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Title: Liquid-phase mega-electron-volt ultrafast electron diffraction

Abstract

The conversion of light into usable chemical and mechanical energy is pivotal to several biological and chemical processes, many of which occur in solution. To understand the structure–function relationships mediating these processes, a technique with high spatial and temporal resolutions is required. Here, we report on the design and commissioning of a liquid-phase mega-electron-volt (MeV) ultrafast electron diffraction instrument for the study of structural dynamics in solution. Limitations posed by the shallow penetration depth of electrons and the resulting information loss due to multiple scattering and the technical challenge of delivering liquids to vacuum were overcome through the use of MeV electrons and a gas-accelerated thin liquid sheet jet. To demonstrate the capabilities of this instrument, the structure of water and its network were resolved up to the 3rd hydration shell with a spatial resolution of 0.6 Å; preliminary time-resolved experiments demonstrated a temporal resolution of 200 fs.

Authors:
ORCiD logo [1]; ORCiD logo [2];  [3]; ORCiD logo [3];  [3];  [4];  [5];  [6];  [3];  [3];  [3];  [7]; ORCiD logo [3];  [3];  [3];  [3];  [3]; ORCiD logo [4]; ORCiD logo [8];  [4] more »;  [3] « less
+ Show Author Affiliations
  1. Univ. of Nebraska-Lincoln, NE (United States)
  2. Stanford Univ., Stanford, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford PULSE Inst.
  3. SLAC National Accelerator Lab., Menlo Park, CA (United States)
  4. SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford PULSE Inst.
  5. Univ. of Nebraska-Lincoln, Lincoln, NE (United States)
  6. Stanford Univ., CA (United States). Dept. of Physics
  7. Stony Brook Univ., NY (United States). Dept. of Physics and Astronomy
  8. SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford PULSE Inst.; SLAC National Accelerator Lab., Menlo Park, CA (United States)
Publication Date:
Research Org.:
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences, and Biosciences Division; Melvin and Joan Lane Stanford Graduate Fellowship
OSTI Identifier:
1601104
Alternate Identifier(s):
OSTI ID: 1603722
Grant/Contract Number:  
AC02-76SF00515; AC02-05-CH11231; SC0014170; AC0276SF00515
Resource Type:
Accepted Manuscript
Journal Name:
Structural Dynamics
Additional Journal Information:
Journal Volume: 7; Journal Issue: 2; Journal ID: ISSN 2329-7778
Publisher:
American Crystallographic Association/AIP
Country of Publication:
United States
Language:
English
Subject:
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS

Citation Formats

Nunes, J. P. F., Ledbetter, K., Lin, M., Kozina, M., DePonte, D. P., Biasin, E., Centurion, M., Crissman, C. J., Dunning, M., Guillet, S., Jobe, K., Liu, Y., Mo, M., Shen, X., Sublett, R., Weathersby, S., Yoneda, C., Wolf, Thomas J. A., Yang, J., Cordones, A. A., and Wang, X. J. Liquid-phase mega-electron-volt ultrafast electron diffraction. United States: N. p., 2020. Web. doi:10.1063/1.5144518.
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Nunes, J. P. F., Ledbetter, K., Lin, M., Kozina, M., DePonte, D. P., Biasin, E., Centurion, M., Crissman, C. J., Dunning, M., Guillet, S., Jobe, K., Liu, Y., Mo, M., Shen, X., Sublett, R., Weathersby, S., Yoneda, C., Wolf, Thomas J. A., Yang, J., Cordones, A. A., & Wang, X. J. Liquid-phase mega-electron-volt ultrafast electron diffraction. United States. https://doi.org/10.1063/1.5144518
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Nunes, J. P. F., Ledbetter, K., Lin, M., Kozina, M., DePonte, D. P., Biasin, E., Centurion, M., Crissman, C. J., Dunning, M., Guillet, S., Jobe, K., Liu, Y., Mo, M., Shen, X., Sublett, R., Weathersby, S., Yoneda, C., Wolf, Thomas J. A., Yang, J., Cordones, A. A., and Wang, X. J. Mon . "Liquid-phase mega-electron-volt ultrafast electron diffraction". United States. https://doi.org/10.1063/1.5144518. https://www.osti.gov/servlets/purl/1601104.
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@article{osti_1601104,
title = {Liquid-phase mega-electron-volt ultrafast electron diffraction},
author = {Nunes, J. P. F. and Ledbetter, K. and Lin, M. and Kozina, M. and DePonte, D. P. and Biasin, E. and Centurion, M. and Crissman, C. J. and Dunning, M. and Guillet, S. and Jobe, K. and Liu, Y. and Mo, M. and Shen, X. and Sublett, R. and Weathersby, S. and Yoneda, C. and Wolf, Thomas J. A. and Yang, J. and Cordones, A. A. and Wang, X. J.},
abstractNote = {The conversion of light into usable chemical and mechanical energy is pivotal to several biological and chemical processes, many of which occur in solution. To understand the structure–function relationships mediating these processes, a technique with high spatial and temporal resolutions is required. Here, we report on the design and commissioning of a liquid-phase mega-electron-volt (MeV) ultrafast electron diffraction instrument for the study of structural dynamics in solution. Limitations posed by the shallow penetration depth of electrons and the resulting information loss due to multiple scattering and the technical challenge of delivering liquids to vacuum were overcome through the use of MeV electrons and a gas-accelerated thin liquid sheet jet. To demonstrate the capabilities of this instrument, the structure of water and its network were resolved up to the 3rd hydration shell with a spatial resolution of 0.6 Å; preliminary time-resolved experiments demonstrated a temporal resolution of 200 fs.},
doi = {10.1063/1.5144518},
journal = {Structural Dynamics},
number = 2,
volume = 7,
place = {United States},
year = {Mon Mar 09 00:00:00 EDT 2020},
month = {Mon Mar 09 00:00:00 EDT 2020}
}
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https://doi.org/10.1063/1.5144518
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Mega-electron-volt ultrafast electron diffraction at SLAC National Accelerator Laboratory
journal, July 2015

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Ultrafast Electron Crystallography of Interfacial Water
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Ultrafast X-ray Diffraction of Transient Molecular Structures in Solution
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Thymine Dimerization in DNA Is an Ultrafast Photoreaction
journal, February 2007

Heterogeneous to homogeneous melting transition visualized with ultrafast electron diffraction
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tinyMD: A Portable and Scalable Implementation for Pairwise Interactions Simulations
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