Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model
Abstract
A direct contact transmission challenge model was used to simulate natural foot-and-mouth disease virus (FMDV) spread from FMDV A24/Cruzeiro/BRA/55 infected ‘seeder’ steers to naïve or vaccinated steers previously immunized with a replication-deficient human adenovirus-vectored FMDV A24/Cruzeiro/BRA/55 capsid-based subunit vaccine (AdtA24). In two independent vaccine efficacy trials, AdtA24 was administered once intramuscularly in the neck 7 days prior to contact with FMDV A24/Cruzeiro/BRA/55-infected seeder steers.
- Publication Date:
- Research Org.:
- Oak Ridge Associated Univ., Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1618781
- Alternate Identifier(s):
- OSTI ID: 1626876
- Grant/Contract Number:
- number DE-AC05-06OR23100; AC05-06OR23100
- Resource Type:
- Published Article
- Journal Name:
- BMC Veterinary Research
- Additional Journal Information:
- Journal Name: BMC Veterinary Research Journal Volume: 14 Journal Issue: 1; Journal ID: ISSN 1746-6148
- Publisher:
- Springer Science + Business Media
- Country of Publication:
- United Kingdom
- Language:
- English
- Subject:
- Veterinary Sciences; foot-and-mouth disease virus; FMDV A24/Cruzeiro/BRA/55; Replication-deficient human adenovirusvectored vaccine; DIVA; Vaccine efficacy
Citation Formats
Neilan, John G., Schutta, Christopher, Barrera, José, Pisano, Melia, Zsak, Laszlo, Hartwig, Ethan, Rasmussen, Max V., Kamicker, Barbara J., Ettyreddy, Damodar, Brough, Douglas E., Butman, Bryan T., and Brake, David A. Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model. United Kingdom: N. p., 2018.
Web. doi:10.1186/s12917-018-1582-1.
Neilan, John G., Schutta, Christopher, Barrera, José, Pisano, Melia, Zsak, Laszlo, Hartwig, Ethan, Rasmussen, Max V., Kamicker, Barbara J., Ettyreddy, Damodar, Brough, Douglas E., Butman, Bryan T., & Brake, David A. Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model. United Kingdom. https://doi.org/10.1186/s12917-018-1582-1
Neilan, John G., Schutta, Christopher, Barrera, José, Pisano, Melia, Zsak, Laszlo, Hartwig, Ethan, Rasmussen, Max V., Kamicker, Barbara J., Ettyreddy, Damodar, Brough, Douglas E., Butman, Bryan T., and Brake, David A. Wed .
"Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model". United Kingdom. https://doi.org/10.1186/s12917-018-1582-1.
@article{osti_1618781,
title = {Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model},
author = {Neilan, John G. and Schutta, Christopher and Barrera, José and Pisano, Melia and Zsak, Laszlo and Hartwig, Ethan and Rasmussen, Max V. and Kamicker, Barbara J. and Ettyreddy, Damodar and Brough, Douglas E. and Butman, Bryan T. and Brake, David A.},
abstractNote = {A direct contact transmission challenge model was used to simulate natural foot-and-mouth disease virus (FMDV) spread from FMDV A24/Cruzeiro/BRA/55 infected ‘seeder’ steers to naïve or vaccinated steers previously immunized with a replication-deficient human adenovirus-vectored FMDV A24/Cruzeiro/BRA/55 capsid-based subunit vaccine (AdtA24). In two independent vaccine efficacy trials, AdtA24 was administered once intramuscularly in the neck 7 days prior to contact with FMDV A24/Cruzeiro/BRA/55-infected seeder steers.},
doi = {10.1186/s12917-018-1582-1},
journal = {BMC Veterinary Research},
number = 1,
volume = 14,
place = {United Kingdom},
year = {Wed Aug 29 00:00:00 EDT 2018},
month = {Wed Aug 29 00:00:00 EDT 2018}
}
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https://doi.org/10.1186/s12917-018-1582-1
https://doi.org/10.1186/s12917-018-1582-1
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Works referencing / citing this record:
Immunologic Dose-Response to Adenovirus-Vectored Vaccines in Animals and Humans: A Systematic Review of Dose-Response Studies of Replication Incompetent Adenoviral Vaccine Vectors when Given via an Intramuscular or Subcutaneous Route
journal, March 2020
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