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Title: MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential

Abstract

Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.

Authors:
 [1];  [2];  [3]; ORCiD logo [4]; ORCiD logo [4];  [1];  [5];  [1]
  1. Univ. of New Mexico, Albuquerque, NM (United States)
  2. Kumaun Univ. (India)
  3. Loyola Univ., Chicago, IL (United States)
  4. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  5. Rutgers Univ., Piscataway, NJ (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Laboratory Directed Research and Development (LDRD) Program
OSTI Identifier:
1597372
Report Number(s):
LA-UR-19-31932
Journal ID: ISSN 2073-4425; GENEG9
Grant/Contract Number:  
89233218CNA000001
Resource Type:
Accepted Manuscript
Journal Name:
Genes
Additional Journal Information:
Journal Volume: 10; Journal Issue: 10; Journal ID: ISSN 2073-4425
Publisher:
MDPI
Country of Publication:
United States
Language:
English
Subject:
Biological Science; microRNA; pancreatic cancer; diagnosis; prognosis; potential therapeutic targets

Citation Formats

Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, and Parasher, Gulshan. MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. United States: N. p., 2019. Web. doi:10.3390/genes10100752.
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, & Parasher, Gulshan. MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. United States. doi:10.3390/genes10100752.
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, and Parasher, Gulshan. Wed . "MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential". United States. doi:10.3390/genes10100752. https://www.osti.gov/servlets/purl/1597372.
@article{osti_1597372,
title = {MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential},
author = {Rawat, Manmeet and Kadian, Kavita and Gupta, Yash and Kumar, Anand and Chain, Patrick Sam Guy and Kovbasnjuk, Olga and Kumar, Suneel and Parasher, Gulshan},
abstractNote = {Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.},
doi = {10.3390/genes10100752},
journal = {Genes},
number = 10,
volume = 10,
place = {United States},
year = {2019},
month = {9}
}

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Works referenced in this record:

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype
journal, January 2015


Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer
journal, April 2010

  • Ho, Allen S.; Huang, Xin; Cao, Hongbin
  • Translational Oncology, Vol. 3, Issue 2
  • DOI: 10.1593/tlo.09256

miR-203 inhibits proliferation of HCC cells by targeting survivin: MIR-203 INHIBITS HCC PROLIFERATION VIA SURVIVIN
journal, August 2012

  • Wei, Wang; Wanjun, Liu; Hui, Sun
  • Cell Biochemistry and Function, Vol. 31, Issue 1
  • DOI: 10.1002/cbf.2863

The JAK/STAT signaling pathway
journal, March 2004


MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
journal, February 2009

  • Habbe, Nils; Koorstra, Jan-Bart M.; Mendell, Joshua T.
  • Cancer Biology & Therapy, Vol. 8, Issue 4
  • DOI: 10.4161/cbt.8.4.7338

miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial–mesenchymal transition and the Notch signaling pathway
journal, February 2017

  • Tang, Yan; Tang, Yong; Cheng, Ying-sheng
  • Scientific Reports, Vol. 7, Issue 1
  • DOI: 10.1038/srep38232

The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition
journal, January 2008

  • Paterson, Emily L.; Kolesnikoff, Natasha; Gregory, Philip A.
  • The Scientific World JOURNAL, Vol. 8
  • DOI: 10.1100/tsw.2008.115

Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway
journal, July 2012

  • Zhang, Yan; Fan, Kai-Ji; Sun, Qiang
  • Nucleic Acids Research, Vol. 40, Issue 18
  • DOI: 10.1093/nar/gks667

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
journal, January 2015


Smads and early developmental signaling by the TGFbeta superfamily
journal, August 1998


MicroRNA in pancreatic cancer
journal, June 2016

  • Yonemori, Keiichi; Kurahara, Hiroshi; Maemura, Kosei
  • Journal of Human Genetics, Vol. 62, Issue 1
  • DOI: 10.1038/jhg.2016.59

MicroRNA-100 regulates IGF1-receptor expression in metastatic pancreatic cancer cells
journal, February 2013


MicroRNA-218 inhibits cell invasion and migration of pancreatic cancer via regulating ROBO1
journal, July 2014

  • He, Hang; Hao, Si-jie; Yao, Lie
  • Cancer Biology & Therapy, Vol. 15, Issue 10
  • DOI: 10.4161/cbt.29706

MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior
journal, October 2006

  • Roldo, Claudia; Missiaglia, Edoardo; Hagan, John P.
  • Journal of Clinical Oncology, Vol. 24, Issue 29
  • DOI: 10.1200/JCO.2005.05.5194

MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2
journal, September 2014

  • Wang, Siliang; Chen, Xiaodong; Tang, Meiyue
  • Oncology Reports, Vol. 32, Issue 6
  • DOI: 10.3892/or.2014.3478

Upregulation of miR-150* and miR-630 Induces Apoptosis in Pancreatic Cancer Cells by Targeting IGF-1R
journal, May 2013


Diagnostic and biological significance of microRNA-192 in pancreatic ductal adenocarcinoma
journal, April 2013

  • Zhao, Chenyan; Zhang, Jing; Zhang, Shuhui
  • Oncology Reports, Vol. 30, Issue 1
  • DOI: 10.3892/or.2013.2420

MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer
journal, November 2010


Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs
journal, September 2017


Oncomirs — microRNAs with a role in cancer
journal, April 2006

  • Esquela-Kerscher, Aurora; Slack, Frank J.
  • Nature Reviews Cancer, Vol. 6, Issue 4
  • DOI: 10.1038/nrc1840

MicroRNA-424-5p Suppresses the Expression of SOCS6 in Pancreatic Cancer
journal, May 2013


MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B
journal, June 2011

  • Liffers, Sven-T; Munding, Johanna B.; Vogt, Markus
  • Laboratory Investigation, Vol. 91, Issue 10
  • DOI: 10.1038/labinvest.2011.99

Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival: Micro RNAs in PDAC
journal, June 2009

  • Greither, Thomas; Grochola, Lukasz F.; Udelnow, Andrej
  • International Journal of Cancer, Vol. 126, Issue 1
  • DOI: 10.1002/ijc.24687

MicroRNA-21 in Pancreatic Ductal Adenocarcinoma Tumor-Associated Fibroblasts Promotes Metastasis
journal, August 2013


Tumor-Suppressor genes in pancreatic cancer
journal, December 1998

  • Hruban, Ralph H.; Offerhaus, G. Johan A.; Kern, Scott E.
  • Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 5, Issue 4
  • DOI: 10.1007/s005340050062

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
journal, February 2012

  • Collins, Meredith A.; Bednar, Filip; Zhang, Yaqing
  • Journal of Clinical Investigation, Vol. 122, Issue 2
  • DOI: 10.1172/JCI59227

KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
journal, September 2010

  • Morris, John P.; Wang, Sam C.; Hebrok, Matthias
  • Nature Reviews Cancer, Vol. 10, Issue 10
  • DOI: 10.1038/nrc2899

MicroRNA-200c Modulates the Expression of MUC4 and MUC16 by Directly Targeting Their Coding Sequences in Human Pancreatic Cancer
journal, October 2013


MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells
journal, August 2009


Inhibition of microRNA with antisense oligonucleotides
journal, January 2008


A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition
journal, October 2008


Prospects of miRNA-Based Therapy for Pancreatic Cancer
journal, July 2013


MicroRNA expression and function in cancer
journal, December 2006


MicroRNA-21 is Overexpressed in Pancreatic Cancer and a Potential Predictor of Survival
journal, July 2008

  • Dillhoff, Mary; Liu, James; Frankel, Wendy
  • Journal of Gastrointestinal Surgery, Vol. 12, Issue 12
  • DOI: 10.1007/s11605-008-0584-x

miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway
journal, October 2012


Small-Molecule Inhibitors of MicroRNA miR-21 Function
journal, September 2008

  • Gumireddy, Kiranmai; Young, Douglas D.; Xiong, Xin
  • Angewandte Chemie International Edition, Vol. 47, Issue 39
  • DOI: 10.1002/anie.200801555

Causes and Consequences of MicroRNA Dysregulation
journal, January 2012


Personalized RNA Medicine for Pancreatic Cancer
journal, January 2018


TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
journal, June 2005

  • Chendrimada, Thimmaiah P.; Gregory, Richard I.; Kumaraswamy, Easwari
  • Nature, Vol. 436, Issue 7051
  • DOI: 10.1038/nature03868

MicroRNA-375 targets the 3-phosphoinositide-dependent protein kinase-1 gene in pancreatic carcinoma
journal, August 2013


MicroRNA expression profiling of diagnostic needle aspirates from surgical pancreatic cancer specimens
journal, January 2014


EP300-A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas: Role of EP300 in Metastasis of Pancreatic Cancer
journal, June 2009

  • Mees, Soeren Torge; Mardin, Wolf Arif; Wendel, Claudia
  • International Journal of Cancer, Vol. 126, Issue 1
  • DOI: 10.1002/ijc.24695

MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer
journal, November 2014

  • Listing, H.; Mardin, W. A.; Wohlfromm, S.
  • British Journal of Cancer, Vol. 112, Issue 1
  • DOI: 10.1038/bjc.2014.587

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma
journal, June 2010

  • Young, Douglas D.; Connelly, Colleen M.; Grohmann, Christoph
  • Journal of the American Chemical Society, Vol. 132, Issue 23
  • DOI: 10.1021/ja910275u

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
journal, January 2005


Retinoic Acid Receptor Antagonists Inhibit miR-10a Expression and Block Metastatic Behavior of Pancreatic Cancer
journal, December 2009


Cancer statistics, 2019
journal, October 2018

  • Siegel, Rebecca L.; Miller, Kimberly D.; Jemal, Ahmedin
  • CA: A Cancer Journal for Clinicians, Vol. 69, Issue 1
  • DOI: 10.3322/caac.21551

A pancreatic islet-specific microRNA regulates insulin secretion
journal, November 2004

  • Poy, Matthew N.; Eliasson, Lena; Krutzfeldt, Jan
  • Nature, Vol. 432, Issue 7014
  • DOI: 10.1038/nature03076

MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
journal, January 2007


Oncogenic miR-23a in Pancreatic Ductal Adenocarcinogenesis Via Inhibiting APAF1
journal, February 2015

  • Liu, Ning; Sun, Yuan-Yuan; Zhang, Xiao-Wen
  • Digestive Diseases and Sciences, Vol. 60, Issue 7
  • DOI: 10.1007/s10620-015-3588-x

miR-208-Induced Epithelial to Mesenchymal Transition of Pancreatic Cancer Cells Promotes Cell Metastasis and Invasion
journal, March 2014


MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway
journal, January 2014

  • Zhou, Jian; Song, Shiduo; He, Songbing
  • International Journal of Molecular Medicine, Vol. 33, Issue 4
  • DOI: 10.3892/ijmm.2014.1638

A microRNA meta-signature for pancreatic ductal adenocarcinoma
journal, February 2014

  • Frampton, Adam E.; Giovannetti, Elisa; Jamieson, Nigel B.
  • Expert Review of Molecular Diagnostics, Vol. 14, Issue 3
  • DOI: 10.1586/14737159.2014.893192

miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor
journal, March 2011

  • Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai
  • Biochemical and Biophysical Research Communications, Vol. 406, Issue 4
  • DOI: 10.1016/j.bbrc.2011.02.065

MicroRNA Targeted Therapeutic Approach for Pancreatic Cancer
journal, January 2016

  • Li, Yiwei; Sarkar, Fazlul H.
  • International Journal of Biological Sciences, Vol. 12, Issue 3
  • DOI: 10.7150/ijbs.15017

The microRNA.org resource: targets and expression
journal, December 2007

  • Betel, D.; Wilson, M.; Gabow, A.
  • Nucleic Acids Research, Vol. 36, Issue Database
  • DOI: 10.1093/nar/gkm995

Metazoan MicroRNAs
journal, March 2018


Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers: Circulating MicroRNAs
journal, November 2010

  • Zen, Ke; Zhang, Chen-Yu
  • Medicinal Research Reviews, Vol. 32, Issue 2
  • DOI: 10.1002/med.20215

miR-203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin
journal, May 2013

  • Xu, Dong; Wang, Qingguang; An, Yong
  • Molecular Medicine Reports, Vol. 8, Issue 2
  • DOI: 10.3892/mmr.2013.1504

Expression of MicroRNAs in Patients With Pancreatic Cancer and Its Prognostic Significance
journal, January 2013


Roles for KRAS in Pancreatic Tumor Development and Progression
journal, May 2013


The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS
journal, July 2010


Circulating microRNAs as stable blood-based markers for cancer detection
journal, July 2008

  • Mitchell, P. S.; Parkin, R. K.; Kroh, E. M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 30
  • DOI: 10.1073/pnas.0804549105

Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer
journal, November 2011

  • Morimura, R.; Komatsu, S.; Ichikawa, D.
  • British Journal of Cancer, Vol. 105, Issue 11
  • DOI: 10.1038/bjc.2011.453

Loss of miR-126 is crucial to pancreatic cancer progression
journal, July 2012

  • Frampton, Adam E.; Krell, Jonathan; Jacob, Jimmy
  • Expert Review of Anticancer Therapy, Vol. 12, Issue 7
  • DOI: 10.1586/era.12.67

miRNA-96 Suppresses KRAS and Functions as a Tumor Suppressor Gene in Pancreatic Cancer
journal, July 2010


miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1
journal, June 2013

  • Iwagami, Y.; Eguchi, H.; Nagano, H.
  • British Journal of Cancer, Vol. 109, Issue 2
  • DOI: 10.1038/bjc.2013.320

MicroRNA-gene signaling pathways in pancreatic cancer
journal, January 2013


miRBase: annotating high confidence microRNAs using deep sequencing data
journal, November 2013

  • Kozomara, Ana; Griffiths-Jones, Sam
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt1181

Emerging role of the KRAS-PDK1 axis in pancreatic cancer
journal, January 2014


MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1
journal, July 2012

  • Rachagani, Satyanarayana; Macha, Muzafar A.; Ponnusamy, Moorthy P.
  • Carcinogenesis, Vol. 33, Issue 10
  • DOI: 10.1093/carcin/bgs225

Transforming growth factor-β and breast cancer: Cell cycle arrest by transforming growth factor-β and its disruption in cancer
journal, April 2000

  • Donovan, Jeffrey; Slingerland, Joyce
  • Breast Cancer Research, Vol. 2, Issue 2
  • DOI: 10.1186/bcr43

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
journal, March 2008

  • Morin, R. D.; O'Connor, M. D.; Griffith, M.
  • Genome Research, Vol. 18, Issue 4
  • DOI: 10.1101/gr.7179508

Smad transcription factors
journal, December 2005


Control of translation and mRNA degradation by miRNAs and siRNAs
journal, March 2006


Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
journal, October 2006


The functions and regulation of the PTEN tumour suppressor
journal, April 2012

  • Song, Min Sup; Salmena, Leonardo; Pandolfi, Pier Paolo
  • Nature Reviews Molecular Cell Biology, Vol. 13, Issue 5
  • DOI: 10.1038/nrm3330

MicroRNA in Cancer Prognosis
journal, December 2008

  • Slack, Frank J.; Weidhaas, Joanne B.
  • New England Journal of Medicine, Vol. 359, Issue 25
  • DOI: 10.1056/NEJMe0808667

MicroRNAs Targeting Oncogenes Are Down-Regulated in Pancreatic Malignant Transformation from Benign Tumors
journal, February 2012


MicroRNA signatures in human cancers
journal, November 2006

  • Calin, George A.; Croce, Carlo M.
  • Nature Reviews Cancer, Vol. 6, Issue 11
  • DOI: 10.1038/nrc1997

Inhibition of Transforming Growth Factor β Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness
journal, March 2007

  • Gaspar, Nicholas J.; Li, Lingyun; Kapoun, Ann M.
  • Molecular Pharmacology, Vol. 72, Issue 1
  • DOI: 10.1124/mol.106.029025

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway
journal, December 2010

  • Kent, O. A.; Chivukula, R. R.; Mullendore, M.
  • Genes & Development, Vol. 24, Issue 24
  • DOI: 10.1101/gad.1950610

Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes
journal, December 2004

  • Válóczi, Anna; Hornyik, Csaba; Varga, Nóra
  • Nucleic Acids Research, Vol. 32, Issue 22, p. e175
  • DOI: 10.1093/nar/gnh171

miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
journal, December 2010


MicroRNA-34b Inhibits Pancreatic Cancer Metastasis Through Repressing Smad3
journal, April 2013


Combinatorial microRNA target predictions
journal, April 2005

  • Krek, Azra; Grün, Dominic; Poy, Matthew N.
  • Nature Genetics, Vol. 37, Issue 5
  • DOI: 10.1038/ng1536

Transcriptional regulation and transformation by Myc proteins
journal, August 2005

  • Adhikary, Sovana; Eilers, Martin
  • Nature Reviews Molecular Cell Biology, Vol. 6, Issue 8
  • DOI: 10.1038/nrm1703

miR-34 – a microRNA replacement therapy is headed to the clinic
journal, January 2012


Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer
journal, January 2015

  • Rachagani, Satyanarayana; Macha, Muzafar A.; Heimann, Nicholas
  • Advanced Drug Delivery Reviews, Vol. 81
  • DOI: 10.1016/j.addr.2014.10.020

Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides
journal, January 2006

  • Deo, Monika; Yu, Jenn-Yah; Chung, Kwan-Ho
  • Developmental Dynamics, Vol. 235, Issue 9
  • DOI: 10.1002/dvdy.20847

Potent inhibition of microRNA in vivo without degradation
journal, November 2008

  • Davis, Scott; Propp, Stephanie; Freier, Susan M.
  • Nucleic Acids Research, Vol. 37, Issue 1
  • DOI: 10.1093/nar/gkn904

MicroRNAs in pancreatic malignancy: Progress and promises
journal, June 2014


MicroRNA Alterations of Pancreatic Intraepithelial Neoplasias
journal, November 2011


Silencing of microRNAs in vivo with ‘antagomirs’
journal, October 2005

  • Krützfeldt, Jan; Rajewsky, Nikolaus; Braich, Ravi
  • Nature, Vol. 438, Issue 7068
  • DOI: 10.1038/nature04303

Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer
journal, November 2011

  • Liu, Jianqiang; Gao, Jun; Du, Yiqi
  • International Journal of Cancer, Vol. 131, Issue 3
  • DOI: 10.1002/ijc.26422

MicroRNA-155 Is Regulated by the Transforming Growth Factor  /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA
journal, September 2008

  • Kong, W.; Yang, H.; He, L.
  • Molecular and Cellular Biology, Vol. 28, Issue 22
  • DOI: 10.1128/MCB.00941-08

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
journal, March 2000

  • Hammond, Scott M.; Bernstein, Emily; Beach, David
  • Nature, Vol. 404, Issue 6775
  • DOI: 10.1038/35005107

High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5
journal, February 2018

  • Yuan, Qinggong; Zhang, Yan; Li, Junhui
  • Biochemical and Biophysical Research Communications, Vol. 497, Issue 1
  • DOI: 10.1016/j.bbrc.2018.02.023

Targeting microRNAs in cancer: rationale, strategies and challenges
journal, October 2010

  • Garzon, Ramiro; Marcucci, Guido; Croce, Carlo M.
  • Nature Reviews Drug Discovery, Vol. 9, Issue 10
  • DOI: 10.1038/nrd3179

MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4
journal, February 2016

  • Wei, Xueju; Wang, Weibin; Wang, Lanlan
  • Cancer Medicine, Vol. 5, Issue 4
  • DOI: 10.1002/cam4.626

In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
journal, December 2005

  • Kloosterman, Wigard P.; Wienholds, Erno; de Bruijn, Ewart
  • Nature Methods, Vol. 3, Issue 1
  • DOI: 10.1038/nmeth843

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
journal, October 2007

  • Gironella, M.; Seux, M.; Xie, M. -J.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 41
  • DOI: 10.1073/pnas.0703942104

Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985–1995, using the National Cancer Database11No competing interests declared.
journal, July 1999

  • Sener, Stephen F.; Fremgen, Amy; Menck, Herman R.
  • Journal of the American College of Surgeons, Vol. 189, Issue 1
  • DOI: 10.1016/S1072-7515(99)00075-7

Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers
journal, February 2017

  • Calatayud, Dan; Dehlendorff, Christian; Boisen, Mogens K.
  • Biomarker Research, Vol. 5, Issue 1
  • DOI: 10.1186/s40364-017-0087-6

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
journal, May 2008

  • Burk, Ulrike; Schubert, Jörg; Wellner, Ulrich
  • EMBO reports, Vol. 9, Issue 6
  • DOI: 10.1038/embor.2008.74

The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
journal, October 2015


LPS Induced miR-181a Promotes Pancreatic Cancer Cell Migration via Targeting PTEN and MAP2K4
journal, February 2014


A Comprehensive Assessment of the Role of miRNAs as Biomarkers in Gastroenteropancreatic Neuroendocrine Tumors
journal, January 2018

  • Malczewska, Anna; Kidd, Mark; Matar, Somer
  • Neuroendocrinology, Vol. 107, Issue 1
  • DOI: 10.1159/000487326

MicroRNAs
journal, January 2004


Absolute quantitation of microRNAs with a PCR-based assay
journal, December 2006

  • Duncan, David D.; Eshoo, Mark; Esau, Christine
  • Analytical Biochemistry, Vol. 359, Issue 2, p. 268-270
  • DOI: 10.1016/j.ab.2006.08.022

Dysregulation of miR-15a and miR-214 in human pancreatic cancer
journal, January 2010

  • Zhang, Xing J.; Ye, Hua; Zeng, Cheng W.
  • Journal of Hematology & Oncology, Vol. 3, Issue 1
  • DOI: 10.1186/1756-8722-3-46

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
journal, December 1993


miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells
journal, January 2014

  • Miao, Lifeng; Xiong, Xianze; Lin, Yixin
  • Oncology Letters, Vol. 7, Issue 3
  • DOI: 10.3892/ol.2014.1807

miRNAs in pancreatic cancer: Therapeutic potential, delivery challenges and strategies
journal, January 2015


Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer
journal, January 2014

  • Ganepola, Ganepola AP
  • World Journal of Gastrointestinal Oncology, Vol. 6, Issue 1
  • DOI: 10.4251/wjgo.v6.i1.22

Pancreatic cancer: Current research and future directions
journal, April 2016

  • Falasca, Marco; Kim, Minkyoung; Casari, Ilaria
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1865, Issue 2
  • DOI: 10.1016/j.bbcan.2016.01.001

MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells
journal, October 2011

  • Srivastava, Sanjeev K.; Bhardwaj, Arun; Singh, Seema
  • Carcinogenesis, Vol. 32, Issue 12
  • DOI: 10.1093/carcin/bgr223

The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance
journal, August 2018

  • Biancur, Douglas E.; Kimmelman, Alec C.
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1870, Issue 1
  • DOI: 10.1016/j.bbcan.2018.04.011

MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma
journal, August 2012


MicroRNAs (miRNAs) as Biomarker(s) for Prognosis and Diagnosis of Gastrointestinal (GI) Cancers
journal, January 2014


MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in Its Invasiveness Partially via Suppression of the HOXA1 Gene
journal, March 2012

  • Ohuchida, Kenoki; Mizumoto, Kazuhiro; Lin, Cui
  • Annals of Surgical Oncology, Vol. 19, Issue 7
  • DOI: 10.1245/s10434-012-2252-3

A custom microarray platform for analysis of microRNA gene expression
journal, September 2004

  • Thomson, J. Michael; Parker, Joel; Perou, Charles M.
  • Nature Methods, Vol. 1, Issue 1, p. 47-53
  • DOI: 10.1038/nmeth704

Addressing the challenges of pancreatic cancer: Future directions for improving outcomes
journal, January 2015


miR-216a may inhibit pancreatic tumor growth by targeting JAK2
journal, July 2015


HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96
journal, July 2014


MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
journal, September 2009


Wnt signalling in stem cells and cancer
journal, April 2005


MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood-Based Biomarkers of Disease
journal, September 2009


MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis
journal, May 2007


Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs
journal, November 2005

  • Raymond, Christopher K.; Roberts, Brian S.; Garrett-Engele, Phillip
  • RNA, Vol. 11, Issue 11, p. 1737-1744
  • DOI: 10.1261/rna.2148705

MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis
journal, January 2015

  • Halkova, Tereza; Cuperkova, Romana; Minarik, Marek
  • Gastroenterology Research and Practice, Vol. 2015
  • DOI: 10.1155/2015/892903

Improved targeting of miRNA with antisense oligonucleotides
journal, April 2006


RAS Is Regulated by the let-7 MicroRNA Family
journal, March 2005


SMAD proteins control DROSHA-mediated microRNA maturation
journal, June 2008

  • Davis, Brandi N.; Hilyard, Aaron C.; Lagna, Giorgio
  • Nature, Vol. 454, Issue 7200
  • DOI: 10.1038/nature07086

Most mammalian mRNAs are conserved targets of microRNAs
journal, October 2008

  • Friedman, R. C.; Farh, K. K. -H.; Burge, C. B.
  • Genome Research, Vol. 19, Issue 1
  • DOI: 10.1101/gr.082701.108

The microRNA-218 and ROBO-1 signaling axis correlates with the lymphatic metastasis of pancreatic cancer
journal, June 2013


The prognostic and predictive value of serum CA19.9 in pancreatic cancer
journal, July 2012

  • Humphris, J. L.; Chang, D. K.; Johns, A. L.
  • Annals of Oncology, Vol. 23, Issue 7
  • DOI: 10.1093/annonc/mdr561

Combined Serum CA19-9 and miR-27a-3p in Peripheral Blood Mononuclear Cells to Diagnose Pancreatic Cancer
journal, February 2013


miR-146a Suppresses Invasion of Pancreatic Cancer Cells
journal, February 2010