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Title: Porous Chitin Microbeads for More Sustainable Cosmetics

Abstract

The microbead form is a material architecture that is promising for use in biomedical and cosmetic applications; however, the use of petroleum-based microbeads (i.e., plastics) has raised significant environmental concerns in recent years. Microbeads prepared from renewable polymers could represent a sustainable alternative to these synthetic microbeads. This work explores the use of chitin in preparing biodegradable, biocompatible microbeads of low toxicity. Chitin microbeads were synthesized using the ionic liquid (IL) 1-ethyl-3-methylimidazo-lium acetate ([C2mim][OAc]); the IL was used to both extract chitin directly from waste shrimp shell and to prepare the porous microbeads by coagulation in polypropylene glycol (PPG). The effects of biopolymer source and bead-preparation parameters on the formation of beads were investigated, as well as the effects of the drying conditions on the dry bead structure. It was found that IL-extracted chitin could be used to prepare beads of homogeneous size distribution (with 60% of beads 125-250 μm) and shape, while commercially available practical grade chitin could not, suggesting that high molecular weight chitin is required for bead-material formation. Supercritical CO2 drying and lyophilization of the wet beads led to dry chitin beads with an opaque appearance, porous interiors, and uniform shape. Loading and release studies of representativemore » active compounds (indigo dye and sodium salicylate) into the chitin beads indicated that the dry beads could be easily loaded from an aqueous solution of active and could release 90% of the active compound within 7 h in deionized (DI) water at room temperature.« less

Authors:
 [1];  [2];  [3];  [1];  [3]; ORCiD logo [4]
  1. McGill Univ., Montreal, QC (Canada). Dept. of Chemistry
  2. Mari Signum, Ltd., Rockville, MD (United States)
  3. Univ. of Alabama, Tuscaloosa, AL (United States). Dept. of Chemistry
  4. McGill Univ., Montreal, QC (Canada). Dept. of Chemistry; Univ. of Alabama, Tuscaloosa, AL (United States). Dept. of Chemistry; 525 Solutions, Inc., Tuscaloosa, AL (United States)
Publication Date:
Research Org.:
Univ. of Alabama, Tuscaloosa, AL (United States)
Sponsoring Org.:
USDOE Office of Science (SC); Canada Excellence Research Chairs (CERC) Program
OSTI Identifier:
1593138
Alternate Identifier(s):
OSTI ID: 1593139
Grant/Contract Number:  
SC0010152
Resource Type:
Accepted Manuscript
Journal Name:
ACS Sustainable Chemistry & Engineering
Additional Journal Information:
Journal Volume: 5; Journal Issue: 12; Journal ID: ISSN 2168-0485
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Microspheres; Porous beads; Chitin; Ionic liquids; Cosmetic microbeads; Microspheres, Porous beads, Chitin, Ionic liquids, Cosmetic microbeads

Citation Formats

King, Catherine A., Shamshina, Julia L., Zavgorodnya, Oleksandra, Cutfield, Tatum, Block, Leah E., and Rogers, Robin D. Porous Chitin Microbeads for More Sustainable Cosmetics. United States: N. p., 2017. Web. doi:10.1021/acssuschemeng.7b03053.
King, Catherine A., Shamshina, Julia L., Zavgorodnya, Oleksandra, Cutfield, Tatum, Block, Leah E., & Rogers, Robin D. Porous Chitin Microbeads for More Sustainable Cosmetics. United States. https://doi.org/10.1021/acssuschemeng.7b03053
King, Catherine A., Shamshina, Julia L., Zavgorodnya, Oleksandra, Cutfield, Tatum, Block, Leah E., and Rogers, Robin D. Mon . "Porous Chitin Microbeads for More Sustainable Cosmetics". United States. https://doi.org/10.1021/acssuschemeng.7b03053. https://www.osti.gov/servlets/purl/1593138.
@article{osti_1593138,
title = {Porous Chitin Microbeads for More Sustainable Cosmetics},
author = {King, Catherine A. and Shamshina, Julia L. and Zavgorodnya, Oleksandra and Cutfield, Tatum and Block, Leah E. and Rogers, Robin D.},
abstractNote = {The microbead form is a material architecture that is promising for use in biomedical and cosmetic applications; however, the use of petroleum-based microbeads (i.e., plastics) has raised significant environmental concerns in recent years. Microbeads prepared from renewable polymers could represent a sustainable alternative to these synthetic microbeads. This work explores the use of chitin in preparing biodegradable, biocompatible microbeads of low toxicity. Chitin microbeads were synthesized using the ionic liquid (IL) 1-ethyl-3-methylimidazo-lium acetate ([C2mim][OAc]); the IL was used to both extract chitin directly from waste shrimp shell and to prepare the porous microbeads by coagulation in polypropylene glycol (PPG). The effects of biopolymer source and bead-preparation parameters on the formation of beads were investigated, as well as the effects of the drying conditions on the dry bead structure. It was found that IL-extracted chitin could be used to prepare beads of homogeneous size distribution (with 60% of beads 125-250 μm) and shape, while commercially available practical grade chitin could not, suggesting that high molecular weight chitin is required for bead-material formation. Supercritical CO2 drying and lyophilization of the wet beads led to dry chitin beads with an opaque appearance, porous interiors, and uniform shape. Loading and release studies of representative active compounds (indigo dye and sodium salicylate) into the chitin beads indicated that the dry beads could be easily loaded from an aqueous solution of active and could release 90% of the active compound within 7 h in deionized (DI) water at room temperature.},
doi = {10.1021/acssuschemeng.7b03053},
journal = {ACS Sustainable Chemistry & Engineering},
number = 12,
volume = 5,
place = {United States},
year = {2017},
month = {10}
}

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