A proteomic atlas of senescence-associated secretomes for aging biomarker development
Abstract
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present the "SASP Atlas," a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors originating from multiple senescence inducers and cell types. Each profile consists of hundreds of largely distinct proteins but also includes a subset of proteins elevated in all SASPs. Our analyses identify several candidate biomarkers of cellular senescence that overlap with aging markers in human plasma, including Growth/differentiation factor 15 (GDF15), stanniocalcin 1 (STC1), and serine protease inhibitors (SERPINs), which significantly correlated with age in plasma from a human cohort, the Baltimore Longitudinal Study of Aging (BLSA). Our findings will facilitate the identification of proteins characteristic of senescence-associated phenotypes and catalog potential senescence biomarkers to assess the burden, originating stimulus, and tissue of origin of senescent cells in vivo.
- Authors:
-
[1];
[1];
[2];
[1];
[1];
[3];
- The Buck Inst. for Research on Aging, Novato, CA (United States)
- The Buck Inst. for Research on Aging, Novato, CA (United States); Korea Univ. College of Medicine, Seoul (Korea)
- Univ. of Washington, Seattle, WA (United States)
- National Inst. of Health (NIH), Baltimore, MD (United States)
- The Buck Inst. for Research on Aging, Novato, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- International Review Board (IRB), Barcelona (Spain)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institute on Aging; National Institutes of Health (NIH); Glenn Foundation for Medical Research; SENS Foundation; University of Washington
- OSTI Identifier:
- 1603602
- Grant/Contract Number:
- AC02-05CH11231; AG060906-02; P01AG017242; R01AG051729; 1S10 OD016281; UWPR95794
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Biology (Online)
- Additional Journal Information:
- Journal Name: PLoS Biology (Online); Journal Volume: 18; Journal Issue: 1; Journal ID: ISSN 1545-7885
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; fibroblasts; biomarkers; epithelial cells; senescence; transcriptome analysis; exosomes; blood plasma
Citation Formats
Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit, and Serrano, Manuel. A proteomic atlas of senescence-associated secretomes for aging biomarker development. United States: N. p., 2020.
Web. doi:10.1371/journal.pbio.3000599.
Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit, & Serrano, Manuel. A proteomic atlas of senescence-associated secretomes for aging biomarker development. United States. doi:https://doi.org/10.1371/journal.pbio.3000599
Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit, and Serrano, Manuel. Thu .
"A proteomic atlas of senescence-associated secretomes for aging biomarker development". United States. doi:https://doi.org/10.1371/journal.pbio.3000599. https://www.osti.gov/servlets/purl/1603602.
@article{osti_1603602,
title = {A proteomic atlas of senescence-associated secretomes for aging biomarker development},
author = {Basisty, Nathan and Kale, Abhijit and Jeon, Ok Hee and Kuehnemann, Chisaka and Payne, Therese and Rao, Chirag and Holtz, Anja and Shah, Samah and Sharma, Vagisha and Ferrucci, Luigi and Campisi, Judith and Schilling, Birgit and Serrano, Manuel},
abstractNote = {The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present the "SASP Atlas," a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors originating from multiple senescence inducers and cell types. Each profile consists of hundreds of largely distinct proteins but also includes a subset of proteins elevated in all SASPs. Our analyses identify several candidate biomarkers of cellular senescence that overlap with aging markers in human plasma, including Growth/differentiation factor 15 (GDF15), stanniocalcin 1 (STC1), and serine protease inhibitors (SERPINs), which significantly correlated with age in plasma from a human cohort, the Baltimore Longitudinal Study of Aging (BLSA). Our findings will facilitate the identification of proteins characteristic of senescence-associated phenotypes and catalog potential senescence biomarkers to assess the burden, originating stimulus, and tissue of origin of senescent cells in vivo.},
doi = {10.1371/journal.pbio.3000599},
journal = {PLoS Biology (Online)},
number = 1,
volume = 18,
place = {United States},
year = {2020},
month = {1}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 24 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis
journal, January 2012
- Gillet, Ludovic C.; Navarro, Pedro; Tate, Stephen
- Molecular & Cellular Proteomics, Vol. 11, Issue 6
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
journal, January 2019
- Abdul-Aziz, Amina M.; Sun, Yu; Hellmich, Charlotte
- Blood, Vol. 133, Issue 5
Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells
journal, November 2015
- Capasso, Stefania; Alessio, Nicola; Squillaro, Tiziana
- Oncotarget, Vol. 6, Issue 37
Unmasking Transcriptional Heterogeneity in Senescent Cells
journal, September 2017
- Hernandez-Segura, Alejandra; de Jong, Tristan V.; Melov, Simon
- Current Biology, Vol. 27, Issue 17
Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging
journal, January 2015
- Neves, Joana; Demaria, Marco; Campisi, Judith
- Developmental Cell, Vol. 32, Issue 1
Cerebrospinal Fluid Stanniocalcin-1 as a Biomarker for Alzheimer’s Disease and Other Neurodegenerative Disorders
journal, September 2016
- Shahim, Pashtun; Blennow, Kaj; Johansson, Per
- NeuroMolecular Medicine, Vol. 19, Issue 1
Senescent cells and osteoarthritis: a painful connection
journal, April 2018
- Jeon, Ok Hee; David, Nathaniel; Campisi, Judith
- Journal of Clinical Investigation, Vol. 128, Issue 4
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
journal, August 2015
- Herranz, Nicolás; Gallage, Suchira; Mellone, Massimiliano
- Nature Cell Biology, Vol. 17, Issue 9
Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer
journal, November 2009
- Roy, Roopali; Yang, Jiang; Moses, Marsha A.
- Journal of Clinical Oncology, Vol. 27, Issue 31
Panorama: A Targeted Proteomics Knowledge Base
journal, July 2014
- Sharma, Vagisha; Eckels, Josh; Taylor, Greg K.
- Journal of Proteome Research, Vol. 13, Issue 9
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
journal, January 2010
- Coppé, Jean-Philippe; Desprez, Pierre-Yves; Krtolica, Ana
- Annual Review of Pathology: Mechanisms of Disease, Vol. 5, Issue 1
The oncogenetic role of stanniocalcin 1 in lung adenocarcinoma: a promising serum candidate biomarker for tracking lung adenocarcinoma progression
journal, November 2015
- Du, Yu-Zhen; Gu, Xiao-Hua; Cheng, Shao-Fei
- Tumor Biology, Vol. 37, Issue 4
A senescent cell bystander effect: senescence-induced senescence: Senescence induces senescence
journal, February 2012
- Nelson, Glyn; Wordsworth, James; Wang, Chunfang
- Aging Cell, Vol. 11, Issue 2
Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry
journal, August 2017
- Collins, Ben C.; Hunter, Christie L.; Liu, Yansheng
- Nature Communications, Vol. 8, Issue 1
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
journal, December 2014
- Rai, Taranjit Singh; Cole, John J.; Nelson, David M.
- Genes & Development, Vol. 28, Issue 24
ExoCarta: A Web-Based Compendium of Exosomal Cargo
journal, February 2016
- Keerthikumar, Shivakumar; Chisanga, David; Ariyaratne, Dinuka
- Journal of Molecular Biology, Vol. 428, Issue 4
Multiplexed peptide analysis using data-independent acquisition and Skyline
journal, May 2015
- Egertson, Jarrett D.; MacLean, Brendan; Johnson, Richard
- Nature Protocols, Vol. 10, Issue 6
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
journal, March 2013
- Tchkonia, Tamara; Zhu, Yi; van Deursen, Jan
- Journal of Clinical Investigation, Vol. 123, Issue 3
Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq
journal, May 2016
- Marthandan, S.; Baumgart, M.; Priebe, S.
- PLOS ONE, Vol. 11, Issue 5
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
journal, May 2014
- Franceschi, C.; Campisi, J.
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 69, Issue Suppl 1
MS1 Peptide Ion Intensity Chromatograms in MS2 (SWATH) Data Independent Acquisitions. Improving Post Acquisition Analysis of Proteomic Experiments
journal, May 2015
- Rardin, Matthew J.; Schilling, Birgit; Cheng, Lin-Yang
- Molecular & Cellular Proteomics, Vol. 14, Issue 9
Clinical and Genetic Correlates of Growth Differentiation Factor 15 in the Community
journal, November 2012
- Ho, Jennifer E.; Mahajan, Anubha; Chen, Ming-Huei
- Clinical Chemistry, Vol. 58, Issue 11
GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men
journal, December 2013
- Wallentin, Lars; Zethelius, Björn; Berglund, Lars
- PLoS ONE, Vol. 8, Issue 12
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
journal, December 2014
- Demaria, Marco; Ohtani, Naoko; Youssef, Sameh A.
- Developmental Cell, Vol. 31, Issue 6
Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma
journal, July 2016
- Chen, Yu-Kuei; Tung, Chun-Wei; Lee, Jui-Ying
- Scientific Reports, Vol. 6, Issue 1
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
journal, May 2013
- Davalos, Albert R.; Kawahara, Misako; Malhotra, Gautam K.
- The Journal of Cell Biology, Vol. 201, Issue 4
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
journal, December 2008
- Coppé, Jean-Philippe; Patil, Christopher K.; Rodier, Francis
- PLoS Biology, Vol. 6, Issue 12
Astrocyte Senescence as a Component of Alzheimer’s Disease
journal, September 2012
- Bhat, Rekha; Crowe, Elizabeth P.; Bitto, Alessandro
- PLoS ONE, Vol. 7, Issue 9
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
journal, December 2015
- Chang, Jianhui; Wang, Yingying; Shao, Lijian
- Nature Medicine, Vol. 22, Issue 1
A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen
journal, February 2010
- Coppé, Jean-Philippe; Patil, Christopher K.; Rodier, Francis
- PLoS ONE, Vol. 5, Issue 2
DAMPs as mediators of sterile inflammation in aging-related pathologies
journal, November 2015
- Feldman, Noa; Rotter-Maskowitz, Aviva; Okun, Eitan
- Ageing Research Reviews, Vol. 24
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
journal, November 2006
- Di Micco, Raffaella; Fumagalli, Marzia; Cicalese, Angelo
- Nature, Vol. 444, Issue 7119
STC1 expression is associated with tumor growth and metastasis in breast cancer
journal, November 2014
- Chang, Andy C-M; Doherty, Judy; Huschtscha, Lily I.
- Clinical & Experimental Metastasis, Vol. 32, Issue 1
Senescence-Associated Exosome Release from Human Prostate Cancer Cells
journal, October 2008
- Lehmann, B. D.; Paine, M. S.; Brooks, A. M.
- Cancer Research, Vol. 68, Issue 19
DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’
journal, November 2015
- Huang, Jin; Xie, Yangchun; Sun, Xiaofang
- Ageing Research Reviews, Vol. 24
Plasma proteomic signature of age in healthy humans
journal, July 2018
- Tanaka, Toshiko; Biancotto, Angelique; Moaddel, Ruin
- Aging Cell, Vol. 17, Issue 5
HIV protease inhibitors induce senescence and alter osteoblastic potential of human bone marrow mesenchymal stem cells: beneficial effect of pravastatin
journal, July 2013
- Hernandez-Vallejo, Sandra J.; Beaupere, Carine; Larghero, Jerome
- Aging Cell, Vol. 12, Issue 6
Predictive Properties of Biomarkers GDF-15, NTproBNP, and hs-TnT for Morbidity and Mortality in Patients With Type 2 Diabetes With Nephropathy
journal, March 2017
- Bidadkosh, Arash; Lambooy, Sebastiaan P. H.; Heerspink, Hiddo J.
- Diabetes Care, Vol. 40, Issue 6
Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease
journal, January 2017
- Wollert, Kai C.; Kempf, Tibor; Wallentin, Lars
- Clinical Chemistry, Vol. 63, Issue 1
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
journal, December 2016
- Demaria, Marco; O'Leary, Monique N.; Chang, Jianhui
- Cancer Discovery, Vol. 7, Issue 2
Cellular senescence in the aging and diseased kidney
journal, December 2017
- Valentijn, F. A.; Falke, L. L.; Nguyen, T. Q.
- Journal of Cell Communication and Signaling, Vol. 12, Issue 1
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
journal, February 2016
- Baker, Darren J.; Childs, Bennett G.; Durik, Matej
- Nature, Vol. 530, Issue 7589
Secreted proteins as a fundamental source for biomarker discovery
journal, January 2012
- Stastna, Miroslava; Van Eyk, Jennifer E.
- PROTEOMICS, Vol. 12, Issue 4-5
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
journal, June 2008
- Acosta, Juan C.; O'Loghlen, Ana; Banito, Ana
- Cell, Vol. 133, Issue 6
A repository of assays to quantify 10,000 human proteins by SWATH-MS
journal, September 2014
- Rosenberger, George; Koh, Ching Chiek; Guo, Tiannan
- Scientific Data, Vol. 1, Issue 1
Role of oxidatively induced DNA lesions in human pathogenesis
journal, April 2010
- Sedelnikova, Olga A.; Redon, Christophe E.; Dickey, Jennifer S.
- Mutation Research/Reviews in Mutation Research, Vol. 704, Issue 1-3
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
journal, February 2009
- Bindea, Gabriela; Mlecnik, Bernhard; Hackl, Hubert
- Bioinformatics, Vol. 25, Issue 8
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
journal, June 2008
- Kuilman, Thomas; Michaloglou, Chrysiis; Vredeveld, Liesbeth C. W.
- Cell, Vol. 133, Issue 6
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
journal, October 2016
- Childs, B. G.; Baker, D. J.; Wijshake, T.
- Science, Vol. 354, Issue 6311
Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues
journal, February 2015
- Bruderer, Roland; Bernhardt, Oliver M.; Gandhi, Tejas
- Molecular & Cellular Proteomics, Vol. 14, Issue 5
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
journal, November 2003
- Shannon, P.
- Genome Research, Vol. 13, Issue 11
Biomarkers of Cardiovascular Stress and Incident Chronic Kidney Disease
journal, November 2013
- Ho, Jennifer E.; Hwang, Shih-Jen; Wollert, Kai C.
- Clinical Chemistry, Vol. 59, Issue 11
Association of Growth Differentiation Factor-15 with Coronary Atherosclerosis and Mortality in a Young, Multiethnic Population: Observations from the Dallas Heart Study
journal, January 2012
- Rohatgi, Anand; Patel, Parag; Das, Sandeep R.
- Clinical Chemistry, Vol. 58, Issue 1
Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults: The Rancho Bernardo Study
journal, May 2011
- Daniels, Lori B.; Clopton, Paul; Laughlin, Gail A.
- Circulation, Vol. 123, Issue 19
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
journal, July 2009
- Rodier, Francis; Coppé, Jean-Philippe; Patil, Christopher K.
- Nature Cell Biology, Vol. 11, Issue 8
Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
journal, June 2016
- Özcan, Servet; Alessio, Nicola; Acar, Mustafa
- Aging, Vol. 8, Issue 7
Panorama Public: A Public Repository for Quantitative Data Sets Processed in Skyline
journal, February 2018
- Sharma, Vagisha; Eckels, Josh; Schilling, Birgit
- Molecular & Cellular Proteomics, Vol. 17, Issue 6
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
journal, November 2011
- Baker, Darren J.; Wijshake, Tobias; Tchkonia, Tamar
- Nature, Vol. 479, Issue 7372
Transcriptome signature of cellular senescence
journal, June 2019
- Casella, Gabriel; Munk, Rachel; Kim, Kyoung Mi
- Nucleic Acids Research, Vol. 47, Issue 14
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
journal, June 2013
- Acosta, Juan Carlos; Banito, Ana; Wuestefeld, Torsten
- Nature Cell Biology, Vol. 15, Issue 8
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells
journal, September 2019
- Wiley, Christopher D.; Liu, Su; Limbad, Chandani
- Cell Reports, Vol. 28, Issue 13
Stanniocalcin-1, a new biomarker of glioma progression, is associated with prognosis of patients
journal, March 2015
- Su, Jingyuan; Guo, Bingyu; Zhang, Tingting
- Tumor Biology, Vol. 36, Issue 8
Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
journal, June 2019
- Borghesan, Michela; Fafián-Labora, Juan; Eleftheriadou, Olga
- Cell Reports, Vol. 27, Issue 13
Stanniocalcin-1 Inhibits Renal Ischemia/Reperfusion Injury via an AMP-Activated Protein Kinase-Dependent Pathway
journal, July 2014
- Pan, Jenny Szu-Chin; Huang, Luping; Belousova, Tatiana
- Journal of the American Society of Nephrology, Vol. 26, Issue 2
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
journal, March 2006
- Théry, Clotilde; Amigorena, Sebastian; Raposo, Graça
- Current Protocols in Cell Biology, Vol. 30, Issue 1
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
journal, March 2017
- Baar, Marjolein P.; Brandt, Renata M. C.; Putavet, Diana A.
- Cell, Vol. 169, Issue 1
Janus-Faced PIDD: A Sensor for DNA Damage-Induced Cell Death or Survival?
journal, September 2012
- McCoy, Francis; Eckard, Laura; Nutt, Leta K.
- Molecular Cell, Vol. 47, Issue 5
Emerging roles of extracellular vesicles in cellular senescence and aging
journal, February 2018
- Takasugi, Masaki
- Aging Cell, Vol. 17, Issue 2
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
journal, November 2002
- Bonifati, V.
- Science, Vol. 299, Issue 5604
Amyloid Precursor Protein Processing and Alzheimer's Disease
journal, July 2011
- O'Brien, Richard J.; Wong, Philip C.
- Annual Review of Neuroscience, Vol. 34, Issue 1
Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers
journal, February 2019
- Jeon, Ok Hee; Wilson, David R.; Clement, Cristina C.
- JCI Insight, Vol. 4, Issue 7
MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis
journal, April 2008
- Rosas, Ivan O.; Richards, Thomas J.; Konishi, Kazuhisa
- PLoS Medicine, Vol. 5, Issue 4
Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer
journal, August 2015
- Fucikova, Jitka; Moserova, Irena; Urbanova, Linda
- Frontiers in Immunology, Vol. 6
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
journal, November 2015
- Garg, Abhishek D.; Galluzzi, Lorenzo; Apetoh, Lionel
- Frontiers in Immunology, Vol. 6
Cystatin C in Alzheimer's disease
journal, January 2012
- Kaur, Gurjinder; Levy, Efrat
- Frontiers in Molecular Neuroscience, Vol. 5
Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples
journal, January 2016
- Belov, Larissa; Matic, Kieran J.; Hallal, Susannah
- Journal of Extracellular Vesicles, Vol. 5, Issue 1
The emerging role of senescent cells in tissue homeostasis and pathophysiology
journal, January 2015
- Tominaga, Kaoru
- Pathobiology of Aging & Age-related Diseases, Vol. 5, Issue 1
Myriad Functions of Stanniocalcin-1 (STC1) Cover Multiple Therapeutic Targets in the Complicated Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)
journal, January 2015
- Ohkouchi, Shinya; Ono, Manabu; Kobayashi, Makoto
- Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol. 9s1
Works referencing / citing this record:
Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging
journal, July 2020
- Boroni, Mariana; Zonari, Alessandra; Reis de Oliveira, Carolina
- Clinical Epigenetics, Vol. 12, Issue 1