DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Perfluorodecalin to enhance reactive species delivery in plasma-biomaterial interactions

Journal Article · · Journal of Physics. D, Applied Physics

Treatment of biological tissue by non-thermal atmospheric pressure plasmas in air can often cause beneficial biological outcomes, commonly by generation and delivery of reactive oxygen and nitrogen species (RONS). Biological plasma treatment is often mediated through plasma-liquid interactions, wherein plasma-generated RONS are dissolved into the liquid phase and subsequently initiate liquid-phase chemistry. In this paper we report observations on plasma-liquid interactions using a biologically inert perfluorocarbon solvent—perfluorodecalin (PFD)—that is known to be useful in other biomedical applications. The present paper concerns thin films of liquid PFD applied to porous and non-porous surfaces and subsequent plasma exposure of these films. With PFD application as a thin film prior to plasma exposure, we observe evidence of delayed, but ultimately enhanced RONS delivery to non-porous surfaces and through porous underlying surfaces. We demonstrate that PFD dissolves and retains relatively high concentrations of plasma-produced RONS, especially NO2. When the thin liquid film of PFD evaporates during plasma exposure, there appears to be a relatively rapid release of dissolved RONS, potentially aiding certain applications.

Research Organization:
Northern Illinois Univ., DeKalb, IL (United States); Univ. of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Fusion Energy Sciences (FES)
Grant/Contract Number:
SC0001934; SC0012500
OSTI ID:
1610598
Journal Information:
Journal of Physics. D, Applied Physics, Vol. 52, Issue 35; ISSN 0022-3727
Publisher:
IOP PublishingCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 1 work
Citation information provided by
Web of Science

References (29)

Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium journal March 2018
Thermodynamics of dissolved nitrogen, nitrous oxide, and ammonia in perfluorodecalin journal October 2017
Nonequilibrium volume plasma chemical processing journal January 1991
Quantification of air plasma chemistry for surface disinfection journal October 2014
Temperature dependent ultraviolet-visible absorption cross sections of N 2 O and N 2 O 4 : Low-temperature measurements of the equilibrium constant for 2NO 2 ⇌ N 2 O 4 journal January 1994
Ozone correlates with antibacterial effects from indirect air dielectric barrier discharge treatment of water journal March 2013
Evaluated Kinetic and Photochemical Data for Atmospheric Chemistry, Organic Species: Supplement VII journal March 1999
Evaluated kinetic and photochemical data for atmospheric chemistry: Volume I - gas phase reactions of Ox, HOx, NOx and SOx species journal January 2004
Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics journal April 2009
New UV-Flux Measurement Method Using Ozone Photolysis Rate journal January 2001
Absolute absorption cross sections of ozone in the 185- to 350-nm wavelength range journal January 1986
Thermal Hydrosilylation of Undecylenic Acid with Porous Silicon journal January 2002
Ozone-Loaded Solvents for use in Water Treatment journal December 2003
Mechanisms of Selective Antitumor Action of Cold Atmospheric Plasma-Derived Reactive Oxygen and Nitrogen Species: Mechanisms of Selective Antitumor Action… journal October 2016
Low temperature plasma biomedicine: A tutorial review journal August 2014
Plasma–liquid interactions: a review and roadmap journal September 2016
UV absorption cross sections of nitrous oxide (N 2 O) and carbon tetrachloride (CCl 4 ) between 210 and 350 K and the atmospheric implications journal January 2010
Two-phase ozonation of chlorinated organics journal April 1995
Guiding Self-Assembly with the Tip of an Atomic Force Microscope journal May 2002
La photolyse de l'ozone a 253.7 nm: Desactivation de O(1D) et de O2(1Σ)par les gaz de l'atmosphere journal January 1975
Cold atmospheric plasma, a novel promising anti-cancer treatment modality journal November 2016
Degradation p-Chloronitrobenzene in Ozone-loaded System with Perfluorodecalin Solvent journal June 2011
Artificial Blood Substitutes: First Steps on the Long Route to Clinical Utility journal January 2016
Evaluated Chemical Kinetic Rate Constants for Various Gas Phase Reactions journal January 1973
Mechanisms of Plasma Medicine: Coupling Plasma Physics, Biochemistry, and Biology journal July 2017
ReviewMethods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids journal August 2005
The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology journal June 2012
Plasma Treatment of Onychomycosis: Plasma Treatment of Onychomycosis journal April 2016
Ozone Generation from Oxygen and Air: Discharge Physics and Reaction Mechanisms journal September 1988