Silica Nanodepletors: Targeting and Clearing Alzheimer's β‐Amyloid Plaques

Jung, Huijin; Chung, You Jung; Wilton, Rosemarie; Lee, Chang Heon; Lee, Byung Il; Lim, Jinyeong; Lee, Hyojin; Choi, Jong‐Ho; Kang, Hyuno; Lee, Byeongdu; Rozhkova, Elena A.; Park, Chan Beum; Lee, Joonseok

doi:10.1002/adfm.201910475

Title: Silica Nanodepletors: Targeting and Clearing Alzheimer's β‐Amyloid Plaques

Journal Article · 17 February 2020 · Advanced Functional Materials

DOI: https://doi.org/10.1002/adfm.201910475 · OSTI ID:1599932

Jung, Huijin ^[1];

^[2]; Wilton, Rosemarie ^[3];

^[2]; Lee, Byung Il ^[2]; Lim, Jinyeong ^[4]; Lee, Hyojin ^[5]; Choi, Jong‐Ho ^[6]; Kang, Hyuno ^[7]; Lee, Byeongdu ^[8]; Rozhkova, Elena A. ^[9]; Park, Chan Beum ^[2];

^[10]

Molecular Recognition Research Center Korea Institute of Science and Technology (KIST) Department of HY‐KIST Bio‐convergence Hanyang University Seoul 02792 Republic of Korea, Department of Chemistry Korea University Seoul 02841 Republic of Korea
Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak‐ro, Yuseong‐gu Daejeon 34141 Republic of Korea
Biosciences Argonne National Laboratory Argonne IL 60439 USA
Gwangju Center Korea Basic Science Institute (KBSI) Gwangju 61186 Republic of Korea
Center for Biomaterials Biomedical Research Institute KIST Seoul 02792 Republic of Korea
Department of Chemistry Korea University Seoul 02841 Republic of Korea
Division of Analytical Science Korea Basic Science Institute (KBSI) Daejeon 34133 Republic of Korea
X‐ray Science Division Argonne National Laboratory Argonne IL 60439 USA
Center for Nanoscale Materials Argonne National Laboratory Argonne IL 60439 USA
Molecular Recognition Research Center Korea Institute of Science and Technology (KIST) Department of HY‐KIST Bio‐convergence Hanyang University Seoul 02792 Republic of Korea

Abstract Abnormal accumulation of β‐amyloid (Aβ) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress Aβ aggregate formation, thereby attenuating Aβ‐induced neurotoxicity. Here, the design of Aβ nanodepletors consisting of ultralarge mesoporous silica nanostructures and anti‐Aβ single‐chain variable fragments, with the goal of targeting and eliminating aggregative Aβ monomers, is reported. The Aβ nanodepletors impart a notable decline in Aβ aggregate formation, resulting in significant mitigation of Aβ‐induced neurotoxicity in vitro. Furthermore, stereotaxic injections of Aβ nanodepletors into the brain of an AD mouse model system successfully suppress Aβ plaque formation in vivo up to ≈30%, suggesting that Aβ nanodepletors can serve as a promising antiamylodoisis material.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1599932

Journal Information:: Advanced Functional Materials, Journal Name: Advanced Functional Materials Journal Issue: 15 Vol. 30; ISSN 1616-301X

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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