Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison
Abstract
The advent of X-ray free-electron lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single-shot diffraction snapshots obtained before the particle is destroyed by the intense femtosecond pulse. This program requires the ability to determine the orientation of the particle giving rise to each snapshot at signal levels as low as ~10-2 photons per pixel. Two apparently different approaches have recently demonstrated this capability. Here we show they represent different implementations of the same fundamental approach, and identify the primary factors limiting their performance.
- Authors:
-
- Univ. of Wisconsin, Milwaukee, WI (United States)
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Milwaukee, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1598203
- Grant/Contract Number:
- SC0002164
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Acta Crystallographica. Section A, Foundations of Crystallography
- Additional Journal Information:
- Journal Volume: 67; Journal Issue: 5; Journal ID: ISSN 0108-7673
- Publisher:
- International Union of Crystallography
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
Citation Formats
Moths, Brian, and Ourmazd, Abbas. Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison. United States: N. p., 2011.
Web. doi:10.1107/S0108767311019611.
Moths, Brian, & Ourmazd, Abbas. Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison. United States. https://doi.org/10.1107/S0108767311019611
Moths, Brian, and Ourmazd, Abbas. Wed .
"Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison". United States. https://doi.org/10.1107/S0108767311019611. https://www.osti.gov/servlets/purl/1598203.
@article{osti_1598203,
title = {Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison},
author = {Moths, Brian and Ourmazd, Abbas},
abstractNote = {The advent of X-ray free-electron lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single-shot diffraction snapshots obtained before the particle is destroyed by the intense femtosecond pulse. This program requires the ability to determine the orientation of the particle giving rise to each snapshot at signal levels as low as ~10-2 photons per pixel. Two apparently different approaches have recently demonstrated this capability. Here we show they represent different implementations of the same fundamental approach, and identify the primary factors limiting their performance.},
doi = {10.1107/S0108767311019611},
journal = {Acta Crystallographica. Section A, Foundations of Crystallography},
number = 5,
volume = 67,
place = {United States},
year = {Wed Jul 06 00:00:00 EDT 2011},
month = {Wed Jul 06 00:00:00 EDT 2011}
}
Web of Science
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