DNA origami protection and molecular interfacing through engineered sequence-defined peptoids

Wang, Shih-Ting; Gray, Melissa A.; Xuan, Sunting; Lin, Yiyang; Byrnes, James; Nguyen, Andy I.; Todorova, Nevena; Stevens, Molly M.; Bertozzi, Carolyn R.; Zuckermann, Ronald N.; Gang, Oleg

doi:10.1073/pnas.1919749117

Title: DNA origami protection and molecular interfacing through engineered sequence-defined peptoids

Journal Article · 12 March 2020 · Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.1919749117 · OSTI ID:1604260

Wang, Shih-Ting ^[1]; Gray, Melissa A. ^[2];

^[3]; Lin, Yiyang ^[4]; Byrnes, James ^[5]; Nguyen, Andy I. ^[3];

^[6]; Stevens, Molly M. ^[4];

^[7];

^[3]; Gang, Oleg ^[1]

Brookhaven National Lab. (BNL), Upton, NY (United States). Center for Functional Nanomaterials (CFN)
Stanford Univ., CA (United States). Dept. of Chemistry
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Imperial College, London (United Kingdom)
Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
Royal Melbourne Inst. of Technology (Australia)
Stanford Univ., CA (United States). Dept. of Chemistry and Howard Hughes Medical Inst.

DNA nanotechnology provides a structural toolkit for the fabrication of programmable DNA nano-constructs; however, their use in biomedical applications is challenging due the limited structural integrity in complex biological fluids. Here, we report a class of tailorable molecular coatings, peptoids, which can efficiently stabilize three-dimensional wireframed DNA constructs under a variety of biomedically relevant conditions, including magnesium-ion depletion and presence of degrading nuclease. Furthermore, we show that peptoid-coated DNA constructs offer a controllable anticancer drug release and an ability to display functional biomolecules on the DNA surfaces. Our study demonstrates an approach for building multifunctional and environmentally robust DNA-based molecular structures for nanomedicine and biosensing.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0012704; AC02-05CH11231; SC0008772; KP1605010

OSTI ID:: 1604260

Alternate ID(s):: OSTI ID: 1607714

Report Number(s):: BNL-213757-2020-JAAM

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 12; ISSN 0027-8424

Publisher:: National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 77 works

Citation information provided by
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Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility Auvinen, Henni; Zhang, Hongbo Advanced Healthcare Materials, Vol. 6, Issue 18 https://doi.org/10.1002/adhm.201700692	journal	July 2017

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Title: DNA origami protection and molecular interfacing through engineered sequence-defined peptoids

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