Mechanism of IRSp53 inhibition by 14-3-3

Kast, David J.; Dominguez, Roberto

doi:10.1038/s41467-019-08317-8

Title: Mechanism of IRSp53 inhibition by 14-3-3

Journal Article · 29 January 2019 · Nature Communications

DOI: https://doi.org/10.1038/s41467-019-08317-8 · OSTI ID:1624132

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Univ. of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (United States). Department of Physiology; DOE/OSTI
Univ. of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (United States). Department of Physiology

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Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-98CH10886

OSTI ID:: 1624132

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 10; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

References (124)

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Kahn, Barbara B.; Alquier, Thierry; Carling, David Cell Metabolism, Vol. 1, Issue 1 https://doi.org/10.1016/j.cmet.2004.12.003	journal	January 2005
Proteomic, Functional, and Domain-Based Analysis of In Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization Jin, Jing; Smith, F. Donelson; Stark, Chris Current Biology, Vol. 14, Issue 16 https://doi.org/10.1016/j.cub.2004.07.051	journal	August 2004
Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins Saarikangas, Juha; Zhao, Hongxia; Pykäläinen, Anette Current Biology, Vol. 19, Issue 2 https://doi.org/10.1016/j.cub.2008.12.029	journal	January 2009
Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia Segal, Dagan; Dhanyasi, Nagaraju; Schejter, Eyal D. Developmental Cell, Vol. 38, Issue 3 https://doi.org/10.1016/j.devcel.2016.07.010	journal	August 2016
Association study of six candidate genes asymmetrically expressed in the two cerebral hemispheres suggests the involvement of BAIAP2 in autism Toma, Claudio; Hervás, Amaia; Balmaña, Noemí Journal of Psychiatric Research, Vol. 45, Issue 2 https://doi.org/10.1016/j.jpsychires.2010.09.001	journal	February 2011
Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex Rosenberg, Madelaine M.; Yang, Fang; Giovanni, Monica Molecular and Cellular Neuroscience, Vol. 38, Issue 2 https://doi.org/10.1016/j.mcn.2008.02.006	journal	June 2008
Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis Banko, Max R.; Allen, Jasmina J.; Schaffer, Bethany E. Molecular Cell, Vol. 44, Issue 6 https://doi.org/10.1016/j.molcel.2011.11.005	journal	December 2011
IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders Kang, Jaeseung; Park, Haram; Kim, Eunjoon Neuropharmacology, Vol. 100 https://doi.org/10.1016/j.neuropharm.2015.06.019	journal	January 2016
The 14-3-3 proteins in regulation of cellular metabolism Kleppe, Rune; Martinez, Aurora; Døskeland, Stein Ove Seminars in Cell & Developmental Biology, Vol. 22, Issue 7 https://doi.org/10.1016/j.semcdb.2011.08.008	journal	September 2011
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis Gardino, Alexandra K.; Yaffe, Michael B. Seminars in Cell & Developmental Biology, Vol. 22, Issue 7 https://doi.org/10.1016/j.semcdb.2011.09.008	journal	September 2011
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions Scita, Giorgio; Confalonieri, Stefano; Lappalainen, Pekka Trends in Cell Biology, Vol. 18, Issue 2 https://doi.org/10.1016/j.tcb.2007.12.002	journal	February 2008
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity Yaffe, Michael B.; Rittinger, Katrin; Volinia, Stefano Cell, Vol. 91, Issue 7 https://doi.org/10.1016/s0092-8674(00)80487-0	journal	December 1997
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex Krugmann, Sonja; Jordens, Ingrid; Gevaert, Kris Current Biology, Vol. 11, Issue 21 https://doi.org/10.1016/s0960-9822(01)00506-1	journal	October 2001
14-3-3 Regulates Actin Dynamics by Stabilizing Phosphorylated Cofilin Gohla, Antje; Bokoch, Gary M. Current Biology, Vol. 12, Issue 19 https://doi.org/10.1016/s0960-9822(02)01184-3	journal	October 2002
A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry Nesvizhskii, Alexey I.; Keller, Andrew; Kolker, Eugene Analytical Chemistry, Vol. 75, Issue 17 https://doi.org/10.1021/ac0341261	journal	September 2003
Modulators of 14-3-3 Protein–Protein Interactions Stevers, Loes M.; Sijbesma, Eline; Botta, Maurizio Journal of Medicinal Chemistry, Vol. 61, Issue 9 https://doi.org/10.1021/acs.jmedchem.7b00574	journal	October 2017
Two 14-3-3 Binding Motifs Are Required for Stable Association of Forkhead Transcription Factor FOXO4 with 14-3-3 Proteins and Inhibition of DNA Binding Obsil, Tomas; Ghirlando, Rodolfo; Anderson, D. Eric Biochemistry, Vol. 42, Issue 51 https://doi.org/10.1021/bi0352724	journal	December 2003
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP Disanza, Andrea; Bisi, Sara; Winterhoff, Moritz The EMBO Journal, Vol. 32, Issue 20 https://doi.org/10.1038/emboj.2013.208	journal	September 2013
A probability-based approach for high-throughput protein phosphorylation analysis and site localization Beausoleil, Sean A.; Villén, Judit; Gerber, Scott A. Nature Biotechnology, Vol. 24, Issue 10 https://doi.org/10.1038/nbt1240	journal	September 2006
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8–IRSp53 complex Disanza, Andrea; Mantoani, Sara; Hertzog, Maud Nature Cell Biology, Vol. 8, Issue 12 https://doi.org/10.1038/ncb1502	journal	November 2006
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot Eiseler, Tim; Döppler, Heike; Yan, Irene K. Nature Cell Biology, Vol. 11, Issue 5 https://doi.org/10.1038/ncb1861	journal	March 2009
IRSp53 senses negative membrane curvature and phase separates along membrane tubules Prévost, Coline; Zhao, Hongxia; Manzi, John Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms9529	journal	October 2015
Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression Chung, Woosuk; Choi, Su Yeon; Lee, Eunee Nature Neuroscience, Vol. 18, Issue 3 https://doi.org/10.1038/nn.3927	journal	January 2015
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response Reinhardt, H. Christian; Yaffe, Michael B. Nature Reviews Molecular Cell Biology, Vol. 14, Issue 9 https://doi.org/10.1038/nrm3640	journal	August 2013
The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation Liu, P-S; Jong, T-H; Maa, M-C Oncogene, Vol. 29, Issue 27 https://doi.org/10.1038/onc.2010.144	journal	April 2010
Structural interface between LRRK2 and 14-3-3 protein Stevers, Loes M.; de Vries, Rens M. J. M.; Doveston, Richard G. Biochemical Journal, Vol. 474, Issue 7 https://doi.org/10.1042/bcj20161078	journal	March 2017
Bioinformatic and experimental survey of 14-3-3-binding sites Johnson, Catherine; Crowther, Sandra; Stafford, Margaret J. Biochemical Journal, Vol. 427, Issue 1 https://doi.org/10.1042/bj20091834	journal	March 2010
Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors Nishimura, Tamako; Morone, Nobuhiro; Suetsugu, Shiro Biochemical Society Transactions, Vol. 46, Issue 2 https://doi.org/10.1042/bst20170322	journal	March 2018
14-3-3 stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion Boudreau, A.; Tanner, K.; Wang, D. Proceedings of the National Academy of Sciences, Vol. 110, Issue 41 https://doi.org/10.1073/pnas.1315022110	journal	September 2013
Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR Stevers, Loes M.; Lam, Chan V.; Leysen, Seppe F. R. Proceedings of the National Academy of Sciences, Vol. 113, Issue 9 https://doi.org/10.1073/pnas.1516631113	journal	February 2016
mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation Goh, Wah Ing; Lim, Kim Buay; Sudhaharan, Thankiah Journal of Biological Chemistry, Vol. 287, Issue 7 https://doi.org/10.1074/jbc.m111.305102	journal	December 2011
The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics Lim, Kim Buay; Bu, Wenyu; Goh, Wah Ing Journal of Biological Chemistry, Vol. 283, Issue 29 https://doi.org/10.1074/jbc.m710185200	journal	April 2008
The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity Sawallisch, Corinna; Berhörster, Kerstin; Disanza, Andrea Journal of Biological Chemistry, Vol. 284, Issue 14 https://doi.org/10.1074/jbc.m808425200	journal	February 2009
Optimization of WAVE2 complex–induced actin polymerization by membrane-bound IRSp53, PIP3, and Rac Suetsugu, Shiro; Kurisu, Shusaku; Oikawa, Tsukasa Journal of Cell Biology, Vol. 173, Issue 4 https://doi.org/10.1083/jcb.200509067	journal	May 2006
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/s0907444910007493	journal	March 2010
Insulin receptor substrate of 53kDa links postsynaptic shank to PSD-95 Soltau, Michaela; Berhorster, Kerstin; Kindler, Stefan Journal of Neurochemistry, Vol. 90, Issue 3 https://doi.org/10.1111/j.1471-4159.2004.02523.x	journal	August 2004
The regulation and function of mammalian AMPK-related kinases Bright, N. J.; Thornton, C.; Carling, D. Acta Physiologica, Vol. 196, Issue 1 https://doi.org/10.1111/j.1748-1716.2009.01971.x	journal	May 2009
Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range Udenfriend, S.; Stein, S.; Bohlen, P. Science, Vol. 178, Issue 4063 https://doi.org/10.1126/science.178.4063.871	journal	November 1972
IRSp53/Eps8 Complex Is Important for Positive Regulation of Rac and Cancer Cell Motility/Invasiveness Funato, Yosuke; Terabayashi, Takeshi; Suenaga, Naoko Cancer Research, Vol. 64, Issue 15 https://doi.org/10.1158/0008-5472.can-04-0327	journal	August 2004
Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1 Oda, K.; Shiratsuchi, T.; Nishimori, H. Cytogenetic and Genome Research, Vol. 84, Issue 1-2 https://doi.org/10.1159/000015219	journal	January 1999
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination Chauhan, B. K.; Disanza, A.; Choi, S. -Y. Development, Vol. 136, Issue 21 https://doi.org/10.1242/dev.042242	journal	October 2009
IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena Nakagawa, H. Journal of Cell Science, Vol. 116, Issue 12 https://doi.org/10.1242/jcs.00462	journal	May 2003
Different functional modes of BAR domain proteins in formation and plasticity of mammalian postsynapses Kessels, M. M.; Qualmann, B. Journal of Cell Science, Vol. 128, Issue 17 https://doi.org/10.1242/jcs.174193	journal	August 2015
IRSp53 Mediates Podosome Formation via VASP in NIH-Src Cells Oikawa, Tsukasa; Okamura, Hitomi; Dietrich, Franziska PLoS ONE, Vol. 8, Issue 3 https://doi.org/10.1371/journal.pone.0060528	journal	March 2013
The neuronal proteins CIPP, Cypin and IRSp53 form a tripartite complex mediated by PDZ and SH3 domains Barilari, Manuela; Dente, Luciana Biological Chemistry, Vol. 391, Issue 10 https://doi.org/10.1515/bc.2010.118	journal	October 2010
Regulation of Dendritic Spine Morphogenesis by Insulin Receptor Substrate 53, a Downstream Effector of Rac1 and Cdc42 Small GTPases Choi, J. Journal of Neuroscience, Vol. 25, Issue 4 https://doi.org/10.1523/jneurosci.3212-04.2005	journal	January 2005
Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion Chazeau, Anaël; Mehidi, Amine; Nair, Deepak The EMBO Journal, Vol. 33, Issue 23 https://doi.org/10.15252/embj.201488837	journal	October 2014
Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1) Petrvalska, Olivia; Kosek, Dalibor; Kukacka, Zdenek Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2016-04598	text	January 2016
14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis Cornell, Brett; Toyo-oka, Kazuhito Frontiers in Molecular Neuroscience, Vol. 10 https://doi.org/10.3389/fnmol.2017.00318	journal	October 2017
Rho Small G-Protein-Dependent Binding of mDia to an Src Homology 3 Domain-Containing IRSp53/BAIAP2 Fujiwara, Takeshi; Mammoto, Akiko; Kim, Yongman Biochemical and Biophysical Research Communications, Vol. 271, Issue 3 https://doi.org/10.1006/bbrc.2000.2671	journal	May 2000
The Insulin Receptor Substrate IRSp53 Links Postsynaptic shank1 to the Small G-Protein cdc42 Soltau, M. Molecular and Cellular Neuroscience, Vol. 21, Issue 4 https://doi.org/10.1006/mcne.2002.1201	journal	December 2002
How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis Yaffe, Michael B. FEBS Letters, Vol. 513, Issue 1 https://doi.org/10.1016/S0014-5793(01)03288-4	journal	December 2001
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity Yaffe, Michael B.; Rittinger, Katrin; Volinia, Stefano Cell, Vol. 91, Issue 7 https://doi.org/10.1016/S0092-8674(00)80487-0	journal	December 1997
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex Krugmann, Sonja; Jordens, Ingrid; Gevaert, Kris Current Biology, Vol. 11, Issue 21 https://doi.org/10.1016/S0960-9822(01)00506-1	journal	October 2001
14-3-3 Regulates Actin Dynamics by Stabilizing Phosphorylated Cofilin Gohla, Antje; Bokoch, Gary M. Current Biology, Vol. 12, Issue 19 https://doi.org/10.1016/S0960-9822(02)01184-3	journal	October 2002
Case-Control Study of Six Genes Asymmetrically Expressed in the Two Cerebral Hemispheres: Association of BAIAP2 with Attention-Deficit/Hyperactivity Disorder Ribasés, Marta; Bosch, Rosa; Hervás, Amaia Biological Psychiatry, Vol. 66, Issue 10 https://doi.org/10.1016/j.biopsych.2009.06.024	journal	November 2009
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Kahn, Barbara B.; Alquier, Thierry; Carling, David Cell Metabolism, Vol. 1, Issue 1 https://doi.org/10.1016/j.cmet.2004.12.003	journal	January 2005
Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction Schaffer, Bethany E.; Levin, Rebecca S.; Hertz, Nicholas T. Cell Metabolism, Vol. 22, Issue 5 https://doi.org/10.1016/j.cmet.2015.09.009	journal	November 2015
Proteomic, Functional, and Domain-Based Analysis of In Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization Jin, Jing; Smith, F. Donelson; Stark, Chris Current Biology, Vol. 14, Issue 16 https://doi.org/10.1016/j.cub.2004.07.051	journal	August 2004
Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins Saarikangas, Juha; Zhao, Hongxia; Pykäläinen, Anette Current Biology, Vol. 19, Issue 2 https://doi.org/10.1016/j.cub.2008.12.029	journal	January 2009
Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia Segal, Dagan; Dhanyasi, Nagaraju; Schejter, Eyal D. Developmental Cell, Vol. 38, Issue 3 https://doi.org/10.1016/j.devcel.2016.07.010	journal	August 2016
Association study of six candidate genes asymmetrically expressed in the two cerebral hemispheres suggests the involvement of BAIAP2 in autism Toma, Claudio; Hervás, Amaia; Balmaña, Noemí Journal of Psychiatric Research, Vol. 45, Issue 2 https://doi.org/10.1016/j.jpsychires.2010.09.001	journal	February 2011
Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex Rosenberg, Madelaine M.; Yang, Fang; Giovanni, Monica Molecular and Cellular Neuroscience, Vol. 38, Issue 2 https://doi.org/10.1016/j.mcn.2008.02.006	journal	June 2008
Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis Banko, Max R.; Allen, Jasmina J.; Schaffer, Bethany E. Molecular Cell, Vol. 44, Issue 6 https://doi.org/10.1016/j.molcel.2011.11.005	journal	December 2011
IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders Kang, Jaeseung; Park, Haram; Kim, Eunjoon Neuropharmacology, Vol. 100 https://doi.org/10.1016/j.neuropharm.2015.06.019	journal	January 2016
The 14-3-3 proteins in regulation of cellular metabolism Kleppe, Rune; Martinez, Aurora; Døskeland, Stein Ove Seminars in Cell & Developmental Biology, Vol. 22, Issue 7 https://doi.org/10.1016/j.semcdb.2011.08.008	journal	September 2011
14-3-3 Proteins: Diverse functions in cell proliferation and cancer progression Freeman, Alyson K.; Morrison, Deborah K. Seminars in Cell & Developmental Biology, Vol. 22, Issue 7 https://doi.org/10.1016/j.semcdb.2011.08.009	journal	September 2011
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis Gardino, Alexandra K.; Yaffe, Michael B. Seminars in Cell & Developmental Biology, Vol. 22, Issue 7 https://doi.org/10.1016/j.semcdb.2011.09.008	journal	September 2011
Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator Sluchanko, Nikolai N.; Beelen, Steven; Kulikova, Alexandra A. Structure, Vol. 25, Issue 2 https://doi.org/10.1016/j.str.2016.12.005	journal	February 2017
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions Scita, Giorgio; Confalonieri, Stefano; Lappalainen, Pekka Trends in Cell Biology, Vol. 18, Issue 2 https://doi.org/10.1016/j.tcb.2007.12.002	journal	February 2008
The Phenix software for automated determination of macromolecular structures Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Methods, Vol. 55, Issue 1 https://doi.org/10.1016/j.ymeth.2011.07.005	journal	September 2011
A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry Nesvizhskii, Alexey I.; Keller, Andrew; Kolker, Eugene Analytical Chemistry, Vol. 75, Issue 17 https://doi.org/10.1021/ac0341261	journal	September 2003
Modulators of 14-3-3 Protein–Protein Interactions Stevers, Loes M.; Sijbesma, Eline; Botta, Maurizio Journal of Medicinal Chemistry, Vol. 61, Issue 9 https://doi.org/10.1021/acs.jmedchem.7b00574	journal	October 2017
Two 14-3-3 Binding Motifs Are Required for Stable Association of Forkhead Transcription Factor FOXO4 with 14-3-3 Proteins and Inhibition of DNA Binding Obsil, Tomas; Ghirlando, Rodolfo; Anderson, D. Eric Biochemistry, Vol. 42, Issue 51 https://doi.org/10.1021/bi0352724	journal	December 2003
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling Miki, Hiroaki; Yamaguchi, Hideki; Suetsugu, Shiro Nature, Vol. 408, Issue 6813 https://doi.org/10.1038/35047107	journal	December 2000
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP Disanza, Andrea; Bisi, Sara; Winterhoff, Moritz The EMBO Journal, Vol. 32, Issue 20 https://doi.org/10.1038/emboj.2013.208	journal	September 2013
Recognition of an intra‐chain tandem 14‐3‐3 binding site within PKCε Kostelecky, Brenda; Saurin, Adrian T.; Purkiss, Andrew EMBO reports, Vol. 10, Issue 9 https://doi.org/10.1038/embor.2009.150	journal	July 2009
De novo mutations in schizophrenia implicate synaptic networks Fromer, Menachem; Pocklington, Andrew J.; Kavanagh, David H. Nature, Vol. 506, Issue 7487 https://doi.org/10.1038/nature12929	journal	January 2014
A probability-based approach for high-throughput protein phosphorylation analysis and site localization Beausoleil, Sean A.; Villén, Judit; Gerber, Scott A. Nature Biotechnology, Vol. 24, Issue 10 https://doi.org/10.1038/nbt1240	journal	September 2006
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8–IRSp53 complex Disanza, Andrea; Mantoani, Sara; Hertzog, Maud Nature Cell Biology, Vol. 8, Issue 12 https://doi.org/10.1038/ncb1502	journal	November 2006
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot Eiseler, Tim; Döppler, Heike; Yan, Irene K. Nature Cell Biology, Vol. 11, Issue 5 https://doi.org/10.1038/ncb1861	journal	March 2009
IRSp53 senses negative membrane curvature and phase separates along membrane tubules Prévost, Coline; Zhao, Hongxia; Manzi, John Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms9529	journal	October 2015
Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression Chung, Woosuk; Choi, Su Yeon; Lee, Eunee Nature Neuroscience, Vol. 18, Issue 3 https://doi.org/10.1038/nn.3927	journal	January 2015
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response Reinhardt, H. Christian; Yaffe, Michael B. Nature Reviews Molecular Cell Biology, Vol. 14, Issue 9 https://doi.org/10.1038/nrm3640	journal	August 2013
Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors Kast, David J.; Yang, Changsong; Disanza, Andrea Nature Structural & Molecular Biology, Vol. 21, Issue 4 https://doi.org/10.1038/nsmb.2781	journal	March 2014
The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation Liu, P-S; Jong, T-H; Maa, M-C Oncogene, Vol. 29, Issue 27 https://doi.org/10.1038/onc.2010.144	journal	April 2010
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome Sharma, Deepti; De Falco, Louis; Padavattan, Sivaraman Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-13641-0	journal	December 2019
Structural interface between LRRK2 and 14-3-3 protein Stevers, Loes M.; de Vries, Rens M. J. M.; Doveston, Richard G. Biochemical Journal, Vol. 474, Issue 7 https://doi.org/10.1042/BCJ20161078	journal	March 2017
Bioinformatic and experimental survey of 14-3-3-binding sites Johnson, Catherine; Crowther, Sandra; Stafford, Margaret J. Biochemical Journal, Vol. 427, Issue 1 https://doi.org/10.1042/BJ20091834	journal	March 2010
Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors Nishimura, Tamako; Morone, Nobuhiro; Suetsugu, Shiro Biochemical Society Transactions, Vol. 46, Issue 2 https://doi.org/10.1042/BST20170322	journal	March 2018
ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53: ProSAP/Shank interaction with IRSp53 Bockmann, J.; Kreutz, M. R.; Gundelfinger, E. D. Journal of Neurochemistry, Vol. 83, Issue 4 https://doi.org/10.1046/j.1471-4159.2002.01204.x	journal	November 2002
14-3-3 stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion Boudreau, A.; Tanner, K.; Wang, D. Proceedings of the National Academy of Sciences, Vol. 110, Issue 41 https://doi.org/10.1073/pnas.1315022110	journal	September 2013
Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR Stevers, Loes M.; Lam, Chan V.; Leysen, Seppe F. R. Proceedings of the National Academy of Sciences, Vol. 113, Issue 9 https://doi.org/10.1073/pnas.1516631113	journal	February 2016
Protein Kinase D Controls Actin Polymerization and Cell Motility through Phosphorylation of Cortactin Eiseler, Tim; Hausser, Angelika; De Kimpe, Line Journal of Biological Chemistry, Vol. 285, Issue 24 https://doi.org/10.1074/jbc.M109.093880	journal	April 2010
mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation Goh, Wah Ing; Lim, Kim Buay; Sudhaharan, Thankiah Journal of Biological Chemistry, Vol. 287, Issue 7 https://doi.org/10.1074/jbc.M111.305102	journal	December 2011
Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1) Petrvalska, Olivia; Kosek, Dalibor; Kukacka, Zdenek Journal of Biological Chemistry, Vol. 291, Issue 39 https://doi.org/10.1074/jbc.M116.724310	journal	August 2016
The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics Lim, Kim Buay; Bu, Wenyu; Goh, Wah Ing Journal of Biological Chemistry, Vol. 283, Issue 29 https://doi.org/10.1074/jbc.M710185200	journal	April 2008
The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity Sawallisch, Corinna; Berhörster, Kerstin; Disanza, Andrea Journal of Biological Chemistry, Vol. 284, Issue 14 https://doi.org/10.1074/jbc.M808425200	journal	February 2009
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells Franz-Wachtel, Mirita; Eisler, Stephan A.; Krug, Karsten Molecular & Cellular Proteomics, Vol. 11, Issue 5 https://doi.org/10.1074/mcp.M111.016014	journal	April 2012
Optimization of WAVE2 complex–induced actin polymerization by membrane-bound IRSp53, PIP3, and Rac Suetsugu, Shiro; Kurisu, Shusaku; Oikawa, Tsukasa Journal of Cell Biology, Vol. 173, Issue 4 https://doi.org/10.1083/jcb.200509067	journal	May 2006
Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain–like mechanism Mattila, Pieta K.; Pykäläinen, Anette; Saarikangas, Juha Journal of Cell Biology, Vol. 176, Issue 7 https://doi.org/10.1083/jcb.200609176	journal	March 2007
The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell–ECM signaling Cohen, David; Fernandez, Dawn; Lázaro-Diéguez, Francisco The Journal of Cell Biology, Vol. 192, Issue 3 https://doi.org/10.1083/jcb.201007002	journal	January 2011
14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides Madeira, Fábio; Tinti, Michele; Murugesan, Gavuthami Bioinformatics, Vol. 31, Issue 14 https://doi.org/10.1093/bioinformatics/btv133	journal	March 2015
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations Hornbeck, Peter V.; Zhang, Bin; Murray, Beth Nucleic Acids Research, Vol. 43, Issue D1 https://doi.org/10.1093/nar/gku1267	journal	December 2014
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Insulin receptor substrate of 53kDa links postsynaptic shank to PSD-95 Soltau, Michaela; Berhorster, Kerstin; Kindler, Stefan Journal of Neurochemistry, Vol. 90, Issue 3 https://doi.org/10.1111/j.1471-4159.2004.02523.x	journal	August 2004
Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease: 14-3-3 in neurodegenerative disease Mackie, Shaun; Aitken, Alastair FEBS Journal, Vol. 272, Issue 16 https://doi.org/10.1111/j.1742-4658.2005.04832.x	journal	August 2005
Structural insights of the MLF1/14-3-3 interaction: The 14-3-3ε/MLF1 crystal structure Molzan, Manuela; Weyand, Michael; Rose, Rolf FEBS Journal, Vol. 279, Issue 4 https://doi.org/10.1111/j.1742-4658.2011.08445.x	journal	January 2012
The regulation and function of mammalian AMPK-related kinases Bright, N. J.; Thornton, C.; Carling, D. Acta Physiologica, Vol. 196, Issue 1 https://doi.org/10.1111/j.1748-1716.2009.01971.x	journal	May 2009
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1 Luerman, Gregory C.; Nguyen, Chuong; Samaroo, Harry Journal of Neurochemistry, Vol. 128, Issue 4 https://doi.org/10.1111/jnc.12483	journal	November 2013
Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range Udenfriend, S.; Stein, S.; Bohlen, P. Science, Vol. 178, Issue 4063 https://doi.org/10.1126/science.178.4063.871	journal	November 1972
Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization Robens, Jeffrey M.; Yeow-Fong, Lee; Ng, Elsa Molecular and Cellular Biology, Vol. 30, Issue 3 https://doi.org/10.1128/MCB.01574-08	journal	November 2009
IRSp53/Eps8 Complex Is Important for Positive Regulation of Rac and Cancer Cell Motility/Invasiveness Funato, Yosuke; Terabayashi, Takeshi; Suenaga, Naoko Cancer Research, Vol. 64, Issue 15 https://doi.org/10.1158/0008-5472.CAN-04-0327	journal	August 2004
Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1 Oda, K.; Shiratsuchi, T.; Nishimori, H. Cytogenetic and Genome Research, Vol. 84, Issue 1-2 https://doi.org/10.1159/000015219	journal	January 1999
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination Chauhan, B. K.; Disanza, A.; Choi, S. -Y. Development, Vol. 136, Issue 21 https://doi.org/10.1242/dev.042242	journal	October 2009
IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena Nakagawa, H. Journal of Cell Science, Vol. 116, Issue 12 https://doi.org/10.1242/jcs.00462	journal	May 2003
Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2 Abou-Kheir, W.; Isaac, B.; Yamaguchi, H. Journal of Cell Science, Vol. 121, Issue 3 https://doi.org/10.1242/jcs.010272	journal	January 2008
Different functional modes of BAR domain proteins in formation and plasticity of mammalian postsynapses Kessels, M. M.; Qualmann, B. Journal of Cell Science, Vol. 128, Issue 17 https://doi.org/10.1242/jcs.174193	journal	August 2015
IRSp53 Mediates Podosome Formation via VASP in NIH-Src Cells Oikawa, Tsukasa; Okamura, Hitomi; Dietrich, Franziska PLoS ONE, Vol. 8, Issue 3 https://doi.org/10.1371/journal.pone.0060528	journal	March 2013
The neuronal proteins CIPP, Cypin and IRSp53 form a tripartite complex mediated by PDZ and SH3 domains Barilari, Manuela; Dente, Luciana Biological Chemistry, Vol. 391, Issue 10 https://doi.org/10.1515/bc.2010.118	journal	October 2010
Regulation of Dendritic Spine Morphogenesis by Insulin Receptor Substrate 53, a Downstream Effector of Rac1 and Cdc42 Small GTPases Choi, J. Journal of Neuroscience, Vol. 25, Issue 4 https://doi.org/10.1523/JNEUROSCI.3212-04.2005	journal	January 2005
Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion Chazeau, Anaël; Mehidi, Amine; Nair, Deepak The EMBO Journal, Vol. 33, Issue 23 https://doi.org/10.15252/embj.201488837	journal	October 2014
Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1) Petrvalska, Olivia; Kosek, Dalibor; Kukacka, Zdenek Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2016-04598	text	January 2016
14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis Cornell, Brett; Toyo-oka, Kazuhito Frontiers in Molecular Neuroscience, Vol. 10 https://doi.org/10.3389/fnmol.2017.00318	journal	October 2017

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Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell–Cell Transmission Yu, Fei‐Long; Miao, Huan; Xia, Jinjin PROTEOMICS, Vol. 19, Issue 23 https://doi.org/10.1002/pmic.201900009	journal	October 2019
IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration Kast, David J.; Dominguez, Roberto Molecular Biology of the Cell, Vol. 30, Issue 11 https://doi.org/10.1091/mbc.e18-09-0600	journal	May 2019

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