skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex

; ; ;
Publication Date:
Sponsoring Org.:
OSTI Identifier:
Grant/Contract Number:  
Resource Type:
Published Article
Journal Name:
Frontiers in Microbiology
Additional Journal Information:
Journal Name: Frontiers in Microbiology Journal Volume: 10; Journal ID: ISSN 1664-302X
Frontiers Media SA
Country of Publication:

Citation Formats

Gonçalves, A. Pedro, Chow, Karen M., Cea-Sánchez, Sara, and Glass, N. Louise. WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex. Switzerland: N. p., 2020. Web. doi:10.3389/fmicb.2019.03162.
Gonçalves, A. Pedro, Chow, Karen M., Cea-Sánchez, Sara, & Glass, N. Louise. WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex. Switzerland. doi:10.3389/fmicb.2019.03162.
Gonçalves, A. Pedro, Chow, Karen M., Cea-Sánchez, Sara, and Glass, N. Louise. Wed . "WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex". Switzerland. doi:10.3389/fmicb.2019.03162.
title = {WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex},
author = {Gonçalves, A. Pedro and Chow, Karen M. and Cea-Sánchez, Sara and Glass, N. Louise},
abstractNote = {},
doi = {10.3389/fmicb.2019.03162},
journal = {Frontiers in Microbiology},
number = ,
volume = 10,
place = {Switzerland},
year = {2020},
month = {1}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.3389/fmicb.2019.03162

Save / Share:

Works referenced in this record:

HAM-5 Functions As a MAP Kinase Scaffold during Cell Fusion in Neurospora crassa
journal, November 2014

Fine-tuning of the Msn2/4–mediated yeast stress responses as revealed by systematic deletion of Msn2/4 partners
journal, September 2011

  • Sadeh, Amit; Movshovich, Natalia; Volokh, Misha
  • Molecular Biology of the Cell, Vol. 22, Issue 17
  • DOI: 10.1091/mbc.e10-12-1007

Communicate and Fuse: How Filamentous Fungi Establish and Maintain an Interconnected Mycelial Network
journal, March 2019

Deregulation ofCLN1 andCLN2 in theSaccharomyces cerevisiae whi2 Mutant
journal, June 1997

Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures
journal, April 2018

  • Riquelme, Meritxell; Aguirre, Jesús; Bartnicki-García, Salomon
  • Microbiology and Molecular Biology Reviews, Vol. 82, Issue 2
  • DOI: 10.1128/MMBR.00068-17

Born to bind: the BTB protein–protein interaction domain
journal, January 2006

  • Perez-Torrado, Roberto; Yamada, Daisuke; Defossez, Pierre-Antoine
  • BioEssays, Vol. 28, Issue 12
  • DOI: 10.1002/bies.20500

Integration of Self and Non-self Recognition Modulates Asexual Cell-to-Cell Communication in Neurospora crassa
journal, February 2019

The Genomic Landscape of Compensatory Evolution
journal, August 2014

Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts
journal, October 2014

  • Shin, Nah-Young; Choi, Hyewon; Neff, Lynn
  • The Journal of Cell Biology, Vol. 207, Issue 1
  • DOI: 10.1083/jcb.201401137

RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion
journal, February 2016

Genes which control cell proliferation in the yeast Saccharomyces cerevisiae
journal, November 1980

  • Sudbery, Peter E.; Goodey, Andrew R.; Carter, Bruce L. A.
  • Nature, Vol. 288, Issue 5789
  • DOI: 10.1038/288401a0

Rvs161p Interacts with Fus2p to Promote Cell Fusion in Saccharomyces cerevisiae
journal, May 1998

  • Brizzio, Valeria; Gammie, Alison E.; Rose, Mark D.
  • The Journal of Cell Biology, Vol. 141, Issue 3
  • DOI: 10.1083/jcb.141.3.567

Filamentous growth of the budding yeast Saccharomyces cerevisiae induced by overexpression of the WHI2 gene
journal, June 1997

The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast
journal, December 2008

Spatio-temporal MAPK dynamics mediate cell behavior coordination during fungal somatic cell fusion
journal, March 2018

  • Serrano, Antonio; Illgen, Julia; Brandt, Ulrike
  • Journal of Cell Science, Vol. 131, Issue 9
  • DOI: 10.1242/jcs.213462

Early Colony Establishment in Neurospora crassa Requires a MAP Kinase Regulatory Network
journal, September 2013

Identification and Characterization of Genes Required for Cell-to-Cell Fusion in Neurospora crassa
journal, June 2011

  • Fu, Ci; Iyer, Priyadarshini; Herkal, Amrita
  • Eukaryotic Cell, Vol. 10, Issue 8
  • DOI: 10.1128/EC.05003-11

Nuclear Dynamics, Mitosis, and the Cytoskeleton during the Early Stages of Colony Initiation in Neurospora crassa
journal, March 2010

  • Roca, M. Gabriela; Kuo, Hsiao-Che; Lichius, Alexander
  • Eukaryotic Cell, Vol. 9, Issue 8
  • DOI: 10.1128/EC.00329-09

end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae.
journal, December 1995

  • Munn, A. L.; Stevenson, B. J.; Geli, M. I.
  • Molecular Biology of the Cell, Vol. 6, Issue 12
  • DOI: 10.1091/mbc.6.12.1721

Whi2 signals low leucine availability to halt yeast growth and cell death
journal, August 2018

  • Teng, Xinchen; Yau, Eric; Sing, Cierra
  • FEMS Yeast Research, Vol. 18, Issue 8
  • DOI: 10.1093/femsyr/foy095

Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication
journal, November 2017

  • Schneider, Daniel J.; Speth, Jennifer M.; Penke, Loka R.
  • Journal of Biological Chemistry, Vol. 292, Issue 51
  • DOI: 10.1074/jbc.M117.792416

Genome-wide Consequences of Deleting Any Single Gene
journal, November 2013

Allorecognition upon Fungal Cell-Cell Contact Determines Social Cooperation and Impacts the Acquisition of Multicellularity
journal, September 2019

Membrane curvature directs the localization of Cdc42p to novel foci required for cell–cell fusion
journal, October 2017

  • Smith, Jean A.; Hall, Allison E.; Rose, Mark D.
  • The Journal of Cell Biology, Vol. 216, Issue 12
  • DOI: 10.1083/jcb.201703169

Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae.
journal, November 1994

  • Berkower, C.; Loayza, D.; Michaelis, S.
  • Molecular Biology of the Cell, Vol. 5, Issue 11
  • DOI: 10.1091/mbc.5.11.1185

The Fungal Genetics Stock Center: a repository for 50 years of fungal genetics research
journal, January 2010

NIH Image to ImageJ: 25 years of image analysis
journal, June 2012

  • Schneider, Caroline A.; Rasband, Wayne S.; Eliceiri, Kevin W.
  • Nature Methods, Vol. 9, Issue 7
  • DOI: 10.1038/nmeth.2089

The actin motor MYO-5 effect in the intracellular organization of Neurospora crassa
journal, April 2019

  • Ramírez-del Villar, Arianne; Roberson, Robert W.; Callejas-Negrete, Olga A.
  • Fungal Genetics and Biology, Vol. 125
  • DOI: 10.1016/j.fgb.2018.11.008

The NDR Kinase Scaffold HYM1/MO25 Is Essential for MAK2 MAP Kinase Signaling in Neurospora crassa
journal, September 2012

Membrane curvature and mechanisms of dynamic cell membrane remodelling
journal, November 2005

  • McMahon, Harvey T.; Gallop, Jennifer L.
  • Nature, Vol. 438, Issue 7068
  • DOI: 10.1038/nature04396

InterProScan 5: genome-scale protein function classification
journal, January 2014

The hallmarks of cell-cell fusion
journal, December 2017

  • Hernández, Javier M.; Podbilewicz, Benjamin
  • Development, Vol. 144, Issue 24
  • DOI: 10.1242/dev.155523

Ras1-Induced Hyphal Development in Candida albicans Requires the Formin Bni1
journal, October 2005

Endocytosis Is Essential for Pathogenic Development in the Corn Smut Fungus Ustilago maydis
journal, June 2006

A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors
journal, June 2006

  • Colot, H. V.; Park, G.; Turner, G. E.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 27
  • DOI: 10.1073/pnas.0601456103

Hyphal homing, fusion and mycelial interconnectedness
journal, March 2004

Confocal microscopy of FM4-64 as a tool for analysing endocytosis and vesicle trafficking in living fungal hyphae
journal, June 2000

Neurospora v. a Synthetic Medium Favoring Sexual Reproduction
journal, December 1947

A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa
journal, January 2018

Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism
journal, March 2004

Whi2 is a conserved negative regulator of TORC1 in response to low amino acids
journal, August 2018

The genome sequence of the filamentous fungus Neurospora crassa
journal, April 2003

  • Galagan, James E.; Calvo, Sarah E.; Borkovich, Katherine A.
  • Nature, Vol. 422, Issue 6934
  • DOI: 10.1038/nature01554

Fungal Communication Requires the MAK-2 Pathway Elements STE-20 and RAS-2, the NRC-1 Adapter STE-50 and the MAP Kinase Scaffold HAM-5
journal, November 2014

Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae
journal, June 2017

A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery
journal, October 2005

Multiple Functions of the Eya Phosphotyrosine Phosphatase
journal, December 2015

Global analysis of protein localization in budding yeast
journal, October 2003

  • Huh, Won-Ki; Falvo, James V.; Gerke, Luke C.
  • Nature, Vol. 425, Issue 6959
  • DOI: 10.1038/nature02026

High-Throughput Identification of Adaptive Mutations in Experimentally Evolved Yeast Populations
journal, October 2016

GFP as a tool to analyze the organization, dynamics and function of nuclei and microtubules in Neurospora crassa
journal, October 2004

  • Freitag, Michael; Hickey, Patrick C.; Raju, Namboori B.
  • Fungal Genetics and Biology, Vol. 41, Issue 10
  • DOI: 10.1016/j.fgb.2004.06.008

Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast
journal, February 2009

  • Leadsham, J. E.; Miller, K.; Ayscough, K. R.
  • Journal of Cell Science, Vol. 122, Issue 5
  • DOI: 10.1242/jcs.042424

Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis
journal, May 1999

  • Takei, Kohji; Slepnev, Vladimir I.; Haucke, Volker
  • Nature Cell Biology, Vol. 1, Issue 1
  • DOI: 10.1038/9004

Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations
journal, July 2013

  • Lang, Gregory I.; Rice, Daniel P.; Hickman, Mark J.
  • Nature, Vol. 500, Issue 7464
  • DOI: 10.1038/nature12344

Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects
journal, August 2008

  • Cheng, W-C; Teng, X.; Park, H. K.
  • Cell Death & Differentiation, Vol. 15, Issue 12
  • DOI: 10.1038/cdd.2008.117

Clathrin- and Arp2/3-Independent Endocytosis in the Fungal Pathogen Candida albicans
journal, August 2013

The social network: deciphering fungal language
journal, May 2011

  • Leeder, Abigail C.; Palma-Guerrero, Javier; Glass, N. Louise
  • Nature Reviews Microbiology, Vol. 9, Issue 6
  • DOI: 10.1038/nrmicro2580

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability
journal, October 2014

  • Pang, Hong-Bo; Braun, Gary B.; Friman, Tomas
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms5904

Clathrin localization and dynamics in Aspergillus nidulans : Clathrin in
journal, November 2016

  • Schultzhaus, Z.; Johnson, T. B.; Shaw, B. D.
  • Molecular Microbiology, Vol. 103, Issue 2
  • DOI: 10.1111/mmi.13557

Isolation of yeast mutants defective for localization of vacuolar vital dyes
journal, September 1998

  • Zheng, B.; Wu, J. N.; Schober, W.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 20
  • DOI: 10.1073/pnas.95.20.11721

Conidial anastomosis tubes in filamentous fungi
journal, August 2005

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors
journal, July 1993

  • Davis, Ng; Horecka, Jl; Sprague, Gf
  • The Journal of Cell Biology, Vol. 122, Issue 1
  • DOI: 10.1083/jcb.122.1.53

Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression
journal, June 2002

Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2
journal, March 2011

  • Mendl, N.; Occhipinti, A.; Muller, M.
  • Journal of Cell Science, Vol. 124, Issue 8
  • DOI: 10.1242/jcs.076406

Structure and Distribution of Organelles and Cellular Location of Calcium Transporters in Neurospora crassa
journal, October 2009

  • Bowman, Barry J.; Draskovic, Marija; Freitag, Michael
  • Eukaryotic Cell, Vol. 8, Issue 12
  • DOI: 10.1128/EC.00174-09

Genetic Mapping of MAPK-Mediated Complex Traits Across S. cerevisiae
journal, January 2015

Characterization of the Yeast Amphiphysins Rvs161p and Rvs167p Reveals Roles for the Rvs Heterodimer In Vivo
journal, March 2006

  • Friesen, Helena; Humphries, Christine; Ho, Yuen
  • Molecular Biology of the Cell, Vol. 17, Issue 3
  • DOI: 10.1091/mbc.e05-06-0476

Mitophagy, mitochondrial dynamics and the general stress response in yeast
journal, September 2011

  • Müller, Matthias; Reichert, Andreas S.
  • Biochemical Society Transactions, Vol. 39, Issue 5
  • DOI: 10.1042/BST0391514

Oscillatory recruitment of signaling proteins to cell tips promotes coordinated behavior during cell fusion
journal, November 2009

  • Fleissner, A.; Leeder, A. C.; Roca, M. G.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 46
  • DOI: 10.1073/pnas.0907039106