Advancing Chelation Chemistry for Actinium and Other +3 f-Elements, Am, Cm, and La

Stein, Benjamin W.; Morgenstern, Amanda; Batista, Enrique R.; Birnbaum, Eva R.; Bone, Sharon E.; Cary, Samantha K.; Ferrier, Maryline G.; John, Kevin D.; Pacheco, Juan Lezama; Kozimor, Stosh A.; Mocko, Veronika; Scott, Brian L.; Yang, Ping

doi:10.1021/jacs.9b10354

Title: Advancing Chelation Chemistry for Actinium and Other +3 f-Elements, Am, Cm, and La

Journal Article · 02 December 2019 · Journal of the American Chemical Society

DOI: https://doi.org/10.1021/jacs.9b10354 · OSTI ID:1605392

Stein, Benjamin W. ^[1];

^[1];

^[1]; Birnbaum, Eva R. ^[1];

^[1];

;

^[1]; John, Kevin D. ^[1]; Pacheco, Juan Lezama ^[2];

^[1]; Mocko, Veronika ^[1]; Scott, Brian L. ^[1];

^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Stanford Univ., CA (United States)

A major chemical challenge facing implementation of ²²⁵Ac in targeted alpha therapy—an emerging technology that has potential for treatment of disease—is identifying an ²²⁵Ac chelator that is compatible with in vivo applications. It is unclear how to tailor a chelator for Ac binding because Ac coordination chemistry is poorly defined. Most Ac chemistry is inferred from radiochemical experiments carried out on microscopic scales. Of the few Ac compounds that have been characterized spectroscopically, success has only been reported for simple inorganic ligands. Toward advancing understanding in Ac chelation chemistry, we have developed a method for characterizing Ac complexes that contain highly complex chelating agents using small quantities (μg) of ²²⁷Ac. We successfully characterized the chelation of Ac³⁺ by DOTP^8– using EXAFS, NMR, and DFT techniques. To develop confidence and credibility in the Ac results, comparisons with +3 cations (Am, Cm, and La) that could be handled on the mg scale were carried out. We discovered that all M³⁺ cations (M = Ac, Am, Cm, La) were completely encapsulated within the binding pocket of the DOTP^8– macrocycle. Further, the computational results highlighted the stability of the M(DOTP)^5– complexes.

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Research Organization:: SLAC National Accelerator Laboratory, Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)

Sponsoring Organization:: Agnew National Security Fellowship; Glenn T. Seaborg Institute; Hoffman Distinguished Postdoctoral Fellowship; National Institute of General Medical Sciences (NIGMS); National Institutes of Health (NIH); USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)

Grant/Contract Number:: 89233218CNA000001; AC02-76SF00515

OSTI ID:: 1605392

Journal Information:: Journal of the American Chemical Society, Journal Name: Journal of the American Chemical Society Journal Issue: 49 Vol. 141; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (75)

Technetium: Chemistry and Radiopharmaceutical Applications Schwochau, Klaus https://doi.org/10.1002/9783527613366	book	February 2000
Comparing the 2,2′-Biphenylenedithiophosphinate Binding of Americium with Neodymium and Europium Cross, Justin N.; Macor, Joseph A.; Bertke, Jeffery A. Angewandte Chemie International Edition, Vol. 55, Issue 41 https://doi.org/10.1002/anie.201606367	journal	September 2016
Spectroscopic and Computational Characterization of Diethylenetriaminepentaacetic Acid/Transplutonium Chelates: Evidencing Heterogeneity in the Heavy Actinide(III) Series Deblonde, Gauthier J. -P.; Kelley, Morgan P.; Su, Jing Angewandte Chemie International Edition, Vol. 57, Issue 17 https://doi.org/10.1002/anie.201709183	journal	March 2018
An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy Thiele, Nikki A.; Brown, Victoria; Kelly, James M. Angewandte Chemie International Edition, Vol. 56, Issue 46 https://doi.org/10.1002/anie.201709532	journal	October 2017
X-ray Crystal Structure of a Sodium Salt of [Gd(DOTP)]5−: Implications for Its Second-Sphere Relaxivity and the23Na NMR Hyperfine Shift Effects of [Tm(DOTP)]5− Avecilla, Fernando; Peters, Joop A.; Geraldes, Carlos F. G. C. European Journal of Inorganic Chemistry, Vol. 2003, Issue 23 https://doi.org/10.1002/ejic.200300312	journal	December 2003
Local Structure in Americium and Californium Hexacyanoferrates - Comparison with Their Lanthanide Analogues Dupouy, Gaelle; Bonhoure, Isabelle; Conradson, Steven D. European Journal of Inorganic Chemistry, Vol. 2011, Issue 10 https://doi.org/10.1002/ejic.201001004	journal	February 2011
Optimized Slater-type basis sets for the elements 1-118 Van Lenthe, E.; Baerends, E. J. Journal of Computational Chemistry, Vol. 24, Issue 9 https://doi.org/10.1002/jcc.10255	journal	May 2003
Chemistry with ADF te Velde, G.; Bickelhaupt, F. M.; Baerends, E. J. Journal of Computational Chemistry, Vol. 22, Issue 9, p. 931-967 https://doi.org/10.1002/jcc.1056	journal	January 2001
Gd(DOTP)5- outer-sphere relaxation enhancement promoted by nitrogen bases Aime, Silvio; Botta, Mauro; Terreno, Enzo Magnetic Resonance in Medicine, Vol. 30, Issue 5 https://doi.org/10.1002/mrm.1910300509	journal	November 1993
Towards an order- N DFT method Fonseca Guerra, C.; Snijders, J. G.; te Velde, G. Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta), Vol. 99, Issue 6 https://doi.org/10.1007/s002140050353	journal	November 1998
An implementation of the conductor-like screening model of solvation within the Amsterdam density functional package Pye, Cory C.; Ziegler, Tom Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta), Vol. 101, Issue 6 https://doi.org/10.1007/s002140050457	journal	May 1999
Cancer radioimmunotherapy with alpha-emitting nuclides Couturier, Olivier; Supiot, Stéphane; Degraef-Mougin, Marie European Journal of Nuclear Medicine and Molecular Imaging, Vol. 32, Issue 5 https://doi.org/10.1007/s00259-005-1803-2	journal	April 2005
213Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience Kratochwil, C.; Giesel, F. L.; Bruchertseifer, F. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 41, Issue 11 https://doi.org/10.1007/s00259-014-2857-9	journal	July 2014
A comparative evaluation of Ac225 vs Bi213 as therapeutic radioisotopes for targeted alpha therapy for cancer Allen, Barry J. Australasian Physical & Engineering Sciences in Medicine, Vol. 40, Issue 2 https://doi.org/10.1007/s13246-017-0534-6	journal	March 2017
An overview of targeted alpha therapy Kim, Young-Seung; Brechbiel, Martin W. Tumor Biology, Vol. 33, Issue 3 https://doi.org/10.1007/s13277-011-0286-y	journal	December 2011
Tricyclopentadienyl-curium Laubereau, P. G.; Burns, John H. Inorganic and Nuclear Chemistry Letters, Vol. 6, Issue 1 https://doi.org/10.1016/0020-1650(70)80285-9	journal	January 1970
The crystal structure of actinium metal and actinium hydride Farr, J. D.; Giorgi, A. L.; Bowman, M. G. Journal of Inorganic and Nuclear Chemistry, Vol. 18 https://doi.org/10.1016/0022-1902(61)80369-2	journal	March 1961
The lattice constants of actinium(III) oxalate deca-hydrate Weigel, F.; Hauske, H. Journal of the Less Common Metals, Vol. 55, Issue 2 https://doi.org/10.1016/0022-5088(77)90198-9	journal	October 1977
The magnetic behavior of trivalent americium compounds Soderholm, L.; Edelstein, N.; Moriss, L. R. Journal of Magnetism and Magnetic Materials, Vol. 54-57 https://doi.org/10.1016/0304-8853(86)90724-9	journal	February 1986
31P and 23Na NMR lanthanide induced shifts in axially symmetric macrocyclic phosphonate complexes Dean Sherry, A.; Geraldes, C. F. G. C.; Cacheris, W. P. Inorganica Chimica Acta, Vol. 139, Issue 1-2 https://doi.org/10.1016/S0020-1693(00)84059-1	journal	December 1987
Design and synthesis of 225Ac radioimmunopharmaceuticals McDevitt, Michael R.; Ma, Dangshe; Simon, Jim Applied Radiation and Isotopes, Vol. 57, Issue 6 https://doi.org/10.1016/S0969-8043(02)00167-7	journal	December 2002
Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications Miederer, Matthias; Scheinberg, David A.; McDevitt, Michael R. Advanced Drug Delivery Reviews, Vol. 60, Issue 12 https://doi.org/10.1016/j.addr.2008.04.009	journal	September 2008
Syntheses, structures and catalytic properties of one-dimensional lanthanide-dotp compounds [dotpH8=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis-(methylenephosphonic acid)] Yang, Ting-Hai; Zhou, Kai; Bao, Song-Song Inorganic Chemistry Communications, Vol. 11, Issue 9 https://doi.org/10.1016/j.inoche.2008.05.036	journal	September 2008
Spontaneous Partitioning of Californium from Curium: Curious Cases from the Crystallization of Curium Coordination Complexes Cary, Samantha K.; Silver, Mark A.; Liu, Guokui Inorganic Chemistry, Vol. 54, Issue 23 https://doi.org/10.1021/acs.inorgchem.5b02052	journal	November 2015
Combined EXAFS Spectroscopic and Quantum Chemical Study on the Complex Formation of Am(III) with Formate Fröhlich, Daniel R.; Kremleva, Alena; Rossberg, André Inorganic Chemistry, Vol. 56, Issue 12 https://doi.org/10.1021/acs.inorgchem.7b00035	journal	May 2017
Bond Covalency and Oxidation State of Actinide Ions Complexed with Therapeutic Chelating Agent 3,4,3-LI(1,2-HOPO) Kelley, Morgan P.; Deblonde, Gauthier J. -P.; Su, Jing Inorganic Chemistry, Vol. 57, Issue 9 https://doi.org/10.1021/acs.inorgchem.8b00345	journal	April 2018
Synthesis and Characterization of the Actinium Aquo Ion Ferrier, Maryline G.; Stein, Benjamin W.; Batista, Enrique R. ACS Central Science, Vol. 3, Issue 3 https://doi.org/10.1021/acscentsci.6b00356	journal	February 2017
NMR study of solution structures and dynamics of lanthanide(III) complexes of DOTA Aime, Silvio; Botta, Mauro; Ermondi, Giuseppe Inorganic Chemistry, Vol. 31, Issue 21 https://doi.org/10.1021/ic00047a016	journal	October 1992
Thermodynamic study of lanthanide complexes of 1,4,7-triazacyclononane-N,N',N"-triacetic acid and 1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid Cacheris, W. P.; Nickle, S. K.; Sherry, A. D. Inorganic Chemistry, Vol. 26, Issue 6 https://doi.org/10.1021/ic00253a038	journal	March 1987
Synthesis, protonation sequence, and NMR studies of polyazamacrocyclic methylenephosphonates Geraldes, C. F. G. C.; Sherry, A. D.; Cacheris, W. P. Inorganic Chemistry, Vol. 28, Issue 17 https://doi.org/10.1021/ic00316a018	journal	August 1989
Synthesis and NMR Studies of New DOTP-like Lanthanide(III) Complexes Containing a Hydrophobic Substituent on One Phosphonate Side Arm Li, Xiaodong; Zhang, Shanrong; Zhao, Piyu Inorganic Chemistry, Vol. 40, Issue 26 https://doi.org/10.1021/ic010291s	journal	December 2001
Structural Variations Across the Lanthanide Series of Macrocyclic DOTA Complexes: Insights into the Design of Contrast Agents for Magnetic Resonance Imaging Benetollo, F.; Bombieri, G.; Calabi, L. Inorganic Chemistry, Vol. 42, Issue 1 https://doi.org/10.1021/ic025790n	journal	January 2003
Microchemical preparation of tricyclopentadienyl compounds of berkelium, californium, and some lanthanide elements Laubereau, Peter G.; Burns, John H. Inorganic Chemistry, Vol. 9, Issue 5 https://doi.org/10.1021/ic50087a018	journal	May 1970
Characterization of Lanthanide(III) DOTP Complexes: Thermodynamics, Protonation, and Coordination to Alkali Metal Ions Sherry, A. D.; Ren, J.; Huskens, J. Inorganic Chemistry, Vol. 35, Issue 16 https://doi.org/10.1021/ic9600590	journal	January 1996
A Novel Compound in the Lanthanide(III) DOTA Series. X-ray Crystal and Molecular Structure of the Complex Na[La(DOTA)La(HDOTA)]·10H ₂ O Aime, Silvio; Barge, Alessandro; Benetollo, Franco Inorganic Chemistry, Vol. 36, Issue 19 https://doi.org/10.1021/ic9704501	journal	September 1997
The Preparation and Identification of Some Pure Actinium Compounds ¹ Fried, Sherman; Hagemann, French; Zachariasen, W. H. Journal of the American Chemical Society, Vol. 72, Issue 2 https://doi.org/10.1021/ja01158a034	journal	February 1950
Improved in Vivo Stability of Actinium-225 Macrocyclic Complexes Deal, Kim A.; Davis, Ila A.; Mirzadeh, Saed Journal of Medicinal Chemistry, Vol. 42, Issue 15 https://doi.org/10.1021/jm990141f	journal	July 1999
Accurate Energies and Structures for Large Water Clusters Using the X3LYP Hybrid Density Functional Su, Julius T.; Xu, Xin; Goddard, William A. The Journal of Physical Chemistry A, Vol. 108, Issue 47 https://doi.org/10.1021/jp047502+	journal	November 2004
Hydration Shell Structure and Dynamics of Curium(III) in Aqueous Solution: First Principles and Empirical Studies Atta-Fynn, Raymond; Bylaska, Eric J.; Schenter, Gregory K. The Journal of Physical Chemistry A, Vol. 115, Issue 18 https://doi.org/10.1021/jp201043f	journal	May 2011
Hydrolysis of Ferric Ion in Water and Conformational Equilibrium Martin, Richard L.; Hay, P. Jeffrey; Pratt, Lawrence R. The Journal of Physical Chemistry A, Vol. 102, Issue 20 https://doi.org/10.1021/jp980229p	journal	May 1998
Spectroscopic and computational investigation of actinium coordination chemistry Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12312	journal	August 2016
Emergence of californium as the second transitional element in the actinide series Cary, Samantha K.; Vasiliu, Monica; Baumbach, Ryan E. Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms7827	journal	April 2015
Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer McDevitt, Michael R.; Thorek, Daniel L. J.; Hashimoto, Takeshi Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04107-w	journal	April 2018
Interaction of Cm( iii ) and Am( iii ) with human serum transferrin studied by time-resolved laser fluorescence and EXAFS spectroscopy Bauer, Nicole; Fröhlich, Daniel R.; Panak, Petra J. Dalton Trans., Vol. 43, Issue 18 https://doi.org/10.1039/C3DT53371A	journal	January 2014
The first example of ab initio calculations of f–f transitions for the case of [Eu(DOTP)] ⁵⁻ complex—experiment versus theory Janicki, Rafał; Kędziorski, Andrzej; Mondry, Anna Physical Chemistry Chemical Physics, Vol. 18, Issue 40 https://doi.org/10.1039/C6CP05284C	journal	January 2016
A series of dithiocarbamates for americium, curium, and californium Cary, Samantha K.; Su, Jing; Galley, Shane S. Dalton Transactions, Vol. 47, Issue 41 https://doi.org/10.1039/C8DT02658K	journal	January 2018
The coordination chemistry of Cm ^III , Am ^III , and Ac ^III in nitrate solutions: an actinide L ₃ -edge EXAFS study Ferrier, Maryline G.; Stein, Benjamin W.; Bone, Sharon E. Chemical Science, Vol. 9, Issue 35 https://doi.org/10.1039/C8SC02270D	journal	January 2018
Synthesis, crystal structures and NMR and luminescence spectra of lanthanide complexes of 1,4,7,10-tetraazacyclododecane with N-methylene(phenyl)phosphinic acid pendant arms † Rohovec, Jan; Vojtíšek, Pavel; Hermann, Petr Journal of the Chemical Society, Dalton Transactions, Issue 20 https://doi.org/10.1039/a905460j	journal	January 1999
The Difficult Chore of Measuring Coordination by EXAFS Ravel, B.; Kelly, S. D. X-RAY ABSORPTION FINE STRUCTURE - XAFS13: 13th International Conference, AIP Conference Proceedings https://doi.org/10.1063/1.2644458	conference	January 2007
Relativistic regular two‐component Hamiltonians Lenthe, E. van; Baerends, E. J.; Snijders, J. G. The Journal of Chemical Physics, Vol. 99, Issue 6 https://doi.org/10.1063/1.466059	journal	September 1993
Relativistic total energy using regular approximations van Lenthe, E.; Baerends, E. J.; Snijders, J. G. The Journal of Chemical Physics, Vol. 101, Issue 11 https://doi.org/10.1063/1.467943	journal	December 1994
Near-edge x-ray-absorption fine structure of Pb: A comparison of theory and experiment Newville, M.; Līviņš, P.; Yacoby, Y. Physical Review B, Vol. 47, Issue 21 https://doi.org/10.1103/PhysRevB.47.14126	journal	June 1993
Multiple-scattering calculations of x-ray-absorption spectra Zabinsky, S. I.; Rehr, J. J.; Ankudinov, A. Physical Review B, Vol. 52, Issue 4 https://doi.org/10.1103/PhysRevB.52.2995	journal	July 1995
High-order multiple-scattering calculations of x-ray-absorption fine structure Rehr, J. J.; Albers, R. C.; Zabinsky, S. I. Physical Review Letters, Vol. 69, Issue 23 https://doi.org/10.1103/PhysRevLett.69.3397	journal	December 1992
Theoretical approaches to x-ray absorption fine structure Rehr, J. J.; Albers, R. C. Reviews of Modern Physics, Vol. 72, Issue 3 https://doi.org/10.1103/RevModPhys.72.621	journal	July 2000
A short history of SHELX Sheldrick, George M. Acta Crystallographica Section A Foundations of Crystallography, Vol. 64, Issue 1, p. 112-122 https://doi.org/10.1107/S0108767307043930	journal	December 2007
Crystal chemical studies of the 5f-series of elements. I. New structure types Zachariasen, W. H. Acta Crystallographica, Vol. 1, Issue 5 https://doi.org/10.1107/S0365110X48000703	journal	November 1948
Crystal chemical studies of the 5f-series of elements. VI. The Ce2S3–Ce3S4 type of structure Zachariasen, W. H. Acta Crystallographica, Vol. 2, Issue 1 https://doi.org/10.1107/S0365110X49000126	journal	March 1949
Crystal chemical studies of the 5f-series of elements. XII. New compounds representing known structure types Zachariasen, W. H. Acta Crystallographica, Vol. 2, Issue 6 https://doi.org/10.1107/S0365110X49001016	journal	December 1949
Significance tests on the crystallographic R factor Hamilton, W. C. Acta Crystallographica, Vol. 18, Issue 3 https://doi.org/10.1107/S0365110X65001081	journal	May 1965
Structure validation in chemical crystallography Spek, Anthony L. Acta Crystallographica Section D Biological Crystallography, Vol. 65, Issue 2, p. 148-155 https://doi.org/10.1107/S090744490804362X	journal	January 2009
ATHENA , ARTEMIS , HEPHAESTUS : data analysis for X-ray absorption spectroscopy using IFEFFIT Ravel, B.; Newville, M. Journal of Synchrotron Radiation, Vol. 12, Issue 4 https://doi.org/10.1107/S0909049505012719	journal	June 2005
The pH dependence of Am(III) complexation with acetate: an EXAFS study Fröhlich, Daniel R.; Skerencak-Frech, Andrej; Bauer, Nicole Journal of Synchrotron Radiation, Vol. 22, Issue 1 https://doi.org/10.1107/S1600577514022498	journal	January 2015
Tumor Therapy with Targeted Atomic Nanogenerators McDevitt, M. R. Science, Vol. 294, Issue 5546 https://doi.org/10.1126/science.1064126	journal	November 2001
Alpha-Particle Emitting Atomic Generator (Actinium-225)-Labeled Trastuzumab (Herceptin) Targeting of Breast Cancer Spheroids: Efficacy *versus* HER2/ *neu* Expression Ballangrud, Åse M.; Yang, Wei-Hong; Palm, Stig Clinical Cancer Research, Vol. 10, Issue 13 https://doi.org/10.1158/1078-0432.CCR-03-0800	journal	July 2004
XAFS for Everyone Calvin, Scott https://doi.org/10.1201/b14843	book	May 2013
SIXPack a Graphical User Interface for XAS Analysis Using IFEFFIT Webb, S. M. Physica Scripta https://doi.org/10.1238/Physica.Topical.115a01011	journal	January 2005
Further conventions for NMR shielding and chemical shifts (IUPAC Recommendations 2008) Harris, Robin K.; Becker, Edwin D.; Cabral de Menezes, Sonia M. Pure and Applied Chemistry, Vol. 80, Issue 1 https://doi.org/10.1351/pac200880010059	journal	January 2008
Alpha-Emitters for Immuno-Therapy: A Review of Recent Developments from Chemistry to Clinics Huclier-Markai, Sandrine; Alliot, Cyrille; Varmenot, Nicolas Current Topics in Medicinal Chemistry, Vol. 12, Issue 23 https://doi.org/10.2174/1568026611212230002	journal	March 2013
In vivo Evaluation of Free and Chelated Accelerator-produced Actinium- 225 - Radiation Dosimetry and Toxicity Results Jiang, Zewei; Revskaya, Ekaterina; Fisher, Darrell R. Current Radiopharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.2174/1874471011666180423120707	journal	October 2018
Dosimetry and Radiobiology of Alpha-Particle Emitting Radionuclides Sgouros, George; Hobbs, Robert; Josefsson, Anders Current Radiopharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.2174/1874471011666180426130058	journal	October 2018
An Overview of Targeted Alpha Therapy with ²²⁵ Actinium and ²¹³ Bismuth Morgenstern, Alfred; Apostolidis, Christos; Kratochwil, Clemens Current Radiopharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.2174/1874471011666180502104524	journal	October 2018
Clinical Studies with Bismuth-213 and Actinium-225 for Hematologic Malignancies Jurcic, Joseph G. Current Radiopharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.2174/1874471011666180525102814	journal	October 2018
225Ac-PSMA-617 for PSMA-Targeted -Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer Kratochwil, C.; Bruchertseifer, F.; Giesel, F. L. Journal of Nuclear Medicine, Vol. 57, Issue 12 https://doi.org/10.2967/jnumed.116.178673	journal	July 2016
Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with ²²⁵ Ac-PSMA-617: Swimmer-Plot Analysis Suggests Efficacy Regarding Duration of Tumor Control Kratochwil, Clemens; Bruchertseifer, Frank; Rathke, Hendrik Journal of Nuclear Medicine, Vol. 59, Issue 5 https://doi.org/10.2967/jnumed.117.203539	journal	January 2018

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Extended X-ray absorption fine structure
Mechanisms of action
Nuclear magnetic resonance spectroscopy
Scattering

Title: Advancing Chelation Chemistry for Actinium and Other +3 f-Elements, Am, Cm, and La

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