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Title: Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves

Abstract

Control of cells behavior through topography of substrates is a vital theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano- and microscale topography requires processing by lithography, microprinting, etching, etc. In this work, we present a different approach based on anisotropic elastic properties of polymerized smectic A (SmA) liquid crystal elastomer (LCE). When the SmA liquid crystal coating is deposited onto a substrate with planar alignment of the molecules, it develops nanogrooves at its free surface. After photopolymerization, these nanogrooves show an excellent ability to align human dermal fibroblasts (hDFs) over large areas. The alignment quality is good for both bare SmA LCE substrates and for substrates coated with fibronectin. The SmA LCE nano-topographies show a high potential for tissue engineering.

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [1]; ORCiD logo [1]
  1. Kent State Univ., Kent, OH (United States)
Publication Date:
Research Org.:
Kent State Univ., Kent, OH (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1597484
Grant/Contract Number:  
SC0019105
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Biomedical Materials Research. Part A
Additional Journal Information:
Journal Volume: 108; Journal Issue: 5; Journal ID: ISSN 1549-3296
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; liquid crystal elastomer substrates; human dermal fibroblast alignment; nanotopography; biological cell alignment

Citation Formats

Babakhanova, Greta, Krieger, Jess, Li, Bing‐Xiang, Turiv, Taras, Kim, Min‐Ho, and Lavrentovich, Oleg D. Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves. United States: N. p., 2020. Web. doi:10.1002/jbm.a.36896.
Babakhanova, Greta, Krieger, Jess, Li, Bing‐Xiang, Turiv, Taras, Kim, Min‐Ho, & Lavrentovich, Oleg D. Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves. United States. doi:https://doi.org/10.1002/jbm.a.36896
Babakhanova, Greta, Krieger, Jess, Li, Bing‐Xiang, Turiv, Taras, Kim, Min‐Ho, and Lavrentovich, Oleg D. Sat . "Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves". United States. doi:https://doi.org/10.1002/jbm.a.36896. https://www.osti.gov/servlets/purl/1597484.
@article{osti_1597484,
title = {Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves},
author = {Babakhanova, Greta and Krieger, Jess and Li, Bing‐Xiang and Turiv, Taras and Kim, Min‐Ho and Lavrentovich, Oleg D.},
abstractNote = {Control of cells behavior through topography of substrates is a vital theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano- and microscale topography requires processing by lithography, microprinting, etching, etc. In this work, we present a different approach based on anisotropic elastic properties of polymerized smectic A (SmA) liquid crystal elastomer (LCE). When the SmA liquid crystal coating is deposited onto a substrate with planar alignment of the molecules, it develops nanogrooves at its free surface. After photopolymerization, these nanogrooves show an excellent ability to align human dermal fibroblasts (hDFs) over large areas. The alignment quality is good for both bare SmA LCE substrates and for substrates coated with fibronectin. The SmA LCE nano-topographies show a high potential for tissue engineering.},
doi = {10.1002/jbm.a.36896},
journal = {Journal of Biomedical Materials Research. Part A},
number = 5,
volume = 108,
place = {United States},
year = {2020},
month = {2}
}

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