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Title: Matter-wave interference of a native polypeptide

Abstract

The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our timedomain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide’s quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [2];  [1];  [3]; ORCiD logo [1]
  1. Univ. of Vienna (Austria)
  2. Imperial College, London (United Kingdom)
  3. Stanford Univ., CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States)
Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE; Austrian Science Fund (FWF); European Research Council (ERC); National Science Foundation (NSF)
OSTI Identifier:
1616995
Grant/Contract Number:  
AC02-76SF00515; 320694; TG-MCB090110
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 11; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; Atomic and molecular interactions with photons; Mass spectrometry; Matter waves and particle beams

Citation Formats

Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., and Arndt, M. Matter-wave interference of a native polypeptide. United States: N. p., 2020. Web. doi:10.1038/s41467-020-15280-2.
Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., & Arndt, M. Matter-wave interference of a native polypeptide. United States. doi:https://doi.org/10.1038/s41467-020-15280-2
Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., and Arndt, M. Thu . "Matter-wave interference of a native polypeptide". United States. doi:https://doi.org/10.1038/s41467-020-15280-2. https://www.osti.gov/servlets/purl/1616995.
@article{osti_1616995,
title = {Matter-wave interference of a native polypeptide},
author = {Shayeghi, A. and Rieser, P. and Richter, G. and Sezer, U. and Rodewald, J. H. and Geyer, P. and Martinez, T. J. and Arndt, M.},
abstractNote = {The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our timedomain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide’s quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.},
doi = {10.1038/s41467-020-15280-2},
journal = {Nature Communications},
number = 1,
volume = 11,
place = {United States},
year = {2020},
month = {3}
}

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