skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

This content will become publicly available on November 7, 2020

Title: Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Abstract

While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose the concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science - Office of Basic Energy Sciences - Scientific User Facilities Division; USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1605134
Alternate Identifier(s):
OSTI ID: 1563002
Grant/Contract Number:  
[AC02-06CH11357]
Resource Type:
Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
[ Journal Volume: 11; Journal Issue: 41]
Country of Publication:
United States
Language:
English

Citation Formats

Rozhkova, Elena A., Lee, Byeongdu, Prasad, Judy A., Liu, Yuzi, and Shevchenko, Elena V. Hypoxia-induced biosynthesis of gold nanoparticles in the living brain. United States: N. p., 2019. Web. doi:10.1039/c9nr05794c.
Rozhkova, Elena A., Lee, Byeongdu, Prasad, Judy A., Liu, Yuzi, & Shevchenko, Elena V. Hypoxia-induced biosynthesis of gold nanoparticles in the living brain. United States. doi:10.1039/c9nr05794c.
Rozhkova, Elena A., Lee, Byeongdu, Prasad, Judy A., Liu, Yuzi, and Shevchenko, Elena V. Thu . "Hypoxia-induced biosynthesis of gold nanoparticles in the living brain". United States. doi:10.1039/c9nr05794c.
@article{osti_1605134,
title = {Hypoxia-induced biosynthesis of gold nanoparticles in the living brain},
author = {Rozhkova, Elena A. and Lee, Byeongdu and Prasad, Judy A. and Liu, Yuzi and Shevchenko, Elena V.},
abstractNote = {While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose the concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.},
doi = {10.1039/c9nr05794c},
journal = {Nanoscale},
number = [41],
volume = [11],
place = {United States},
year = {2019},
month = {11}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on November 7, 2020
Publisher's Version of Record

Save / Share:

Works referenced in this record:

The biochemical consequences of hypoxia.
journal, January 1977


Cellular Mechanisms of Brain Energy Metabolism. Relevance to Functional Brain Imaging and to Neurodegenerative Disordersa
journal, January 1996


The definition of stroke
journal, January 2017

  • Coupland, Alexander P.; Thapar, Ankur; Qureshi, Mahim I.
  • Journal of the Royal Society of Medicine, Vol. 110, Issue 1
  • DOI: 10.1177/0141076816680121

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
journal, March 2017


Hypoxic-ischemic brain injury: Pathophysiology, neuropathology and mechanisms
journal, January 2010


Brain Levels of NADH and NAD + Under Hypoxic and Hypoglycaemic Conditions In Vitro
journal, July 1988


NAD+ and NADH in brain functions, brain diseases and brain aging
journal, January 2007

  • Ying, Weihai
  • Frontiers in Bioscience, Vol. 12, Issue 1
  • DOI: 10.2741/2194

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
journal, April 2016


Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
journal, December 2013


Nanoscale Materials for Tackling Brain Cancer: Recent Progress and Outlook
journal, April 2011


Microfabricated magnetic structures for future medicine: from sensors to cell actuators
journal, October 2012

  • Vitol, Elina A.; Novosad, Valentyn; Rozhkova, Elena A.
  • Nanomedicine, Vol. 7, Issue 10
  • DOI: 10.2217/nnm.12.133

Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance
journal, December 2016


Stimuli-Responsive Magnetic Nanomicelles as Multifunctional Heat and Cargo Delivery Vehicles
journal, December 2012

  • Kim, Dong-Hyun; Vitol, Elina A.; Liu, Jing
  • Langmuir, Vol. 29, Issue 24
  • DOI: 10.1021/la3044158

Efficient Cisplatin Pro-Drug Delivery Visualized with Sub-100 nm Resolution: Interfacing Engineered Thermosensitive Magnetomicelles with a Living System
journal, June 2014

  • Vitol, Elina A.; Rozhkova, Elena A.; Rose, Volker
  • Advanced Materials Interfaces, Vol. 1, Issue 7
  • DOI: 10.1002/admi.201400182

Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells
journal, February 2018


Ceria Nanoparticles that can Protect against Ischemic Stroke
journal, September 2012

  • Kim, Chi Kyung; Kim, Taeho; Choi, In-Young
  • Angewandte Chemie International Edition, Vol. 51, Issue 44
  • DOI: 10.1002/anie.201203780

Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia
journal, September 2011


Custom Cerium Oxide Nanoparticles Protect against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain
journal, November 2013

  • Heckman, Karin L.; DeCoteau, William; Estevez, Ana
  • ACS Nano, Vol. 7, Issue 12
  • DOI: 10.1021/nn403743b

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease
journal, January 2016


Gold Nanoparticles for Biology and Medicine
journal, April 2010

  • Giljohann, David A.; Seferos, Dwight S.; Daniel, Weston L.
  • Angewandte Chemie International Edition, Vol. 49, Issue 19, p. 3280-3294
  • DOI: 10.1002/anie.200904359

Gold Nanoparticles in Biology: Beyond Toxicity to Cellular Imaging
journal, December 2008

  • Murphy, Catherine J.; Gole, Anand M.; Stone, John W.
  • Accounts of Chemical Research, Vol. 41, Issue 12
  • DOI: 10.1021/ar800035u

Gold Nanoparticles: A Revival in Precious Metal Administration to Patients
journal, October 2011

  • Thakor, A. S.; Jokerst, J.; Zavaleta, C.
  • Nano Letters, Vol. 11, Issue 10
  • DOI: 10.1021/nl202559p

Antioxidant activity of nanomaterials
journal, January 2018

  • Valgimigli, Luca; Baschieri, Andrea; Amorati, Riccardo
  • Journal of Materials Chemistry B, Vol. 6, Issue 14
  • DOI: 10.1039/C8TB00107C

Antioxidant-potentiality of gold–chitosan nanocomposites
journal, October 2003


Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging
journal, January 2013


Interactions between the Isolated Oxygenase and Reductase Domains of Neuronal Nitric-oxide Synthase: ASSESSING THE ROLE OF CALMODULIN
journal, May 2002

  • Rozhkova, E. A.; Fujimoto, N.; Sagami, I.
  • Journal of Biological Chemistry, Vol. 277, Issue 19
  • DOI: 10.1074/jbc.M200642200

Gold nanoparticles: Catalyst for the oxidation of NADH to NAD+
journal, November 2005


Quantifying thiol–gold interactions towards the efficient strength control
journal, July 2014

  • Xue, Yurui; Li, Xun; Li, Hongbin
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms5348

Scaling of Topologically Similar Functional Modules Defines Mouse Primary Auditory and Somatosensory Microcircuitry
journal, August 2013


Small Angle X-ray Scattering for Nanoparticle Research
journal, April 2016


Heterogeneous nucleation and shape transformation of multicomponent metallic nanostructures
journal, November 2014

  • Kwon, Soon Gu; Krylova, Galyna; Phillips, Patrick J.
  • Nature Materials, Vol. 14, Issue 2
  • DOI: 10.1038/nmat4115

Determination of Nanocrystal Sizes:  A Comparison of TEM, SAXS, and XRD Studies of Highly Monodisperse CoPt 3 Particles
journal, March 2005

  • Borchert, Holger; Shevchenko, Elena V.; Robert, Aymeric
  • Langmuir, Vol. 21, Issue 5
  • DOI: 10.1021/la0477183

Ferreting out the secrets of plant ferritin ‐ A review
journal, January 1982


Genome of Geobacter sulfurreducens: Metal Reduction in Subsurface Environments
journal, December 2003

  • Methe, B. A.; Nelson, K. E.; Eisen, J. A.
  • Science, Vol. 302, Issue 5652, p. 1967-1969
  • DOI: 10.1126/science.1088727

Genome sequence of the dissimilatory metal ion–reducing bacterium Shewanella oneidensis
journal, October 2002

  • Heidelberg, John F.; Paulsen, Ian T.; Nelson, Karen E.
  • Nature Biotechnology, Vol. 20, Issue 11
  • DOI: 10.1038/nbt749

Magnetotactic bacteria
journal, October 1975


Rapid in situ biosynthesis of gold nanoparticles in living platelets for multimodal biomedical imaging
journal, March 2018


Rapid and accurate tumor-target bio-imaging through specific in vivo biosynthesis of a fluorescent europium complex
journal, January 2016

  • Ye, Jing; Wang, Jianling; Li, Qiwei
  • Biomaterials Science, Vol. 4, Issue 4
  • DOI: 10.1039/C5BM00528K

In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters
journal, January 2013

  • Wang, Jianling; Zhang, Gen; Li, Qiwei
  • Scientific Reports, Vol. 3, Issue 1
  • DOI: 10.1038/srep01157

Visualizing reactive oxygen species inside cancer cells after stimulation with polycyclic aromatic hydrocarbon via spontaneous formation of Au nanoclusters
journal, February 2015


Near-infrared fluorescence imaging of cancer cells and tumors through specific biosynthesis of silver nanoclusters
journal, March 2014

  • Gao, Shengping; Chen, Donghua; Li, Qiwei
  • Scientific Reports, Vol. 4, Issue 1
  • DOI: 10.1038/srep04384

In Situ Biosynthesis of Fluorescent Platinum Nanoclusters: Toward Self-Bioimaging-Guided Cancer Theranostics
journal, August 2015

  • Chen, Donghua; Zhao, Chunqiu; Ye, Jing
  • ACS Applied Materials & Interfaces, Vol. 7, Issue 32
  • DOI: 10.1021/acsami.5b05805

Intracellular accumulation and immunological properties of fluorescent gold nanoclusters in human dendritic cells
journal, March 2015


The golden age: gold nanoparticles for biomedicine
journal, January 2012

  • Dreaden, Erik C.; Alkilany, Alaaldin M.; Huang, Xiaohua
  • Chem. Soc. Rev., Vol. 41, Issue 7
  • DOI: 10.1039/C1CS15237H

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection
journal, March 2016

  • Tran, Mei T.; Zsengeller, Zsuzsanna K.; Berg, Anders H.
  • Nature, Vol. 531, Issue 7595
  • DOI: 10.1038/nature17184

Restoration of brain circulation and cellular functions hours post-mortem
journal, April 2019