DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: mSphere of Influence: Comprehensive Genetic Analysis

Journal Article · · mSphere
ORCiD logo [1]
  1. Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin—Madison, Madison, Wisconsin, USA, Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA, Department of Medical Microbiology and Immunology, University of Wisconsin—Madison, Madison, Wisconsin, USA, Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin—Madison, Madison, Wisconsin, USA

Jason M. Peters works in the fields of antibiotic resistance and biofuel production. In this mSphere of Influence article, he reflects on how the paper “A global genetic interaction network maps a wiring diagram of cellular function” by Costanzo et al. (Science 353:aaf1420, 2016, https://doi.org/10.1126/science.aaf1420 ) has impacted his work by highlighting the power of gene networks to uncover new biology.

Sponsoring Organization:
USDOE
Grant/Contract Number:
SC0018409
OSTI ID:
1604099
Journal Information:
mSphere, Journal Name: mSphere Vol. 5 Journal Issue: 2; ISSN 2379-5042
Publisher:
American Society for MicrobiologyCopyright Statement
Country of Publication:
United States
Language:
English

References (9)

Systematic exploration of essential yeast gene function with temperature-sensitive mutants journal March 2011
Global Mapping of the Yeast Genetic Interaction Network journal February 2004
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria journal June 2016
A global genetic interaction network maps a wiring diagram of cellular function journal September 2016
Genetic interaction mapping in mammalian cells using CRISPR interference journal May 2017
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis journal August 1999
Mapping the Genetic Landscape of Human Cells journal August 2018
The Genetic Landscape of a Cell journal January 2010
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions journal January 2007