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Title: Radiation and Risk of Liver, Biliary Tract, and Pancreatic Cancers among Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958–2009

Abstract

The Life Span Study (LSS) of atomic bomb survivors has consistently demonstrated significant excess radiation-related risks of liver cancer since the first cancer incidence report. Here, we present updated information on radiation risks of liver, biliary tract and pancreatic cancers based on 11 additional years of follow-up since the last report, from 1958 to 2009. The current analyses used improved individual radiation doses and accounted for the effects of alcohol consumption, smoking and body mass index. The study participants included 105,444 LSS participants with known individual radiation dose and no known history of cancer at the start of follow-up. Cases were the first primary incident cancers of the liver (including intrahepatic bile duct), biliary tract (gallbladder and other and unspecified parts of biliary tract) or pancreas identified through linkage with population-based cancer registries in Hiroshima and Nagasaki. Poisson regression methods were used to estimate excess relative risks (ERRs) and excess absolute risks (EARs) associated with DS02R1 doses for liver (liver and biliary tract cancers) or pancreas (pancreatic cancer). We identified 2,016 incident liver cancer cases during the follow-up period. Radiation dose was significantly associated with liver cancer risk (ERR per Gy: 0.53, 95% CI: 0.23 to 0.89; EAR per 10,000more » person-year Gy: 5.32, 95% CI: 2.49 to 8.51). There was no evidence for curvature in the radiation dose response (P=0.344). ERRs by age-at-exposure categories were significantly increased among those who were exposed at 0–9, 10–19 and 20–29 years, but not significantly increased after age 30 years, although there was no statistical evidence of heterogeneity in these ERRs (P = 0.378). The radiation ERRs were not affected by adjustment for smoking, alcohol consumption or body mass index. As in previously reported studies, radiation dose was not associated with risk of biliary tract cancer (ERR per Gy: –0.02, 95% CI: –0.25 to 0.30). Radiation dose was associated with a nonsignificant increase in pancreatic cancer risk (ERR per Gy: 0.38, 95% CI: <0 to 0.83). The increased risk was statistically significant among women (ERR per Gy: 0.70, 95% CI: 0.12 to 1.45), but not among men.« less

Authors:
 [1];  [1];  [1];  [2];  [1];  [1];  [1];  [1];  [3];  [3];  [1]
  1. Radiation Effects Research Foundation, Hiroshima (Japan)
  2. Hirosoft International Corporation, Eureka, CA (United States)
  3. National Cancer Inst., Rockville, MD (United States)
Publication Date:
Research Org.:
National Academy of Sciences, Washington, DC (United States)
Sponsoring Org.:
USDOE Office of Environment, Health, Safety and Security (AU)
OSTI Identifier:
1613770
Grant/Contract Number:  
HS0000031
Resource Type:
Accepted Manuscript
Journal Name:
Radiation Research
Additional Journal Information:
Journal Volume: 192; Journal Issue: 3; Journal ID: ISSN 0033-7587
Publisher:
Radiation Research Society
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology, Nuclear Medicine & Medical Imaging

Citation Formats

Sadakane, Atsuko, French, Benjamin, Brenner, Alina V., Preston, Dale L., Sugiyama, Hiromi, Grant, Eric J., Sakata, Ritsu, Utada, Mai, Cahoon, Elizabeth K., Mabuchi, Kiyohiko, and Ozasa, Kotaro. Radiation and Risk of Liver, Biliary Tract, and Pancreatic Cancers among Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958–2009. United States: N. p., 2019. Web. doi:10.1667/rr15341.1.
Sadakane, Atsuko, French, Benjamin, Brenner, Alina V., Preston, Dale L., Sugiyama, Hiromi, Grant, Eric J., Sakata, Ritsu, Utada, Mai, Cahoon, Elizabeth K., Mabuchi, Kiyohiko, & Ozasa, Kotaro. Radiation and Risk of Liver, Biliary Tract, and Pancreatic Cancers among Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958–2009. United States. https://doi.org/10.1667/rr15341.1
Sadakane, Atsuko, French, Benjamin, Brenner, Alina V., Preston, Dale L., Sugiyama, Hiromi, Grant, Eric J., Sakata, Ritsu, Utada, Mai, Cahoon, Elizabeth K., Mabuchi, Kiyohiko, and Ozasa, Kotaro. Wed . "Radiation and Risk of Liver, Biliary Tract, and Pancreatic Cancers among Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958–2009". United States. https://doi.org/10.1667/rr15341.1. https://www.osti.gov/servlets/purl/1613770.
@article{osti_1613770,
title = {Radiation and Risk of Liver, Biliary Tract, and Pancreatic Cancers among Atomic Bomb Survivors in Hiroshima and Nagasaki: 1958–2009},
author = {Sadakane, Atsuko and French, Benjamin and Brenner, Alina V. and Preston, Dale L. and Sugiyama, Hiromi and Grant, Eric J. and Sakata, Ritsu and Utada, Mai and Cahoon, Elizabeth K. and Mabuchi, Kiyohiko and Ozasa, Kotaro},
abstractNote = {The Life Span Study (LSS) of atomic bomb survivors has consistently demonstrated significant excess radiation-related risks of liver cancer since the first cancer incidence report. Here, we present updated information on radiation risks of liver, biliary tract and pancreatic cancers based on 11 additional years of follow-up since the last report, from 1958 to 2009. The current analyses used improved individual radiation doses and accounted for the effects of alcohol consumption, smoking and body mass index. The study participants included 105,444 LSS participants with known individual radiation dose and no known history of cancer at the start of follow-up. Cases were the first primary incident cancers of the liver (including intrahepatic bile duct), biliary tract (gallbladder and other and unspecified parts of biliary tract) or pancreas identified through linkage with population-based cancer registries in Hiroshima and Nagasaki. Poisson regression methods were used to estimate excess relative risks (ERRs) and excess absolute risks (EARs) associated with DS02R1 doses for liver (liver and biliary tract cancers) or pancreas (pancreatic cancer). We identified 2,016 incident liver cancer cases during the follow-up period. Radiation dose was significantly associated with liver cancer risk (ERR per Gy: 0.53, 95% CI: 0.23 to 0.89; EAR per 10,000 person-year Gy: 5.32, 95% CI: 2.49 to 8.51). There was no evidence for curvature in the radiation dose response (P=0.344). ERRs by age-at-exposure categories were significantly increased among those who were exposed at 0–9, 10–19 and 20–29 years, but not significantly increased after age 30 years, although there was no statistical evidence of heterogeneity in these ERRs (P = 0.378). The radiation ERRs were not affected by adjustment for smoking, alcohol consumption or body mass index. As in previously reported studies, radiation dose was not associated with risk of biliary tract cancer (ERR per Gy: –0.02, 95% CI: –0.25 to 0.30). Radiation dose was associated with a nonsignificant increase in pancreatic cancer risk (ERR per Gy: 0.38, 95% CI: <0 to 0.83). The increased risk was statistically significant among women (ERR per Gy: 0.70, 95% CI: 0.12 to 1.45), but not among men.},
doi = {10.1667/rr15341.1},
journal = {Radiation Research},
number = 3,
volume = 192,
place = {United States},
year = {Wed Jul 10 00:00:00 EDT 2019},
month = {Wed Jul 10 00:00:00 EDT 2019}
}

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