Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions
Abstract
Summary This study was designed to evaluate the relation between dysplastic squamous epithelium in the esophageal mucosa and the development of metachronous secondary primary malignancies (mSPM) other than esophagus after endoscopic resection (ER) in patients with early esophageal squamous cell carcinoma (SCC). We studied 330 patients with early esophageal SCC who underwent ER as a post hoc analysis of a prospective multicenter cohort study (UMIN Clinical Trials Registry ID UMIN000001676). Lugol-voiding lesions (LVL) were graded into 3 categories (A = no lesion; B = 1 to 9 lesions; C ≥ 10 lesions). The following variables were studied: (i) the incidences of mSPM other than esophagus; (ii) the standardized incidence ratios (SIRs) of mSPM; (iii) the cumulative incidence and total number of mSPM other than esophagus; and (iv) predictors of mSPM other than esophagus on analysis with a multivariate Cox proportional-hazards model. After a median follow-up of 46.6 months, mSPM other than esophagus was diagnosed in a total of 73 patients (90 lesions). Among the 106 patients in group C, 37 patients had mSPM (51 lesions), including head and neck cancer in 14 patients (24 lesions) and gastric cancer in 12 patients (16 lesions). The SIR of mSPM was 3.61 in this study subjects. An increase in themore »
- Authors:
-
- Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan
- Department of Health Promotion, National Institute of Public Health, Wako, Japan
- Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
- Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
- Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
- Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
- Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan
- Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan
- Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
- Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan
- Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
- Department of Endoscopy Center, Kawasaki Municipal Kawasaki Hospital, Kawasaki, Japan
- Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Clinical Research Unit, National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Japan
- Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan
- Publication Date:
- Sponsoring Org.:
- USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
- OSTI Identifier:
- 1599462
- Resource Type:
- Published Article
- Journal Name:
- Diseases of the Esophagus
- Additional Journal Information:
- Journal Name: Diseases of the Esophagus Journal Volume: 33 Journal Issue: 9; Journal ID: ISSN 1120-8694
- Publisher:
- Oxford University Press
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Citation Formats
Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Shimizu, Yuichi, Takemura, Kenichi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Nakayama, Norisuke, Kubota, Yutaro, Matsuo, Yasumasa, Kawakubo, Hirofumi, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu. Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions. Country unknown/Code not available: N. p., 2020.
Web. doi:10.1093/dote/doz110.
Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Shimizu, Yuichi, Takemura, Kenichi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Nakayama, Norisuke, Kubota, Yutaro, Matsuo, Yasumasa, Kawakubo, Hirofumi, Ishikawa, Hideki, Yokoyama, Akira, & Muto, Manabu. Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions. Country unknown/Code not available. doi:10.1093/dote/doz110.
Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Shimizu, Yuichi, Takemura, Kenichi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Nakayama, Norisuke, Kubota, Yutaro, Matsuo, Yasumasa, Kawakubo, Hirofumi, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu. Wed .
"Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions". Country unknown/Code not available. doi:10.1093/dote/doz110.
@article{osti_1599462,
title = {Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions},
author = {Katada, Chikatoshi and Yokoyama, Tetsuji and Yano, Tomonori and Oda, Ichiro and Shimizu, Yuichi and Takemura, Kenichi and Koike, Tomoyuki and Takizawa, Kohei and Hirao, Motohiro and Okada, Hiroyuki and Nakayama, Norisuke and Kubota, Yutaro and Matsuo, Yasumasa and Kawakubo, Hirofumi and Ishikawa, Hideki and Yokoyama, Akira and Muto, Manabu},
abstractNote = {Summary This study was designed to evaluate the relation between dysplastic squamous epithelium in the esophageal mucosa and the development of metachronous secondary primary malignancies (mSPM) other than esophagus after endoscopic resection (ER) in patients with early esophageal squamous cell carcinoma (SCC). We studied 330 patients with early esophageal SCC who underwent ER as a post hoc analysis of a prospective multicenter cohort study (UMIN Clinical Trials Registry ID UMIN000001676). Lugol-voiding lesions (LVL) were graded into 3 categories (A = no lesion; B = 1 to 9 lesions; C ≥ 10 lesions). The following variables were studied: (i) the incidences of mSPM other than esophagus; (ii) the standardized incidence ratios (SIRs) of mSPM; (iii) the cumulative incidence and total number of mSPM other than esophagus; and (iv) predictors of mSPM other than esophagus on analysis with a multivariate Cox proportional-hazards model. After a median follow-up of 46.6 months, mSPM other than esophagus was diagnosed in a total of 73 patients (90 lesions). Among the 106 patients in group C, 37 patients had mSPM (51 lesions), including head and neck cancer in 14 patients (24 lesions) and gastric cancer in 12 patients (16 lesions). The SIR of mSPM was 3.61 in this study subjects. An increase in the LVL grade (A to B to C) was associated with a progressive increase in the cumulative incidence rate of mSPM other than esophagus (P = 0.017 for A vs. C, P = 0.023 for B vs. C). An increase in the LVL grade (A to B to C) was also associated with a progressive increase in the total number of mSPM other than esophagus per 100 person-years (primary events, relative risk [RR] = 1.66 and 3.24 for grades B and C, respectively, vs. A, P = 0.002 for trend; all events, RR = 1.81 and 4.66 for grades B and C, respectively, vs. A, P < 0.0001 for trend). LVL grade C was a strong predictor of mSPM other than esophagus (RR = 3.41 for A vs. C). LVL grade may be a useful predictor of the risk of mSPM other than esophagus after ER in patients with early esophageal SCC.},
doi = {10.1093/dote/doz110},
journal = {Diseases of the Esophagus},
number = 9,
volume = 33,
place = {Country unknown/Code not available},
year = {2020},
month = {2}
}
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DOI: 10.1093/dote/doz110
DOI: 10.1093/dote/doz110
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Works referenced in this record:
Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men
journal, September 2011
- Yokoyama, Akira; Hirota, Teruyuki; Omori, Tai
- International Journal of Cancer, Vol. 130, Issue 12
Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck
journal, November 2016
- Katada, Chikatoshi; Yokoyama, Tetsuji; Yano, Tomonori
- Gastroenterology, Vol. 151, Issue 5
Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol
journal, September 2007
- Matsuda, T.; Matsumoto, A.; Uchida, M.
- Carcinogenesis, Vol. 28, Issue 11
Effects of ALDH2 Genotype, PPI Treatment and L-Cysteine on Carcinogenic Acetaldehyde in Gastric Juice and Saliva after Intragastric Alcohol Administration
journal, April 2015
- Maejima, Ryuhei; Iijima, Katsunori; Kaihovaara, Pertti
- PLOS ONE, Vol. 10, Issue 4
Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region
journal, February 2005
- Muto, Manabu; Takahashi, Mari; Ohtsu, Atsushi
- Carcinogenesis, Vol. 26, Issue 5
Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast)
journal, March 2008
- Paget, Vincent; Lechevrel, Mathilde; Sichel, Francois
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Vol. 652, Issue 1
Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
journal, June 2013
- Wyss, Annah; Hashibe, Mia; Chuang, Shu-Chun
- American Journal of Epidemiology, Vol. 178, Issue 5
Risk of Second Primary Malignancy After Esophagectomy for Squamous Cell Carcinoma of the Thoracic Esophagus
journal, December 2003
- Matsubara, Toshiki; Yamada, Kazuhiko; Nakagawa, Aya
- Journal of Clinical Oncology, Vol. 21, Issue 23
Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan
journal, January 2004
- Lee, Chien-Hung; Lee, Jang-Ming; Wu, Deng-Chyang
- International Journal of Cancer, Vol. 113, Issue 3
A review of human carcinogens—Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish
journal, November 2009
- Secretan, Béatrice; Straif, Kurt; Baan, Robert
- The Lancet Oncology, Vol. 10, Issue 11
Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics
journal, July 2012
- Yukawa, Yoshiyuki; Muto, Manabu; Hori, Kimiko
- Cancer Science, Vol. 103, Issue 9
DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis
journal, April 2005
- Brooks, Philip J.; Theruvathu, Jacob A.
- Alcohol, Vol. 35, Issue 3
Salivary Acetaldehyde Concentration According to Alcoholic Beverage Consumed and Aldehyde Dehydrogenase-2 Genotype
journal, September 2008
- Yokoyama, Akira; Tsutsumi, Eri; Imazeki, Hiromi
- Alcoholism: Clinical and Experimental Research, Vol. 32, Issue 9
Factors associated with the presence of multiple Lugol-voiding lesions in patients with esophageal squamous-cell carcinoma: Risk of multiple Lugol-voiding lesions
journal, September 2012
- Katada, C.; Muto, M.; Tanabe, S.
- Diseases of the Esophagus, Vol. 27, Issue 5
Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer
journal, October 2002
- Muto, M.
- Carcinogenesis, Vol. 23, Issue 10
Risk of Second Primary Cancer among Esophageal Cancer Patients: a Pooled Analysis of 13 Cancer Registries
journal, June 2008
- Chuang, S. -C.; Hashibe, M.; Scelo, G.
- Cancer Epidemiology Biomarkers & Prevention, Vol. 17, Issue 6
Second primary carcinoma in the gastric tube constructed as an esophageal substitute after esophagectomy1 1No competing interests declared.
journal, May 2002
- Sugiura, Teiichi; Kato, Hoichi; Tachimori, Yuji
- Journal of the American College of Surgeons, Vol. 194, Issue 5
Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
journal, May 2007
- Hashibe, M.; Brennan, P.; Benhamou, S.
- JNCI Journal of the National Cancer Institute, Vol. 99, Issue 10
Risk of second primary cancer after treatment for esophageal cancer: a pooled analysis of nine cancer registries: Esophageal cancer and risk of second primary cancer
journal, November 2011
- Zhu, G.; Chen, Y.; Zhu, Z.
- Diseases of the Esophagus, Vol. 25, Issue 6
Multiple Primary Carcinomas with Esophageal Squamous Cell Cancer: Clinicopathologic Outcome
journal, December 2004
- Natsugoe, Shoji; Matsumoto, Masataka; Okumura, Hiroshi
- World Journal of Surgery, Vol. 29, Issue 1
Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients
journal, August 2000
- Muto, M.
- Gut, Vol. 47, Issue 2
Lugol-Voiding Lesions Are an Important Risk Factor for a Second Primary Squamous Cell Carcinoma in Patients With Esosphageal Cancer or Head and Neck Cancer
journal, January 2011
- Hori, Keisuke; Okada, Hiroyuki; Kawahara, Yoshiro
- American Journal of Gastroenterology, Vol. 106, Issue 5
Risk of superficial squamous cell carcinoma developing in the head and neck region in patients with esophageal squamous cell carcinoma
journal, June 2012
- Katada, Chikatoshi; Muto, Manabu; Nakayama, Meijin
- The Laryngoscope, Vol. 122, Issue 6