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Title: Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

Abstract

While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose herein the novel concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [1]; ORCiD logo [1]
  1. Argonne National Lab. (ANL), Lemont, IL (United States). Center for Nanoscale Materials
  2. Argonne National Lab., Lemont, IL (United States). X-ray Science Division
  3. Univ. of Chicago, IL (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1605134
Alternate Identifier(s):
OSTI ID: 1563002
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
Journal Volume: 11; Journal Issue: 41; Journal ID: ISSN 2040-3364
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Rozhkova, Elena A., Lee, Byeongdu, Prasad, Judy A., Liu, Yuzi, and Shevchenko, Elena V. Hypoxia-induced biosynthesis of gold nanoparticles in the living brain. United States: N. p., 2019. Web. doi:10.1039/c9nr05794c.
Rozhkova, Elena A., Lee, Byeongdu, Prasad, Judy A., Liu, Yuzi, & Shevchenko, Elena V. Hypoxia-induced biosynthesis of gold nanoparticles in the living brain. United States. doi:https://doi.org/10.1039/c9nr05794c
Rozhkova, Elena A., Lee, Byeongdu, Prasad, Judy A., Liu, Yuzi, and Shevchenko, Elena V. Fri . "Hypoxia-induced biosynthesis of gold nanoparticles in the living brain". United States. doi:https://doi.org/10.1039/c9nr05794c. https://www.osti.gov/servlets/purl/1605134.
@article{osti_1605134,
title = {Hypoxia-induced biosynthesis of gold nanoparticles in the living brain},
author = {Rozhkova, Elena A. and Lee, Byeongdu and Prasad, Judy A. and Liu, Yuzi and Shevchenko, Elena V.},
abstractNote = {While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose herein the novel concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.},
doi = {10.1039/c9nr05794c},
journal = {Nanoscale},
number = 41,
volume = 11,
place = {United States},
year = {2019},
month = {9}
}

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