skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.

Authors:
ORCiD logo [1];  [2];  [3]; ORCiD logo [4]; ORCiD logo [5]; ORCiD logo [6]; ORCiD logo [7]; ORCiD logo [8];  [9]; ORCiD logo [10];  [11];  [12]; ORCiD logo [13]; ORCiD logo [14];  [15]; ORCiD logo [2]
  1. Univ. of California, Davis, CA (United States)
  2. Univ. of Massachusetts, Amherst, MA (United States)
  3. Univ. of California, Berkeley, CA (United States)
  4. Sutter Hospital, San Francisco, CA (United States)
  5. Organisation for Economic Co-operation and Development, Paris (France)
  6. North Carolina State Univ., Raleigh, NC (United States)
  7. World Health Organization, Lyon (France)
  8. Brunel Univ., London (United Kingdom)
  9. United States Environmental Protection Agency (EPA), Washington, DC (United States)
  10. Univ. of California, San Francisco, CA (United States)
  11. Univ. of California, Berkeley, CA (United States); Maastricht Univ. (Netherlands)
  12. National Inst. for Environmental Studies, Ibaraki (Japan)
  13. National Inst. of Environmental Health Science, Durham, NC (United States)
  14. Univ. of Texas, Austin, TX (United States)
  15. California Environmental Protection Agency, Sacramento, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
National Institute of Environmental Health Sciences; California Environmental Protection Agency (EPA); National Institutes of Health (NIH); ESEPA; USDOD; Office of Environmental Health Hazard Assessment; Japan Society for the Promotion of Science (JSPS)
OSTI Identifier:
1599837
Grant/Contract Number:  
AC02-05CH11231; 17-E0023; P42ES004705; R01ES023254; R56ES020662; 1ZIAES070065; R01ES028110; P01ES022841; R01ES027051; RD-83543301; AR160055; 17-E0024; KAKENHI-PROJECT-15H01749
Resource Type:
Accepted Manuscript
Journal Name:
Nature Reviews Endocrinology
Additional Journal Information:
Journal Volume: 16; Journal Issue: 1; Journal ID: ISSN 1759-5029
Country of Publication:
United States
Language:
English
Subject:
chemical safety; endocrinology; risk factors

Citation Formats

La Merrill, Michele A., Vandenberg, Laura N., Smith, Martyn T., Goodson, William, Browne, Patience, Patisaul, Heather B., Guyton, Kathryn Z., Kortenkamp, Andreas, Cogliano, Vincent J., Woodruff, Tracey J., Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S., Gore, Andrea C., Zeise, Lauren, and Zoeller, R. Thomas. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. United States: N. p., 2019. Web. doi:10.1038/s41574-019-0273-8.
La Merrill, Michele A., Vandenberg, Laura N., Smith, Martyn T., Goodson, William, Browne, Patience, Patisaul, Heather B., Guyton, Kathryn Z., Kortenkamp, Andreas, Cogliano, Vincent J., Woodruff, Tracey J., Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S., Gore, Andrea C., Zeise, Lauren, & Zoeller, R. Thomas. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. United States. doi:10.1038/s41574-019-0273-8.
La Merrill, Michele A., Vandenberg, Laura N., Smith, Martyn T., Goodson, William, Browne, Patience, Patisaul, Heather B., Guyton, Kathryn Z., Kortenkamp, Andreas, Cogliano, Vincent J., Woodruff, Tracey J., Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S., Gore, Andrea C., Zeise, Lauren, and Zoeller, R. Thomas. Tue . "Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification". United States. doi:10.1038/s41574-019-0273-8. https://www.osti.gov/servlets/purl/1599837.
@article{osti_1599837,
title = {Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification},
author = {La Merrill, Michele A. and Vandenberg, Laura N. and Smith, Martyn T. and Goodson, William and Browne, Patience and Patisaul, Heather B. and Guyton, Kathryn Z. and Kortenkamp, Andreas and Cogliano, Vincent J. and Woodruff, Tracey J. and Rieswijk, Linda and Sone, Hideko and Korach, Kenneth S. and Gore, Andrea C. and Zeise, Lauren and Zoeller, R. Thomas},
abstractNote = {Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.},
doi = {10.1038/s41574-019-0273-8},
journal = {Nature Reviews Endocrinology},
number = 1,
volume = 16,
place = {United States},
year = {2019},
month = {11}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Save / Share:

Works referenced in this record:

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
journal, June 2009

  • Diamanti-Kandarakis, Evanthia; Bourguignon, Jean-Pierre; Giudice, Linda C.
  • Endocrine Reviews, Vol. 30, Issue 4
  • DOI: 10.1210/er.2009-0002

How Ligands Illuminate GPCR Molecular Pharmacology
journal, July 2017


Mammary gland development: cell fate specification, stem cells and the microenvironment
journal, March 2015

  • Inman, J. L.; Robertson, C.; Mott, J. D.
  • Development, Vol. 142, Issue 6
  • DOI: 10.1242/dev.087643

Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption
journal, December 2006

  • Thomas, Peter; Dong, Jing
  • The Journal of Steroid Biochemistry and Molecular Biology, Vol. 102, Issue 1-5
  • DOI: 10.1016/j.jsbmb.2006.09.017