A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice

Bubier, Jason A.; Philip, Vivek M.; Quince, Christopher; Campbell, James; Zhou, Yanjiao; Vishnivetskaya, Tatiana; Duvvuru, Suman; Blair, Rachel Hageman; Ndukum, Juliet; Donohue, Kevin D.; Foster, Carmen M.; Mellert, David J.; Weinstock, George; Culiat, Cymbeline T.; O’Hara, Bruce F.; Palumbo, Anthony V.; Podar, Mircea; Chesler, Elissa J.

doi:10.1534/genetics.119.303013

Title: A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice

Journal Article · 01 January 2020 · Genetics

DOI: https://doi.org/10.1534/genetics.119.303013 · OSTI ID:1606767

^[1]; Philip, Vivek M. ^[2]; Quince, Christopher ^[3]; Campbell, James ^[4]; Zhou, Yanjiao ^[1]; Vishnivetskaya, Tatiana ^[5]; Duvvuru, Suman ^[5]; Blair, Rachel Hageman ^[6]; Ndukum, Juliet ^[1]; Donohue, Kevin D. ^[7];

^[4]; Mellert, David J. ^[1];

^[1]; Culiat, Cymbeline T. ^[5]; O’Hara, Bruce F. ^[7];

^[4];

^[2]

The Jackson Lab, Bar Harbor, ME (United States)
The Jackson Lab, Bar Harbor, ME (United States); Univ. of Tennessee, Knoxville, TN (United States). Genome Science and Technology Program; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division
Univ. of Glasgow, Scotland (United Kingdom)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division
Univ. of Tennessee, Knoxville, TN (United States). Genome Science and Technology Program; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division
State Univ. of New York (SUNY), Buffalo, NY (United States)
Signal Solutions, LLC, Lexington, KY (United States); Univ. of Kentucky, Lexington, KY (United States)

The microbiome influences health and disease through complex networks of host genetics, genomics, microbes, and environment. Identifying the mechanisms of these interactions has remained challenging. Systems genetics in laboratory mice (Mus musculus) enables data-driven discovery of biological network components and mechanisms of host–microbial interactions underlying disease phenotypes. To examine the interplay among the whole host genome, transcriptome, and microbiome, we mapped QTL and correlated the abundance of cecal messenger RNA, luminal microflora, physiology, and behavior in a highly diverse Collaborative Cross breeding population. One such relationship, regulated by a variant on chromosome 7, was the association of Odoribacter (Bacteroidales) abundance and sleep phenotypes. In a test of this association in the BKS.Cg-Dock7^m +/+ Lepr^db/J mouse model of obesity and diabetes, known to have abnormal sleep and colonization by Odoribacter, treatment with antibiotics altered sleep in a genotype-dependent fashion. The many other relationships extracted from this study can be used to interrogate other diseases, microbes, and mechanisms.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1606767

Journal Information:: Genetics, Journal Name: Genetics Journal Issue: 3 Vol. 214; ISSN 0016-6731

Publisher:: Genetics Society of AmericaCopyright Statement

Country of Publication:: United States

Language:: English

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Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits McKnite, Autumn M.; Perez-Munoz, Maria Elisa; Lu, Lu PLoS ONE, Vol. 7, Issue 6 https://doi.org/10.1371/journal.pone.0039191	journal	June 2012
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A Bayesian Framework for Inference of the Genotype–Phenotype Map for Segregating Populations Hageman, Rachael S.; Leduc, Magalie S.; Korstanje, Ron Genetics, Vol. 187, Issue 4 https://doi.org/10.1534/genetics.110.123273	journal	January 2011
Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors Jaehyoung, Kim,; A., Peterson, Daniel; Min, Zhang, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/1kzz-dv32	text	January 2010
Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice Elin, Org,; W., Parks, Brian; Mark, Kirby, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/6cq1-7t54	text	January 2013
The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics R., Branstetter, Lisa; W., Threadgill, David; W., Williams, Robert The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/rh06-vk98	text	January 2008
Quantitative Trait Locus Mapping Methods for Diversity Outbred Mice P., Simecek,; A., Churchill, G.; A., Palmer, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/wzcj-rb50	text	January 2014
Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue Geurts, Lucie; Lazarevic, Vladimir; Derrien, Muriel Frontiers in Microbiology, Vol. 2 https://doi.org/10.3389/fmicb.2011.00149	journal	January 2011

Cited By (1)

Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity Montgomery, Theresa L.; Künstner, Axel; Kennedy, Josephine J. Proceedings of the National Academy of Sciences, Vol. 117, Issue 44 https://doi.org/10.1073/pnas.2002817117	journal	October 2020

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