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Title: Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off–on cytotoxicity

Abstract

PEG- b -PPS bicontinuous nanospheres resist degradation and stably retain payloads within cells. When loaded with a photosensitizing agent, these nanospheres demonstrate off–on inducible photo-responsive release of cytotoxic agents into the cytosol of cells.

Authors:
 [1];  [2];  [3];  [1];  [2];  [1]; ORCiD logo [4]
  1. Department of Biomedical Engineering, Northwestern University, Evanston, USA
  2. Interdepartmental Biological Sciences Program, Northwestern University, Evanston, USA
  3. Chemistry of Life Processes Institute, Northwestern University, Evanston, USA
  4. Department of Biomedical Engineering, Northwestern University, Evanston, USA, Interdepartmental Biological Sciences Program
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1601310
Grant/Contract Number:  
[AC02-06CH11357]
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Nanoscale
Additional Journal Information:
[Journal Name: Nanoscale Journal Volume: 12 Journal Issue: 9]; Journal ID: ISSN 2040-3364
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Bobbala, Sharan, Allen, Sean D., Yi, Sijia, Vincent, Michael, Frey, Molly, Karabin, Nicholas B., and Scott, Evan A. Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off–on cytotoxicity. United Kingdom: N. p., 2020. Web. doi:10.1039/C9NR10921H.
Bobbala, Sharan, Allen, Sean D., Yi, Sijia, Vincent, Michael, Frey, Molly, Karabin, Nicholas B., & Scott, Evan A. Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off–on cytotoxicity. United Kingdom. doi:10.1039/C9NR10921H.
Bobbala, Sharan, Allen, Sean D., Yi, Sijia, Vincent, Michael, Frey, Molly, Karabin, Nicholas B., and Scott, Evan A. Thu . "Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off–on cytotoxicity". United Kingdom. doi:10.1039/C9NR10921H.
@article{osti_1601310,
title = {Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off–on cytotoxicity},
author = {Bobbala, Sharan and Allen, Sean D. and Yi, Sijia and Vincent, Michael and Frey, Molly and Karabin, Nicholas B. and Scott, Evan A.},
abstractNote = {PEG- b -PPS bicontinuous nanospheres resist degradation and stably retain payloads within cells. When loaded with a photosensitizing agent, these nanospheres demonstrate off–on inducible photo-responsive release of cytotoxic agents into the cytosol of cells.},
doi = {10.1039/C9NR10921H},
journal = {Nanoscale},
number = [9],
volume = [12],
place = {United Kingdom},
year = {2020},
month = {3}
}

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