Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas

Abstract

Abstract Microalgae hold great promises as sustainable cellular factories for the production of alternative fuels, feeds, and biopharmaceuticals for human health. While the biorefinery approach for fuels along with the coproduction of high-value compounds with industrial, therapeutic, or nutraceutical applications have the potential to make algal biofuels more economically viable, a number of challenges continue to hamper algal production systems at all levels. One such hurdle includes the metabolic trade-off often observed between the increased yields of desired products, such as triacylglycerols (TAG), and the growth of an organism. Initial genetic engineering strategies to improve lipid productivity in microalgae, which focused on overproducing the enzymes involved in fatty acid and TAG biosynthesis or inactivating competing carbon (C) metabolism, have seen some successes albeit at the cost of often greatly reduced biomass. Emergent approaches that aim at modifying the dynamics of entire metabolic pathways by engineering of pertinent transcription factors or signaling networks appear to have successfully achieved a balance between growth and neutral lipid accumulation. However, the biological knowledge of key signaling networks and molecular components linking these two processes is still incomplete in photosynthetic eukaryotes, making it difficult to optimize metabolic engineering strategies for microalgae. Here, we focus onmore » nitrogen (N) starvation of the model green microalga, Chlamydomonas reinhardtii , to present the current understanding of the nutrient-dependent switch between proliferation and quiescence, and the drastic reprogramming of metabolism that results in the storage of C compounds following N starvation. We discuss the potential components mediating the transcriptional repression of cell cycle genes and the establishment of quiescence in Chlamydomonas, and highlight the importance of signaling pathways such as those governed by the target of rapamycin (TOR) and sucrose nonfermenting-related (SnRK) kinases in the coordination of metabolic status with cellular growth. A better understanding of how the cell division cycle is regulated in response to nutrient scarcity and of the signaling pathways linking cellular growth to energy and lipid homeostasis, is essential to improve the prospects of biofuels and biomass production in microalgae.« less

Authors:
; ORCiD logo
Publication Date:
Research Org.:
Michigan State Univ., East Lansing, MI (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1618772
Alternate Identifier(s):
OSTI ID: 1800733
Grant/Contract Number:  
FG02-91ER20021
Resource Type:
Published Article
Journal Name:
Biotechnology for Biofuels
Additional Journal Information:
Journal Name: Biotechnology for Biofuels Journal Volume: 12 Journal Issue: 1; Journal ID: ISSN 1754-6834
Publisher:
BioMed Central
Country of Publication:
Netherlands
Language:
English
Subject:
09 BIOMASS FUELS; Chlamydomonas; quiescence; nitrogen deprivation; triacylglycerols; cell cycle; DREAM complex; TOR; SnRK/CKIN; biofuel; biomass

Citation Formats

Takeuchi, Tomomi, and Benning, Christoph. Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas. Netherlands: N. p., 2019. Web. doi:10.1186/s13068-019-1635-0.
Copy to clipboard
Takeuchi, Tomomi, & Benning, Christoph. Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas. Netherlands. https://doi.org/10.1186/s13068-019-1635-0
Copy to clipboard
Takeuchi, Tomomi, and Benning, Christoph. Mon . "Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas". Netherlands. https://doi.org/10.1186/s13068-019-1635-0.
Copy to clipboard
@article{osti_1618772,
title = {Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas},
author = {Takeuchi, Tomomi and Benning, Christoph},
abstractNote = {Abstract Microalgae hold great promises as sustainable cellular factories for the production of alternative fuels, feeds, and biopharmaceuticals for human health. While the biorefinery approach for fuels along with the coproduction of high-value compounds with industrial, therapeutic, or nutraceutical applications have the potential to make algal biofuels more economically viable, a number of challenges continue to hamper algal production systems at all levels. One such hurdle includes the metabolic trade-off often observed between the increased yields of desired products, such as triacylglycerols (TAG), and the growth of an organism. Initial genetic engineering strategies to improve lipid productivity in microalgae, which focused on overproducing the enzymes involved in fatty acid and TAG biosynthesis or inactivating competing carbon (C) metabolism, have seen some successes albeit at the cost of often greatly reduced biomass. Emergent approaches that aim at modifying the dynamics of entire metabolic pathways by engineering of pertinent transcription factors or signaling networks appear to have successfully achieved a balance between growth and neutral lipid accumulation. However, the biological knowledge of key signaling networks and molecular components linking these two processes is still incomplete in photosynthetic eukaryotes, making it difficult to optimize metabolic engineering strategies for microalgae. Here, we focus on nitrogen (N) starvation of the model green microalga, Chlamydomonas reinhardtii , to present the current understanding of the nutrient-dependent switch between proliferation and quiescence, and the drastic reprogramming of metabolism that results in the storage of C compounds following N starvation. We discuss the potential components mediating the transcriptional repression of cell cycle genes and the establishment of quiescence in Chlamydomonas, and highlight the importance of signaling pathways such as those governed by the target of rapamycin (TOR) and sucrose nonfermenting-related (SnRK) kinases in the coordination of metabolic status with cellular growth. A better understanding of how the cell division cycle is regulated in response to nutrient scarcity and of the signaling pathways linking cellular growth to energy and lipid homeostasis, is essential to improve the prospects of biofuels and biomass production in microalgae.},
doi = {10.1186/s13068-019-1635-0},
journal = {Biotechnology for Biofuels},
number = 1,
volume = 12,
place = {Netherlands},
year = {Mon Dec 23 00:00:00 EST 2019},
month = {Mon Dec 23 00:00:00 EST 2019}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1186/s13068-019-1635-0
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Citation Metrics:
Cited by: 29 works
Citation information provided by
Web of Science
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

System-level network analysis of nitrogen starvation and recovery in Chlamydomonas reinhardtii reveals potential new targets for increased lipid accumulation
journal, December 2014

  • Valledor, Luis; Furuhashi, Takeshi; Recuenco-Muñoz, Luis
  • Biotechnology for Biofuels, Vol. 7, Issue 1
  • DOI: 10.1186/s13068-014-0171-1

The CHR site: definition and genome-wide identification of a cell cycle transcriptional element
journal, August 2014

  • Müller, Gerd A.; Wintsche, Axel; Stangner, Konstanze
  • Nucleic Acids Research, Vol. 42, Issue 16
  • DOI: 10.1093/nar/gku696

Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
journal, April 2013

  • Shi, L.; Tu, B. P.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 18
  • DOI: 10.1073/pnas.1302490110

Valuable products from biotechnology of microalgae
journal, August 2004

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast
journal, February 1998

  • Noda, Takeshi; Ohsumi, Yoshinori
  • Journal of Biological Chemistry, Vol. 273, Issue 7
  • DOI: 10.1074/jbc.273.7.3963

Algae biofuels: versatility for the future of bioenergy
journal, June 2012

Molecular Organization of Target of Rapamycin Complex 2
journal, July 2005

  • Wullschleger, Stephan; Loewith, Robbie; Oppliger, Wolfgang
  • Journal of Biological Chemistry, Vol. 280, Issue 35
  • DOI: 10.1074/jbc.M505553200

Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae
journal, June 2007

A Late Mitotic Regulatory Network Controlling Cyclin Destruction in Saccharomyces cerevisiae
journal, October 1998

  • Jaspersen, Sue L.; Charles, Julia F.; Tinker-Kulberg, Rachel L.
  • Molecular Biology of the Cell, Vol. 9, Issue 10
  • DOI: 10.1091/mbc.9.10.2803

Recessive Antimorphic Alleles Overcome Functionally Redundant Loci to Reveal TSO1 Function in Arabidopsis Flowers and Meristems
journal, November 2011

TOR signaling in plants: conservation and innovation
journal, July 2018

The effect of rapamycin on biodiesel-producing protist Euglena gracilis
journal, February 2016

SNF1/AMPK/SnRK1 kinases, global regulators at the heart of energy control?
journal, January 2007

The inhibition of TOR in the model diatom Phaeodactylum tricornutum promotes a get-fat growth regime
journal, September 2017

Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction
journal, February 2011

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3
journal, May 2015

  • Thompson, Benjamin J.; Bhansali, Rahul; Diebold, Lauren
  • Journal of Experimental Medicine, Vol. 212, Issue 6
  • DOI: 10.1084/jem.20150002

Mutations of the AtYAK1 Kinase Suppress TOR Deficiency in Arabidopsis
journal, June 2019

Redox state-dependent modulation of plant SnRK1 kinase activity differs from AMPK regulation in animals
journal, October 2017

  • Wurzinger, Bernhard; Mair, Andrea; Fischer-Schrader, Katrin
  • FEBS Letters, Vol. 591, Issue 21
  • DOI: 10.1002/1873-3468.12852

Chlamydomonas as a model for biofuels and bio‐products production
journal, February 2015

  • Scranton, Melissa A.; Ostrand, Joseph T.; Fields, Francis J.
  • The Plant Journal, Vol. 82, Issue 3
  • DOI: 10.1111/tpj.12780

Rapamycin passes the torch: a new generation of mTOR inhibitors
journal, October 2011

  • Benjamin, Don; Colombi, Marco; Moroni, Christoph
  • Nature Reviews Drug Discovery, Vol. 10, Issue 11
  • DOI: 10.1038/nrd3531

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
journal, May 2011

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
journal, December 1999

  • Hardwick, J. S.; Kuruvilla, F. G.; Tong, J. K.
  • Proceedings of the National Academy of Sciences, Vol. 96, Issue 26
  • DOI: 10.1073/pnas.96.26.14866

mTOR Signaling in Growth, Metabolism, and Disease
journal, March 2017

Lineage-specific chromatin signatures reveal a regulator of lipid metabolism in microalgae
journal, July 2015

Metabolism of acyl‐lipids in Chlamydomonas reinhardtii
journal, March 2015

  • Li‐Beisson, Yonghua; Beisson, Fred; Riekhof, Wayne
  • The Plant Journal, Vol. 82, Issue 3
  • DOI: 10.1111/tpj.12787

ChlamyNET: a Chlamydomonas gene co-expression network reveals global properties of the transcriptome and the early setup of key co-expression patterns in the green lineage
journal, March 2016

  • Romero-Campero, Francisco J.; Perez-Hurtado, Ignacio; Lucas-Reina, Eva
  • BMC Genomics, Vol. 17, Issue 1
  • DOI: 10.1186/s12864-016-2564-y

Systemic analysis of inducible target of rapamycin mutants reveal a general metabolic switch controlling growth in Arabidopsis thaliana
journal, January 2013

  • Caldana, Camila; Li, Yan; Leisse, Andrea
  • The Plant Journal, Vol. 73, Issue 6
  • DOI: 10.1111/tpj.12080

Phytoplankton Lipids: Interspecific Differences and Effects of Nitrate, Silicate and Light-Dark Cycles1
journal, December 1981

RNA-Seq Analysis of Sulfur-Deprived Chlamydomonas Cells Reveals Aspects of Acclimation Critical for Cell Survival
journal, June 2010

  • González-Ballester, David; Casero, David; Cokus, Shawn
  • The Plant Cell, Vol. 22, Issue 6
  • DOI: 10.1105/tpc.109.071167

Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
journal, August 2017

Lipid metabolism in microalgae distinguishes itself
journal, April 2013

Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
journal, January 2009

  • Rodolfi, Liliana; Chini Zittelli, Graziella; Bassi, Niccolò
  • Biotechnology and Bioengineering, Vol. 102, Issue 1
  • DOI: 10.1002/bit.22033

HILIC- and SCX-Based Quantitative Proteomics of Chlamydomonas reinhardtii during Nitrogen Starvation Induced Lipid and Carbohydrate Accumulation
journal, October 2012

  • Longworth, Joseph; Noirel, Josselin; Pandhal, Jagroop
  • Journal of Proteome Research, Vol. 11, Issue 12
  • DOI: 10.1021/pr300692t

The Chemical Composition of Chlorella; Effect of Environmental Conditions
journal, January 1949

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
journal, April 2011

  • Litovchick, L.; Florens, L. A.; Swanson, S. K.
  • Genes & Development, Vol. 25, Issue 8
  • DOI: 10.1101/gad.2034211

Target of Rapamycin Inhibition in Chlamydomonas reinhardtii Triggers de Novo Amino Acid Synthesis by Enhancing Nitrogen Assimilation
journal, September 2018

  • Mubeen, Umarah; Jüppner, Jessica; Alpers, Jessica
  • The Plant Cell, Vol. 30, Issue 10
  • DOI: 10.1105/tpc.18.00159

Mechanism of Metabolic Control
journal, November 2000

  • Komeili, Arash; Wedaman, Karen P.; O'Shea, Erin K.
  • The Journal of Cell Biology, Vol. 151, Issue 4
  • DOI: 10.1083/jcb.151.4.863

Nutrient sensing and TOR signaling in yeast and mammals
journal, December 2016

Arabidopsis TSO1 and MYB3R1 form a regulatory module to coordinate cell proliferation with differentiation in shoot and root
journal, March 2018

  • Wang, Wanpeng; Sijacic, Paja; Xu, Pengbo
  • Proceedings of the National Academy of Sciences, Vol. 115, Issue 13
  • DOI: 10.1073/pnas.1715903115

Gametogenesis, gametes and zygotes: An ecological perspective on sexual reproduction in the algae
journal, September 1992

Target of rapamycin (TOR) plays a critical role in triacylglycerol accumulation in microalgae
journal, September 2015

Elemental Economy
book, January 2012

Target of Rapamycin and LST8 Proteins Associate with Membranes from the Endoplasmic Reticulum in the Unicellular Green Alga Chlamydomonas reinhardtii
journal, November 2007

  • Díaz-Troya, Sandra; Florencio, Francisco J.; Crespo, José L.
  • Eukaryotic Cell, Vol. 7, Issue 2
  • DOI: 10.1128/EC.00361-07

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
journal, July 2004

Advancing oleaginous microorganisms to produce lipid via metabolic engineering technology
journal, October 2013

TSO1 is a novel protein that modulates cytokinesis and cell expansion in Arabidopsis
journal, May 2000

Oxidative Stress Contributes to Autophagy Induction in Response to Endoplasmic Reticulum Stress in Chlamydomonas reinhardtii
journal, August 2014

  • Perez-Martin, M.; Perez-Perez, M. E.; Lemaire, S. D.
  • PLANT PHYSIOLOGY, Vol. 166, Issue 2
  • DOI: 10.1104/pp.114.243659

An Indexed, Mapped Mutant Library Enables Reverse Genetics Studies of Biological Processes in Chlamydomonas reinhardtii
journal, January 2016

  • Li, Xiaobo; Zhang, Ru; Patena, Weronika
  • The Plant Cell, Vol. 28, Issue 2
  • DOI: 10.1105/tpc.15.00465

Cell cycle control by timer and sizer in Chlamydomonas
journal, August 1983

  • Donnan, Lorraine; John, Peter C. L.
  • Nature, Vol. 304, Issue 5927
  • DOI: 10.1038/304630a0

Role for a Drosophila Myb-containing protein complex in site-specific DNA replication
journal, December 2002

  • Beall, Eileen L.; Manak, J. Robert; Zhou, Sharleen
  • Nature, Vol. 420, Issue 6917
  • DOI: 10.1038/nature01228

The Down syndrome-related protein kinase DYRK1A phosphorylates p27 Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation
journal, May 2014

  • Soppa, Ulf; Schumacher, Julian; Florencio Ortiz, Victoria
  • Cell Cycle, Vol. 13, Issue 13
  • DOI: 10.4161/cc.29104

Identification of regulatory network hubs that control lipid metabolism in Chlamydomonas reinhardtii
journal, May 2015

  • Gargouri, Mahmoud; Park, Jeong-Jin; Holguin, F. Omar
  • Journal of Experimental Botany, Vol. 66, Issue 15
  • DOI: 10.1093/jxb/erv217

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
journal, June 1998

Three Acyltransferases and Nitrogen-responsive Regulator Are Implicated in Nitrogen Starvation-induced Triacylglycerol Accumulation in Chlamydomonas
journal, March 2012

  • Boyle, Nanette R.; Page, Mark Dudley; Liu, Bensheng
  • Journal of Biological Chemistry, Vol. 287, Issue 19
  • DOI: 10.1074/jbc.M111.334052

Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells
journal, December 2016

Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase
journal, March 2019

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.
journal, January 1975

PHYSIOLOGICAL AND BIOCHEMICAL ASPECTS OF GROWTH AND GAMETOGENESIS IN CHLAMYDOMONAS REINHARDTII
journal, September 1970

Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants
journal, November 2017

  • Schepetilnikov, Mikhail; Ryabova, Lyubov A.
  • Plant Physiology, Vol. 176, Issue 2
  • DOI: 10.1104/pp.17.01243

Transgenic expression of CBBP, a CXC domain protein, establishes paramutation in maize
journal, March 2010

  • Brzeska, K.; Brzeski, J.; Smith, J.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 12
  • DOI: 10.1073/pnas.1001576107

Chlororespiration: an adaptation to nitrogen deficiency in Chlamydomonas reinhardtii.
journal, June 1991

  • Peltier, G.; Schmidt, G. W.
  • Proceedings of the National Academy of Sciences, Vol. 88, Issue 11
  • DOI: 10.1073/pnas.88.11.4791

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.
journal, January 1975

The Arabidopsis CDPK-SnRK Superfamily of Protein Kinases
journal, June 2003

  • Hrabak, Estelle M.; Chan, Catherine W. M.; Gribskov, Michael
  • Plant Physiology, Vol. 132, Issue 2
  • DOI: 10.1104/pp.102.011999

Isolation and Characterization of Chlamydomonas Autophagy-Related Mutants in Nutrient-Deficient Conditions
journal, October 2018

  • Kajikawa, Masataka; Yamauchi, Marika; Shinkawa, Haruka
  • Plant and Cell Physiology, Vol. 60, Issue 1
  • DOI: 10.1093/pcp/pcy193

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
journal, December 1999

  • Beck, Thomas; Hall, Michael N.
  • Nature, Vol. 402, Issue 6762
  • DOI: 10.1038/45287

A chloroplast pathway for the de novo biosynthesis of triacylglycerol in Chlamydomonas reinhardtii
journal, May 2011

A mating type-linked mutation that disrupts the uniparental inheritance of chloroplast DNA also disrupts cell-size control in Chlamydomonas.
journal, December 1995

  • Armbrust, E. V.; Ibrahim, A.; Goodenough, U. W.
  • Molecular Biology of the Cell, Vol. 6, Issue 12
  • DOI: 10.1091/mbc.6.12.1807

The Central Role of a SNRK2 Kinase in Sulfur Deprivation Responses
journal, March 2008

  • Gonzalez-Ballester, David; Pollock, Steve V.; Pootakham, Wirulda
  • Plant Physiology, Vol. 147, Issue 1
  • DOI: 10.1104/pp.108.116137

The sucrose non-fermenting-1-related (SnRK) family of protein kinases: potential for manipulation to improve stress tolerance and increase yield
journal, October 2010

  • Coello, P.; Hey, S. J.; Halford, N. G.
  • Journal of Experimental Botany, Vol. 62, Issue 3
  • DOI: 10.1093/jxb/erq331

Tor Kinases Are in Distinct Membrane-associated Protein Complexes in Saccharomyces cerevisiae
journal, March 2003

  • Wedaman, Karen P.; Reinke, Aaron; Anderson, Scott
  • Molecular Biology of the Cell, Vol. 14, Issue 3
  • DOI: 10.1091/mbc.e02-09-0609

Autophagy Is Required for Maintenance of Amino Acid Levels and Protein Synthesis under Nitrogen Starvation
journal, July 2005

  • Onodera, Jun; Ohsumi, Yoshinori
  • Journal of Biological Chemistry, Vol. 280, Issue 36
  • DOI: 10.1074/jbc.M506736200

Transcriptional repression by MYB 3R proteins regulates plant organ growth
journal, June 2015

  • Kobayashi, Kosuke; Suzuki, Toshiya; Iwata, Eriko
  • The EMBO Journal, Vol. 34, Issue 15
  • DOI: 10.15252/embj.201490899

Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to rapamycin susceptibility
journal, January 2007

Elucidating the composition and conservation of the autophagy pathway in photosynthetic eukaryotes
journal, April 2015

Oil accumulation is controlled by carbon precursor supply for fatty acid synthesis in Chlamydomonas reinhardtii
journal, May 2012

  • Fan, Jilian; Yan, Chengshi; Andre, Carl
  • Plant and Cell Physiology, Vol. 53, Issue 8
  • DOI: 10.1093/pcp/pcs082

CPP1, a DNA-binding protein involved in the expression of a soybean leghemoglobin c3 gene
journal, June 2000

  • Cvitanich, C.; Pallisgaard, N.; Nielsen, K. A.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 14
  • DOI: 10.1073/pnas.090468497

Evidence for a selective destabilization of an integral membrane protein, the cytochrome b6/f complex, during gametogenesis in Chlamydomonas reinhardtii
journal, February 1992

Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters
journal, July 2016

  • Marceau, Aimee H.; Felthousen, Jessica G.; Goetsch, Paul D.
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms12301

Metabolic regulation of triacylglycerol accumulation in the green algae: identification of potential targets for engineering to improve oil yield
journal, January 2016

  • Goncalves, Elton C.; Wilkie, Ann C.; Kirst, Matias
  • Plant Biotechnology Journal, Vol. 14, Issue 8
  • DOI: 10.1111/pbi.12523

Evolution of the TOR Pathway
journal, October 2011

  • van Dam, Teunis J. P.; Zwartkruis, Fried J. T.; Bos, Johannes L.
  • Journal of Molecular Evolution, Vol. 73, Issue 3-4
  • DOI: 10.1007/s00239-011-9469-9

The Chlamydomonas genome project: a decade on
journal, October 2014

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex
journal, September 2000

  • Kamada, Yoshiaki; Funakoshi, Tomoko; Shintani, Takahiro
  • The Journal of Cell Biology, Vol. 150, Issue 6
  • DOI: 10.1083/jcb.150.6.1507

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
journal, January 2003

Regulation of the Chlamydomonas Cell Cycle by a Stable, Chromatin-Associated Retinoblastoma Tumor Suppressor Complex
journal, October 2010

  • Olson, Bradley J. S. C.; Oberholzer, Michael; Li, Yubing
  • The Plant Cell, Vol. 22, Issue 10
  • DOI: 10.1105/tpc.110.076067

The DREAM complex: master coordinator of cell cycle-dependent gene expression
journal, July 2013

  • Sadasivam, Subhashini; DeCaprio, James A.
  • Nature Reviews Cancer, Vol. 13, Issue 8
  • DOI: 10.1038/nrc3556

The Chlamydomonas cell cycle
journal, March 2015

  • Cross, Frederick R.; Umen, James G.
  • The Plant Journal, Vol. 82, Issue 3
  • DOI: 10.1111/tpj.12795

Assessment of Environmental Stresses for Enhanced Microalgal Biofuel Production – An Overview
journal, July 2014

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes
journal, November 2011

  • Müller, Gerd A.; Quaas, Marianne; Schümann, Michael
  • Nucleic Acids Research, Vol. 40, Issue 4
  • DOI: 10.1093/nar/gkr793

Architecture of human mTOR complex 1
journal, December 2015

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
journal, April 2008

Quantitative in vivo phosphoproteomics reveals reversible signaling processes during nitrogen starvation and recovery in the biofuel model organism Chlamydomonas reinhardtii
journal, November 2017

  • Roustan, Valentin; Bakhtiari, Shiva; Roustan, Pierre-Jean
  • Biotechnology for Biofuels, Vol. 10, Issue 1
  • DOI: 10.1186/s13068-017-0949-z

TOR Signaling and Nutrient Sensing
journal, April 2016

Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes
journal, February 2017

  • Li, Xiaojuan; Cai, Wenguo; Liu, Yanlin
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 10
  • DOI: 10.1073/pnas.1618782114

AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint
journal, April 2005

Relevance of nutrient media composition for hydrogen production in Chlamydomonas
journal, May 2015

  • Gonzalez-Ballester, David; Jurado-Oller, Jose Luis; Fernandez, Emilio
  • Photosynthesis Research, Vol. 125, Issue 3
  • DOI: 10.1007/s11120-015-0152-7

The Nuclear cell Cycle in Chlamydomonas (Chlorophyceae)
journal, June 1982

Cell Volume and the Control of the Chlamydomonas Cell Cycle
journal, April 1982

  • Craigie, R. A.; Cavalier-Smith, T.
  • Journal of Cell Science, Vol. 54, Issue 1
  • DOI: 10.1242/jcs.54.1.173

The Regulation of Photosynthetic Structure and Function during Nitrogen Deprivation in Chlamydomonas reinhardtii
journal, December 2014

  • Juergens, Matthew T.; Deshpande, Rahul R.; Lucker, Ben F.
  • Plant Physiology, Vol. 167, Issue 2
  • DOI: 10.1104/pp.114.250530

Staying alive: Metabolic adaptations to quiescence
journal, May 2012

  • Valcourt, James R.; Lemons, Johanna M. S.; Haley, Erin M.
  • Cell Cycle, Vol. 11, Issue 9
  • DOI: 10.4161/cc.19879

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
journal, October 2004

  • Jacinto, Estela; Loewith, Robbie; Schmidt, Anja
  • Nature Cell Biology, Vol. 6, Issue 11
  • DOI: 10.1038/ncb1183

A Review on the Assessment of Stress Conditions for Simultaneous Production of Microalgal Lipids and Carotenoids
journal, May 2016

  • Minhas, Amritpreet K.; Hodgson, Peter; Barrow, Colin J.
  • Frontiers in Microbiology, Vol. 7
  • DOI: 10.3389/fmicb.2016.00546

Turnover of chloroplast and cytoplasmic ribosomes during gametogenesis in Chlamydomonas reinhardi
journal, July 1976

Hyper-accumulation of starch and oil in a Chlamydomonas mutant affected in a plant-specific DYRK kinase
journal, March 2016

  • Schulz-Raffelt, Miriam; Chochois, Vincent; Auroy, Pascaline
  • Biotechnology for Biofuels, Vol. 9, Issue 1
  • DOI: 10.1186/s13068-016-0469-2

The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy
journal, August 2008

Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes
journal, October 2004

Potential for green microalgae to produce hydrogen, pharmaceuticals and other high value products in a combined process
journal, June 2012

Genetic Engineering of Algae for Enhanced Biofuel Production
journal, February 2010

  • Radakovits, R.; Jinkerson, R. E.; Darzins, A.
  • Eukaryotic Cell, Vol. 9, Issue 4, p. 486-501
  • DOI: 10.1128/EC.00364-09

The role of TOR in autophagy regulation from yeast to plants and mammals
journal, October 2008

  • Díaz-Troya, Sandra; Pérez-Pérez, María Esther; Florencio, Francisco J.
  • Autophagy, Vol. 4, Issue 7
  • DOI: 10.4161/auto.6555

CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast
journal, June 2004

AMPK and autophagy get connected: AMPK and autophagy get connected
journal, February 2011

Genome-wide identification and characterization of CKIN/SnRK gene family in Chlamydomonas reinhardtii
journal, January 2019

Metabolite Profiling of Chlamydomonas reinhardtii under Nutrient Deprivation
journal, November 2005

A Galactoglycerolipid Lipase Is Required for Triacylglycerol Accumulation and Survival Following Nitrogen Deprivation in Chlamydomonas reinhardtii
journal, November 2012

  • Li, Xiaobo; Moellering, Eric R.; Liu, Bensheng
  • The Plant Cell, Vol. 24, Issue 11
  • DOI: 10.1105/tpc.112.105106

Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex
journal, May 2011

Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Signaling in Plants
journal, December 2011

Production of therapeutic proteins in the chloroplast of Chlamydomonas reinhardtii
journal, August 2014

  • Almaraz-Delgado, Alma Lorena; Flores-Uribe, José; Pérez-España, Víctor Hugo
  • AMB Express, Vol. 4, Issue 1
  • DOI: 10.1186/s13568-014-0057-4

The Normalcy of Dormancy: Common Themes in Microbial Quiescence
journal, June 2013

  • Rittershaus, Emily S. C.; Baek, Seung-Hun; Sassetti, Christopher M.
  • Cell Host & Microbe, Vol. 13, Issue 6
  • DOI: 10.1016/j.chom.2013.05.012

Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
journal, May 2008

Quiescent Fibroblasts Exhibit High Metabolic Activity
journal, October 2010

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
journal, June 1992

TOR Signaling in Growth and Metabolism
journal, February 2006

Microalgae-based biorefinery – From biofuels to natural products
journal, May 2013

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex
journal, December 2004

Nitrogen-Sparing Mechanisms in Chlamydomonas Affect the Transcriptome, the Proteome, and Photosynthetic Metabolism
journal, April 2014

  • Schmollinger, Stefan; Mühlhaus, Timo; Boyle, Nanette R.
  • The Plant Cell, Vol. 26, Issue 4
  • DOI: 10.1105/tpc.113.122523

Nitrogen-dependent regulation of photosynthetic gene expression
journal, April 1989

  • Plumley, F. G.; Schmidt, G. W.
  • Proceedings of the National Academy of Sciences, Vol. 86, Issue 8
  • DOI: 10.1073/pnas.86.8.2678

Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
journal, October 1993

Cell Cycle Regulation via p53 Phosphorylation by a 5′-AMP Activated Protein Kinase Activator, 5-Aminoimidazole- 4-Carboxamide-1-β--Ribofuranoside, in a Human Hepatocellular Carcinoma Cell Line
journal, September 2001

  • Imamura, Kazuhiro; Ogura, Tsutomu; Kishimoto, Atsuhiro
  • Biochemical and Biophysical Research Communications, Vol. 287, Issue 2
  • DOI: 10.1006/bbrc.2001.5627

Cdk-inhibitors and exit from quiescence in primitive haematopoietic cell subsets
journal, February 2004

Does Arabidopsis thaliana DREAM of cell cycle control?
journal, June 2015

Transcriptional Engineering of Microalgae: Prospects for High-Value Chemicals
journal, February 2017

Intraflagellar transport
journal, November 2002

  • Rosenbaum, Joel L.; Witman, George B.
  • Nature Reviews Molecular Cell Biology, Vol. 3, Issue 11
  • DOI: 10.1038/nrm952

G1 events and regulation of cell proliferation
journal, November 1989

Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation
journal, August 2016

  • Nukarinen, Ella; Nägele, Thomas; Pedrotti, Lorenzo
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep31697

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae
journal, December 2002

Microalgae for biodiesel production and other applications: A review
journal, January 2010

  • Mata, Teresa M.; Martins, António A.; Caetano, Nidia. S.
  • Renewable and Sustainable Energy Reviews, Vol. 14, Issue 1, p. 217-232
  • DOI: 10.1016/j.rser.2009.07.020

Cell growth control: little eukaryotes make big contributions
journal, October 2006

Photosynthetic biomanufacturing in green algae; production of recombinant proteins for industrial, nutritional, and medical uses
journal, March 2014

Biodiesel from microalgae
journal, May 2007

The Essence of Quiescence
journal, November 2011

TAG, You’re it! Chlamydomonas as a reference organism for understanding algal triacylglycerol accumulation
journal, June 2012

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
journal, January 2007

  • Liang, Jiyong; Shao, Shan H.; Xu, Zhi-Xiang
  • Nature Cell Biology, Vol. 9, Issue 2
  • DOI: 10.1038/ncb1537

Reactive Oxygen Species and Autophagy in Plants and Algae
journal, June 2012

  • Pérez-Pérez, María Esther; Lemaire, Stéphane D.; Crespo, José L.
  • Plant Physiology, Vol. 160, Issue 1
  • DOI: 10.1104/pp.112.199992

TOR controls translation initiation and early G1 progression in yeast.
journal, January 1996

  • Barbet, N. C.; Schneider, U.; Helliwell, S. B.
  • Molecular Biology of the Cell, Vol. 7, Issue 1
  • DOI: 10.1091/mbc.7.1.25

The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control
journal, August 2015

  • Hindupur, Sravanth K.; González, Asier; Hall, Michael N.
  • Cold Spring Harbor Perspectives in Biology, Vol. 7, Issue 8
  • DOI: 10.1101/cshperspect.a019141

Conservation and degradation of cytoplasmic and chloroplast ribosomes in Chlamydomonas reinhardtii
journal, May 1971

Inhibition of Protein Synthesis by TOR Inactivation Revealed a Conserved Regulatory Mechanism of the BiP Chaperone in Chlamydomonas
journal, August 2011

  • Díaz-Troya, Sandra; Pérez-Pérez, María Esther; Pérez-Martín, Marta
  • Plant Physiology, Vol. 157, Issue 2
  • DOI: 10.1104/pp.111.179861

Gametic differentiation in Chlamydomonas reinhardtii. I. Production of gametes and their fine structure
journal, November 1975

The chloroplast transformation toolbox: selectable markers and marker removal: Markers for chloroplast transformation
journal, March 2011

The Path to Triacylglyceride Obesity in the sta6 Strain of Chlamydomonas reinhardtii
journal, February 2014

  • Goodenough, Ursula; Blaby, Ian; Casero, David
  • Eukaryotic Cell, Vol. 13, Issue 5
  • DOI: 10.1128/EC.00013-14

Molecular techniques to interrogate and edit the Chlamydomonas nuclear genome
journal, March 2015

  • Jinkerson, Robert E.; Jonikas, Martin C.
  • The Plant Journal, Vol. 82, Issue 3
  • DOI: 10.1111/tpj.12801

The biogenesis and functions of lipid bodies in animals, plants and microorganisms
journal, September 2001

Edible oils from microalgae: insights in TAG accumulation
journal, October 2014

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
journal, January 2009

  • Thoreen, Carson C.; Kang, Seong A.; Chang, Jae Won
  • Journal of Biological Chemistry, Vol. 284, Issue 12
  • DOI: 10.1074/jbc.M900301200

AMPK: a nutrient and energy sensor that maintains energy homeostasis
journal, March 2012

  • Hardie, D. Grahame; Ross, Fiona A.; Hawley, Simon A.
  • Nature Reviews Molecular Cell Biology, Vol. 13, Issue 4
  • DOI: 10.1038/nrm3311

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
journal, January 2016

Sac3, an Snf1-like Serine/Threonine Kinase That Positively and Negatively Regulates the Responses of Chlamydomonas to Sulfur Limitation
journal, June 1999

  • Davies, John P.; Yildiz, Fitnat H.; Grossman, Arthur R.
  • The Plant Cell, Vol. 11, Issue 6
  • DOI: 10.1105/tpc.11.6.1179

Biofuels from algae: challenges and potential
journal, September 2010

  • Hannon, Michael; Gimpel, Javier; Tran, Miller
  • Biofuels, Vol. 1, Issue 5
  • DOI: 10.4155/bfs.10.44

TOR (target of rapamycin) is a key regulator of triacylglycerol accumulation in microalgae
journal, February 2016

Mechanism and challenges in commercialisation of algal biofuels
journal, January 2011

Inhibition of Target of Rapamycin Signaling and Stress Activate Autophagy in Chlamydomonas reinhardtii
journal, January 2010

  • Pérez-Pérez, María Esther; Florencio, Francisco J.; Crespo, José L.
  • Plant Physiology, Vol. 152, Issue 4
  • DOI: 10.1104/pp.109.152520

Induction of triacylglycerol synthesis in yeast by cell cycle arrest
journal, April 2019

  • Madeira, Juliana B.; Matos, Gabriel S.; Messias, Laryssa S.
  • FEMS Yeast Research, Vol. 19, Issue 3
  • DOI: 10.1093/femsyr/foz030

A new class of cyclin dependent kinase in Chlamydomonas is required for coupling cell size to cell division
journal, March 2016

Tomato FK506 Binding Protein 12KD (FKBP12) Mediates the Interaction between Rapamycin and Target of Rapamycin (TOR)
journal, November 2016

The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts
journal, August 1978

Biodiesel from algae: challenges and prospects
journal, June 2010

Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets
journal, July 2018

  • Werth, Emily G.; McConnell, Evan W.; Couso Lianez, Inmaculada
  • New Phytologist, Vol. 221, Issue 1
  • DOI: 10.1111/nph.15339

PSR1 Is a Global Transcriptional Regulator of Phosphorus Deficiency Responses and Carbon Storage Metabolism in Chlamydomonas reinhardtii
journal, December 2015

  • Bajhaiya, Amit K.; Dean, Andrew P.; Zeef, Leo A. H.
  • Plant Physiology, Vol. 170, Issue 3
  • DOI: 10.1104/pp.15.01907

A New Description of Cellular Quiescence
journal, March 2006

Trends and novel strategies for enhancing lipid accumulation and quality in microalgae
journal, March 2016

  • Singh, Poonam; Kumari, Sheena; Guldhe, Abhishek
  • Renewable and Sustainable Energy Reviews, Vol. 55
  • DOI: 10.1016/j.rser.2015.11.001

Regulation of meristem organization and cell division by TSO1, an Arabidopsis gene with cysteine-rich repeats
journal, May 2000

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
journal, October 2011

  • Alers, S.; Loffler, A. S.; Wesselborg, S.
  • Molecular and Cellular Biology, Vol. 32, Issue 1
  • DOI: 10.1128/MCB.06159-11

Physiological role of neutral lipid accumulation in eukaryotic microalgae under stresses
journal, February 2012

Control of cell division by a retinoblastoma protein homolog in Chlamydomonas
journal, July 2001

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex
journal, October 2006

  • Harrison, M. M.; Ceol, C. J.; Lu, X.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 45
  • DOI: 10.1073/pnas.0608461103

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
journal, September 2011

  • Mihaylova, Maria M.; Shaw, Reuben J.
  • Nature Cell Biology, Vol. 13, Issue 9
  • DOI: 10.1038/ncb2329

Minibrain drives the Dacapo-dependent cell cycle exit of neurons in the Drosophila brain by promoting asense and prospero expression
journal, August 2016

  • Shaikh, Mirja N.; Gutierrez-Aviño, Francisco; Colonques, Jordi
  • Development, Vol. 143, Issue 17
  • DOI: 10.1242/dev.134338

SNF1/AMPK pathways in yeast
journal, January 2008

  • Hedbacker, Kristina
  • Frontiers in Bioscience, Vol. 13, Issue 13
  • DOI: 10.2741/2854

Stress-induced neutral lipid biosynthesis in microalgae — Molecular, cellular and physiological insights
journal, September 2016

  • Zienkiewicz, Krzysztof; Du, Zhi-Yan; Ma, Wei
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1861, Issue 9
  • DOI: 10.1016/j.bbalip.2016.02.008

High Lipid Induction in Microalgae for Biodiesel Production
journal, May 2012

  • Sharma, Kalpesh K.; Schuhmann, Holger; Schenk, Peer M.
  • Energies, Vol. 5, Issue 5
  • DOI: 10.3390/en5051532

Geriatric muscle stem cells switch reversible quiescence into senescence
journal, February 2014

  • Sousa-Victor, Pedro; Gutarra, Susana; García-Prat, Laura
  • Nature, Vol. 506, Issue 7488
  • DOI: 10.1038/nature13013

Mutations in MYB3R1 and MYB3R4 Cause Pleiotropic Developmental Defects and Preferential Down-Regulation of Multiple G2/M-Specific Genes in Arabidopsis
journal, August 2011

  • Haga, Nozomi; Kobayashi, Kosuke; Suzuki, Takamasa
  • Plant Physiology, Vol. 157, Issue 2
  • DOI: 10.1104/pp.111.180836

Autophagic flux is required for the synthesis of triacylglycerols and ribosomal protein turnover in Chlamydomonas
journal, October 2017

  • Couso, Inmaculada; Pérez-Pérez, María Esther; Martínez-Force, Enrique
  • Journal of Experimental Botany, Vol. 69, Issue 6
  • DOI: 10.1093/jxb/erx372

Systemic Cold Stress Adaptation of Chlamydomonas reinhardtii
journal, April 2013

  • Valledor, Luis; Furuhashi, Takeshi; Hanak, Anne-Mette
  • Molecular & Cellular Proteomics, Vol. 12, Issue 8
  • DOI: 10.1074/mcp.M112.026765

Changes in Transcript Abundance in Chlamydomonas reinhardtii following Nitrogen Deprivation Predict Diversion of Metabolism
journal, October 2010

  • Miller, Rachel; Wu, Guangxi; Deshpande, Rahul R.
  • Plant Physiology, Vol. 154, Issue 4
  • DOI: 10.1104/pp.110.165159

LINC, a Human Complex That is Related to pRB-Containing Complexes in Invertebrates Regulates the Expression of G 2 /M Genes
journal, August 2007

  • Schmit, Fabienne; Korenjak, Michael; Mannefeld, Mirijam
  • Cell Cycle, Vol. 6, Issue 15
  • DOI: 10.4161/cc.6.15.4512

Inhibition of Target of Rapamycin Signaling by Rapamycin in the Unicellular Green Alga Chlamydomonas reinhardtii
journal, November 2005

  • Crespo, José L.; Díaz-Troya, Sandra; Florencio, Francisco J.
  • Plant Physiology, Vol. 139, Issue 4
  • DOI: 10.1104/pp.105.070847

The response of Chlamydomonas reinhardtii to nitrogen deprivation: a systems biology analysis
journal, February 2015

  • Park, Jeong-Jin; Wang, Hongxia; Gargouri, Mahmoud
  • The Plant Journal, Vol. 81, Issue 4
  • DOI: 10.1111/tpj.12747

Convergent energy and stress signaling
journal, September 2008

Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas
journal, November 2019

  • Couso, Inmaculada; Pérez-Pérez, María Esther; Ford, Megan M.
  • The Plant Cell, Vol. 32, Issue 1
  • DOI: 10.1105/tpc.19.00179

Arabidopsis TSO1 Regulates Directional Processes in Cells During Floral Organogenesis
journal, September 1998

TOR signaling in invertebrates
journal, December 2009

  • Soulard, Alexandre; Cohen, Adiel; Hall, Michael N.
  • Current Opinion in Cell Biology, Vol. 21, Issue 6
  • DOI: 10.1016/j.ceb.2009.08.007

Systems-Level Analysis of Nitrogen Starvation-Induced Modifications of Carbon Metabolism in a Chlamydomonas reinhardtii Starchless Mutant
journal, November 2013

Wastewater treatment high rate algal ponds for biofuel production
journal, January 2011

CO2 bio-mitigation using microalgae
journal, May 2008

The potential of sustainable algal biofuel production using wastewater resources
journal, January 2011

Rapid Triacylglycerol Turnover in Chlamydomonas reinhardtii Requires a Lipase with Broad Substrate Specificity
journal, October 2012

  • Li, Xiaobo; Benning, Christoph; Kuo, Min-Hao
  • Eukaryotic Cell, Vol. 11, Issue 12
  • DOI: 10.1128/EC.00268-12

Recovery from N Deprivation Is a Transcriptionally and Functionally Distinct State in Chlamydomonas
journal, December 2017

  • Tsai, Chia-Hong; Uygun, Sahra; Roston, Rebecca
  • Plant Physiology, Vol. 176, Issue 3
  • DOI: 10.1104/pp.17.01546

Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator
journal, June 2017

  • Ajjawi, Imad; Verruto, John; Aqui, Moena
  • Nature Biotechnology, Vol. 35, Issue 7
  • DOI: 10.1038/nbt.3865

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
journal, August 1991

Cell Size Checkpoint Control by the Retinoblastoma Tumor Suppressor Pathway
journal, October 2006

Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene
journal, April 2002

  • Menand, B.; Desnos, T.; Nussaume, L.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 9
  • DOI: 10.1073/pnas.092141899

RBF Binding to both Canonical E2F Targets and Noncanonical Targets Depends on Functional dE2F/dDP Complexes
journal, August 2012

  • Korenjak, M.; Anderssen, E.; Ramaswamy, S.
  • Molecular and Cellular Biology, Vol. 32, Issue 21
  • DOI: 10.1128/MCB.00536-12

A TOR-YAK1 signaling axis controls cell cycle, meristem activity and plant growth in Arabidopsis
journal, January 2019

  • Barrada, Adam; Djendli, Meriem; Desnos, Thierry
  • Development, Vol. 146, Issue 3
  • DOI: 10.1242/dev.171298

Targeting TOR signaling for enhanced lipid productivity in algae
journal, February 2020

Molecular mechanisms of mTOR-mediated translational control
journal, April 2009

  • Ma, Xiaoju Max; Blenis, John
  • Nature Reviews Molecular Cell Biology, Vol. 10, Issue 5
  • DOI: 10.1038/nrm2672

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells
journal, January 2005

  • Walkley, Carl R.; Fero, Matthew L.; Chien, Wei-Ming
  • Nature Cell Biology, Vol. 7, Issue 2
  • DOI: 10.1038/ncb1214

Conservation and diversification of three-repeat Myb transcription factors in plants
journal, February 2005

Snf1-related protein kinases (SnRKs) act within an intricate network that links metabolic and stress signalling in plants
journal, March 2009

  • Halford, Nigel G.; Hey, Sandra J.
  • Biochemical Journal, Vol. 419, Issue 2
  • DOI: 10.1042/BJ20082408

Cell-cycle regulation in green algae dividing by multiple fission
journal, January 2014

  • Bišová, Kateřina; Zachleder, Vilém
  • Journal of Experimental Botany, Vol. 65, Issue 10
  • DOI: 10.1093/jxb/ert466

Decoding the stem cell quiescence cycle - lessons from yeast for regenerative biology
journal, December 2015

  • Dhawan, J.; Laxman, S.
  • Journal of Cell Science, Vol. 128, Issue 24
  • DOI: 10.1242/jcs.177758

Regulation of the Chlamydomonas cell cycle by light and dark.
journal, April 1980

Glucose–TOR signalling reprograms the transcriptome and activates meristems
journal, March 2013

  • Xiong, Yan; McCormack, Matthew; Li, Lei
  • Nature, Vol. 496, Issue 7444
  • DOI: 10.1038/nature12030

Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence
journal, May 2007

atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expression
journal, July 1994

The protein Compromised Hydrolysis of Triacylglycerols 7 (CHT7) acts as a repressor of cellular quiescence in Chlamydomonas
journal, October 2014

  • Tsai, C. -H.; Warakanont, J.; Takeuchi, T.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 44
  • DOI: 10.1073/pnas.1414567111

Biological Methods for Cell-Cycle Synchronization of Mammalian Cells
journal, June 2001

  • Davis, Penny K.; Ho, Alan; Dowdy, Steven F.
  • BioTechniques, Vol. 30, Issue 6
  • DOI: 10.2144/01306rv01

SOL1 and SOL2 regulate fate transition and cell divisions in the Arabidopsis stomatal lineage
journal, January 2019

  • Simmons, Abigail R.; Davies, Kelli A.; Wang, Wanpeng
  • Development, Vol. 146, Issue 3
  • DOI: 10.1242/dev.171066

Algae Grown on Dairy and Municipal Wastewater for Simultaneous Nutrient Removal and Lipid Production for Biofuel Feedstock
journal, November 2009

Electron Microscopic Evidence for Chloroplast Fusion in Zygotes of Chlamydomonos reinhardii
journal, October 1970

Prevalence, Evolution, and cis -Regulation of Diel Transcription in Chlamydomonas reinhardtii
journal, October 2014

  • Panchy, Nicholas; Wu, Guangxi; Newton, Linsey
  • G3: Genes|Genomes|Genetics, Vol. 4, Issue 12
  • DOI: 10.1534/g3.114.015032

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2
journal, June 2015

Engineering the metabolic pathways of lipid biosynthesis to develop robust microalgal strains for biodiesel production
journal, January 2020

  • Shahid, Ayesha; Rehman, Abd ur; Usman, Muhammad
  • Biotechnology and Applied Biochemistry, Vol. 67, Issue 1
  • DOI: 10.1002/bab.1812

TSO1 functions in cell division during Arabidopsis flower development
journal, February 1997

Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact.
journal, July 1986

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
journal, July 2002

    Sort by:
    [ × clear filter / sort ]

    Similar Records in DOE PAGES and OSTI.GOV collections: