Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

La Merrill, Michele A.; Vandenberg, Laura N.; Smith, Martyn T.; Goodson, William; Browne, Patience; Patisaul, Heather B.; Guyton, Kathryn Z.; Kortenkamp, Andreas; Cogliano, Vincent J.; Woodruff, Tracey J.; Rieswijk, Linda; Sone, Hideko; Korach, Kenneth S.; Gore, Andrea C.; Zeise, Lauren; Zoeller, R. Thomas

doi:10.1038/s41574-019-0273-8

Title: Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Journal Article · 11 November 2019 · Nature Reviews Endocrinology

DOI: https://doi.org/10.1038/s41574-019-0273-8 · OSTI ID:1599837

^[1]; Vandenberg, Laura N. ^[2]; Smith, Martyn T. ^[3];

^[4];

^[5];

^[6];

^[7];

^[8]; Cogliano, Vincent J. ^[9];

^[10]; Rieswijk, Linda ^[11]; Sone, Hideko ^[12];

^[13];

^[14]; Zeise, Lauren ^[15];

^[2]

Univ. of California, Davis, CA (United States)
Univ. of Massachusetts, Amherst, MA (United States)
Univ. of California, Berkeley, CA (United States)
Sutter Hospital, San Francisco, CA (United States)
Organisation for Economic Co-operation and Development, Paris (France)
North Carolina State Univ., Raleigh, NC (United States)
World Health Organization, Lyon (France)
Brunel Univ., London (United Kingdom)
United States Environmental Protection Agency (EPA), Washington, DC (United States)
Univ. of California, San Francisco, CA (United States)
Univ. of California, Berkeley, CA (United States); Maastricht Univ. (Netherlands)
National Inst. for Environmental Studies, Ibaraki (Japan)
National Inst. of Environmental Health Science, Durham, NC (United States)
Univ. of Texas, Austin, TX (United States)
California Environmental Protection Agency, Sacramento, CA (United States)

Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Institute of Environmental Health Sciences; California Environmental Protection Agency (EPA); National Institutes of Health (NIH); ESEPA; USDOD; Office of Environmental Health Hazard Assessment; Japan Society for the Promotion of Science

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1599837

Journal Information:: Nature Reviews Endocrinology, Journal Name: Nature Reviews Endocrinology Journal Issue: 1 Vol. 16; ISSN 1759-5029

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

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