MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential
Abstract
Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.
- Authors:
-
- Univ. of New Mexico, Albuquerque, NM (United States)
- Kumaun Univ. (India)
- Loyola Univ., Chicago, IL (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Rutgers Univ., Piscataway, NJ (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 1597372
- Report Number(s):
- LA-UR-19-31932
Journal ID: ISSN 2073-4425; GENEG9
- Grant/Contract Number:
- 89233218CNA000001
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Genes
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 10; Journal ID: ISSN 2073-4425
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; Biological Science; microRNA; pancreatic cancer; diagnosis; prognosis; potential therapeutic targets
Citation Formats
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, and Parasher, Gulshan. MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. United States: N. p., 2019.
Web. doi:10.3390/genes10100752.
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, & Parasher, Gulshan. MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. United States. doi:10.3390/genes10100752.
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, and Parasher, Gulshan. Wed .
"MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential". United States. doi:10.3390/genes10100752. https://www.osti.gov/servlets/purl/1597372.
@article{osti_1597372,
title = {MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential},
author = {Rawat, Manmeet and Kadian, Kavita and Gupta, Yash and Kumar, Anand and Chain, Patrick Sam Guy and Kovbasnjuk, Olga and Kumar, Suneel and Parasher, Gulshan},
abstractNote = {Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.},
doi = {10.3390/genes10100752},
journal = {Genes},
number = 10,
volume = 10,
place = {United States},
year = {2019},
month = {9}
}
Works referenced in this record:
Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype
journal, January 2015
- Jiang, Jianxin; Yu, Chao; Chen, Meiyuan
- Oncotarget, Vol. 6, Issue 5
Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer
journal, April 2010
- Ho, Allen S.; Huang, Xin; Cao, Hongbin
- Translational Oncology, Vol. 3, Issue 2
miR-203 inhibits proliferation of HCC cells by targeting survivin: MIR-203 INHIBITS HCC PROLIFERATION VIA SURVIVIN
journal, August 2012
- Wei, Wang; Wanjun, Liu; Hui, Sun
- Cell Biochemistry and Function, Vol. 31, Issue 1
The JAK/STAT signaling pathway
journal, March 2004
- Rawlings, J. S.
- Journal of Cell Science, Vol. 117, Issue 8
MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
journal, February 2009
- Habbe, Nils; Koorstra, Jan-Bart M.; Mendell, Joshua T.
- Cancer Biology & Therapy, Vol. 8, Issue 4
miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial–mesenchymal transition and the Notch signaling pathway
journal, February 2017
- Tang, Yan; Tang, Yong; Cheng, Ying-sheng
- Scientific Reports, Vol. 7, Issue 1
The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition
journal, January 2008
- Paterson, Emily L.; Kolesnikoff, Natasha; Gregory, Philip A.
- The Scientific World JOURNAL, Vol. 8
Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway
journal, July 2012
- Zhang, Yan; Fan, Kai-Ji; Sun, Qiang
- Nucleic Acids Research, Vol. 40, Issue 18
Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
journal, January 2015
- Ma, Jia; Fang, Binbin; Zeng, Fanpeng
- Oncotarget, Vol. 6, Issue 3
Smads and early developmental signaling by the TGFbeta superfamily
journal, August 1998
- Whitman, M.
- Genes & Development, Vol. 12, Issue 16
MicroRNA in pancreatic cancer
journal, June 2016
- Yonemori, Keiichi; Kurahara, Hiroshi; Maemura, Kosei
- Journal of Human Genetics, Vol. 62, Issue 1
MicroRNA-100 regulates IGF1-receptor expression in metastatic pancreatic cancer cells
journal, February 2013
- Huang, Js; Egger, Me; Grizzle, We
- Biotechnic & Histochemistry, Vol. 88, Issue 7
MicroRNA-218 inhibits cell invasion and migration of pancreatic cancer via regulating ROBO1
journal, July 2014
- He, Hang; Hao, Si-jie; Yao, Lie
- Cancer Biology & Therapy, Vol. 15, Issue 10
MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior
journal, October 2006
- Roldo, Claudia; Missiaglia, Edoardo; Hagan, John P.
- Journal of Clinical Oncology, Vol. 24, Issue 29
MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2
journal, September 2014
- Wang, Siliang; Chen, Xiaodong; Tang, Meiyue
- Oncology Reports, Vol. 32, Issue 6
Upregulation of miR-150* and miR-630 Induces Apoptosis in Pancreatic Cancer Cells by Targeting IGF-1R
journal, May 2013
- Farhana, Lulu; Dawson, Marcia I.; Murshed, Farhan
- PLoS ONE, Vol. 8, Issue 5
Diagnostic and biological significance of microRNA-192 in pancreatic ductal adenocarcinoma
journal, April 2013
- Zhao, Chenyan; Zhang, Jing; Zhang, Shuhui
- Oncology Reports, Vol. 30, Issue 1
MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer
journal, November 2010
- Hao, Jun; Zhang, Shuyu; Zhou, Yingqi
- FEBS Letters, Vol. 585, Issue 1
Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs
journal, September 2017
- Church, Victoria A.; Pressman, Sigal; Isaji, Mamiko
- Cell Reports, Vol. 20, Issue 13
Oncomirs — microRNAs with a role in cancer
journal, April 2006
- Esquela-Kerscher, Aurora; Slack, Frank J.
- Nature Reviews Cancer, Vol. 6, Issue 4
MicroRNA-424-5p Suppresses the Expression of SOCS6 in Pancreatic Cancer
journal, May 2013
- Wu, Kemin; Hu, Guohuang; He, Xin
- Pathology & Oncology Research, Vol. 19, Issue 4
MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B
journal, June 2011
- Liffers, Sven-T; Munding, Johanna B.; Vogt, Markus
- Laboratory Investigation, Vol. 91, Issue 10
Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival: Micro RNAs in PDAC
journal, June 2009
- Greither, Thomas; Grochola, Lukasz F.; Udelnow, Andrej
- International Journal of Cancer, Vol. 126, Issue 1
MicroRNA-21 in Pancreatic Ductal Adenocarcinoma Tumor-Associated Fibroblasts Promotes Metastasis
journal, August 2013
- Kadera, Brian E.; Li, Luyi; Toste, Paul A.
- PLoS ONE, Vol. 8, Issue 8
Tumor-Suppressor genes in pancreatic cancer
journal, December 1998
- Hruban, Ralph H.; Offerhaus, G. Johan A.; Kern, Scott E.
- Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 5, Issue 4
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
journal, February 2012
- Collins, Meredith A.; Bednar, Filip; Zhang, Yaqing
- Journal of Clinical Investigation, Vol. 122, Issue 2
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
journal, September 2010
- Morris, John P.; Wang, Sam C.; Hebrok, Matthias
- Nature Reviews Cancer, Vol. 10, Issue 10
MicroRNA-375 and MicroRNA-221: Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer
journal, February 2011
- Basu, A.; Alder, H.; Khiyami, A.
- Genes & Cancer, Vol. 2, Issue 2
MicroRNA-200c Modulates the Expression of MUC4 and MUC16 by Directly Targeting Their Coding Sequences in Human Pancreatic Cancer
journal, October 2013
- Radhakrishnan, Prakash; Mohr, Ashley M.; Grandgenett, Paul M.
- PLoS ONE, Vol. 8, Issue 10
MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells
journal, August 2009
- Ji, Qing; Hao, Xinbao; Zhang, Min
- PLoS ONE, Vol. 4, Issue 8
Inhibition of microRNA with antisense oligonucleotides
journal, January 2008
- Esau, Christine C.
- Methods, Vol. 44, Issue 1
A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition
journal, October 2008
- Bracken, C. P.; Gregory, P. A.; Kolesnikoff, N.
- Cancer Research, Vol. 68, Issue 19
Prospects of miRNA-Based Therapy for Pancreatic Cancer
journal, July 2013
- Pai, Priya; Rachagani, Satyanarayana; Are, Chandrakanth
- Current Drug Targets, Vol. 14, Issue 10
MicroRNA expression and function in cancer
journal, December 2006
- Garzon, Ramiro; Fabbri, Muller; Cimmino, Amelia
- Trends in Molecular Medicine, Vol. 12, Issue 12
MicroRNA-21 is Overexpressed in Pancreatic Cancer and a Potential Predictor of Survival
journal, July 2008
- Dillhoff, Mary; Liu, James; Frankel, Wendy
- Journal of Gastrointestinal Surgery, Vol. 12, Issue 12
MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls
journal, May 2013
- Li, A.; Yu, J.; Kim, H.
- Clinical Cancer Research, Vol. 19, Issue 13
miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway
journal, October 2012
- Hu, Yongjun; Ou, Yanglu; Wu, Kemin
- Tumor Biology, Vol. 33, Issue 6
Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
journal, January 2013
- Wang, P.; Chen, L.; Zhang, J.
- Oncogene, Vol. 33, Issue 4
Small-Molecule Inhibitors of MicroRNA miR-21 Function
journal, September 2008
- Gumireddy, Kiranmai; Young, Douglas D.; Xiong, Xin
- Angewandte Chemie International Edition, Vol. 47, Issue 39
Causes and Consequences of MicroRNA Dysregulation
journal, January 2012
- Iorio, Marilena V.; Croce, Carlo M.
- The Cancer Journal, Vol. 18, Issue 3
Personalized RNA Medicine for Pancreatic Cancer
journal, January 2018
- Gilles, Maud-Emmanuelle; Hao, Liangliang; Huang, Ling
- Clinical Cancer Research, Vol. 24, Issue 7
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
journal, June 2005
- Chendrimada, Thimmaiah P.; Gregory, Richard I.; Kumaraswamy, Easwari
- Nature, Vol. 436, Issue 7051
MicroRNA-375 targets the 3-phosphoinositide-dependent protein kinase-1 gene in pancreatic carcinoma
journal, August 2013
- Song, Shi-Duo; Zhou, Jian; Zhou, Jin
- Oncology Letters, Vol. 6, Issue 4
MicroRNA expression profiling of diagnostic needle aspirates from surgical pancreatic cancer specimens
journal, January 2014
- Hong, Tae Ho; Park, Il Young
- Annals of Surgical Treatment and Research, Vol. 87, Issue 6
EP300-A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas: Role of EP300 in Metastasis of Pancreatic Cancer
journal, June 2009
- Mees, Soeren Torge; Mardin, Wolf Arif; Wendel, Claudia
- International Journal of Cancer, Vol. 126, Issue 1
MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer
journal, November 2014
- Listing, H.; Mardin, W. A.; Wohlfromm, S.
- British Journal of Cancer, Vol. 112, Issue 1
MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
journal, January 2010
- Yu, Jun; Ohuchida, Kenoki; Mizumoto, Kazuhiro
- Molecular Cancer, Vol. 9, Issue 1
Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma
journal, June 2010
- Young, Douglas D.; Connelly, Colleen M.; Grohmann, Christoph
- Journal of the American Chemical Society, Vol. 132, Issue 23
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
journal, January 2005
- Lewis, Benjamin P.; Burge, Christopher B.; Bartel, David P.
- Cell, Vol. 120, Issue 1
Retinoic Acid Receptor Antagonists Inhibit miR-10a Expression and Block Metastatic Behavior of Pancreatic Cancer
journal, December 2009
- Weiss, Frank Ulrich; Marques, Ines J.; Woltering, Joost M.
- Gastroenterology, Vol. 137, Issue 6
The Loss of miR-26a-Mediated Post-Transcriptional Regulation of Cyclin E2 in Pancreatic Cancer Cell Proliferation and Decreased Patient Survival
journal, October 2013
- Deng, Jingjing; He, Miaoxia; Chen, Lizao
- PLoS ONE, Vol. 8, Issue 10
Cancer statistics, 2019
journal, October 2018
- Siegel, Rebecca L.; Miller, Kimberly D.; Jemal, Ahmedin
- CA: A Cancer Journal for Clinicians, Vol. 69, Issue 1
A pancreatic islet-specific microRNA regulates insulin secretion
journal, November 2004
- Poy, Matthew N.; Eliasson, Lena; Krutzfeldt, Jan
- Nature, Vol. 432, Issue 7014
MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
journal, January 2007
- Szafranska, A. E.; Davison, T. S.; John, J.
- Oncogene, Vol. 26, Issue 30
Oncogenic miR-23a in Pancreatic Ductal Adenocarcinogenesis Via Inhibiting APAF1
journal, February 2015
- Liu, Ning; Sun, Yuan-Yuan; Zhang, Xiao-Wen
- Digestive Diseases and Sciences, Vol. 60, Issue 7
miR-208-Induced Epithelial to Mesenchymal Transition of Pancreatic Cancer Cells Promotes Cell Metastasis and Invasion
journal, March 2014
- Liu, Anan; Shao, Chenghao; Jin, Gang
- Cell Biochemistry and Biophysics, Vol. 69, Issue 2
MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway
journal, January 2014
- Zhou, Jian; Song, Shiduo; He, Songbing
- International Journal of Molecular Medicine, Vol. 33, Issue 4
A microRNA meta-signature for pancreatic ductal adenocarcinoma
journal, February 2014
- Frampton, Adam E.; Giovannetti, Elisa; Jamieson, Nigel B.
- Expert Review of Molecular Diagnostics, Vol. 14, Issue 3
miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor
journal, March 2011
- Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai
- Biochemical and Biophysical Research Communications, Vol. 406, Issue 4
MicroRNA Targeted Therapeutic Approach for Pancreatic Cancer
journal, January 2016
- Li, Yiwei; Sarkar, Fazlul H.
- International Journal of Biological Sciences, Vol. 12, Issue 3
The microRNA.org resource: targets and expression
journal, December 2007
- Betel, D.; Wilson, M.; Gabow, A.
- Nucleic Acids Research, Vol. 36, Issue Database
Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers: Circulating MicroRNAs
journal, November 2010
- Zen, Ke; Zhang, Chen-Yu
- Medicinal Research Reviews, Vol. 32, Issue 2
miR-203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin
journal, May 2013
- Xu, Dong; Wang, Qingguang; An, Yong
- Molecular Medicine Reports, Vol. 8, Issue 2
Expression of MicroRNAs in Patients With Pancreatic Cancer and Its Prognostic Significance
journal, January 2013
- Papaconstantinou, Ioannis G.; Manta, Asimina; Gazouli, Maria
- Pancreas, Vol. 42, Issue 1
Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation
journal, February 2012
- Du, Jian; Wang, Jingwen; Tan, Guang
- Medical Oncology, Vol. 29, Issue 4
Roles for KRAS in Pancreatic Tumor Development and Progression
journal, May 2013
- di Magliano, Marina Pasca; Logsdon, Craig D.
- Gastroenterology, Vol. 144, Issue 6
The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS
journal, July 2010
- Zhao, Wu-Gan; Yu, Shuang-Ni; Lu, Zhao-Hui
- Carcinogenesis, Vol. 31, Issue 10
Circulating microRNAs as stable blood-based markers for cancer detection
journal, July 2008
- Mitchell, P. S.; Parkin, R. K.; Kroh, E. M.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 30
Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer
journal, November 2011
- Morimura, R.; Komatsu, S.; Ichikawa, D.
- British Journal of Cancer, Vol. 105, Issue 11
Loss of miR-126 is crucial to pancreatic cancer progression
journal, July 2012
- Frampton, Adam E.; Krell, Jonathan; Jacob, Jimmy
- Expert Review of Anticancer Therapy, Vol. 12, Issue 7
miRNA-96 Suppresses KRAS and Functions as a Tumor Suppressor Gene in Pancreatic Cancer
journal, July 2010
- Yu, S.; Lu, Z.; Liu, C.
- Cancer Research, Vol. 70, Issue 14
miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1
journal, June 2013
- Iwagami, Y.; Eguchi, H.; Nagano, H.
- British Journal of Cancer, Vol. 109, Issue 2
MicroRNA-gene signaling pathways in pancreatic cancer
journal, January 2013
- Iliopoulos, Dimitrios; Drakaki, Alexandra
- Biomedical Journal, Vol. 36, Issue 5
miRBase: annotating high confidence microRNAs using deep sequencing data
journal, November 2013
- Kozomara, Ana; Griffiths-Jones, Sam
- Nucleic Acids Research, Vol. 42, Issue D1
Emerging role of the KRAS-PDK1 axis in pancreatic cancer
journal, January 2014
- Ferro, Riccardo
- World Journal of Gastroenterology, Vol. 20, Issue 31
MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1
journal, July 2012
- Rachagani, Satyanarayana; Macha, Muzafar A.; Ponnusamy, Moorthy P.
- Carcinogenesis, Vol. 33, Issue 10
Transforming growth factor-β and breast cancer: Cell cycle arrest by transforming growth factor-β and its disruption in cancer
journal, April 2000
- Donovan, Jeffrey; Slingerland, Joyce
- Breast Cancer Research, Vol. 2, Issue 2
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
journal, February 2004
- Bohnsack, M. T.
- RNA, Vol. 10, Issue 2
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
journal, March 2008
- Morin, R. D.; O'Connor, M. D.; Griffith, M.
- Genome Research, Vol. 18, Issue 4
Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group
journal, May 2007
- Moore, Malcolm J.; Goldstein, David; Hamm, John
- Journal of Clinical Oncology, Vol. 25, Issue 15
Smad transcription factors
journal, December 2005
- Massague, J.
- Genes & Development, Vol. 19, Issue 23
Control of translation and mRNA degradation by miRNAs and siRNAs
journal, March 2006
- Valencia-Sanchez, M. A.
- Genes & Development, Vol. 20, Issue 5
Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
journal, October 2006
- Ridley, Anne J.
- Trends in Cell Biology, Vol. 16, Issue 10
The functions and regulation of the PTEN tumour suppressor
journal, April 2012
- Song, Min Sup; Salmena, Leonardo; Pandolfi, Pier Paolo
- Nature Reviews Molecular Cell Biology, Vol. 13, Issue 5
Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1
journal, June 2013
- Huang, Chen; Li, Haidong; Wu, Weidong
- Oncology Reports, Vol. 30, Issue 3
MicroRNA-221 Mediates the Effects of PDGF-BB on Migration, Proliferation, and the Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells
journal, August 2013
- Su, Anping; He, Sirong; Tian, Bole
- PLoS ONE, Vol. 8, Issue 8
An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe
journal, January 2005
- Liang, R. -Q.
- Nucleic Acids Research, Vol. 33, Issue 2
MicroRNA in Cancer Prognosis
journal, December 2008
- Slack, Frank J.; Weidhaas, Joanne B.
- New England Journal of Medicine, Vol. 359, Issue 25
MicroRNAs Targeting Oncogenes Are Down-Regulated in Pancreatic Malignant Transformation from Benign Tumors
journal, February 2012
- Jiao, Long R.; Frampton, Adam E.; Jacob, Jimmy
- PLoS ONE, Vol. 7, Issue 2
MicroRNA signatures in human cancers
journal, November 2006
- Calin, George A.; Croce, Carlo M.
- Nature Reviews Cancer, Vol. 6, Issue 11
Inhibition of Transforming Growth Factor β Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness
journal, March 2007
- Gaspar, Nicholas J.; Li, Lingyun; Kapoun, Ann M.
- Molecular Pharmacology, Vol. 72, Issue 1
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway
journal, December 2010
- Kent, O. A.; Chivukula, R. R.; Mullendore, M.
- Genes & Development, Vol. 24, Issue 24
Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes
journal, December 2004
- Válóczi, Anna; Hornyik, Csaba; Varga, Nóra
- Nucleic Acids Research, Vol. 32, Issue 22, p. e175
miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
journal, December 2010
- Ma, Yihui; Yu, Shuangni; Zhao, Wugan
- Cancer Letters, Vol. 298, Issue 2
MicroRNA-34b Inhibits Pancreatic Cancer Metastasis Through Repressing Smad3
journal, April 2013
- Liu, C.; Cheng, H.; Shi, S.
- Current Molecular Medicine, Vol. 13, Issue 4
Down-regulation of MicroRNA-494 via Loss of SMAD4 Increases FOXM1 and β-Catenin Signaling in Pancreatic Ductal Adenocarcinoma Cells
journal, August 2014
- Li, Lei; Li, Zhaoshen; Kong, Xiangyu
- Gastroenterology, Vol. 147, Issue 2
Combinatorial microRNA target predictions
journal, April 2005
- Krek, Azra; Grün, Dominic; Poy, Matthew N.
- Nature Genetics, Vol. 37, Issue 5
Transcriptional regulation and transformation by Myc proteins
journal, August 2005
- Adhikary, Sovana; Eilers, Martin
- Nature Reviews Molecular Cell Biology, Vol. 6, Issue 8
MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity
journal, May 2010
- Giovannetti, Elisa; Funel, Niccola; Peters, Godefridus J.
- Cancer Research, Vol. 70, Issue 11
miR-34 – a microRNA replacement therapy is headed to the clinic
journal, January 2012
- Bader, Andreas G.
- Frontiers in Genetics, Vol. 3
Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer
journal, January 2015
- Rachagani, Satyanarayana; Macha, Muzafar A.; Heimann, Nicholas
- Advanced Drug Delivery Reviews, Vol. 81
Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides
journal, January 2006
- Deo, Monika; Yu, Jenn-Yah; Chung, Kwan-Ho
- Developmental Dynamics, Vol. 235, Issue 9
Potent inhibition of microRNA in vivo without degradation
journal, November 2008
- Davis, Scott; Propp, Stephanie; Freier, Susan M.
- Nucleic Acids Research, Vol. 37, Issue 1
MicroRNAs in pancreatic malignancy: Progress and promises
journal, June 2014
- Srivastava, Sanjeev K.; Arora, Sumit; Singh, Seema
- Cancer Letters, Vol. 347, Issue 2
MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias
journal, November 2011
- Yu, J.; Li, A.; Hong, S. -M.
- Clinical Cancer Research, Vol. 18, Issue 4
Silencing of microRNAs in vivo with ‘antagomirs’
journal, October 2005
- Krützfeldt, Jan; Rajewsky, Nikolaus; Braich, Ravi
- Nature, Vol. 438, Issue 7068
Aberrant Expression miR-196a Is Associated With Abnormal Apoptosis, Invasion, and Proliferation of Pancreatic Cancer Cells
journal, January 2013
- Liu, Minghao; Du, Yiqi; Gao, Jun
- Pancreas, Vol. 42, Issue 7
Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer
journal, November 2011
- Liu, Jianqiang; Gao, Jun; Du, Yiqi
- International Journal of Cancer, Vol. 131, Issue 3
MicroRNA-155 Is Regulated by the Transforming Growth Factor /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA
journal, September 2008
- Kong, W.; Yang, H.; He, L.
- Molecular and Cellular Biology, Vol. 28, Issue 22
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
journal, March 2000
- Hammond, Scott M.; Bernstein, Emily; Beach, David
- Nature, Vol. 404, Issue 6775
High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5
journal, February 2018
- Yuan, Qinggong; Zhang, Yan; Li, Junhui
- Biochemical and Biophysical Research Communications, Vol. 497, Issue 1
Targeting microRNAs in cancer: rationale, strategies and challenges
journal, October 2010
- Garzon, Ramiro; Marcucci, Guido; Croce, Carlo M.
- Nature Reviews Drug Discovery, Vol. 9, Issue 10
MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4
journal, February 2016
- Wei, Xueju; Wang, Weibin; Wang, Lanlan
- Cancer Medicine, Vol. 5, Issue 4
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
journal, December 2005
- Kloosterman, Wigard P.; Wienholds, Erno; de Bruijn, Ewart
- Nature Methods, Vol. 3, Issue 1
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
journal, October 2007
- Gironella, M.; Seux, M.; Xie, M. -J.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 41
Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985–1995, using the National Cancer Database11No competing interests declared.
journal, July 1999
- Sener, Stephen F.; Fremgen, Amy; Menck, Herman R.
- Journal of the American College of Surgeons, Vol. 189, Issue 1
Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers
journal, February 2017
- Calatayud, Dan; Dehlendorff, Christian; Boisen, Mogens K.
- Biomarker Research, Vol. 5, Issue 1
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
journal, May 2008
- Burk, Ulrike; Schubert, Jörg; Wellner, Ulrich
- EMBO reports, Vol. 9, Issue 6
The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
journal, October 2015
- Liu, Rui; Zhang, Haiyang; Wang, Xia
- Oncotarget, Vol. 6, Issue 41
LPS Induced miR-181a Promotes Pancreatic Cancer Cell Migration via Targeting PTEN and MAP2K4
journal, February 2014
- Liu, Jianhui; Xu, Dong; Wang, Qingguang
- Digestive Diseases and Sciences, Vol. 59, Issue 7
A Comprehensive Assessment of the Role of miRNAs as Biomarkers in Gastroenteropancreatic Neuroendocrine Tumors
journal, January 2018
- Malczewska, Anna; Kidd, Mark; Matar, Somer
- Neuroendocrinology, Vol. 107, Issue 1
Absolute quantitation of microRNAs with a PCR-based assay
journal, December 2006
- Duncan, David D.; Eshoo, Mark; Esau, Christine
- Analytical Biochemistry, Vol. 359, Issue 2, p. 268-270
Dysregulation of miR-15a and miR-214 in human pancreatic cancer
journal, January 2010
- Zhang, Xing J.; Ye, Hua; Zeng, Cheng W.
- Journal of Hematology & Oncology, Vol. 3, Issue 1
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
journal, December 1993
- Lee, Rosalind C.; Feinbaum, Rhonda L.; Ambros, Victor
- Cell, Vol. 75, Issue 5
miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells
journal, January 2014
- Miao, Lifeng; Xiong, Xianze; Lin, Yixin
- Oncology Letters, Vol. 7, Issue 3
miRNAs in pancreatic cancer: Therapeutic potential, delivery challenges and strategies
journal, January 2015
- Chitkara, Deepak; Mittal, Anupama; Mahato, Ram I.
- Advanced Drug Delivery Reviews, Vol. 81
Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer
journal, January 2014
- Ganepola, Ganepola AP
- World Journal of Gastrointestinal Oncology, Vol. 6, Issue 1
Pancreatic cancer: Current research and future directions
journal, April 2016
- Falasca, Marco; Kim, Minkyoung; Casari, Ilaria
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1865, Issue 2
MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells
journal, October 2011
- Srivastava, Sanjeev K.; Bhardwaj, Arun; Singh, Seema
- Carcinogenesis, Vol. 32, Issue 12
The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance
journal, August 2018
- Biancur, Douglas E.; Kimmelman, Alec C.
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1870, Issue 1
Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells
journal, August 2009
- Li, Y.; VandenBoom, T. G.; Kong, D.
- Cancer Research, Vol. 69, Issue 16
MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma
journal, August 2012
- Schultz, Nicolai A.; Werner, Jens; Willenbrock, Hanni
- Modern Pathology, Vol. 25, Issue 12
Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma
journal, January 2009
- Park, Jong-Kook; Lee, Eun Joo; Esau, Christine
- Pancreas, Vol. 38, Issue 7
MicroRNAs (miRNAs) as Biomarker(s) for Prognosis and Diagnosis of Gastrointestinal (GI) Cancers
journal, January 2014
- Macha, Muzafar; Seshacharyulu, Parthasarathy; Krishn, Shiv
- Current Pharmaceutical Design, Vol. 20, Issue 33
MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in Its Invasiveness Partially via Suppression of the HOXA1 Gene
journal, March 2012
- Ohuchida, Kenoki; Mizumoto, Kazuhiro; Lin, Cui
- Annals of Surgical Oncology, Vol. 19, Issue 7
A custom microarray platform for analysis of microRNA gene expression
journal, September 2004
- Thomson, J. Michael; Parker, Joel; Perou, Charles M.
- Nature Methods, Vol. 1, Issue 1, p. 47-53
Addressing the challenges of pancreatic cancer: Future directions for improving outcomes
journal, January 2015
- Hidalgo, Manuel; Cascinu, Stefano; Kleeff, Jörg
- Pancreatology, Vol. 15, Issue 1
miR-216a may inhibit pancreatic tumor growth by targeting JAK2
journal, July 2015
- Hou, Bao-hua; Jian, Zhi-xiang; Cui, Peng
- FEBS Letters, Vol. 589, Issue 17
HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96
journal, July 2014
- Feng, Jin; Yu, Junbo; Pan, Xiaolin
- Oncotarget, Vol. 5, Issue 14
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
journal, September 2009
- Olson, P.; Lu, J.; Zhang, H.
- Genes & Development, Vol. 23, Issue 18
Wnt signalling in stem cells and cancer
journal, April 2005
- Reya, Tannishtha; Clevers, Hans
- Nature, Vol. 434, Issue 7035
MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood-Based Biomarkers of Disease
journal, September 2009
- Wang, J.; Chen, J.; Chang, P.
- Cancer Prevention Research, Vol. 2, Issue 9
MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis
journal, May 2007
- Bloomston, Mark; Frankel, Wendy L.; Petrocca, Fabio
- JAMA, Vol. 297, Issue 17
Randomized phase III trial comparing FOLFIRINOX (F: 5FU/leucovorin [LV], irinotecan [I], and oxaliplatin [O]) versus gemcitabine (G) as first-line treatment for metastatic pancreatic adenocarcinoma (MPA): Preplanned interim analysis results of the PRODIGE 4/ACCORD 11 trial.
journal, May 2010
- Conroy, T.; Desseigne, F.; Ychou, M.
- Journal of Clinical Oncology, Vol. 28, Issue 15_suppl
Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs
journal, November 2005
- Raymond, Christopher K.; Roberts, Brian S.; Garrett-Engele, Phillip
- RNA, Vol. 11, Issue 11, p. 1737-1744
MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis
journal, January 2015
- Halkova, Tereza; Cuperkova, Romana; Minarik, Marek
- Gastroenterology Research and Practice, Vol. 2015
Improved targeting of miRNA with antisense oligonucleotides
journal, April 2006
- Davis, S.
- Nucleic Acids Research, Vol. 34, Issue 8
RAS Is Regulated by the let-7 MicroRNA Family
journal, March 2005
- Johnson, Steven M.; Grosshans, Helge; Shingara, Jaclyn
- Cell, Vol. 120, Issue 5
SMAD proteins control DROSHA-mediated microRNA maturation
journal, June 2008
- Davis, Brandi N.; Hilyard, Aaron C.; Lagna, Giorgio
- Nature, Vol. 454, Issue 7200
Most mammalian mRNAs are conserved targets of microRNAs
journal, October 2008
- Friedman, R. C.; Farh, K. K. -H.; Burge, C. B.
- Genome Research, Vol. 19, Issue 1
The microRNA-218 and ROBO-1 signaling axis correlates with the lymphatic metastasis of pancreatic cancer
journal, June 2013
- He, Hang; Di, Yang; Liang, Minrui
- Oncology Reports, Vol. 30, Issue 2
The prognostic and predictive value of serum CA19.9 in pancreatic cancer
journal, July 2012
- Humphris, J. L.; Chang, D. K.; Johns, A. L.
- Annals of Oncology, Vol. 23, Issue 7
Combined Serum CA19-9 and miR-27a-3p in Peripheral Blood Mononuclear Cells to Diagnose Pancreatic Cancer
journal, February 2013
- Wang, W. -S.; Liu, L. -X.; Li, G. -P.
- Cancer Prevention Research, Vol. 6, Issue 4
miR-146a Suppresses Invasion of Pancreatic Cancer Cells
journal, February 2010
- Li, Y.; VandenBoom, T. G.; Wang, Z.
- Cancer Research, Vol. 70, Issue 4
An Undesired Effect of Chemotherapy: GEMCITABINE PROMOTES PANCREATIC CANCER CELL INVASIVENESS THROUGH REACTIVE OXYGEN SPECIES-DEPENDENT, NUCLEAR FACTOR κB- AND HYPOXIA-INDUCIBLE FACTOR 1α-MEDIATED UP-REGULATION OF CXCR4
journal, June 2013
- Arora, Sumit; Bhardwaj, Arun; Singh, Seema
- Journal of Biological Chemistry, Vol. 288, Issue 29