Misclassification of primary liver cancer in the Life Span Study of atomic bomb survivors
Abstract
Primary liver cancer is difficult to diagnose accurately at death, due to metastases from nearby organs and to concomitant diseases, such as chronic hepatitis and cirrhosis. Trends in diagnostic accuracy could affect radiation risk estimates for incident liver cancer by altering background rates or by impacting risk modification by sex and age. We quantified the potential impact of death‐certificate inaccuracies on radiation risk estimates for liver cancer in the Life Span Study of atomic bomb survivors. True‐positive and false‐negative rates were obtained from a previous study that compared death‐certificate causes of death with those based on pathological review, from 1958 to 1987. We assumed various scenarios for misclassification rates after 1987. We obtained estimated true positives and estimated false negatives by stratified sampling from binomial distributions with probabilities given by the true‐positive and false‐negative rates, respectively. Poisson regression methods were applied to highly stratified person‐year tables of corrected case counts and accrued person years. During the study period (1958–2009), there were 1,885 cases of liver cancer, which included 383 death‐certificate‐only (DCO) cases; 1,283 cases with chronic liver disease as the underlying cause of death; and 150 DCO cases of pancreatic cancer among 105,444 study participants. Across the range of scenariosmore »
- Authors:
-
[1];
- Department of Statistics Radiation Effects Research Foundation Hiroshima Japan
- Department of Epidemiology Radiation Effects Research Foundation Hiroshima Japan
- Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland
- Hirosoft International Corporation Eureka California
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1599913
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- International Journal of Cancer
- Additional Journal Information:
- Journal Name: International Journal of Cancer Journal Volume: 147 Journal Issue: 5; Journal ID: ISSN 0020-7136
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- United States
- Language:
- English
Citation Formats
French, Benjamin, Sadakane, Atsuko, Cologne, John, Mabuchi, Kiyohiko, Ozasa, Kotaro, and Preston, Dale L. Misclassification of primary liver cancer in the Life Span Study of atomic bomb survivors. United States: N. p., 2020.
Web. doi:10.1002/ijc.32887.
French, Benjamin, Sadakane, Atsuko, Cologne, John, Mabuchi, Kiyohiko, Ozasa, Kotaro, & Preston, Dale L. Misclassification of primary liver cancer in the Life Span Study of atomic bomb survivors. United States. https://doi.org/10.1002/ijc.32887
French, Benjamin, Sadakane, Atsuko, Cologne, John, Mabuchi, Kiyohiko, Ozasa, Kotaro, and Preston, Dale L. Sat .
"Misclassification of primary liver cancer in the Life Span Study of atomic bomb survivors". United States. https://doi.org/10.1002/ijc.32887.
@article{osti_1599913,
title = {Misclassification of primary liver cancer in the Life Span Study of atomic bomb survivors},
author = {French, Benjamin and Sadakane, Atsuko and Cologne, John and Mabuchi, Kiyohiko and Ozasa, Kotaro and Preston, Dale L.},
abstractNote = {Primary liver cancer is difficult to diagnose accurately at death, due to metastases from nearby organs and to concomitant diseases, such as chronic hepatitis and cirrhosis. Trends in diagnostic accuracy could affect radiation risk estimates for incident liver cancer by altering background rates or by impacting risk modification by sex and age. We quantified the potential impact of death‐certificate inaccuracies on radiation risk estimates for liver cancer in the Life Span Study of atomic bomb survivors. True‐positive and false‐negative rates were obtained from a previous study that compared death‐certificate causes of death with those based on pathological review, from 1958 to 1987. We assumed various scenarios for misclassification rates after 1987. We obtained estimated true positives and estimated false negatives by stratified sampling from binomial distributions with probabilities given by the true‐positive and false‐negative rates, respectively. Poisson regression methods were applied to highly stratified person‐year tables of corrected case counts and accrued person years. During the study period (1958–2009), there were 1,885 cases of liver cancer, which included 383 death‐certificate‐only (DCO) cases; 1,283 cases with chronic liver disease as the underlying cause of death; and 150 DCO cases of pancreatic cancer among 105,444 study participants. Across the range of scenarios considered, radiation risk estimates based on corrected case counts were attenuated, on average, by 13–30%. Our results indicated that radiation risk estimates for liver cancer were potentially sensitive to death‐certificate inaccuracies. Additional data are needed to inform misclassification rates in recent years.},
doi = {10.1002/ijc.32887},
journal = {International Journal of Cancer},
number = 5,
volume = 147,
place = {United States},
year = {Sat Feb 15 00:00:00 EST 2020},
month = {Sat Feb 15 00:00:00 EST 2020}
}
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