In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Jiang, Wei; Birtley, James R.; Hung, Shu-Chen; Wang, Weiqi; Chiou, Shin-Heng; Macaubas, Claudia; Kornum, Birgitte; Tian, Lu; Huang, Huang; Adler, Lital; Weaver, Grant; Lu, Liying; Ilstad-Minnihan, Alexandra; Somasundaram, Sriram; Ayyangar, Sashi; Davis, Mark M.; Stern, Lawrence J.; Mellins, Elizabeth D.

doi:10.1038/s41467-019-13234-x

Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4⁺ T cells in narcolepsy patients and controls

Abstract

Not provided.

Authors:

^[1];

^[2]; Hung, Shu-Chen ^[3];

^[4]; Chiou, Shin-Heng ^[5]; Macaubas, Claudia ^[3]; Kornum, Birgitte ^[6]; Tian, Lu ^[7];

^[5]; Adler, Lital ^[1];

^[2]; Lu, Liying ^[2]; Ilstad-Minnihan, Alexandra ^[1];

^[1]; Ayyangar, Sashi ^[1];

^[8];

^[2];

^[3]

Stanford Univ., CA (United States), University School of Medicine, Dept. of Pediatrics - Human Gene Therapy
University of Massachusetts Medical School, MA (United States), Dept of Pathology
Stanford Univ., CA (United States), University School of Medicine, Dept. of Pediatrics - Human Gene Therapy; Stanford Univ., CA (United States), University School of Medicine, Stanford Immunology
Stanford Univ., CA (United States), University School of Medicine, Human Immune Monitoring Ctr
Stanford Univ., CA (United States), University School of Medicine, Institute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology
Danish Center for Sleep Medicine, Dept of Clinical Neurophysiology, (Denmark)
Stanford Univ., CA (United States), University School of Medicine, Dept of Biomedical Data Science
Stanford Univ., CA (United States), University School of Medicine, Stanford Immunology;Stanford Univ., CA (United States), Institute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology; Stanford Univ., CA (United States), Howard Hughes Medical Institute

Publication Date:: 2019-11-20

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE Office of Science (SC)

OSTI Identifier:: 1624216

Grant/Contract Number:: AC02-06CH11357

Resource Type:: Accepted Manuscript

Journal Name:: Nature Communications

Additional Journal Information:: Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 2041-1723

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: English

Subject:: Science & Technology - Other Topics

Citation Formats


                    Jiang, Wei, Birtley, James R., Hung, Shu-Chen, Wang, Weiqi, Chiou, Shin-Heng, Macaubas, Claudia, Kornum, Birgitte, Tian, Lu, Huang, Huang, Adler, Lital, Weaver, Grant, Lu, Liying, Ilstad-Minnihan, Alexandra, Somasundaram, Sriram, Ayyangar, Sashi, Davis, Mark M., Stern, Lawrence J., and Mellins, Elizabeth D. In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls.  United States: N. p., 2019. 
Web.  doi:10.1038/s41467-019-13234-x.

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                    Jiang, Wei, Birtley, James R., Hung, Shu-Chen, Wang, Weiqi, Chiou, Shin-Heng, Macaubas, Claudia, Kornum, Birgitte, Tian, Lu, Huang, Huang, Adler, Lital, Weaver, Grant, Lu, Liying, Ilstad-Minnihan, Alexandra, Somasundaram, Sriram, Ayyangar, Sashi, Davis, Mark M., Stern, Lawrence J., & Mellins, Elizabeth D. In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls.  United States.  https://doi.org/10.1038/s41467-019-13234-x

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                    Jiang, Wei, Birtley, James R., Hung, Shu-Chen, Wang, Weiqi, Chiou, Shin-Heng, Macaubas, Claudia, Kornum, Birgitte, Tian, Lu, Huang, Huang, Adler, Lital, Weaver, Grant, Lu, Liying, Ilstad-Minnihan, Alexandra, Somasundaram, Sriram, Ayyangar, Sashi, Davis, Mark M., Stern, Lawrence J., and Mellins, Elizabeth D. Wed .  
"In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls".  United States.  https://doi.org/10.1038/s41467-019-13234-x.  https://www.osti.gov/servlets/purl/1624216.

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@article{osti_1624216,

  title        = {In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls},

  author       = {Jiang, Wei and Birtley, James R. and Hung, Shu-Chen and Wang, Weiqi and Chiou, Shin-Heng and Macaubas, Claudia and Kornum, Birgitte and Tian, Lu and Huang, Huang and Adler, Lital and Weaver, Grant and Lu, Liying and Ilstad-Minnihan, Alexandra and Somasundaram, Sriram and Ayyangar, Sashi and Davis, Mark M. and Stern, Lawrence J. and Mellins, Elizabeth D.},

  abstractNote = {Not provided.},

  doi          = {10.1038/s41467-019-13234-x},

  journal      = {Nature Communications},

  number       = 1,

  volume       = 10,

  place        = {United States},

  year         = {2019},

  month        = {11}

}

Copy to clipboard

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https://doi.org/10.1038/s41467-019-13234-x

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Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Abstract

Citation Formats

The Epidemiology of Narcolepsy journal, January 2007

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains journal, September 2000

DQ (rather than DR) gene marks susceptibility to narcolepsy journal, April 1992

DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe journal, January 2014

Narcolepsy is strongly associated with the T-cell receptor alpha locus journal, May 2009

Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic journal, October 2013

Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy journal, December 2018

Common variants in P2RY11 are associated with narcolepsy journal, December 2010

ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy journal, February 2013

Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients journal, March 2010

Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus journal, September 2015

Detection of Autoantibodies Against Hypocretin, hcrtr1, and hcrtr2 in Narcolepsy: Anti-Hcrt System Antibody in Narcolepsy journal, May 2006

Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 journal, July 2015

Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases journal, December 2017

CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice journal, September 2016

CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens journal, February 2019

Re-examining the Nature and Function of Self-Reactive T cells journal, February 2016

High-dimensional single-cell analysis reveals the immune signature of narcolepsy journal, November 2016

Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells journal, January 2017

CD4+ T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1 journal, December 2016

T cells in patients with narcolepsy target self-antigens of hypocretin neurons journal, September 2018

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding journal, July 2018

Linking T-cell receptor sequence to functional phenotype at the single-cell level journal, June 2014

Identifying specificity groups in the T cell receptor repertoire journal, June 2017

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization journal, June 2013

Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults journal, February 2013

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes journal, August 2016

Functionally Impaired HIV-Specific CD8 T Cells Show High Affinity TCR-Ligand Interactions journal, October 2004

Discrepancy between ELISPOT IFN- secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life journal, August 2001

Dissection of T-cell Antigen Specificity in Human Melanoma journal, February 2012

Epstein-Barr virus nuclear antigen 1-specific CD4 + T cells directly kill Epstein-Barr virus-carrying natural killer and T cells journal, August 2008

Improved methods for predicting peptide binding affinity to MHC class II molecules journal, February 2018

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy journal, February 2004

Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior journal, February 1998

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens journal, March 2017

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining journal, August 2016

T cell immunodominance is dictated by the positively selecting self-peptide journal, January 2014

Development of a novel cell sorting method that samples population diversity in flow cytometry: Development of a Novel Cell Sorting Method journal, May 2015

Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease journal, May 2018

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens journal, February 2016

TGF-β: A Master of All T Cell Trades journal, August 2008

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis journal, May 2008

Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection journal, August 2013

Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation journal, January 2019

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms journal, January 2007

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides journal, July 2018

Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c –I-E k journal, April 2011

Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland journal, March 2012

Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china journal, August 2011

iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM journal, March 2011

Scaling and assessment of data quality journal, December 2005

Solving structures of protein complexes by molecular replacement with Phaser journal, December 2006

Coot model-building tools for molecular graphics journal, November 2004

Joint X-ray and neutron refinement with phenix.refine journal, October 2010

Collaboration gets the most out of software journal, September 2013

International Classification of Sleep Disorders-Third Edition journal, November 2014

Addendum journal, March 1998

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins journal, March 2020

High-dimensional single-cell analysis reveals the immune signature of narcolepsy text, January 2016

Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation text, January 2019

Title: In vivo clonal expansion and phenotypes of hypocretin-specific CD4⁺ T cells in narcolepsy patients and controls

The Epidemiology of Narcolepsy
journal, January 2007

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
journal, September 2000

DQ (rather than DR) gene marks susceptibility to narcolepsy
journal, April 1992

DQB1 Locus Alone Explains Most of the Risk and Protection in Narcolepsy with Cataplexy in Europe
journal, January 2014

Narcolepsy is strongly associated with the T-cell receptor alpha locus
journal, May 2009

Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic
journal, October 2013

Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy
journal, December 2018

Common variants in P2RY11 are associated with narcolepsy
journal, December 2010

ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
journal, February 2013

Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients
journal, March 2010

Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus
journal, September 2015

Detection of Autoantibodies Against Hypocretin, hcrtr1, and hcrtr2 in Narcolepsy: Anti-Hcrt System Antibody in Narcolepsy
journal, May 2006

Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2
journal, July 2015

Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases
journal, December 2017

CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice
journal, September 2016

CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
journal, February 2019

Re-examining the Nature and Function of Self-Reactive T cells
journal, February 2016

High-dimensional single-cell analysis reveals the immune signature of narcolepsy
journal, November 2016

Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells
journal, January 2017

CD4+ T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1
journal, December 2016

T cells in patients with narcolepsy target self-antigens of hypocretin neurons
journal, September 2018

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding
journal, July 2018

Linking T-cell receptor sequence to functional phenotype at the single-cell level
journal, June 2014

Identifying specificity groups in the T cell receptor repertoire
journal, June 2017

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization
journal, June 2013

Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults
journal, February 2013

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes
journal, August 2016

Functionally Impaired HIV-Specific CD8 T Cells Show High Affinity TCR-Ligand Interactions
journal, October 2004

Discrepancy between ELISPOT IFN- secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life
journal, August 2001

Dissection of T-cell Antigen Specificity in Human Melanoma
journal, February 2012

Epstein-Barr virus nuclear antigen 1-specific CD4 ⁺ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells
journal, August 2008

Improved methods for predicting peptide binding affinity to MHC class II molecules
journal, February 2018

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
journal, February 2004

Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
journal, February 1998

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens
journal, March 2017

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining
journal, August 2016

T cell immunodominance is dictated by the positively selecting self-peptide
journal, January 2014

Development of a novel cell sorting method that samples population diversity in flow cytometry: Development of a Novel Cell Sorting Method
journal, May 2015

Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
journal, May 2018

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
journal, February 2016

TGF-β: A Master of All T Cell Trades
journal, August 2008

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
journal, May 2008

Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection
journal, August 2013

Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation
journal, January 2019

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
journal, January 2007

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides
journal, July 2018

Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c –I-E ^k
journal, April 2011

Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland
journal, March 2012

Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china
journal, August 2011

iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
journal, March 2011

Scaling and assessment of data quality
journal, December 2005

Solving structures of protein complexes by molecular replacement with Phaser
journal, December 2006

Coot model-building tools for molecular graphics
journal, November 2004

Joint X-ray and neutron refinement with phenix.refine
journal, October 2010

Collaboration gets the most out of software
journal, September 2013

International Classification of Sleep Disorders-Third Edition
journal, November 2014

Addendum
journal, March 1998

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins
journal, March 2020

High-dimensional single-cell analysis reveals the immune signature of narcolepsy
text, January 2016

Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation
text, January 2019