Vaccination of pigs with a codon-pair bias de-optimized live attenuated influenza vaccine protects from homologous challenge

Kaplan, Bryan S.; Souza, Carine K.; Gauger, Phillip C.; Stauft, Charles B.; Robert Coleman, J.; Mueller, Steffen; Vincent, Amy L.

doi:10.1016/j.vaccine.2018.01.027

Title: Vaccination of pigs with a codon-pair bias de-optimized live attenuated influenza vaccine protects from homologous challenge

Full Record
Other Related Research

Authors:

; Souza, Carine K.; Gauger, Phillip C.; Stauft, Charles B.; Robert Coleman, J.; Mueller, Steffen; Vincent, Amy L.

Publication Date:: 2018-02-01

Sponsoring Org.:: USDOE

OSTI Identifier:: 1617387

Resource Type:: Published Article

Journal Name:: Vaccine

Additional Journal Information:: Journal Name: Vaccine Journal Volume: 36 Journal Issue: 8; Journal ID: ISSN 0264-410X

Publisher:: Elsevier

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Kaplan, Bryan S., Souza, Carine K., Gauger, Phillip C., Stauft, Charles B., Robert Coleman, J., Mueller, Steffen, and Vincent, Amy L.. Vaccination of pigs with a codon-pair bias de-optimized live attenuated influenza vaccine protects from homologous challenge.  United Kingdom: N. p., 2018. 
Web.  https://doi.org/10.1016/j.vaccine.2018.01.027.

Copy to clipboard


                    Kaplan, Bryan S., Souza, Carine K., Gauger, Phillip C., Stauft, Charles B., Robert Coleman, J., Mueller, Steffen, & Vincent, Amy L.. Vaccination of pigs with a codon-pair bias de-optimized live attenuated influenza vaccine protects from homologous challenge.  United Kingdom.  https://doi.org/10.1016/j.vaccine.2018.01.027

Copy to clipboard


                    Kaplan, Bryan S., Souza, Carine K., Gauger, Phillip C., Stauft, Charles B., Robert Coleman, J., Mueller, Steffen, and Vincent, Amy L.. Thu .  
"Vaccination of pigs with a codon-pair bias de-optimized live attenuated influenza vaccine protects from homologous challenge".  United Kingdom.  https://doi.org/10.1016/j.vaccine.2018.01.027.

Copy to clipboard


                    
@article{osti_1617387,

  title        = {Vaccination of pigs with a codon-pair bias de-optimized live attenuated influenza vaccine protects from homologous challenge},

  author       = {Kaplan, Bryan S. and Souza, Carine K. and Gauger, Phillip C. and Stauft, Charles B. and Robert Coleman, J. and Mueller, Steffen and Vincent, Amy L.},

  abstractNote = {},

  doi          = {10.1016/j.vaccine.2018.01.027},

  journal      = {Vaccine},

  number       = 8,

  volume       = 36,

  place        = {United Kingdom},

  year         = {2018},

  month        = {2}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
https://doi.org/10.1016/j.vaccine.2018.01.027

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 6 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets

Journal Article Joseph, Tomy ; MedImmune Inc., Mountain View, CA 94043 ; McAuliffe, Josephine ; ... - Virology

The appearance of human infections caused by avian influenza A H7 subtype viruses underscores their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. A live attenuated H7N3 virus vaccine was generated by reverse genetics using the HA and NA genes of a low pathogenicity A/chicken/BC/CN-6/04 (H7N3) virus and the six internal protein genes of the cold-adapted A/Ann Arbor/6/60 ca (H2N2) virus. The reassortant H7N3 BC 04 ca vaccine virus was temperature sensitive and showed attenuation in mice and ferrets. Intranasal immunization with one dose of the vaccine protected mice and ferrets whenmore »« less
https://doi.org/10.1016/j.virol.2008.05.021
Suppressing active replication of a live attenuated simian immunodeficiency virus vaccine does not abrogate protection from challenge

Journal Article Gabriel, Benjamin ; Fiebig, Uwe ; Hohn, Oliver ; ... - Virology

Although safety concerns preclude the use of live attenuated HIV vaccines in humans, they provide a useful system for identifying the elusive correlates of protective immunity in the SIV/macaque animal model. However, a number of pieces of evidence suggest that protection may result from prior occupancy of susceptible target cells by the vaccine virus rather than the immune response. To address this, we developed a Nef-deletion variant of an RT-SHIV whose active replication could be shut off by treatment with RT-inhibitors. Groups of macaques were inoculated with the ∆Nef-RT-SHIV and immune responses allowed to develop before antiretroviral treatment and subsequentmore »« less
https://doi.org/10.1016/J.VIROL.2015.11.030
Brugia malayi: vaccination of jirds with /sup 60/cobalt-attenuated infective stage larvae protects against homologous challenge

Journal Article Yates, J A ; Higashi, G I - Am. J. Trop. Med. Hyg.; (United States)

Vaccination of inbred jirds (Meriones unguiculatus) with /sup 60/cobalt radiation-attenuated Brugia malayi infective stage larvae (L3) protected against homologous challenge given either subcutaneously (sc) or by the intraperitoneal (ip) route. Groups of jirds vaccinated once sc with 75, 15 Krad L3 showed from 69% to 91% reduction in recovered worms after ip challenge infection compared to infection in non-vaccinated control jirds, while 75% reduction in mean worm burden was seen in jirds receiving sc challenge infection. A single sc vaccination with 75, 10 or 20 Krad L3 produced no protection (10 Krad) and 64% reduction in recovered worms (20 Krad).more »« less
Enhancement of the safety of live influenza vaccine by attenuating mutations from cold-adapted hemagglutinin

Journal Article Lee, Yoon Jae ; Laboratory of Molecular Medicine, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul ; Vaccine Translational Research Center, Yonsei University, Seoul ; ... - Virology

In our previous study, X-31ca-based H5N1 LAIVs, in particular, became more virulent in mice than the X-31ca MDV, possibly by the introduction of the surface antigens of highly pathogenic H5N1 influenza virus, implying that additional attenuation is needed in this cases to increase the safety level of the vaccine. In this report we suggest an approach to further increase the safety of LAIV through additional cold-adapted mutations in the hemagglutinin. The cold-adaptation of X-31 virus resulted in four amino acid mutations in the HA. We generated a panel of 7:1 reassortant viruses each carrying the hemagglutinins with individual single aminomore »« less
https://doi.org/10.1016/J.VIROL.2016.01.022
The cold adapted and temperature sensitive influenza A/Ann Arbor/6/60 virus, the master donor virus for live attenuated influenza vaccines, has multiple defects in replication at the restrictive temperature

Journal Article Chan, Winnie ; Zhou, Helen ; Kemble, George ; ... - Virology

We have previously determined that the temperature sensitive (ts) and attenuated (att) phenotypes of the cold adapted influenza A/Ann Arbor/6/60 strain (MDV-A), the master donor virus for the live attenuated influenza A vaccines (FluMist), are specified by the five amino acids in the PB1, PB2 and NP gene segments. To understand how these loci control the ts phenotype of MDV-A, replication of MDV-A at the non-permissive temperature (39 deg. C) was compared with recombinant wild-type A/Ann Arbor/6/60 (rWt). The mRNA and protein synthesis of MDV-A in the infected MDCK cells were not significantly reduced at 39 deg. C during amore »« less
https://doi.org/10.1016/j.virol.2008.07.027

Similar Records