Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880

Jagtap, Sujit Sadashiv; Bedekar, Ashwini Ashok; Liu, Jing-Jing; Jin, Yong-Su; Rao, Christopher V.

doi:10.1186/s13068-019-1586-5

Title: Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880

Journal Article · 18 October 2019 · Biotechnology for Biofuels

DOI: https://doi.org/10.1186/s13068-019-1586-5 · OSTI ID:1618767

Jagtap, Sujit Sadashiv ^[1]; Bedekar, Ashwini Ashok ^[1]; Liu, Jing-Jing ^[1]; Jin, Yong-Su ^[1]; Rao, Christopher V. ^[1]

Univ. of Illinois, Urbana-Champaign, IL (United States)

Sugar alcohols are commonly used as low-calorie sweeteners and can serve as potential building blocks for bio-based chemicals. Previous work has shown that the oleaginous yeast Rhodosporidium toruloides IFO0880 can natively produce arabitol from xylose at relatively high titers, suggesting that it may be a useful host for sugar alcohol production. In this work, we explored whether R. toruloides can produce additional sugar alcohols. Rhodosporidium toruloides is able to produce galactitol from galactose. During growth in nitrogen-rich medium, R. toruloides produced 3.2 ± 0.6 g/L, and 8.4 ± 0.8 g/L galactitol from 20 to 40 g/L galactose, respectively. In addition, R. toruloides was able to produce galactitol from galactose at reduced titers during growth in nitrogen-poor medium, which also induces lipid production. These results suggest that R. toruloides can potentially be used for the co-production of lipids and galactitol from galactose. We further characterized the mechanism for galactitol production, including identifying and biochemically characterizing the critical aldose reductase. Intracellular metabolite analysis was also performed to further understand galactose metabolism. Rhodosporidium toruloides has traditionally been used for the production of lipids and lipid-based chemicals. Our work demonstrates that R. toruloides can also produce galactitol, which can be used to produce polymers with applications in medicine and as a precursor for anti-cancer drugs. Collectively, our results further establish that R. toruloidescan produce multiple value-added chemicals from a wide range of sugars.

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Research Organization:: Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0018420

OSTI ID:: 1618767

Alternate ID(s):: OSTI ID: 1571254

Journal Information:: Biotechnology for Biofuels, Vol. 12, Issue 1; ISSN 1754-6834

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 23 works

Citation information provided by
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59 BASIC BIOLOGICAL SCIENCES
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MOESM10 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006076 The current record is supplemented by this image	image	January 2019
MOESM5 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006118 The current record is supplemented by this image	image	January 2019
MOESM4 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006112 The current record is supplemented by this image	image	January 2019
MOESM8 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006130.v1 The current record is supplemented by this image	image	January 2019
MOESM9 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006133.v1 The current record is supplemented by this image	image	January 2019
MOESM2 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006097.v1 The current record is supplemented by this image	image	January 2019
MOESM11 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006085 The current record is supplemented by this text	text	January 2019
MOESM10 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006076.v1 The current record is supplemented by this image	image	January 2019
MOESM3 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006106.v1 The current record is supplemented by this image	image	January 2019
MOESM7 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006127.v1 The current record is supplemented by this image	image	January 2019
MOESM6 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006121 The current record is supplemented by this image	image	January 2019
MOESM4 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006112.v1 The current record is supplemented by this image	image	January 2019
MOESM7 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006127 The current record is supplemented by this image	image	January 2019
MOESM1 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006091 The current record is supplemented by this image	image	January 2019
MOESM2 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006097 The current record is supplemented by this image	image	January 2019
MOESM8 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006130 The current record is supplemented by this image	image	January 2019
Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.c.4705133 The current record is supplemented by this collection	collection	January 2019
Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.c.4705133.v1 The current record is supplemented by this collection	collection	January 2019
MOESM9 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006133 The current record is supplemented by this image	image	January 2019
MOESM6 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006121.v1 The current record is supplemented by this image	image	January 2019
MOESM11 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006085.v1 The current record is supplemented by this text	text	January 2019
MOESM1 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006091.v1 The current record is supplemented by this image	image	January 2019
MOESM3 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006106 The current record is supplemented by this image	image	January 2019
MOESM5 of Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 Jagtap, Sujit; Bedekar, Ashwini; Liu, Jing-Jing https://doi.org/10.6084/m9.figshare.10006118.v1 The current record is supplemented by this image	image	January 2019