Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Rozhkova, Elena A.; Lee, Byeongdu; Prasad, Judy A.; Liu, Yuzi; Shevchenko, Elena V.

doi:10.1039/c9nr05794c

Title: Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Journal Article · 20 September 2019 · Nanoscale

DOI: https://doi.org/10.1039/c9nr05794c · OSTI ID:1605134

^[1];

^[2];

^[3];

^[1];

^[1]

Argonne National Lab. (ANL), Lemont, IL (United States). Center for Nanoscale Materials
Argonne National Lab., Lemont, IL (United States). X-ray Science Division
Univ. of Chicago, IL (United States)

While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose herein the novel concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1605134

Journal Information:: Nanoscale, Journal Name: Nanoscale Journal Issue: 41 Vol. 11; ISSN NANOHL; ISSN 2040-3364

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

References (51)

Nanoscale Materials for Tackling Brain Cancer: Recent Progress and Outlook Rozhkova, Elena A. Advanced Materials, Vol. 23, Issue 24 https://doi.org/10.1002/adma.201004714	journal	April 2011
Efficient Cisplatin Pro-Drug Delivery Visualized with Sub-100 nm Resolution: Interfacing Engineered Thermosensitive Magnetomicelles with a Living System Vitol, Elina A.; Rozhkova, Elena A.; Rose, Volker Advanced Materials Interfaces, Vol. 1, Issue 7 https://doi.org/10.1002/admi.201400182	journal	June 2014
Ceria Nanoparticles that can Protect against Ischemic Stroke Kim, Chi Kyung; Kim, Taeho; Choi, In-Young Angewandte Chemie, Vol. 124, Issue 44 https://doi.org/10.1002/ange.201203780	journal	September 2012
Gold Nanoparticles for Biology and Medicine Giljohann, David A.; Seferos, Dwight S.; Daniel, Weston L. Angewandte Chemie International Edition, Vol. 49, Issue 19, p. 3280-3294 https://doi.org/10.1002/anie.200904359	journal	April 2010
Ceria Nanoparticles that can Protect against Ischemic Stroke Kim, Chi Kyung; Kim, Taeho; Choi, In-Young Angewandte Chemie International Edition, Vol. 51, Issue 44 https://doi.org/10.1002/anie.201203780	journal	September 2012
Antioxidant-potentiality of gold–chitosan nanocomposites Esumi, Kunio; Takei, Naoko; Yoshimura, Tomokazu Colloids and Surfaces B: Biointerfaces, Vol. 32, Issue 2 https://doi.org/10.1016/S0927-7765(03)00151-6	journal	October 2003
Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging He, Weiwei; Zhou, Yu-Ting; Wamer, Wayne G. Biomaterials, Vol. 34, Issue 3 https://doi.org/10.1016/j.biomaterials.2012.10.010	journal	January 2013
Intracellular accumulation and immunological properties of fluorescent gold nanoclusters in human dendritic cells Fernández, Tahia D.; Pearson, John R.; Leal, Manuel Pernia Biomaterials, Vol. 43 https://doi.org/10.1016/j.biomaterials.2014.11.045	journal	March 2015
Mechanism of pH-switchable peroxidase and catalase-like activities of gold, silver, platinum and palladium Li, Junnan; Liu, Wenqi; Wu, Xiaochun Biomaterials, Vol. 48 https://doi.org/10.1016/j.biomaterials.2015.01.012	journal	April 2015
Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance Lee, Joonseok; Gordon, Andrew C.; Kim, Hacksung Biomaterials, Vol. 109 https://doi.org/10.1016/j.biomaterials.2016.09.013	journal	December 2016
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging Gomes, Ana P.; Price, Nathan L.; Ling, Alvin J. Y. Cell, Vol. 155, Issue 7 https://doi.org/10.1016/j.cell.2013.11.037	journal	December 2013
Rapid in situ biosynthesis of gold nanoparticles in living platelets for multimodal biomedical imaging Jin, Juan; Liu, Taotao; Li, Mingxi Colloids and Surfaces B: Biointerfaces, Vol. 163 https://doi.org/10.1016/j.colsurfb.2018.01.009	journal	March 2018
Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia Estevez, A. Y.; Pritchard, S.; Harper, K. Free Radical Biology and Medicine, Vol. 51, Issue 6 https://doi.org/10.1016/j.freeradbiomed.2011.06.006	journal	September 2011
Gold nanoparticles: Catalyst for the oxidation of NADH to NAD+ Huang, Xiaohua; El-Sayed, Ivan H.; Yi, Xiaobing Journal of Photochemistry and Photobiology B: Biology, Vol. 81, Issue 2 https://doi.org/10.1016/j.jphotobiol.2005.05.010	journal	November 2005
Visualizing reactive oxygen species inside cancer cells after stimulation with polycyclic aromatic hydrocarbon via spontaneous formation of Au nanoclusters Pilapong, Chalermchai; Pongpiajun, Siwatt; Mankhetkorn, Samlee Materials Letters, Vol. 140 https://doi.org/10.1016/j.matlet.2014.10.157	journal	February 2015
Small Angle X-ray Scattering for Nanoparticle Research Li, Tao; Senesi, Andrew J.; Lee, Byeongdu Chemical Reviews, Vol. 116, Issue 18 https://doi.org/10.1021/acs.chemrev.5b00690	journal	April 2016
In Situ Biosynthesis of Fluorescent Platinum Nanoclusters: Toward Self-Bioimaging-Guided Cancer Theranostics Chen, Donghua; Zhao, Chunqiu; Ye, Jing ACS Applied Materials & Interfaces, Vol. 7, Issue 32 https://doi.org/10.1021/acsami.5b05805	journal	August 2015
Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease Kwon, Hyek Jin; Cha, Moon-Yong; Kim, Dokyoon ACS Nano, Vol. 10, Issue 2 https://doi.org/10.1021/acsnano.5b08045	journal	January 2016
Gold Nanoparticles in Biology: Beyond Toxicity to Cellular Imaging Murphy, Catherine J.; Gole, Anand M.; Stone, John W. Accounts of Chemical Research, Vol. 41, Issue 12 https://doi.org/10.1021/ar800035u	journal	December 2008
Determination of Nanocrystal Sizes: A Comparison of TEM, SAXS, and XRD Studies of Highly Monodisperse CoPt ₃ Particles Borchert, Holger; Shevchenko, Elena V.; Robert, Aymeric Langmuir, Vol. 21, Issue 5 https://doi.org/10.1021/la0477183	journal	March 2005
Stimuli-Responsive Magnetic Nanomicelles as Multifunctional Heat and Cargo Delivery Vehicles Kim, Dong-Hyun; Vitol, Elina A.; Liu, Jing Langmuir, Vol. 29, Issue 24 https://doi.org/10.1021/la3044158	journal	December 2012
Gold Nanoparticles: A Revival in Precious Metal Administration to Patients Thakor, A. S.; Jokerst, J.; Zavaleta, C. Nano Letters, Vol. 11, Issue 10 https://doi.org/10.1021/nl202559p	journal	October 2011
Custom Cerium Oxide Nanoparticles Protect against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain Heckman, Karin L.; DeCoteau, William; Estevez, Ana ACS Nano, Vol. 7, Issue 12 https://doi.org/10.1021/nn403743b	journal	November 2013
PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection Tran, Mei T.; Zsengeller, Zsuzsanna K.; Berg, Anders H. Nature, Vol. 531, Issue 7595 https://doi.org/10.1038/nature17184	journal	March 2016
Genome sequence of the dissimilatory metal ion–reducing bacterium Shewanella oneidensis Heidelberg, John F.; Paulsen, Ian T.; Nelson, Karen E. Nature Biotechnology, Vol. 20, Issue 11 https://doi.org/10.1038/nbt749	journal	October 2002
Quantifying thiol–gold interactions towards the efficient strength control Xue, Yurui; Li, Xun; Li, Hongbin Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5348	journal	July 2014
Heterogeneous nucleation and shape transformation of multicomponent metallic nanostructures Kwon, Soon Gu; Krylova, Galyna; Phillips, Patrick J. Nature Materials, Vol. 14, Issue 2 https://doi.org/10.1038/nmat4115	journal	November 2014
Restoration of brain circulation and cellular functions hours post-mortem Vrselja, Zvonimir; Daniele, Stefano G.; Silbereis, John Nature, Vol. 568, Issue 7752 https://doi.org/10.1038/s41586-019-1099-1	journal	April 2019
Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells Farooq, Muhammad U.; Novosad, Valentyn; Rozhkova, Elena A. Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-21331-y	journal	February 2018
In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters Wang, Jianling; Zhang, Gen; Li, Qiwei Scientific Reports, Vol. 3, Issue 1 https://doi.org/10.1038/srep01157	journal	January 2013
Near-infrared fluorescence imaging of cancer cells and tumors through specific biosynthesis of silver nanoclusters Gao, Shengping; Chen, Donghua; Li, Qiwei Scientific Reports, Vol. 4, Issue 1 https://doi.org/10.1038/srep04384	journal	March 2014
The golden age: gold nanoparticles for biomedicine Dreaden, Erik C.; Alkilany, Alaaldin M.; Huang, Xiaohua Chem. Soc. Rev., Vol. 41, Issue 7 https://doi.org/10.1039/C1CS15237H	journal	January 2012
Rapid and accurate tumor-target bio-imaging through specific in vivo biosynthesis of a fluorescent europium complex Ye, Jing; Wang, Jianling; Li, Qiwei Biomaterials Science, Vol. 4, Issue 4 https://doi.org/10.1039/C5BM00528K	journal	January 2016
Antioxidant activity of nanomaterials Valgimigli, Luca; Baschieri, Andrea; Amorati, Riccardo Journal of Materials Chemistry B, Vol. 6, Issue 14 https://doi.org/10.1039/C8TB00107C	journal	January 2018
Interactions between the Isolated Oxygenase and Reductase Domains of Neuronal Nitric-oxide Synthase: ASSESSING THE ROLE OF CALMODULIN Rozhkova, E. A.; Fujimoto, N.; Sagami, I. Journal of Biological Chemistry, Vol. 277, Issue 19 https://doi.org/10.1074/jbc.M200642200	journal	May 2002
Ferreting out the secrets of plant ferritin ‐ A review Seckback, Joseph Journal of Plant Nutrition, Vol. 5, Issue 4-7 https://doi.org/10.1080/01904168209362966	journal	January 1982
Synthesis of Hybrid Gold/Iron Oxide Nanoparticles in Block Copolymer Micelles for Imaging, Drug Delivery, and Magnetic Hyperthermia IEEE Transactions on Magnetics, Vol. 45, Issue 10 https://doi.org/10.1109/TMAG.2009.2024000	journal	October 2009
Brain Levels of NADH and NAD ⁺ Under Hypoxic and Hypoglycaemic Conditions In Vitro Garofalo, O.; Cox, D. W. G.; Bachelard, H. S. Journal of Neurochemistry, Vol. 51, Issue 1 https://doi.org/10.1111/j.1471-4159.1988.tb04851.x	journal	July 1988
Cellular Mechanisms of Brain Energy Metabolism. Relevance to Functional Brain Imaging and to Neurodegenerative Disordersa Magistretti, P. J.; Pellerin, L. Annals of the New York Academy of Sciences, Vol. 777, Issue 1 https://doi.org/10.1111/j.1749-6632.1996.tb34449.x	journal	January 1996
Genome of Geobacter sulfurreducens: Metal Reduction in Subsurface Environments Methe, B. A.; Nelson, K. E.; Eisen, J. A. Science, Vol. 302, Issue 5652, p. 1967-1969 https://doi.org/10.1126/science.1088727	journal	December 2003
Magnetotactic bacteria Blakemore, R. Science, Vol. 190, Issue 4212 https://doi.org/10.1126/science.170679	journal	October 1975
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice Zhang, H.; Ryu, D.; Wu, Y. Science, Vol. 352, Issue 6292 https://doi.org/10.1126/science.aaf2693	journal	April 2016
Geobacter sulfurreducens sp. nov., a hydrogen- and acetate-oxidizing dissimilatory metal-reducing microorganism. Caccavo, F.; Lonergan, D. J.; Lovley, D. R. Applied and Environmental Microbiology, Vol. 60, Issue 10 https://doi.org/10.1128/AEM.60.10.3752-3759.1994	journal	January 1994
The biochemical consequences of hypoxia. Alberti, K. G. Journal of Clinical Pathology, Vol. s3-11, Issue 1 https://doi.org/10.1136/jcp.s3-11.1.14	journal	January 1977
Magnetotactic Bacteria Blakemore, R. P. Annual Review of Microbiology, Vol. 36, Issue 1 https://doi.org/10.1146/annurev.mi.36.100182.001245	journal	October 1982
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association Benjamin, Emelia J.; Blaha, Michael J.; Chiuve, Stephanie E. Circulation, Vol. 135, Issue 10 https://doi.org/10.1161/CIR.0000000000000485	journal	March 2017
The definition of stroke Coupland, Alexander P.; Thapar, Ankur; Qureshi, Mahim I. Journal of the Royal Society of Medicine, Vol. 110, Issue 1 https://doi.org/10.1177/0141076816680121	journal	January 2017
Scaling of Topologically Similar Functional Modules Defines Mouse Primary Auditory and Somatosensory Microcircuitry Sadovsky, A. J.; MacLean, J. N. Journal of Neuroscience, Vol. 33, Issue 35 https://doi.org/10.1523/JNEUROSCI.1977-13.2013	journal	August 2013
Microfabricated magnetic structures for future medicine: from sensors to cell actuators Vitol, Elina A.; Novosad, Valentyn; Rozhkova, Elena A. Nanomedicine, Vol. 7, Issue 10 https://doi.org/10.2217/nnm.12.133	journal	October 2012
NAD+ and NADH in brain functions, brain diseases and brain aging Ying, Weihai Frontiers in Bioscience, Vol. 12, Issue 1 https://doi.org/10.2741/2194	journal	January 2007
Hypoxic-ischemic brain injury: Pathophysiology, neuropathology and mechanisms Busl, Katharina M.; Greer, David M. NeuroRehabilitation, Vol. 26, Issue 1 https://doi.org/10.3233/NRE-2010-0531	journal	January 2010

Similar Records

Products and methods for organ protection with noble nanoparticles

Patent · 2024 · OSTI ID:2542441

Rozhkova, Elena A.; Shevchenko, Elena

Biosynthesis of Gold Nanoparticles Using Pseudomonas Aeruginosa

Journal Article · 2007 · AIP Conference Proceedings · OSTI ID:21054896

Abd El-Aziz, M; Badr, Y; Mahmoud, M A

Structure, magnetic and cytotoxic behaviour of solvothermally grown Fe3O4@Au core-shell nanoparticles

Journal Article · 2018 · Materials Characterization · OSTI ID:22805080

Pinon-Hernandez, J. R.; Estevez-Gonzalez, M.; Pal, U.; +2 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Citation Formats

References (51)

Similar Records

Related Subjects