A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors

Bürger, Marco; Willige, Björn C.; Chory, Joanne

doi:10.1038/s41467-017-02347-w

Title: A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors

Journal Article · 19 December 2017 · Nature Communications

DOI: https://doi.org/10.1038/s41467-017-02347-w · OSTI ID:1624065

^[1]; Willige, Björn C. ^[1]; Chory, Joanne ^[2]

Salk Institute for Biological Studies,La Jolla, CA, (United States). Plant Biology Laboratory
Salk Institute for Biological Studies, La Jolla, CA, (United States). Plant Biology Laboratory; Salk Institute for Biological Studies, La Jolla, CA, (United States). Howard Hughes Medical Institute

Several Pseudomonas<\em> and Xanthomonas<\em> species are plant pathogens that infect the model organism Arabidopsis<\em> thaliana<\em> and important crops such as Brassica<\em>. Resistant plants contain the infection by rapid cell death of the infected area through the hypersensitive response (HR). A family of highly related α/β hydrolases is involved in diverse processes in all domains of life. Functional details of their catalytic machinery, however, remained unclear. We report the crystal structures of α/β hydrolases representing two different clades of the family, including the protein SOBER1, which suppresses AvrBsT-incited HR in Arabidopsis<\em>. Our results reveal a unique hydrophobic anchor mechanism that defines a previously unknown family of protein deacetylases. Furthermore, this study identifies a lid-loop as general feature for substrate turnover in acyl-protein thioesterases and the described family of deacetylases. Furthermore, we found that SOBER1’s biological function is not restricted to Arabidopsis<\em> thaliana<\em> and not limited to suppress HR induced by AvrBsT.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1624065

Journal Information:: Nature Communications, Vol. 8, Issue 1; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Building Blocks for Plant Gene Assembly Karimi, Mansour; Bleys, Annick; Vanderhaeghen, Rudy Plant Physiology, Vol. 145, Issue 4 https://doi.org/10.1104/pp.107.110411	journal	October 2007
Type III Protein Secretion in Plant Pathogenic Bacteria Büttner, Daniela; He, Sheng Yang Plant Physiology, Vol. 150, Issue 4 https://doi.org/10.1104/pp.109.139089	journal	May 2009
A Conserved Carboxylesterase Is a SUPPRESSOR OF AVRBST-ELICITED RESISTANCE in Arabidopsis Cunnac, Sébastien; Wilson, Ariane; Nuwer, Jamie The Plant Cell, Vol. 19, Issue 2 https://doi.org/10.1105/tpc.106.048710	journal	February 2007
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A Bacterial Acetyltransferase Destroys Plant Microtubule Networks and Blocks Secretion Lee, Amy Huei-Yi; Hurley, Brenden; Felsensteiner, Corinna PLoS Pathogens, Vol. 8, Issue 2 https://doi.org/10.1371/journal.ppat.1002523	journal	February 2012
Bacterial Effector Activates Jasmonate Signaling by Directly Targeting JAZ Transcriptional Repressors Jiang, Shushu; Yao, Jian; Ma, Ka-Wai PLoS Pathogens, Vol. 9, Issue 10 https://doi.org/10.1371/journal.ppat.1003715	journal	October 2013
AvrBsT Acetylates Arabidopsis ACIP1, a Protein that Associates with Microtubules and Is Required for Immunity Cheong, Mi Sun; Kirik, Angela; Kim, Jung-Gun PLoS Pathogens, Vol. 10, Issue 2 https://doi.org/10.1371/journal.ppat.1003952	journal	February 2014
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Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard. Terwilliger, Thomas C.; Grosse-Kunstleve, Ralf W.; Afonine, Pavel V. International Union of Crystallography (IUCr) https://doi.org/10.17863/cam.52329	journalarticle	January 2008

Cited By (5)

Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones Bürger, Marco; Chory, Joanne Communications Biology, Vol. 1, Issue 1 https://doi.org/10.1038/s42003-018-0214-4	journal	December 2018
Arabidopsis thaliana SOBER1 (SUPPRESSOR OF AVRBST-ELICITED RESISTANCE 1) suppresses plant immunity triggered by multiple bacterial acetyltransferase effectors Choi, Sera; Jayaraman, Jay; Sohn, Kee Hoon New Phytologist, Vol. 219, Issue 1 https://doi.org/10.1111/nph.15125	journal	March 2018
Epigenetic silencing of a multifunctional plant stress regulator Zander, Mark; Willige, Björn C.; He, Yupeng eLife, Vol. 8 https://doi.org/10.7554/elife.47835	journal	August 2019
Publisher Correction: Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones Bürger, Marco; Chory, Joanne Communications Biology, Vol. 2, Issue 1 https://doi.org/10.1038/s42003-018-0258-5	journal	January 2019
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