The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii

doi:10.1111/mmi.14411

This content will become publicly available on November 18, 2020

Title: The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii

Authors:

Cao, Shinuo ^[1]; Chen, Heming ^[1]; Liang, Xiaohan ^[2]; Fu, Jiawen ^[1]; Wang, Shida ^[1]; Zheng, Jun ^[1]; Zhang, Zhaoxia ^[1]; Pang, Yu ^[1]; Wang, Jingfei ^[1]; Shen, Bang ^[2];

^[1]

State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin People’s Republic of China
State Key Laboratory of Agricultural Microbiology Huazhong Agricultural University Wuhan Hubei Province People’s Republic of China

Publication Date:: 2019-11-19

Sponsoring Org.:: USDOE Office of Electricity Delivery and Energy Reliability (OE), Power Systems Engineering Research and Development (R&D) (OE-10)

OSTI Identifier:: 1598059

Grant/Contract Number:: 2017YFD0500400

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Molecular microbiology

Additional Journal Information:: Journal Name: Molecular microbiology Journal Volume: 113 Journal Issue: 1; Journal ID: ISSN 0950-382X

Publisher:: Wiley-Blackwell

Country of Publication:: FAO

Language:: English

Citation Formats


                    Cao, Shinuo, Chen, Heming, Liang, Xiaohan, Fu, Jiawen, Wang, Shida, Zheng, Jun, Zhang, Zhaoxia, Pang, Yu, Wang, Jingfei, Shen, Bang, and Jia, Honglin. The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii.  FAO: N. p., 2019. 
        Web.  doi:10.1111/mmi.14411.

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                    Cao, Shinuo, Chen, Heming, Liang, Xiaohan, Fu, Jiawen, Wang, Shida, Zheng, Jun, Zhang, Zhaoxia, Pang, Yu, Wang, Jingfei, Shen, Bang, & Jia, Honglin. The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii.  FAO.  doi:10.1111/mmi.14411.

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                    Cao, Shinuo, Chen, Heming, Liang, Xiaohan, Fu, Jiawen, Wang, Shida, Zheng, Jun, Zhang, Zhaoxia, Pang, Yu, Wang, Jingfei, Shen, Bang, and Jia, Honglin. Tue .  
        "The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii".  FAO.  doi:10.1111/mmi.14411.

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@article{osti_1598059,

  title        = {The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii},

  author       = {Cao, Shinuo and Chen, Heming and Liang, Xiaohan and Fu, Jiawen and Wang, Shida and Zheng, Jun and Zhang, Zhaoxia and Pang, Yu and Wang, Jingfei and Shen, Bang and Jia, Honglin},

  abstractNote = {},

  doi          = {10.1111/mmi.14411},

  journal      = {Molecular microbiology},

  number       = 1,

  volume       = 113,

  place        = {FAO},

  year         = {2019},

  month        = {11}

}

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DOI: 10.1111/mmi.14411

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Works referenced in this record:

Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
journal, October 2013

Tomavo, Stanislas; Slomianny, Christian; Meissner, Markus
PLoS Pathogens, Vol. 9, Issue 10
DOI: 10.1371/journal.ppat.1003629

DOC2 Proteins in Rat Brain: Complementary Distribution and Proposed Function as Vesicular Adapter Proteins in Early Stages of Secretion
journal, March 1997

Verhage, Matthijs; de Vries, Klaas Jan; Røshol, Hilde
Neuron, Vol. 18, Issue 3
DOI: 10.1016/S0896-6273(00)81245-3

The See1p homologue Vps45p binds to the syntaxin Tlg2p
journal, December 1998

Nichols, Benjamin J.; Holthuis, Joost C. M.; Pelham, Hugh R. B.
European Journal of Cell Biology, Vol. 77, Issue 4
DOI: 10.1016/S0171-9335(98)80084-8

Biogenesis of the Inner Membrane Complex Is Dependent on Vesicular Transport by the Alveolate Specific GTPase Rab11B
journal, July 2010

Agop-Nersesian, Carolina; Egarter, Saskia; Langsley, Gordon
PLoS Pathogens, Vol. 6, Issue 7
DOI: 10.1371/journal.ppat.1001029

An endocytic-secretory cycle participates in Toxoplasma gondii in motility
journal, June 2019

Gras, Simon; Jimenez-Ruiz, Elena; Klinger, Christen M.
PLOS Biology, Vol. 17, Issue 6
DOI: 10.1371/journal.pbio.3000060

A t-SNARE of the endocytic pathway must be activated for fusion
journal, December 2001

Paumet, Fabienne; Brügger, Britta; Parlati, Francesco
The Journal of Cell Biology, Vol. 155, Issue 6
DOI: 10.1083/jcb.200104092

Testing the SNARE/SM protein model of membrane fusion
journal, December 2010

Bacaj, T.; Pang, Z. P.; Sudhof, T. C.
Proceedings of the National Academy of Sciences, Vol. 107, Issue 52
DOI: 10.1073/pnas.1017268108

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites
journal, January 2019

Jonscher, Ernst; Flemming, Sven; Schmitt, Marius
Cell Host & Microbe, Vol. 25, Issue 1
DOI: 10.1016/j.chom.2018.11.010

Saccharomyces cerevisiae--a model organism for the studies on vacuolar transport.
journal, December 2001

Kucharczyk, R.; Rytka, J.
Acta Biochimica Polonica, Vol. 48, Issue 4
DOI: 10.18388/abp.2001_3864

Munc18-1 as a key regulator of neurosecretion: Munc18-1 as a key regulator of neurosecretion
journal, July 2010

Han, Gayoung A.; Malintan, Nancy T.; Collins, Brett M.
Journal of Neurochemistry, Vol. 115, Issue 1
DOI: 10.1111/j.1471-4159.2010.06900.x

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
journal, March 2009

Deák, Ferenc; Xu, Yi; Chang, Wen-Pin
The Journal of Cell Biology, Vol. 184, Issue 5
DOI: 10.1083/jcb.200812026

Dynamin−SNARE interactions control trans-SNARE formation in intracellular membrane fusion
journal, April 2013

Alpadi, Kannan; Kulkarni, Aditya; Namjoshi, Sarita
Nature Communications, Vol. 4, Issue 1
DOI: 10.1038/ncomms2724

A Congenital Neutrophil Defect Syndrome Associated with Mutations in VPS45
journal, July 2013

Vilboux, Thierry; Lev, Atar; Malicdan, May Christine V.
New England Journal of Medicine, Vol. 369, Issue 1
DOI: 10.1056/NEJMoa1301296

Building the Perfect Parasite: Cell Division in Apicomplexa
journal, January 2007

Striepen, Boris; Jordan, Carly N.; Reiff, Sarah
PLoS Pathogens, Vol. 3, Issue 6
DOI: 10.1371/journal.ppat.0030078

Membrane Fusion
journal, February 2003

Jahn, Reinhard; Lang, Thorsten; Südhof, Thomas C.
Cell, Vol. 112, Issue 4
DOI: 10.1016/S0092-8674(03)00112-0

A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis
journal, January 2012

Farrell, A.; Thirugnanam, S.; Lorestani, A.
Science, Vol. 335, Issue 6065
DOI: 10.1126/science.1210829

Endocytosis
journal, July 1997

Mukherjee, S.; Ghosh, R. N.; Maxfield, F. R.
Physiological Reviews, Vol. 77, Issue 3
DOI: 10.1152/physrev.1997.77.3.759

Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection
journal, May 2012

Sloves, Pierre-Julien; Delhaye, Stephane; Mouveaux, Thomas
Cell Host & Microbe, Vol. 11, Issue 5
DOI: 10.1016/j.chom.2012.03.006

The enigmatic endosome – sorting the ins and outs of endocytic trafficking
journal, July 2018

Naslavsky, Naava; Caplan, Steve
Journal of Cell Science, Vol. 131, Issue 13
DOI: 10.1242/jcs.216499

Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion
journal, July 1999

Carr, Chavela M.; Grote, Eric; Munson, Mary
The Journal of Cell Biology, Vol. 146, Issue 2
DOI: 10.1083/jcb.146.2.333

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection
journal, April 2016

Sangaré, Lamba Omar; Alayi, Tchilabalo Dilezitoko; Westermann, Benoit
Nature Communications, Vol. 7, Issue 1
DOI: 10.1038/ncomms11191

A novel polymer of tubulin forms the conoid of Toxoplasma gondii
journal, March 2002

Hu, Ke; Roos, David S.; Murray, John M.
The Journal of Cell Biology, Vol. 156, Issue 6
DOI: 10.1083/jcb.200112086

Toxoplasma gondii Syntaxin 6 Is Required for Vesicular Transport Between Endosomal-Like Compartments and the Golgi Complex: Toxoplasma gondii Syntaxin 6 Is a TGN Marker
journal, September 2013

Jackson, Allison J.; Clucas, Caroline; Mamczur, Nicola J.
Traffic
DOI: 10.1111/tra.12102

Brefeldin A: insights into the control of membrane traffic and organelle structure.
journal, March 1992

Klausner, R. D.; Donaldson, J. G.; Lippincott-Schwartz, J.
The Journal of Cell Biology, Vol. 116, Issue 5
DOI: 10.1083/jcb.116.5.1071

Secretory traffic in the eukaryotic parasite Toxoplasma gondii
journal, May 2002

Joiner, Keith A.; Roos, David S.
The Journal of Cell Biology, Vol. 157, Issue 4
DOI: 10.1083/jcb.200112144

An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes
journal, March 2013

Kremer, Katrin; Kamin, Dirk; Rittweger, Eva
PLoS Pathogens, Vol. 9, Issue 3
DOI: 10.1371/journal.ppat.1003213

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii: Cathepsin L in a vacuolar compartment
journal, April 2010

Parussini, Fabiola; Coppens, Isabelle; Shah, Parag P.
Molecular Microbiology, Vol. 76, Issue 6
DOI: 10.1111/j.1365-2958.2010.07181.x

Membrane Fusion: Grappling with SNARE and SM Proteins
journal, January 2009

Sudhof, T. C.; Rothman, J. E.
Science, Vol. 323, Issue 5913
DOI: 10.1126/science.1161748

The Phagosome: Compartment with a License to Kill
journal, January 2007

Haas, Albert
Traffic, Vol. 8, Issue 4
DOI: 10.1111/j.1600-0854.2006.00531.x

Cell Division in Apicomplexan Parasites Is Organized by a Homolog of the Striated Rootlet Fiber of Algal Flagella
journal, December 2012

Francia, Maria E.; Jordan, Carly N.; Patel, Jay D.
PLoS Biology, Vol. 10, Issue 12
DOI: 10.1371/journal.pbio.1001444

Sec1/Munc18 Proteins
journal, August 2000

Jahn, Reinhard
Neuron, Vol. 27, Issue 2
DOI: 10.1016/S0896-6273(00)00029-5

AtVPS45 Is a Positive Regulator of the SYP41/SYP61/VTI12 SNARE Complex Involved in Trafficking of Vacuolar Cargo
journal, February 2009

Zouhar, Jan; Rojo, Enrique; Bassham, Diane C.
Plant Physiology, Vol. 149, Issue 4
DOI: 10.1104/pp.108.134361

Vesicle trafficking: pleasure and pain from SM genes
journal, April 2003

Toonen, Ruud F. G.; Verhage, Matthijs
Trends in Cell Biology, Vol. 13, Issue 4
DOI: 10.1016/S0962-8924(03)00031-X

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division
journal, April 2017

Venugopal, Kannan; Werkmeister, Elisabeth; Barois, Nicolas
PLOS Pathogens, Vol. 13, Issue 4
DOI: 10.1371/journal.ppat.1006331

Rab11A-Controlled Assembly of the Inner Membrane Complex Is Required for Completion of Apicomplexan Cytokinesis
journal, January 2009

Agop-Nersesian, Carolina; Naissant, Bernina; Ben Rached, Fathia
PLoS Pathogens, Vol. 5, Issue 1
DOI: 10.1371/journal.ppat.1000270

Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma
journal, March 2016

Bullen, Hayley E.; Jia, Yonggen; Yamaryo-Botté, Yoshiki
Cell Host & Microbe, Vol. 19, Issue 3
DOI: 10.1016/j.chom.2016.02.006

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1
journal, January 2012

Morgera, Francesca; Sallah, Margaret R.; Dubuke, Michelle L.
Molecular Biology of the Cell, Vol. 23, Issue 2
DOI: 10.1091/mbc.E11-08-0670

Endosome maturation factors Rabenosyn‐5/VPS45 and caveolin‐1 regulate ciliary membrane and polycystin‐2 homeostasis
journal, March 2018

Scheidel, Noémie; Kennedy, Julie; Blacque, Oliver E.
The EMBO Journal, Vol. 37, Issue 9
DOI: 10.15252/embj.201798248

The Exocyst at a Glance
journal, August 2015

Wu, B.; Guo, W.
Journal of Cell Science, Vol. 128, Issue 16
DOI: 10.1242/jcs.156398

Tethering the assembly of SNARE complexes
journal, January 2014

Hong, WanJin; Lev, Sima
Trends in Cell Biology, Vol. 24, Issue 1
DOI: 10.1016/j.tcb.2013.09.006

A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus
journal, May 2006

Gubbels, M. -J.
Journal of Cell Science, Vol. 119, Issue 11
DOI: 10.1242/jcs.02949

A Complete Set of SNAREs in Yeast: A Complete Set of SNAREs in Yeast
journal, November 2003

Burri, Lena; Lithgow, Trevor
Traffic, Vol. 5, Issue 1
DOI: 10.1046/j.1600-0854.2003.00151.x

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii
journal, May 2017

Brown, Kevin M.; Long, Shaojun; Sibley, L. David
mBio, Vol. 8, Issue 3
DOI: 10.1128/mBio.00375-17

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This content will become publicly available on November 18, 2020

Title: The Sec1/Munc18‐like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub‐pellicle network in Toxoplasma gondii

Citation Formats

Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion journal, October 2013

DOC2 Proteins in Rat Brain: Complementary Distribution and Proposed Function as Vesicular Adapter Proteins in Early Stages of Secretion journal, March 1997

The See1p homologue Vps45p binds to the syntaxin Tlg2p journal, December 1998

Biogenesis of the Inner Membrane Complex Is Dependent on Vesicular Transport by the Alveolate Specific GTPase Rab11B journal, July 2010

An endocytic-secretory cycle participates in Toxoplasma gondii in motility journal, June 2019

A t-SNARE of the endocytic pathway must be activated for fusion journal, December 2001

Testing the SNARE/SM protein model of membrane fusion journal, December 2010

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites journal, January 2019

Saccharomyces cerevisiae--a model organism for the studies on vacuolar transport. journal, December 2001

Munc18-1 as a key regulator of neurosecretion: Munc18-1 as a key regulator of neurosecretion journal, July 2010

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming journal, March 2009

Dynamin−SNARE interactions control trans-SNARE formation in intracellular membrane fusion journal, April 2013

A Congenital Neutrophil Defect Syndrome Associated with Mutations in VPS45 journal, July 2013

Building the Perfect Parasite: Cell Division in Apicomplexa journal, January 2007

Membrane Fusion journal, February 2003

A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis journal, January 2012

Endocytosis journal, July 1997

Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection journal, May 2012

The enigmatic endosome – sorting the ins and outs of endocytic trafficking journal, July 2018

Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion journal, July 1999

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection journal, April 2016

A novel polymer of tubulin forms the conoid of Toxoplasma gondii journal, March 2002

Toxoplasma gondii Syntaxin 6 Is Required for Vesicular Transport Between Endosomal-Like Compartments and the Golgi Complex: Toxoplasma gondii Syntaxin 6 Is a TGN Marker journal, September 2013

Brefeldin A: insights into the control of membrane traffic and organelle structure. journal, March 1992

Secretory traffic in the eukaryotic parasite Toxoplasma gondii journal, May 2002

An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes journal, March 2013

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii: Cathepsin L in a vacuolar compartment journal, April 2010

Membrane Fusion: Grappling with SNARE and SM Proteins journal, January 2009

The Phagosome: Compartment with a License to Kill journal, January 2007

Cell Division in Apicomplexan Parasites Is Organized by a Homolog of the Striated Rootlet Fiber of Algal Flagella journal, December 2012

Sec1/Munc18 Proteins journal, August 2000

AtVPS45 Is a Positive Regulator of the SYP41/SYP61/VTI12 SNARE Complex Involved in Trafficking of Vacuolar Cargo journal, February 2009

Vesicle trafficking: pleasure and pain from SM genes journal, April 2003

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division journal, April 2017

Rab11A-Controlled Assembly of the Inner Membrane Complex Is Required for Completion of Apicomplexan Cytokinesis journal, January 2009

Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma journal, March 2016

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1 journal, January 2012

Endosome maturation factors Rabenosyn‐5/VPS45 and caveolin‐1 regulate ciliary membrane and polycystin‐2 homeostasis journal, March 2018

The Exocyst at a Glance journal, August 2015

Tethering the assembly of SNARE complexes journal, January 2014

A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus journal, May 2006

A Complete Set of SNAREs in Yeast: A Complete Set of SNAREs in Yeast journal, November 2003

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii journal, May 2017

Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
journal, October 2013

DOC2 Proteins in Rat Brain: Complementary Distribution and Proposed Function as Vesicular Adapter Proteins in Early Stages of Secretion
journal, March 1997

The See1p homologue Vps45p binds to the syntaxin Tlg2p
journal, December 1998

Biogenesis of the Inner Membrane Complex Is Dependent on Vesicular Transport by the Alveolate Specific GTPase Rab11B
journal, July 2010

An endocytic-secretory cycle participates in Toxoplasma gondii in motility
journal, June 2019

A t-SNARE of the endocytic pathway must be activated for fusion
journal, December 2001

Testing the SNARE/SM protein model of membrane fusion
journal, December 2010

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites
journal, January 2019

Saccharomyces cerevisiae--a model organism for the studies on vacuolar transport.
journal, December 2001

Munc18-1 as a key regulator of neurosecretion: Munc18-1 as a key regulator of neurosecretion
journal, July 2010

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
journal, March 2009

Dynamin−SNARE interactions control trans-SNARE formation in intracellular membrane fusion
journal, April 2013

A Congenital Neutrophil Defect Syndrome Associated with Mutations in VPS45
journal, July 2013

Building the Perfect Parasite: Cell Division in Apicomplexa
journal, January 2007

Membrane Fusion
journal, February 2003

A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis
journal, January 2012

Endocytosis
journal, July 1997

Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection
journal, May 2012

The enigmatic endosome – sorting the ins and outs of endocytic trafficking
journal, July 2018

Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion
journal, July 1999

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection
journal, April 2016

A novel polymer of tubulin forms the conoid of Toxoplasma gondii
journal, March 2002

Toxoplasma gondii Syntaxin 6 Is Required for Vesicular Transport Between Endosomal-Like Compartments and the Golgi Complex: Toxoplasma gondii Syntaxin 6 Is a TGN Marker
journal, September 2013

Brefeldin A: insights into the control of membrane traffic and organelle structure.
journal, March 1992

Secretory traffic in the eukaryotic parasite Toxoplasma gondii
journal, May 2002

An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes
journal, March 2013

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii: Cathepsin L in a vacuolar compartment
journal, April 2010

Membrane Fusion: Grappling with SNARE and SM Proteins
journal, January 2009

The Phagosome: Compartment with a License to Kill
journal, January 2007

Cell Division in Apicomplexan Parasites Is Organized by a Homolog of the Striated Rootlet Fiber of Algal Flagella
journal, December 2012

Sec1/Munc18 Proteins
journal, August 2000

AtVPS45 Is a Positive Regulator of the SYP41/SYP61/VTI12 SNARE Complex Involved in Trafficking of Vacuolar Cargo
journal, February 2009

Vesicle trafficking: pleasure and pain from SM genes
journal, April 2003

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division
journal, April 2017

Rab11A-Controlled Assembly of the Inner Membrane Complex Is Required for Completion of Apicomplexan Cytokinesis
journal, January 2009

Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma
journal, March 2016

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1
journal, January 2012

Endosome maturation factors Rabenosyn‐5/VPS45 and caveolin‐1 regulate ciliary membrane and polycystin‐2 homeostasis
journal, March 2018

The Exocyst at a Glance
journal, August 2015

Tethering the assembly of SNARE complexes
journal, January 2014

A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus
journal, May 2006

A Complete Set of SNAREs in Yeast: A Complete Set of SNAREs in Yeast
journal, November 2003

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii
journal, May 2017