Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain

Madhurapantula, Rama S.; Krell, Gabriel; Morfin, Berenice; Roy, Rajarshi; Lister, Kevin; Orgel, Joseph P. R. O.

doi:10.3390/ijms21030763

Title: Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain

Journal Article · 23 January 2020 · International Journal of Molecular Sciences (Online)

DOI: https://doi.org/10.3390/ijms21030763 · OSTI ID:1597998

^[1]; Krell, Gabriel ^[1]; Morfin, Berenice ^[1]; Roy, Rajarshi ^[2]; Lister, Kevin ^[2];

^[1]

Illinois Inst. of Technology, Chicago, IL (United States)
Corvid Technologies, Mooresville, NC (United States)

Mammalian heart valves are soft tissue assemblies with multi-scale material properties. This is because they are constructs comprising both muscle and non-contractile extracellular matrix proteins (such as collagens and proteoglycans) and transition regions where one form of tissue structure becomes another, significantly different form. The leaflets of the mitral and tricuspid valves are connected to chordae tendinae which, in turn, bind through papillary muscles to the cardiac wall of the ventricle. The transition regions between these tissue subsets are complex and diffuse. Their material composition and mechanical properties have not been previously described with both micro and nanoscopic data recorded simultaneously, as reported here. Annotating the mechanical characteristics of these tissue transitions will be of great value in developing novel implants, improving the state of the surgical simulators and advancing robot-assisted surgery. We present here developments in multi-scale methodology that produce data that can relate mechanical properties to molecular structure using scanning X-ray diffraction. We correlate these data to corresponding tissue level (macro and microscopic) stress and strain, with particular emphasis on the transition regions and present analyses to indicate points of possible failure in these tissues.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: National Institute of General Medical Sciences (NIGMS); National Institutes of Health (NIH); US Army Medical Research and Materiel Command (USAMRDC); USDOE Office of Science (SC)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1597998

Journal Information:: International Journal of Molecular Sciences (Online), Journal Name: International Journal of Molecular Sciences (Online) Journal Issue: 3 Vol. 21; ISSN 1422-0067

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Ruptured mitral chordae tendineae may be a frequent and insignificant complication in the mitral valve prolapse syndrome Grenadier, E.; Keidar, S.; Sahn, D. J. European Heart Journal, Vol. 6, Issue 12 https://doi.org/10.1093/oxfordjournals.eurheartj.a061803	journal	December 1985
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X-ray diffraction reveals blunt-force loading threshold for nanoscopic structural change in ex vivo neuronal tissues Orgel, Joseph; Madhurapantula, Rama S.; Eidsmore, Ashley Journal of Synchrotron Radiation, Vol. 26, Issue 1 https://doi.org/10.1107/s1600577518015035	journal	January 2019
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A comprehensive pipeline for multi-resolution modeling of the mitral valve: Validation, computational efficiency, and predictive capability Drach, Andrew; Khalighi, Amir H.; Sacks, Michael S. International Journal for Numerical Methods in Biomedical Engineering, Vol. 34, Issue 2 https://doi.org/10.1002/cnm.2921	journal	September 2017
Regulation of sarcomere number in skeletal muscle: A comparison of hypotheses Herring, Susan W.; Grimm, Arthur F.; Grimm, Betsy R. Muscle & Nerve, Vol. 7, Issue 2 https://doi.org/10.1002/mus.880070213	journal	February 1984
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Role of Computational Simulations in Heart Valve Dynamics and Design of Valvular Prostheses Chandran, Krishnan B. Cardiovascular Engineering and Technology, Vol. 1, Issue 1 https://doi.org/10.1007/s13239-010-0002-x	journal	February 2010
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Evaluation of Two Flexible Colonoscopy Simulators and Transfer of Skills into Clinical Practice Gomez, Pedro Pablo; Willis, Ross E.; Sickle, Kent Van Journal of Surgical Education, Vol. 72, Issue 2 https://doi.org/10.1016/j.jsurg.2014.08.010	journal	March 2015
Subject-specific finite-element modeling of normal aortic valve biomechanics from 3D+t TEE images Labrosse, Michel R.; Beller, Carsten J.; Boodhwani, Munir Medical Image Analysis, Vol. 20, Issue 1 https://doi.org/10.1016/j.media.2014.11.003	journal	February 2015
TrackMate: An open and extensible platform for single-particle tracking Tinevez, Jean-Yves; Perry, Nick; Schindelin, Johannes Methods, Vol. 115 https://doi.org/10.1016/j.ymeth.2016.09.016	journal	February 2017
Relationship Between Collagen Fibrils, Glycosaminoglycans, and Stress Relaxation in Mitral Valve Chordae Tendineae Liao, Jun; Vesely, Ivan Annals of Biomedical Engineering, Vol. 32, Issue 7 https://doi.org/10.1023/B:ABME.0000032460.97278.e9	journal	July 2004
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Analyzing Contractile Responses in Demembranized Pig Papillary Muscle Fibres: the Influence of Calcium, Resting Force, and Temperature Vahl, C.; Lange, R.; Bauernschmitt, R. The Thoracic and Cardiovascular Surgeon, Vol. 39, Issue 06 https://doi.org/10.1055/s-2007-1019994	journal	December 1991
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Age-Related Changes in Material Behavior of Porcine Mitral and Aortic Valves and Correlation to Matrix Composition Stephens, Elizabeth H.; de Jonge, Nicky; McNeill, Meaghan P. Tissue Engineering Part A, Vol. 16, Issue 3 https://doi.org/10.1089/ten.tea.2009.0288	journal	March 2010
Anatomy of the mitral valve: understanding the mitral valve complex in mitral regurgitation McCarthy, K. P.; Ring, L.; Rana, B. S. European Journal of Echocardiography, Vol. 11, Issue 10 https://doi.org/10.1093/ejechocard/jeq153	journal	November 2010
Ruptured mitral chordae tendineae may be a frequent and insignificant complication in the mitral valve prolapse syndrome Grenadier, E.; Keidar, S.; Sahn, D. J. European Heart Journal, Vol. 6, Issue 12 https://doi.org/10.1093/oxfordjournals.eurheartj.a061803	journal	December 1985
A Systematic Review of Skills Transfer After Surgical Simulation Training Sturm, Lana P.; Windsor, John A.; Cosman, Peter H. Annals of Surgery, Vol. 248, Issue 2 https://doi.org/10.1097/SLA.0b013e318176bf24	journal	January 2008
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X-ray diffraction reveals blunt-force loading threshold for nanoscopic structural change in ex vivo neuronal tissues Orgel, Joseph; Madhurapantula, Rama S.; Eidsmore, Ashley Journal of Synchrotron Radiation, Vol. 26, Issue 1 https://doi.org/10.1107/S1600577518015035	journal	January 2019
X-ray diffraction reveals blunt-force loading threshold for nanoscopic structural change in ex vivo neuronal tissues Orgel, Joseph; Madhurapantula, Rama S.; Eidsmore, Ashley International Union of Crystallography (IUCr) https://doi.org/10.1107/s1600577518015035/fv5095sup1.pdf	text	January 2019
Composition and adaptation of human myotendinous junction and neighboring muscle fibers to heavy resistance training Jakobsen, J. R.; Mackey, A. L.; Knudsen, A. B. Scandinavian Journal of Medicine & Science in Sports, Vol. 27, Issue 12 https://doi.org/10.1111/sms.12794	journal	October 2016
Muscle and Tendon Tissues: Constitutive Modeling and Computational Issues Spyrou, L. A.; Aravas, N. Journal of Applied Mechanics, Vol. 78, Issue 4 https://doi.org/10.1115/1.4003741	journal	April 2011
Chordal rupture. I: aetiology and natural history. Oliveira, D. B.; Dawkins, K. D.; Kay, P. H. Heart, Vol. 50, Issue 4 https://doi.org/10.1136/hrt.50.4.312	journal	October 1983
Computational Modeling of Cardiac Valve Function and Intervention Sun, Wei; Martin, Caitlin; Pham, Thuy Annual Review of Biomedical Engineering, Vol. 16, Issue 1 https://doi.org/10.1146/annurev-bioeng-071813-104517	journal	July 2014
Fluid Mechanics of Heart Valves Yoganathan, Ajit P.; He, Zhaoming; Casey Jones, S. Annual Review of Biomedical Engineering, Vol. 6, Issue 1 https://doi.org/10.1146/annurev.bioeng.6.040803.140111	journal	August 2004
Tennis Leg: Clinical US Study of 141 Patients and Anatomic Investigation of Four Cadavers with MR Imaging and US Delgado, Gonzalo J.; Chung, Christine B.; Lektrakul, Nitaya Radiology, Vol. 224, Issue 1 https://doi.org/10.1148/radiol.2241011067	journal	July 2002
Length and PKA Dependence of Force Generation and Loaded Shortening in Porcine Cardiac Myocytes McDonald, Kerry S.; Hanft, Laurin M.; Domeier, Timothy L. Biochemistry Research International, Vol. 2012 https://doi.org/10.1155/2012/371415	journal	January 2012
Biomechanical and histological evaluation of muscle after controlled strain injury Nikolaou, Pantelis K.; Macdonald, Beth L.; Glisson, Richard R. The American Journal of Sports Medicine, Vol. 15, Issue 1 https://doi.org/10.1177/036354658701500102	journal	January 1987
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valve failure
60 APPLIED LIFE SCIENCES
X-ray diffraction scanning
heart valves
stress–strain relations
tissue transition regions

Title: Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain

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References (88)

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