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Title: Effects of Testosterone Supplementation on Ghrelin and Appetite During and After Severe Energy Deficit in Healthy Men

Abstract

Abstract Background Severe energy deficits cause interrelated reductions in testosterone and fat free mass. Testosterone supplementation may mitigate those decrements, but could also reduce circulating concentrations of the orexigenic hormone ghrelin, thereby exacerbating energy deficit by suppressing appetite. Objective To determine whether testosterone supplementation during severe energy deficit influences fasting and postprandial ghrelin concentrations and appetite. Design and methods Secondary analysis of a randomized, double-blind trial that determined the effects of testosterone supplementation on body composition changes during and following severe energy deficit in nonobese, eugonadal men. Phase 1 (PRE-ED): 14-day run-in; phase 2: 28 days, 55% energy deficit with 200 mg testosterone enanthate weekly (TEST; n = 24) or placebo (PLA; n = 26); phase 3: free-living until body mass recovered (end-of-study; EOS). Fasting and postprandial acyl ghrelin and des-acyl ghrelin concentrations and appetite were secondary outcomes measured during the final week of each phase. Results Fasting acyl ghrelin concentrations, and postprandial acyl and des-acyl ghrelin concentrations increased in PLA during energy deficit then returned to PRE-ED values by EOS, but did not change in TEST (phase-by-group, P < 0.05). Correlations between changes in free testosterone and changes in fasting acyl ghrelin concentrations during energy deficit (ρ = -0.42, P = 0.003) and body mass recovery (ρ = -0.38; P = 0.01) weremore » not mediated by changes in body mass or body composition. Transient increases in appetite during energy deficit were not affected by testosterone treatment. Conclusions Testosterone supplementation during short-term, severe energy deficit in healthy men prevents deficit-induced increases in circulating ghrelin without blunting concomitant increases in appetite. Clinical Trials Registration www.clinicaltrials.gov NCT02734238 (registered 12 April 2016).« less

Authors:
ORCiD logo [1];  [2];  [3];  [1]; ORCiD logo [3]; ORCiD logo [3];  [1]
  1. Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA
  2. Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA, Oak Ridge Institute for Science and Education, Belcamp, MD, USA, Department of Nutrition, Food, and Exercise Sciences, Florida State University, Tallahassee, FL, USA
  3. Louisiana State University’s Pennington Biomedical Research Center, Baton Rouge, LA, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1606622
Grant/Contract Number:  
SC0014664
Resource Type:
Published Article
Journal Name:
Journal of the Endocrine Society
Additional Journal Information:
Journal Name: Journal of the Endocrine Society Journal Volume: 4 Journal Issue: 4; Journal ID: ISSN 2472-1972
Publisher:
The Endocrine Society
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Karl, J. Philip, Berryman, Claire E., Harris, Melissa N., Lieberman, Harris R., Gadde, Kishore M., Rood, Jennifer C., and Pasiakos, Stefan M. Effects of Testosterone Supplementation on Ghrelin and Appetite During and After Severe Energy Deficit in Healthy Men. Country unknown/Code not available: N. p., 2020. Web. doi:10.1210/jendso/bvaa024.
Karl, J. Philip, Berryman, Claire E., Harris, Melissa N., Lieberman, Harris R., Gadde, Kishore M., Rood, Jennifer C., & Pasiakos, Stefan M. Effects of Testosterone Supplementation on Ghrelin and Appetite During and After Severe Energy Deficit in Healthy Men. Country unknown/Code not available. doi:https://doi.org/10.1210/jendso/bvaa024
Karl, J. Philip, Berryman, Claire E., Harris, Melissa N., Lieberman, Harris R., Gadde, Kishore M., Rood, Jennifer C., and Pasiakos, Stefan M. Tue . "Effects of Testosterone Supplementation on Ghrelin and Appetite During and After Severe Energy Deficit in Healthy Men". Country unknown/Code not available. doi:https://doi.org/10.1210/jendso/bvaa024.
@article{osti_1606622,
title = {Effects of Testosterone Supplementation on Ghrelin and Appetite During and After Severe Energy Deficit in Healthy Men},
author = {Karl, J. Philip and Berryman, Claire E. and Harris, Melissa N. and Lieberman, Harris R. and Gadde, Kishore M. and Rood, Jennifer C. and Pasiakos, Stefan M.},
abstractNote = {Abstract Background Severe energy deficits cause interrelated reductions in testosterone and fat free mass. Testosterone supplementation may mitigate those decrements, but could also reduce circulating concentrations of the orexigenic hormone ghrelin, thereby exacerbating energy deficit by suppressing appetite. Objective To determine whether testosterone supplementation during severe energy deficit influences fasting and postprandial ghrelin concentrations and appetite. Design and methods Secondary analysis of a randomized, double-blind trial that determined the effects of testosterone supplementation on body composition changes during and following severe energy deficit in nonobese, eugonadal men. Phase 1 (PRE-ED): 14-day run-in; phase 2: 28 days, 55% energy deficit with 200 mg testosterone enanthate weekly (TEST; n = 24) or placebo (PLA; n = 26); phase 3: free-living until body mass recovered (end-of-study; EOS). Fasting and postprandial acyl ghrelin and des-acyl ghrelin concentrations and appetite were secondary outcomes measured during the final week of each phase. Results Fasting acyl ghrelin concentrations, and postprandial acyl and des-acyl ghrelin concentrations increased in PLA during energy deficit then returned to PRE-ED values by EOS, but did not change in TEST (phase-by-group, P < 0.05). Correlations between changes in free testosterone and changes in fasting acyl ghrelin concentrations during energy deficit (ρ = -0.42, P = 0.003) and body mass recovery (ρ = -0.38; P = 0.01) were not mediated by changes in body mass or body composition. Transient increases in appetite during energy deficit were not affected by testosterone treatment. Conclusions Testosterone supplementation during short-term, severe energy deficit in healthy men prevents deficit-induced increases in circulating ghrelin without blunting concomitant increases in appetite. Clinical Trials Registration www.clinicaltrials.gov NCT02734238 (registered 12 April 2016).},
doi = {10.1210/jendso/bvaa024},
journal = {Journal of the Endocrine Society},
number = 4,
volume = 4,
place = {Country unknown/Code not available},
year = {2020},
month = {3}
}

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DOI: https://doi.org/10.1210/jendso/bvaa024

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