journal	August 2016
Functionally Impaired HIV-Specific CD8 T Cells Show High Affinity TCR-Ligand Interactions Ueno, Takamasa; Tomiyama, Hiroko; Fujiwara, Mamoru The Journal of Immunology, Vol. 173, Issue 9 https://doi.org/10.4049/jimmunol.173.9.5451	journal	October 2004
Discrepancy between ELISPOT IFN- secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life Rubio-Godoy, V.; Dutoit, V.; Rimoldi, D. Proceedings of the National Academy of Sciences, Vol. 98, Issue 18 https://doi.org/10.1073/pnas.181348898	journal	August 2001
Dissection of T-cell Antigen Specificity in Human Melanoma Andersen, R. S.; Thrue, C. A.; Junker, N. Cancer Research, Vol. 72, Issue 7 https://doi.org/10.1158/0008-5472.CAN-11-2614	journal	February 2012
Epstein-Barr virus nuclear antigen 1-specific CD4 ⁺ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells Demachi-Okamura, Ayako; Ito, Yoshinori; Akatsuka, Yoshiki Cancer Science, Vol. 99, Issue 8 https://doi.org/10.1111/j.1349-7006.2008.00852.x	journal	August 2008
Improved methods for predicting peptide binding affinity to MHC class II molecules Jensen, Kamilla Kjaergaard; Andreatta, Massimo; Marcatili, Paolo Immunology, Vol. 154, Issue 3 https://doi.org/10.1111/imm.12889	journal	February 2018
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy Siebold, Christian; Hansen, Bjarke E.; Wyer, Jessica R. Proceedings of the National Academy of Sciences, Vol. 101, Issue 7 https://doi.org/10.1073/pnas.0308458100	journal	February 2004
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior Sakurai, Takeshi; Amemiya, Akira; Ishii, Makoto Cell, Vol. 92, Issue 4 https://doi.org/10.1016/S0092-8674(00)80949-6	journal	February 1998
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens Khodadoust, Michael S.; Olsson, Niclas; Wagar, Lisa E. Nature, Vol. 543, Issue 7647 https://doi.org/10.1038/nature21433	journal	March 2017
Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining Uchtenhagen, Hannes; Rims, Cliff; Blahnik, Gabriele Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12614	journal	August 2016
T cell immunodominance is dictated by the positively selecting self-peptide Lo, Wan-Lin; Solomon, Benjamin D.; Donermeyer, David L. eLife, Vol. 3 https://doi.org/10.7554/eLife.01457	journal	January 2014
Development of a novel cell sorting method that samples population diversity in flow cytometry: Development of a Novel Cell Sorting Method Osborne, Geoffrey W.; Andersen, Stacey B.; Battye, Francis L. Cytometry Part A, Vol. 87, Issue 11 https://doi.org/10.1002/cyto.a.22678	journal	May 2015
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease Risnes, Louise F.; Christophersen, Asbjørn; Dahal-Koirala, Shiva Journal of Clinical Investigation, Vol. 128, Issue 6 https://doi.org/10.1172/JCI98819	journal	May 2018
Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens Le Nours, Jérôme; Praveena, T.; Pellicci, Daniel G. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms10570	journal	February 2016
TGF-β: A Master of All T Cell Trades Li, Ming O.; Flavell, Richard A. Cell, Vol. 134, Issue 3 https://doi.org/10.1016/j.cell.2008.07.025	journal	August 2008
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis Brochet, X.; Lefranc, M. -P.; Giudicelli, V. Nucleic Acids Research, Vol. 36, Issue Web Server https://doi.org/10.1093/nar/gkn316	journal	May 2008
Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection Hua, L.; Yao, S.; Pham, D. Journal of Virology, Vol. 87, Issue 21 https://doi.org/10.1128/JVI.01461-13	journal	August 2013
Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation Mundt, Sarah; Mrdjen, Dunja; Utz, Sebastian G. Science Immunology, Vol. 4, Issue 31 https://doi.org/10.1126/sciimmunol.aau8380	journal	January 2019
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Block, Michelle L.; Zecca, Luigi; Hong, Jau-Shyong Nature Reviews Neuroscience, Vol. 8, Issue 1 https://doi.org/10.1038/nrn2038	journal	January 2007
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides Wan, Xiaoxiao; Zinselmeyer, Bernd H.; Zakharov, Pavel N. Nature, Vol. 560, Issue 7716 https://doi.org/10.1038/s41586-018-0341-6	journal	July 2018
Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c –I-E ^k Newell, Evan W.; Ely, Lauren K.; Kruse, Andrew C. The Journal of Immunology, Vol. 186, Issue 10 https://doi.org/10.4049/jimmunol.1100197	journal	April 2011
Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland Partinen, Markku; Saarenpää-Heikkilä, Outi; Ilveskoski, Ismo PLoS ONE, Vol. 7, Issue 3 https://doi.org/10.1371/journal.pone.0033723	journal	March 2012
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china Han, Fang; Lin, Ling; Warby, Simon C. Annals of Neurology, Vol. 70, Issue 3 https://doi.org/10.1002/ana.22587	journal	August 2011
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444910048675	journal	March 2011
Scaling and assessment of data quality Evans, Philip Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 1, p. 72-82 https://doi.org/10.1107/S0907444905036693	journal	December 2005
Solving structures of protein complexes by molecular replacement with Phaser McCoy, Airlie J. Acta Crystallographica Section D Biological Crystallography, Vol. 63, Issue 1 https://doi.org/10.1107/S0907444906045975	journal	December 2006
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Joint X-ray and neutron refinement with phenix.refine Afonine, Pavel V.; Mustyakimov, Marat; Grosse-Kunstleve, Ralf W. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 11 https://doi.org/10.1107/S0907444910026582	journal	October 2010
Collaboration gets the most out of software Morin, Andrew; Eisenbraun, Ben; Key, Jason eLife, Vol. 2 https://doi.org/10.7554/eLife.01456	journal	September 2013
International Classification of Sleep Disorders-Third Edition Sateia, Michael J. Chest, Vol. 146, Issue 5 https://doi.org/10.1378/chest.14-0970	journal	November 2014
Addendum Sakurai, Takeshi; Amemiya, Akira; Ishii, Makoto Cell, Vol. 92, Issue 5 https://doi.org/10.1016/s0092-8674(02)09256-5	journal	March 1998
Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins Mukherjee, Somnath; Erramilli, Satchal K.; Ammirati, Mark Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-15363-0	journal	March 2020
High-dimensional single-cell analysis reveals the immune signature of narcolepsy Hartmann, Felix J.; Bernard-Valnet, Raphaël; Quériault, Clémence Rockefeller University Press https://doi.org/10.5167/uzh-129050	text	January 2016
Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation Mundt, Sarah; Mrdjen, Dunja; Utz, Sebastian G. American Association for the Advancement of Science https://doi.org/10.5167/uzh-176697	text	January 2019
T cells in patients with narcolepsy target self-antigens of hypocretin neurons Latorre, Daniela; Kallweit, Ulf; Armentani, Eric Macmillan Journals Ltd. https://doi.org/10.7892/boris.120682	text	January 2018
Development of a novel cell sorting method that samples population diversity in flow cytometry: Development of a Novel Cell Sorting Method Osborne, Geoffrey W.; Andersen, Stacey B.; Battye, Francis L. Cytometry Part A, Vol. 87, Issue 11 https://doi.org/10.1002/cyto.a.22678	journal	May 2015
Re-examining the Nature and Function of Self-Reactive T cells Richards, David M.; Kyewski, Bruno; Feuerer, Markus Trends in Immunology, Vol. 37, Issue 2 https://doi.org/10.1016/j.it.2015.12.005	journal	February 2016
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Peyron, Christelle; Faraco, Juliette; Rogers, William Nature Medicine, Vol. 6, Issue 9 https://doi.org/10.1038/79690	journal	September 2000
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens Khodadoust, Michael S.; Olsson, Niclas; Wagar, Lisa E. Nature, Vol. 543, Issue 7647 https://doi.org/10.1038/nature21433	journal	March 2017
Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization Newell, Evan W.; Sigal, Natalia; Nair, Nitya Nature Biotechnology, Vol. 31, Issue 7 https://doi.org/10.1038/nbt.2593	journal	June 2013
Linking T-cell receptor sequence to functional phenotype at the single-cell level Han, Arnold; Glanville, Jacob; Hansmann, Leo Nature Biotechnology, Vol. 32, Issue 7 https://doi.org/10.1038/nbt.2938	journal	June 2014
Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens Le Nours, Jérôme; Praveena, T.; Pellicci, Daniel G. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms10570	journal	February 2016
Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining Uchtenhagen, Hannes; Rims, Cliff; Blahnik, Gabriele Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12614	journal	August 2016
Narcolepsy is strongly associated with the T-cell receptor alpha locus Hallmayer, Joachim; Faraco, Juliette; Lin, Ling Nature Genetics, Vol. 41, Issue 6 https://doi.org/10.1038/ng.372	journal	May 2009
Common variants in P2RY11 are associated with narcolepsy Kornum, Birgitte R.; Kawashima, Minae; Faraco, Juliette Nature Genetics, Vol. 43, Issue 1 https://doi.org/10.1038/ng.734	journal	December 2010
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Block, Michelle L.; Zecca, Luigi; Hong, Jau-Shyong Nature Reviews Neuroscience, Vol. 8, Issue 1 https://doi.org/10.1038/nrn2038	journal	January 2007
Narcolepsy associated with the 2009 H1N1 pandemic in China Wood, Heather Nature Reviews Neurology, Vol. 7, Issue 10 https://doi.org/10.1038/nrneurol.2011.143	journal	October 2011
T cells in coeliac disease: a rational target for diagnosis and therapy Hardy, Melinda Y.; Tye-Din, Jason A. Nature Reviews Gastroenterology & Hepatology, Vol. 15, Issue 10 https://doi.org/10.1038/s41575-018-0043-4	journal	July 2018
pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity Jiang, Wei; Strohman, Michael J.; Somasundaram, Sriram Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep17333	journal	November 2015
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy Siebold, Christian; Hansen, Bjarke E.; Wyer, Jessica R. Proceedings of the National Academy of Sciences, Vol. 101, Issue 7 https://doi.org/10.1073/pnas.0308458100	journal	February 2004
CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice Bernard-Valnet, Raphaël; Yshii, Lidia; Quériault, Clémence Proceedings of the National Academy of Sciences, Vol. 113, Issue 39 https://doi.org/10.1073/pnas.1603325113	journal	September 2016
Discrepancy between ELISPOT IFN- secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life Rubio-Godoy, V.; Dutoit, V.; Rimoldi, D. Proceedings of the National Academy of Sciences, Vol. 98, Issue 18 https://doi.org/10.1073/pnas.181348898	journal	August 2001
Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy Luo, Guo; Ambati, Aditya; Lin, Ling Proceedings of the National Academy of Sciences, Vol. 115, Issue 52 https://doi.org/10.1073/pnas.1818150116	journal	December 2018
High-dimensional single-cell analysis reveals the immune signature of narcolepsy Hartmann, Felix J.; Bernard-Valnet, Raphaël; Quériault, Clémence The Journal of Experimental Medicine, Vol. 213, Issue 12 https://doi.org/10.1084/jem.20160897	journal	November 2016
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis Brochet, X.; Lefranc, M. -P.; Giudicelli, V. Nucleic Acids Research, Vol. 36, Issue Web Server https://doi.org/10.1093/nar/gkn316	journal	May 2008
The Epidemiology of Narcolepsy Longstreth, W. T.; Koepsell, Thomas D.; Ton, Thanh G. Sleep, Vol. 30, Issue 1 https://doi.org/10.1093/sleep/30.1.13	journal	January 2007
Improved Analyses of CD8+ T Cell Specificities Using Multimers of Peptide MHC Complexes Coupled to DNA Barcodes Guillonneau, Carole; David, Laurent; Anegon, Ignacio Transplantation, Vol. 101, Issue 2 https://doi.org/10.1097/tp.0000000000001601	journal	February 2017
Improved methods for predicting peptide binding affinity to MHC class II molecules Jensen, Kamilla Kjaergaard; Andreatta, Massimo; Marcatili, Paolo Immunology, Vol. 154, Issue 3 https://doi.org/10.1111/imm.12889	journal	February 2018
Epstein-Barr virus nuclear antigen 1-specific CD4 ⁺ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells Demachi-Okamura, Ayako; Ito, Yoshinori; Akatsuka, Yoshiki Cancer Science, Vol. 99, Issue 8 https://doi.org/10.1111/j.1349-7006.2008.00852.x	journal	August 2008
Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 Ahmed, Syed Sohail; Volkmuth, Wayne; Duca, José Science Translational Medicine, Vol. 7, Issue 294 https://doi.org/10.1126/scitranslmed.aab2354	journal	July 2015
ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy Faraco, Juliette; Lin, Ling; Kornum, Birgitte Rahbek PLoS Genetics, Vol. 9, Issue 2 https://doi.org/10.1371/journal.pgen.1003270	journal	February 2013
Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic Han, Fang; Faraco, Juliette; Dong, Xiao Song PLoS Genetics, Vol. 9, Issue 10 https://doi.org/10.1371/journal.pgen.1003880	journal	October 2013
Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland Partinen, Markku; Saarenpää-Heikkilä, Outi; Ilveskoski, Ismo PLoS ONE, Vol. 7, Issue 3 https://doi.org/10.1371/journal.pone.0033723	journal	March 2012
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases Luo, Guo; Lin, Ling; Jacob, Louis PLOS ONE, Vol. 12, Issue 12 https://doi.org/10.1371/journal.pone.0187305	journal	December 2017
Functionally Impaired HIV-Specific CD8 T Cells Show High Affinity TCR-Ligand Interactions Ueno, Takamasa; Tomiyama, Hiroko; Fujiwara, Mamoru The Journal of Immunology, Vol. 173, Issue 9 https://doi.org/10.4049/jimmunol.173.9.5451	journal	October 2004
DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe Tafti, Mehdi; Hor, Hyun; Dauvilliers, Yves Sleep, Vol. 37, Issue 1 https://doi.org/10.5665/sleep.3300	journal	January 2014
Isolation of a structural mechanism for uncoupling TCR signaling from peptide-MHC binding. Sibener et al. Sibener, Leah Mendeley https://doi.org/10.17632/sgff3j9sbg.1	dataset	January 2018

Similar Records

In vivo clonal expansion and phenotypes of hypocretin-specific CD4[superscript +] T cells in narcole

Journal Article · 2019 · Nat. Commun. · OSTI ID:1837246

Jiang, Wei; Birtley, James R.; Hung, Shu-Chen; +15 more

In vivo clonal expansion and phenotypes of hypocretin-specific CD4[superscript +] T cells in narcole

Journal Article · 2019 · Nat. Commun. · OSTI ID:1839741

Jiang, Wei; Birtley, James R.; Hung, Shu-Chen; +15 more

Antigen-specific CD4{sup +} effector T cells: Analysis of factors regulating clonal expansion and cytokine production

Journal Article · 2009 · Biochemical and Biophysical Research Communications · OSTI ID:21255936

Ohnuki, Kazunobu; Watanabe, Yuri; Takahashi, Yusuke; +7 more

Related Subjects

Science & Technology - Other Topics

Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Citation Formats

References (93)

Similar Records

Related Subjects

Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4⁺ T cells in narcolepsy patients and controls