Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens
Abstract
Copper (Cu)-only superoxide dismutases (SOD) represent a newly characterized class of extracellular SODs important for virulence of several fungal pathogens. Previous studies of the Cu-only enzyme SOD5 from the opportunistic fungal pathogen Candida albicans have revealed that the active-site structure and Cu binding of SOD5 strongly deviate from those of Cu/Zn-SODs in its animal hosts, making Cu-only SODs a possible target for future antifungal drug design. C. albicans also expresses a Cu-only SOD4 that is highly similar in sequence to SOD5, but is poorly characterized. Here, we compared the biochemical, biophysical, and cell biological properties of C. albicans SOD4 and SOD5. Analyzing the recombinant proteins, we found that, similar to SOD5, Cu-only SOD4 can react with superoxide at rates approaching diffusion limits. Both SODs were monomeric and they exhibited similar binding affinities for their Cu cofactor. In C. albicans cultures, SOD4 and SOD5 were predominantly cell wall proteins. Despite these similarities, the SOD4 and SOD5 genes strongly differed in transcriptional regulation. SOD5 was predominantly induced during hyphal morphogenesis, together with a fungal burst in reactive oxygen species. Conversely, SOD4 expression was specifically up-regulated by iron (Fe) starvation and controlled by the Fe-responsive transcription factor SEF1. Interestingly, Candida tropicalis and themore »
- Publication Date:
- Research Org.:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1771344
- Alternate Identifier(s):
- OSTI ID: 1597258
- Report Number(s):
- BNL-213604-2020-JAAM
Journal ID: ISSN 0021-9258; S0021925817483487; PII: S0021925817483487
- Grant/Contract Number:
- SC0012704
- Resource Type:
- Published Article
- Journal Name:
- Journal of Biological Chemistry
- Additional Journal Information:
- Journal Name: Journal of Biological Chemistry Journal Volume: 295 Journal Issue: 2; Journal ID: ISSN 0021-9258
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; superoxide dismutase; superoxide ion; Candida albicans
Citation Formats
Schatzman, Sabrina S., Peterson, Ryan L., Teka, Mieraf, He, Bixi, Cabelli, Diane E., Cormack, Brendan P., and Culotta, Valeria C. Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens. United States: N. p., 2020.
Web. doi:10.1074/jbc.RA119.011084.
Schatzman, Sabrina S., Peterson, Ryan L., Teka, Mieraf, He, Bixi, Cabelli, Diane E., Cormack, Brendan P., & Culotta, Valeria C. Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens. United States. https://doi.org/10.1074/jbc.RA119.011084
Schatzman, Sabrina S., Peterson, Ryan L., Teka, Mieraf, He, Bixi, Cabelli, Diane E., Cormack, Brendan P., and Culotta, Valeria C. Wed .
"Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens". United States. https://doi.org/10.1074/jbc.RA119.011084.
@article{osti_1771344,
title = {Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens},
author = {Schatzman, Sabrina S. and Peterson, Ryan L. and Teka, Mieraf and He, Bixi and Cabelli, Diane E. and Cormack, Brendan P. and Culotta, Valeria C.},
abstractNote = {Copper (Cu)-only superoxide dismutases (SOD) represent a newly characterized class of extracellular SODs important for virulence of several fungal pathogens. Previous studies of the Cu-only enzyme SOD5 from the opportunistic fungal pathogen Candida albicans have revealed that the active-site structure and Cu binding of SOD5 strongly deviate from those of Cu/Zn-SODs in its animal hosts, making Cu-only SODs a possible target for future antifungal drug design. C. albicans also expresses a Cu-only SOD4 that is highly similar in sequence to SOD5, but is poorly characterized. Here, we compared the biochemical, biophysical, and cell biological properties of C. albicans SOD4 and SOD5. Analyzing the recombinant proteins, we found that, similar to SOD5, Cu-only SOD4 can react with superoxide at rates approaching diffusion limits. Both SODs were monomeric and they exhibited similar binding affinities for their Cu cofactor. In C. albicans cultures, SOD4 and SOD5 were predominantly cell wall proteins. Despite these similarities, the SOD4 and SOD5 genes strongly differed in transcriptional regulation. SOD5 was predominantly induced during hyphal morphogenesis, together with a fungal burst in reactive oxygen species. Conversely, SOD4 expression was specifically up-regulated by iron (Fe) starvation and controlled by the Fe-responsive transcription factor SEF1. Interestingly, Candida tropicalis and the emerging fungal pathogen Candida auris contain a single SOD5-like SOD rather than a pair, and in both fungi, this SOD was induced by Fe starvation. This unexpected link between Fe homeostasis and extracellular Cu-SODs may help many fungi adapt to Fe-limited conditions of their hosts.},
doi = {10.1074/jbc.RA119.011084},
journal = {Journal of Biological Chemistry},
number = 2,
volume = 295,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 2020},
month = {Wed Jan 01 00:00:00 EST 2020}
}
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