Structural and functional characterization of the dominant negative P‐loop lysine mutation in the dynamin superfamily protein Vps1

doi:10.1002/pro.3830

This content will become publicly available on January 30, 2021

Title: Structural and functional characterization of the dominant negative P‐loop lysine mutation in the dynamin superfamily protein Vps1

Authors:

^[1];

^[1]; Hosford, Christopher J. ^[2];

^[2];

^[1]

Department of Cell BiologyUniversity of Pittsburgh School of Medicine Pittsburgh Pennsylvania
Department of Molecular MedicineCornell University Ithaca New York

Publication Date:: 2020-01-31

Sponsoring Org.:: USDOE

OSTI Identifier:: 1596867

Grant/Contract Number:: W‐31‐109‐Eng‐38; DE‐AC02‐06CH11357

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Protein Science

Additional Journal Information:: Journal Name: Protein Science; Journal ID: ISSN 0961-8368

Publisher:: Wiley Blackwell (John Wiley & Sons)

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Tornabene, Bryan A., Varlakhanova, Natalia V., Hosford, Christopher J., Chappie, Joshua S., and Ford, Marijn G. J. Structural and functional characterization of the dominant negative P‐loop lysine mutation in the dynamin superfamily protein Vps1.  United Kingdom: N. p., 2020. 
        Web.  doi:10.1002/pro.3830.

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                    Tornabene, Bryan A., Varlakhanova, Natalia V., Hosford, Christopher J., Chappie, Joshua S., & Ford, Marijn G. J. Structural and functional characterization of the dominant negative P‐loop lysine mutation in the dynamin superfamily protein Vps1.  United Kingdom.  doi:10.1002/pro.3830.

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                    Tornabene, Bryan A., Varlakhanova, Natalia V., Hosford, Christopher J., Chappie, Joshua S., and Ford, Marijn G. J. Fri .  
        "Structural and functional characterization of the dominant negative P‐loop lysine mutation in the dynamin superfamily protein Vps1".  United Kingdom.  doi:10.1002/pro.3830.

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@article{osti_1596867,

  title        = {Structural and functional characterization of the dominant negative P‐loop lysine mutation in the dynamin superfamily protein Vps1},

  author       = {Tornabene, Bryan A. and Varlakhanova, Natalia V. and Hosford, Christopher J. and Chappie, Joshua S. and Ford, Marijn G. J.},

  abstractNote = {},

  doi          = {10.1002/pro.3830},

  journal      = {Protein Science},

  number       = ,

  volume       = ,

  place        = {United Kingdom},

  year         = {2020},

  month        = {1}

}

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Works referenced in this record:

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This content will become publicly available on January 30, 2021

Title: Structural and functional characterization of the dominant negative P‐loop lysine mutation in the dynamin superfamily protein Vps1

Citation Formats

The Mechanism of GTP Hydrolysis by Dynamin II: A Transient Kinetic Study † journal, June 2000

iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM journal, March 2011

An Intramolecular Signaling Element that Modulates Dynamin Function In Vitro and In Vivo journal, August 2009

Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture journal, August 2018

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21 journal, June 1990

Building a fission machine - structural insights into dynamin assembly and activation journal, June 2013

Membrane fission by dynamin: what we know and what we need to know journal, September 2016

Role of Nucleotide Binding and GTPase Domain Dimerization in Dynamin-like Myxovirus Resistance Protein A for GTPase Activation and Antiviral Activity journal, March 2015

Dynamin Self-assembly Stimulates Its GTPase Activity journal, September 1996

Features and development of Coot journal, March 2010

G domain dimerization controls dynamin's assembly-stimulated GTPase activity journal, April 2010

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae journal, July 1998

REFMAC 5 for the refinement of macromolecular crystal structures journal, March 2011

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects. journal, February 1986

A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke journal, September 2011

Mutations in human dynamin block an intermediate stage in coated vesicle formation journal, August 1993

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. journal, August 1990

Fiji: an open-source platform for biological-image analysis journal, June 2012

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein journal, April 2013

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. journal, December 1992

An internal GAP domain negatively regulates presynaptic dynamin in vivo journal, April 2005

Mdv1 Interacts with Assembled Dnm1 to Promote Mitochondrial Division journal, November 2005

Crystal structure of nucleotide-free dynamin journal, September 2011

A Set of Vectors with a Tetracycline-Regulatable Promoter System for Modulated Gene Expression inSaccharomyces cerevisiae journal, July 1997

Classification and evolution of P-loop GTPases and related ATPases journal, March 2002

The crystal structure of dynamin journal, September 2011

A Dynamin Mutant Defines a Superconstricted Prefission State journal, August 2014

The Guanine Nucleotide-Binding Switch in Three Dimensions journal, November 2001

Mitochondrial dynamics and division in budding yeast journal, April 2002

The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast journal, October 1998

The GTPase superfamily: conserved structure and molecular mechanism journal, January 1991

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation journal, November 1994

Cryo-EM of the dynamin polymer assembled on lipid membrane journal, August 2018

The dynamin superfamily: universal membrane tubulation and fission molecules? journal, February 2004

The PDB_REDO server for macromolecular structure model optimization journal, May 2014

The structural biology of the dynamin‐related proteins: New insights into a diverse, multitalented family journal, August 2019

Evolution of cation binding in the active sites of P-loop nucleoside triphosphatases in relation to the basic catalytic mechanism journal, December 2018

Phaser crystallographic software journal, July 2007

The Mechanism of GTP Hydrolysis by Dynamin II: A Transient Kinetic Study †
journal, June 2000

iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
journal, March 2011

An Intramolecular Signaling Element that Modulates Dynamin Function In Vitro and In Vivo
journal, August 2009

Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture
journal, August 2018

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21
journal, June 1990

Building a fission machine - structural insights into dynamin assembly and activation
journal, June 2013

Membrane fission by dynamin: what we know and what we need to know
journal, September 2016

Role of Nucleotide Binding and GTPase Domain Dimerization in Dynamin-like Myxovirus Resistance Protein A for GTPase Activation and Antiviral Activity
journal, March 2015

Dynamin Self-assembly Stimulates Its GTPase Activity
journal, September 1996

Features and development of Coot
journal, March 2010

G domain dimerization controls dynamin's assembly-stimulated GTPase activity
journal, April 2010

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
journal, July 1998

REFMAC 5 for the refinement of macromolecular crystal structures
journal, March 2011

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.
journal, February 1986

A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke
journal, September 2011

Mutations in human dynamin block an intermediate stage in coated vesicle formation
journal, August 1993

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
journal, August 1990

Fiji: an open-source platform for biological-image analysis
journal, June 2012

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein
journal, April 2013

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.
journal, December 1992

An internal GAP domain negatively regulates presynaptic dynamin in vivo
journal, April 2005

Mdv1 Interacts with Assembled Dnm1 to Promote Mitochondrial Division
journal, November 2005

Crystal structure of nucleotide-free dynamin
journal, September 2011

A Set of Vectors with a Tetracycline-Regulatable Promoter System for Modulated Gene Expression inSaccharomyces cerevisiae
journal, July 1997

Classification and evolution of P-loop GTPases and related ATPases
journal, March 2002

The crystal structure of dynamin
journal, September 2011

A Dynamin Mutant Defines a Superconstricted Prefission State
journal, August 2014

The Guanine Nucleotide-Binding Switch in Three Dimensions
journal, November 2001

Mitochondrial dynamics and division in budding yeast
journal, April 2002

The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast
journal, October 1998

The GTPase superfamily: conserved structure and molecular mechanism
journal, January 1991

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
journal, November 1994

Cryo-EM of the dynamin polymer assembled on lipid membrane
journal, August 2018

The dynamin superfamily: universal membrane tubulation and fission molecules?
journal, February 2004

The PDB_REDO server for macromolecular structure model optimization
journal, May 2014

The structural biology of the dynamin‐related proteins: New insights into a diverse, multitalented family
journal, August 2019

Evolution of cation binding in the active sites of P-loop nucleoside triphosphatases in relation to the basic catalytic mechanism
journal, December 2018

Phaser crystallographic software
journal, July 2007