MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential
Abstract
Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.
- Authors:
-
[4];
[4];
- Univ. of New Mexico, Albuquerque, NM (United States)
- Kumaun Univ. (India)
- Loyola Univ., Chicago, IL (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Rutgers Univ., Piscataway, NJ (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- OSTI Identifier:
- 1597372
- Report Number(s):
- LA-UR-19-31932
Journal ID: ISSN 2073-4425; GENEG9
- Grant/Contract Number:
- 89233218CNA000001
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Genes
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 10; Journal ID: ISSN 2073-4425
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; Biological Science; microRNA; pancreatic cancer; diagnosis; prognosis; potential therapeutic targets
Citation Formats
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, and Parasher, Gulshan. MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. United States: N. p., 2019.
Web. doi:10.3390/genes10100752.
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, & Parasher, Gulshan. MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential. United States. https://doi.org/10.3390/genes10100752
Rawat, Manmeet, Kadian, Kavita, Gupta, Yash, Kumar, Anand, Chain, Patrick Sam Guy, Kovbasnjuk, Olga, Kumar, Suneel, and Parasher, Gulshan. Wed .
"MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential". United States. https://doi.org/10.3390/genes10100752. https://www.osti.gov/servlets/purl/1597372.
@article{osti_1597372,
title = {MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential},
author = {Rawat, Manmeet and Kadian, Kavita and Gupta, Yash and Kumar, Anand and Chain, Patrick Sam Guy and Kovbasnjuk, Olga and Kumar, Suneel and Parasher, Gulshan},
abstractNote = {Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA’s in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.},
doi = {10.3390/genes10100752},
journal = {Genes},
number = 10,
volume = 10,
place = {United States},
year = {2019},
month = {9}
}
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