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Title: Matter-wave interference of a native polypeptide

Abstract

The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our timedomain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide’s quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [2];  [1];  [3]; ORCiD logo [1]
  1. Univ. of Vienna (Austria)
  2. Imperial College, London (United Kingdom)
  3. Stanford Univ., CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States)
Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE; Austrian Science Fund (FWF); European Research Council (ERC); National Science Foundation (NSF)
OSTI Identifier:
1616995
Grant/Contract Number:  
AC02-76SF00515; 320694; TG-MCB090110
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 11; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; Atomic and molecular interactions with photons; Mass spectrometry; Matter waves and particle beams

Citation Formats

Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., and Arndt, M. Matter-wave interference of a native polypeptide. United States: N. p., 2020. Web. doi:10.1038/s41467-020-15280-2.
Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., & Arndt, M. Matter-wave interference of a native polypeptide. United States. https://doi.org/10.1038/s41467-020-15280-2
Shayeghi, A., Rieser, P., Richter, G., Sezer, U., Rodewald, J. H., Geyer, P., Martinez, T. J., and Arndt, M. Thu . "Matter-wave interference of a native polypeptide". United States. https://doi.org/10.1038/s41467-020-15280-2. https://www.osti.gov/servlets/purl/1616995.
@article{osti_1616995,
title = {Matter-wave interference of a native polypeptide},
author = {Shayeghi, A. and Rieser, P. and Richter, G. and Sezer, U. and Rodewald, J. H. and Geyer, P. and Martinez, T. J. and Arndt, M.},
abstractNote = {The de Broglie wave nature of matter is a paradigmatic example of quantum physics and it has been exploited in precision measurements of forces and fundamental constants. However, matter-wave interferometry has remained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile and difficult to handle. Here, we demonstrate the wave nature of gramicidin, a natural antibiotic composed of 15 amino acids. Its center of mass is delocalized over more than 20 times the molecular size in our timedomain Talbot-Lau interferometer. We compare the observed interference fringes with a model that includes both a rigorous treatment of the peptide’s quantum wave nature as well as a quantum chemical assessment of its optical properties to distinguish our result from classical predictions. The realization of quantum optics with this prototypical biomolecule paves the way for quantum-assisted measurements on a large class of biologically relevant molecules.},
doi = {10.1038/s41467-020-15280-2},
journal = {Nature Communications},
number = 1,
volume = 11,
place = {United States},
year = {2020},
month = {3}
}

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Works referenced in this record:

Influence of conformational molecular dynamics on matter wave interferometry
journal, March 2010


Pushing the mass limit for intact launch and photoionization of large neutral biopolymers
journal, December 2018


Generating Efficient Quantum Chemistry Codes for Novel Architectures
journal, November 2012

  • Titov, Alexey V.; Ufimtsev, Ivan S.; Luehr, Nathan
  • Journal of Chemical Theory and Computation, Vol. 9, Issue 1
  • DOI: 10.1021/ct300321a

Quantum Test of the Universality of Free Fall
journal, May 2014


Density-functional exchange-energy approximation with correct asymptotic behavior
journal, September 1988


A universal matter-wave interferometer with optical ionization gratings in the time domain
journal, February 2013

  • Haslinger, Philipp; Dörre, Nadine; Geyer, Philipp
  • Nature Physics, Vol. 9, Issue 3
  • DOI: 10.1038/nphys2542

Interleaved atom interferometry for high-sensitivity inertial measurements
journal, December 2018


Laser Desorption/Ionization Mass Spectrometry of Proteins of Mass 100 000 to 250 000 Dalton
journal, June 1989

  • Karas, Michael; Bahr, Ute; Ingendoh, Arndt
  • Angewandte Chemie International Edition in English, Vol. 28, Issue 6
  • DOI: 10.1002/anie.198907601

On the Quantum Correction For Thermodynamic Equilibrium
journal, June 1932


Refined model for Talbot–Lau matter-wave optics with pulsed photodepletion gratings
journal, December 2014

  • Dörre, Nadine; Haslinger, Philipp; Rodewald, Jonas
  • Journal of the Optical Society of America B, Vol. 32, Issue 1
  • DOI: 10.1364/JOSAB.32.000114

Measurement of the fine-structure constant as a test of the Standard Model
journal, April 2018


Quantum-Assisted Metrology of Neutral Vitamins in the Gas Phase
journal, July 2017

  • Mairhofer, Lukas; Eibenberger, Sandra; Cotter, Joseph P.
  • Angewandte Chemie International Edition, Vol. 56, Issue 36
  • DOI: 10.1002/anie.201704916

Testing spontaneous localization theories with matter-wave interferometry
journal, April 2011


Isotope-selective high-order interferometry with large organic molecules in free fall
journal, March 2018

  • Rodewald, Jonas; Dörre, Nadine; Grimaldi, Andrea
  • New Journal of Physics, Vol. 20, Issue 3
  • DOI: 10.1088/1367-2630/aaade2

De Broglie’s meter stick: Making measurements with matter waves
journal, May 2014


Accurate sampling using Langevin dynamics
journal, May 2007


Macroscopicity of Mechanical Quantum Superposition States
journal, April 2013


Choosing a density functional for static molecular polarizabilities
journal, August 2015


Ion formation mechanisms in UV-MALDI
journal, January 2006


New avenues for matter-wave-enhanced spectroscopy
journal, December 2016


Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density
journal, January 1988


Tailoring the volatility and stability of oligopeptides: Fluorous tags
journal, July 2017

  • Schätti, J.; Sezer, U.; Pedalino, S.
  • Journal of Mass Spectrometry, Vol. 52, Issue 8
  • DOI: 10.1002/jms.3959

Quantum test of the equivalence principle for atoms in coherent superposition of internal energy states
journal, June 2017

  • Rosi, G.; D’Amico, G.; Cacciapuoti, L.
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/ncomms15529

Detecting inertial effects with airborne matter-wave interferometry
journal, September 2011

  • Geiger, R.; Ménoret, V.; Stern, G.
  • Nature Communications, Vol. 2, Issue 1
  • DOI: 10.1038/ncomms1479

Quantum superposition of molecules beyond 25 kDa
journal, September 2019


Atom-interferometry constraints on dark energy
journal, August 2015


Quantum Chemistry on Graphical Processing Units. 3. Analytical Energy Gradients, Geometry Optimization, and First Principles Molecular Dynamics
journal, August 2009

  • Ufimtsev, Ivan S.; Martinez, Todd J.
  • Journal of Chemical Theory and Computation, Vol. 5, Issue 10
  • DOI: 10.1021/ct9003004

Concept of an ionizing time-domain matter-wave interferometer
journal, July 2011


Optics and interferometry with atoms and molecules
journal, July 2009

  • Cronin, Alexander D.; Schmiedmayer, Jörg; Pritchard, David E.
  • Reviews of Modern Physics, Vol. 81, Issue 3
  • DOI: 10.1103/RevModPhys.81.1051

Q-Chem: an engine for innovation: Q-Chem: an engine for innovation
journal, November 2012

  • Krylov, Anna I.; Gill, Peter M. W.
  • Wiley Interdisciplinary Reviews: Computational Molecular Science, Vol. 3, Issue 3
  • DOI: 10.1002/wcms.1122

Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989


Quantum superposition at the half-metre scale
journal, December 2015

  • Kovachy, T.; Asenbaum, P.; Overstreet, C.
  • Nature, Vol. 528, Issue 7583
  • DOI: 10.1038/nature16155

Theory of near-field matter-wave interference beyond the eikonal approximation
journal, August 2008


Wave–particle duality of C60 molecules
journal, October 1999

  • Arndt, Markus; Nairz, Olaf; Vos-Andreae, Julian
  • Nature, Vol. 401, Issue 6754
  • DOI: 10.1038/44348

Absolute Absorption Cross Sections from Photon Recoil in a Matter-Wave Interferometer
journal, June 2014


Structure of Isolated Biomolecules by Electron Diffraction−Laser Desorption: Uracil and Guanine
journal, March 2009

  • Gahlmann, Andreas; Park, Sang Tae; Zewail, Ahmed H.
  • Journal of the American Chemical Society, Vol. 131, Issue 8
  • DOI: 10.1021/ja808720j

P EPTIDES AND P ROTEINS IN THE V APOR P HASE
journal, October 2000


Theory of decoherence in a matter wave Talbot-Lau interferometer
journal, November 2004


UV and VUV Ionization of Organic Molecules, Clusters, and Complexes
journal, September 2009

  • Marksteiner, Markus; Haslinger, Philipp; Sclafani, Michele
  • The Journal of Physical Chemistry A, Vol. 113, Issue 37
  • DOI: 10.1021/jp905039f

Phase Shift in an Atom Interferometer due to Spacetime Curvature across its Wave Function
journal, May 2017


Works referencing / citing this record:

Quantum superposition of massive objects and collapse models
journal, November 2011


A universal matter-wave interferometer with optical ionization gratings in the time domain
journal, February 2013

  • Haslinger, Philipp; Dörre, Nadine; Geyer, Philipp
  • Nature Physics, Vol. 9, Issue 3
  • DOI: 10.1038/nphys2542

Testing the limits of quantum mechanical superpositions
journal, April 2014

  • Arndt, Markus; Hornberger, Klaus
  • Nature Physics, Vol. 10, Issue 4
  • DOI: 10.1038/nphys2863

Near-field interferometry of a free-falling nanoparticle from a point-like source
journal, September 2014

  • Bateman, James; Nimmrichter, Stefan; Hornberger, Klaus
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms5788

The Schrödinger–Newton equations beyond Newton
journal, January 2015


Upper Bounds on Spontaneous Wave-Function Collapse Models Using Millikelvin-Cooled Nanocantilevers
journal, March 2016


Isotope-selective high-order interferometry with large organic molecules in free fall
text, January 2018


Stochastic extensions of the regularized Schrödinger-Newton equation
journal, January 2015


Macroscopic quantum states: Measures, fragility, and implementations
journal, May 2018


Experimental methods of molecular matter-wave optics
journal, August 2013


Free Nano-Object Ramsey Interferometry for Large Quantum Superpositions
journal, September 2016


Macroscopic quantum resonators (MAQRO): Testing quantum and gravitational physics with massive mechanical resonators
journal, March 2012

  • Kaltenbaek, Rainer; Hechenblaikner, Gerald; Kiesel, Nikolai
  • Experimental Astronomy, Vol. 34, Issue 2
  • DOI: 10.1007/s10686-012-9292-3

Optomechanical Sensing of Spontaneous Wave-Function Collapse
journal, July 2014


Displacemon Electromechanics: How to Detect Quantum Interference in a Nanomechanical Resonator
journal, May 2018


Observation of Generalized Optomechanical Coupling and Cooling on Cavity Resonance
journal, January 2015


Testing the quantum superposition principle in the frequency domain
journal, March 2014


Cavity cooling of free silicon nanoparticles in high vacuum
journal, November 2013

  • Asenbaum, Peter; Kuhn, Stefan; Nimmrichter, Stefan
  • Nature Communications, Vol. 4, Issue 1
  • DOI: 10.1038/ncomms3743

Macroscopicity of Mechanical Quantum Superposition States
journal, April 2013


Refined model for Talbot–Lau matter-wave optics with pulsed photodepletion gratings
journal, December 2014

  • Dörre, Nadine; Haslinger, Philipp; Rodewald, Jonas
  • Journal of the Optical Society of America B, Vol. 32, Issue 1
  • DOI: 10.1364/josab.32.000114

Quantum superposition of molecules beyond 25 kDa
journal, September 2019


Cooling and manipulation of nanoparticles in high vacuum
conference, September 2016

  • Millen, J.; Kuhn, S.; Patolsky, F.
  • SPIE Nanoscience + Engineering, SPIE Proceedings
  • DOI: 10.1117/12.2238753

Models of wave-function collapse, underlying theories, and experimental tests
journal, April 2013


Dissipative Continuous Spontaneous Localization (CSL) model
journal, August 2015

  • Smirne, Andrea; Bassi, Angelo
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep12518

Dissipative extension of the Ghirardi-Rimini-Weber model
journal, December 2014


Large Quantum Superpositions and Interference of Massive Nanometer-Sized Objects
journal, July 2011


Decoherence as a way to measure extremely soft collisions with dark matter
journal, July 2017


Bounds on quantum collapse models from matter-wave interferometry: calculational details
journal, February 2018

  • Toroš, Marko; Bassi, Angelo
  • Journal of Physics A: Mathematical and Theoretical, Vol. 51, Issue 11
  • DOI: 10.1088/1751-8121/aaabc6

Colloquium : Quantum interference of clusters and molecules
journal, February 2012

  • Hornberger, Klaus; Gerlich, Stefan; Haslinger, Philipp
  • Reviews of Modern Physics, Vol. 84, Issue 1
  • DOI: 10.1103/revmodphys.84.157

Selective Linear or Quadratic Optomechanical Coupling via Measurement
journal, November 2011


Possible role of gravity in collapse of the wave-function: a brief survey of some ideas
journal, July 2015