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Title: Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions

Abstract

Summary This study was designed to evaluate the relation between dysplastic squamous epithelium in the esophageal mucosa and the development of metachronous secondary primary malignancies (mSPM) other than esophagus after endoscopic resection (ER) in patients with early esophageal squamous cell carcinoma (SCC). We studied 330 patients with early esophageal SCC who underwent ER as a post hoc analysis of a prospective multicenter cohort study (UMIN Clinical Trials Registry ID UMIN000001676). Lugol-voiding lesions (LVL) were graded into 3 categories (A = no lesion; B = 1 to 9 lesions; C ≥ 10 lesions). The following variables were studied: (i) the incidences of mSPM other than esophagus; (ii) the standardized incidence ratios (SIRs) of mSPM; (iii) the cumulative incidence and total number of mSPM other than esophagus; and (iv) predictors of mSPM other than esophagus on analysis with a multivariate Cox proportional-hazards model. After a median follow-up of 46.6 months, mSPM other than esophagus was diagnosed in a total of 73 patients (90 lesions). Among the 106 patients in group C, 37 patients had mSPM (51 lesions), including head and neck cancer in 14 patients (24 lesions) and gastric cancer in 12 patients (16 lesions). The SIR of mSPM was 3.61 in this study subjects. An increase in themore » LVL grade (A to B to C) was associated with a progressive increase in the cumulative incidence rate of mSPM other than esophagus (P = 0.017 for A vs. C, P = 0.023 for B vs. C). An increase in the LVL grade (A to B to C) was also associated with a progressive increase in the total number of mSPM other than esophagus per 100 person-years (primary events, relative risk [RR] = 1.66 and 3.24 for grades B and C, respectively, vs. A, P = 0.002 for trend; all events, RR = 1.81 and 4.66 for grades B and C, respectively, vs. A, P < 0.0001 for trend). LVL grade C was a strong predictor of mSPM other than esophagus (RR = 3.41 for A vs. C). LVL grade may be a useful predictor of the risk of mSPM other than esophagus after ER in patients with early esophageal SCC.« less

Authors:
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8];  [9];  [10];  [11];  [12];  [13];  [14];  [15];  [16];  [17]
  1. Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan
  2. Department of Health Promotion, National Institute of Public Health, Wako, Japan
  3. Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
  4. Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
  5. Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  6. Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
  7. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
  8. Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan
  9. Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan
  10. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  11. Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan
  12. Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
  13. Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
  14. Department of Endoscopy Center, Kawasaki Municipal Kawasaki Hospital, Kawasaki, Japan
  15. Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan
  16. Clinical Research Unit, National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Japan
  17. Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1599462
Resource Type:
Published Article
Journal Name:
Diseases of the Esophagus
Additional Journal Information:
Journal Name: Diseases of the Esophagus; Journal ID: ISSN 1120-8694
Publisher:
Oxford University Press
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Shimizu, Yuichi, Takemura, Kenichi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Nakayama, Norisuke, Kubota, Yutaro, Matsuo, Yasumasa, Kawakubo, Hirofumi, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu. Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions. Country unknown/Code not available: N. p., 2020. Web. doi:10.1093/dote/doz110.
Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Shimizu, Yuichi, Takemura, Kenichi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Nakayama, Norisuke, Kubota, Yutaro, Matsuo, Yasumasa, Kawakubo, Hirofumi, Ishikawa, Hideki, Yokoyama, Akira, & Muto, Manabu. Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions. Country unknown/Code not available. doi:10.1093/dote/doz110.
Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Shimizu, Yuichi, Takemura, Kenichi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Nakayama, Norisuke, Kubota, Yutaro, Matsuo, Yasumasa, Kawakubo, Hirofumi, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu. Wed . "Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions". Country unknown/Code not available. doi:10.1093/dote/doz110.
@article{osti_1599462,
title = {Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions},
author = {Katada, Chikatoshi and Yokoyama, Tetsuji and Yano, Tomonori and Oda, Ichiro and Shimizu, Yuichi and Takemura, Kenichi and Koike, Tomoyuki and Takizawa, Kohei and Hirao, Motohiro and Okada, Hiroyuki and Nakayama, Norisuke and Kubota, Yutaro and Matsuo, Yasumasa and Kawakubo, Hirofumi and Ishikawa, Hideki and Yokoyama, Akira and Muto, Manabu},
abstractNote = {Summary This study was designed to evaluate the relation between dysplastic squamous epithelium in the esophageal mucosa and the development of metachronous secondary primary malignancies (mSPM) other than esophagus after endoscopic resection (ER) in patients with early esophageal squamous cell carcinoma (SCC). We studied 330 patients with early esophageal SCC who underwent ER as a post hoc analysis of a prospective multicenter cohort study (UMIN Clinical Trials Registry ID UMIN000001676). Lugol-voiding lesions (LVL) were graded into 3 categories (A = no lesion; B = 1 to 9 lesions; C ≥ 10 lesions). The following variables were studied: (i) the incidences of mSPM other than esophagus; (ii) the standardized incidence ratios (SIRs) of mSPM; (iii) the cumulative incidence and total number of mSPM other than esophagus; and (iv) predictors of mSPM other than esophagus on analysis with a multivariate Cox proportional-hazards model. After a median follow-up of 46.6 months, mSPM other than esophagus was diagnosed in a total of 73 patients (90 lesions). Among the 106 patients in group C, 37 patients had mSPM (51 lesions), including head and neck cancer in 14 patients (24 lesions) and gastric cancer in 12 patients (16 lesions). The SIR of mSPM was 3.61 in this study subjects. An increase in the LVL grade (A to B to C) was associated with a progressive increase in the cumulative incidence rate of mSPM other than esophagus (P = 0.017 for A vs. C, P = 0.023 for B vs. C). An increase in the LVL grade (A to B to C) was also associated with a progressive increase in the total number of mSPM other than esophagus per 100 person-years (primary events, relative risk [RR] = 1.66 and 3.24 for grades B and C, respectively, vs. A, P = 0.002 for trend; all events, RR = 1.81 and 4.66 for grades B and C, respectively, vs. A, P < 0.0001 for trend). LVL grade C was a strong predictor of mSPM other than esophagus (RR = 3.41 for A vs. C). LVL grade may be a useful predictor of the risk of mSPM other than esophagus after ER in patients with early esophageal SCC.},
doi = {10.1093/dote/doz110},
journal = {Diseases of the Esophagus},
number = ,
volume = ,
place = {Country unknown/Code not available},
year = {2020},
month = {2}
}

Journal Article:
Free Publicly Available Full Text
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DOI: 10.1093/dote/doz110

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Works referenced in this record:

Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men
journal, September 2011

  • Yokoyama, Akira; Hirota, Teruyuki; Omori, Tai
  • International Journal of Cancer, Vol. 130, Issue 12
  • DOI: 10.1002/ijc.26296

Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck
journal, November 2016


Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol
journal, September 2007


Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region
journal, February 2005

  • Muto, Manabu; Takahashi, Mari; Ohtsu, Atsushi
  • Carcinogenesis, Vol. 26, Issue 5
  • DOI: 10.1093/carcin/bgi035

Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast)
journal, March 2008

  • Paget, Vincent; Lechevrel, Mathilde; Sichel, Francois
  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Vol. 652, Issue 1
  • DOI: 10.1016/j.mrgentox.2007.11.010

Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
journal, June 2013

  • Wyss, Annah; Hashibe, Mia; Chuang, Shu-Chun
  • American Journal of Epidemiology, Vol. 178, Issue 5
  • DOI: 10.1093/aje/kwt029

Risk of Second Primary Malignancy After Esophagectomy for Squamous Cell Carcinoma of the Thoracic Esophagus
journal, December 2003

  • Matsubara, Toshiki; Yamada, Kazuhiko; Nakagawa, Aya
  • Journal of Clinical Oncology, Vol. 21, Issue 23
  • DOI: 10.1200/JCO.2003.12.074

Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan
journal, January 2004

  • Lee, Chien-Hung; Lee, Jang-Ming; Wu, Deng-Chyang
  • International Journal of Cancer, Vol. 113, Issue 3
  • DOI: 10.1002/ijc.20619

A review of human carcinogens—Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish
journal, November 2009


Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics
journal, July 2012


DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis
journal, April 2005


Salivary Acetaldehyde Concentration According to Alcoholic Beverage Consumed and Aldehyde Dehydrogenase-2 Genotype
journal, September 2008


Risk of Second Primary Cancer among Esophageal Cancer Patients: a Pooled Analysis of 13 Cancer Registries
journal, June 2008


Second primary carcinoma in the gastric tube constructed as an esophageal substitute after esophagectomy1 1No competing interests declared.
journal, May 2002

  • Sugiura, Teiichi; Kato, Hoichi; Tachimori, Yuji
  • Journal of the American College of Surgeons, Vol. 194, Issue 5
  • DOI: 10.1016/S1072-7515(02)01135-3

Multiple Primary Carcinomas with Esophageal Squamous Cell Cancer: Clinicopathologic Outcome
journal, December 2004

  • Natsugoe, Shoji; Matsumoto, Masataka; Okumura, Hiroshi
  • World Journal of Surgery, Vol. 29, Issue 1
  • DOI: 10.1007/s00268-004-7525-y

Lugol-Voiding Lesions Are an Important Risk Factor for a Second Primary Squamous Cell Carcinoma in Patients With Esosphageal Cancer or Head and Neck Cancer
journal, January 2011

  • Hori, Keisuke; Okada, Hiroyuki; Kawahara, Yoshiro
  • American Journal of Gastroenterology, Vol. 106, Issue 5
  • DOI: 10.1038/ajg.2010.489

Risk of superficial squamous cell carcinoma developing in the head and neck region in patients with esophageal squamous cell carcinoma
journal, June 2012

  • Katada, Chikatoshi; Muto, Manabu; Nakayama, Meijin
  • The Laryngoscope, Vol. 122, Issue 6
  • DOI: 10.1002/lary.23249